Strain Name:
C57BL/6J-MtgxR8953Btlr/Mmmh
Stock Number:
068789-MU
Citation ID:
RRID:MMRRC_068789-MU
Other Names:
R8953 (G1)
Major Collection:

Strain Information

Rictor
Name: RPTOR independent companion of MTOR, complex 2
Synonyms: 4921505C17Rik, 6030405M08Rik, D530039E11Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78757
VEGA: 15
Homologene: 34317
Rad54l2
Name: RAD54 like 2 (S. cerevisiae)
Synonyms: Srisnf2l, G630026H09Rik, Arip4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 81000
Homologene: 56698
Etv4
Name: ets variant 4
Synonyms: Pea-3, Pea3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18612
HGNC: HGNC:3493
Homologene: 1504
Fos
Name: FBJ osteosarcoma oncogene
Synonyms: D12Rfj1, c-fos, cFos
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 14281
HGNC: HGNC:3796
Homologene: 3844
Wee1
Name: WEE 1 homolog 1 (S. pombe)
Synonyms: Wee1A
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22390
Homologene: 31152
Pik3c2a
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Synonyms: PI3KC2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18704
HGNC: HGNC:8971
Homologene: 20581
Cmklr2
Name: chemerin chemokine-like receptor 2
Synonyms: Gpr1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241070
HGNC: HGNC:4463
Homologene: 21094
Dcaf1
Name: DDB1 and CUL4 associated factor 1
Synonyms: Vprbp, B930007L02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 321006
Homologene: 8805
Mier3
Name: MIER family member 3
Synonyms: D130064H19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218613
Homologene: 18196
Znfx1
Name: zinc finger, NFX1-type containing 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 98999
Homologene: 10877
Tacc2
Name: transforming, acidic coiled-coil containing protein 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57752
Homologene: 5087
Itprid2
Name: ITPR interacting domain containing 2
Synonyms: Ssfa2, SPAG13, KRAP, CS1, CS-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70599
Homologene: 4912
Ndc1
Name: NDC1 transmembrane nucleoporin
Synonyms: Tmem48, 2810475A17Rik, sks
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72787
Homologene: 41224
Pparg
Name: peroxisome proliferator activated receptor gamma
Synonyms: PPARgamma2, PPARgamma, PPAR-gamma, Ppar-gamma2, Nr1c3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19016
HGNC: HGNC:9236
Homologene: 7899
Ralgapa1
Name: Ral GTPase activating protein, alpha subunit 1
Synonyms: Garnl1, Tulip1, 4930400K19Rik, 2310003F20Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56784
VEGA: 12
Homologene: 84805
Garem1
Name: GRB2 associated regulator of MAPK1 subtype 1
Synonyms: LOC381126, Fam59a, Garem
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 381126
VEGA: 18
Homologene: 11237
Zfp318
Name: zinc finger protein 318
Synonyms: TZF, 2610034E08Rik, D530032D06Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 57908
Homologene: 22808
Lama5
Name: laminin, alpha 5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16776
HGNC: HGNC:6485
Homologene: 4060
Abca17
Name: ATP-binding cassette, sub-family A member 17
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381072
Homologene: 86807
Havcr1
Name: hepatitis A virus cellular receptor 1
Synonyms: Tim1, TIM-1, Timd1, KIM-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 171283
Homologene: 136301
Rpn2
Name: ribophorin II
Synonyms: Rpn-2, 1300012C06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20014
Homologene: 2214
Foxo1
Name: forkhead box O1
Synonyms: Afxh, Fkhr1, FKHR, Foxo1a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56458
HGNC: HGNC:3819
Homologene: 1527
Usp33
Name: ubiquitin specific peptidase 33
Synonyms: 9830169D19Rik, Vdu1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 170822
Homologene: 8996
Ttc13
Name: tetratricopeptide repeat domain 13
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234875
Homologene: 11569
Trhde
Name: TRH-degrading enzyme
Synonyms: 9330155P21Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237553
Homologene: 75007
Atp2b2
Name: ATPase, Ca++ transporting, plasma membrane 2
Synonyms: jog, PMCA2, wms, Tmy, D6Abb2e, Gena300
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11941
HGNC: HGNC:815
Homologene: 56150
Pde4a
Name: phosphodiesterase 4A, cAMP specific
Synonyms: Dpde2, dunce, D9Ertd60e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18577
HGNC: HGNC:8780
Homologene: 4520
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Nlrp1b
Name: NLR family, pyrin domain containing 1B
Synonyms: Nalp1b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 637515
Homologene: 19080
Spta1
Name: spectrin alpha, erythrocytic 1
Synonyms: Spna1, ihj, erythroid, Spna-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20739
Homologene: 74460
Ptgdr2
Name: prostaglandin D2 receptor 2
Synonyms: PGD2 receptor, Crth2, Gpr44
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14764
HGNC: HGNC:4502
Homologene: 3508
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: LOC382552, Dnahcl1, Dnahc17, 2810003K23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Gabra2
Name: gamma-aminobutyric acid type A receptor subunit alpha 2
Synonyms: C630048P16Rik, Gabra-2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14395
HGNC: HGNC:4076
Homologene: 20217
Helz2
Name: helicase with zinc finger 2, transcriptional coactivator
Synonyms: BC006779
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 229003
Homologene: 14118
Unc13c
Name: unc-13 homolog C
Synonyms: D9Ertd414e, Munc13-3, 1500037O19Rik, Unc13h3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208898
Homologene: 45443
Man2b1
Name: mannosidase 2, alpha B1
Synonyms: lysosomal alpha-mannosidase
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17159
HGNC: HGNC:6826
Homologene: 37322
Cacna1s
Name: calcium channel, voltage-dependent, L type, alpha 1S subunit
Synonyms: Cchl1a3, Cav1.1, muscle dysgenesis, DHPR alpha1s, mdg, sj, fmd
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12292
HGNC: HGNC:1397
Homologene: 37257
Map6
Name: microtubule-associated protein 6
Synonyms: F-STOP, Mtap6, 2810411E12Rik, STOP
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17760
HGNC: HGNC:6868
Homologene: 7850
Pklr
Name: pyruvate kinase liver and red blood cell
Synonyms: R-PK, Pk1, Pk-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18770
HGNC: HGNC:9020
Homologene: 37286
Gmip
Name: Gem-interacting protein
Synonyms: 5031419I10Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 78816
Homologene: 9570
Pkn1
Name: protein kinase N1
Synonyms: PRK1, Stk3, Prkcl1, Pkn, F730027O18Rik, PAK1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 320795
HGNC: HGNC:9405
Homologene: 48130
Mertk
Name: MER proto-oncogene tyrosine kinase
Synonyms: Eyk, nmf12, Nyk, Tyro 12, Mer
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17289
HGNC: HGNC:7027
Homologene: 4626
Sh3bp4
Name: SH3-domain binding protein 4
Synonyms: BOG25
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98402
Homologene: 8726
Pip5kl1
Name: phosphatidylinositol-4-phosphate 5-kinase-like 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227733
Homologene: 45457
Kcnk3
Name: potassium channel, subfamily K, member 3
Synonyms: cTBAK-1, Task-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16527
HGNC: HGNC:6278
Homologene: 1692
Zfr2
Name: zinc finger RNA binding protein 2
Synonyms: 9130206N08Rik, 2010013I23Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103406
Homologene: 88124
Plch1
Name: phospholipase C, eta 1
Synonyms: Plcl3, PLCeta1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269437
Homologene: 88833
Rusf1
Name: RUS family member 1
Synonyms: BC017158
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233913
Homologene: 11232
Or5w15
Name: olfactory receptor family 5 subfamily W member 15
Synonyms: Olfr1138, MOR177-8, GA_x6K02T2Q125-49242149-49241214
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258632
Homologene: 74082
Rph3al
Name: rabphilin 3A-like (without C2 domains)
Synonyms: Noc2, 6530413F01Rik, LOC385671
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380714
Homologene: 5078
4930590J08Rik
Name: RIKEN cDNA 4930590J08 gene
Synonyms: LOC381798
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 381798
Homologene: 49985
Csn3
Name: casein kappa
Synonyms: Csnk, CSN10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12994
HGNC: HGNC:2446
Homologene: 3818
Or5p55
Name: olfactory receptor family 5 subfamily P member 55
Synonyms: Olfr476, MOR204-3, GA_x6K02T2PBJ9-10296787-10297719
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258926
Slc6a20b
Name: solute carrier family 6 (neurotransmitter transporter), member 20B
Synonyms: Sit1, Slc6a20, XT3, Xtrp3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22599
Homologene: 130652
Clpp
Name: caseinolytic mitochondrial matrix peptidase proteolytic subunit
Synonyms: D17Wsu160e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 53895
VEGA: 17
HGNC: HGNC:2084
Homologene: 4385
Terb1
Name: telomere repeat binding bouquet formation protein 1
Synonyms: 4930532D21Rik, Ccdc79
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 320022
Homologene: 18330
Or9a4
Name: olfactory receptor family 9 subfamily A member 4
Synonyms: Olfr460, GA_x6K02T2P3E9-6947292-6946348, MOR120-2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 258381
Homologene: 64866
Medag
Name: mesenteric estrogen dependent adipogenesis
Synonyms: 6330406I15Rik, MEDA-4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70717
Homologene: 12364
P2rx3
Name: purinergic receptor P2X, ligand-gated ion channel, 3
Synonyms: P2X3, 4930513E20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228139
HGNC: HGNC:8534
Homologene: 1922
Mapk7
Name: mitogen-activated protein kinase 7
Synonyms: big MAP kinase 1, b2b2346Clo, Erk5-T, BMK1, ERK5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 23939
HGNC: HGNC:6880
Homologene: 2060
Or2m12
Name: olfactory receptor family 2 subfamily M member 12
Synonyms: GA_x54KRFPKG5P-15738260-15737319, MOR279-2, Olfr164
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258443
Homologene: 51725
Otub2
Name: OTU domain, ubiquitin aldehyde binding 2
Synonyms: OTB2, 4930586I02Rik, 2010015L18Rik, OTU2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 68149
Homologene: 57056
Rps20
Name: ribosomal protein S20
Synonyms: Dsk4, 4632426K06Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67427
Homologene: 37417
Pramel51
Name: PRAME like 51
Synonyms: Gm10436
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 100039315
VEGA: 12
Homologene: 103830
Castor1
Name: cytosolic arginine sensor for mTORC1 subunit 1
Synonyms: 2410008K03Rik, Gatsl3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71962
Homologene: 81920
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 63,183,113 bp
  • A to G, chromosome 1 at 89,144,437 bp
  • C to T, chromosome 1 at 136,097,432 bp
  • A to G, chromosome 1 at 174,230,675 bp
  • A to G, chromosome 2 at 32,579,979 bp
  • T to A, chromosome 2 at 76,737,884 bp
  • T to C, chromosome 2 at 79,660,495 bp
  • A to G, chromosome 2 at 85,023,498 bp
  • A to T, chromosome 2 at 87,738,027 bp
  • A to G, chromosome 2 at 128,778,796 bp
  • A to G, chromosome 2 at 157,321,826 bp
  • G to A, chromosome 2 at 167,055,501 bp
  • A to G, chromosome 2 at 180,193,520 bp
  • C to T, chromosome 2 at 181,233,091 bp
  • T to C, chromosome 3 at 52,346,254 bp
  • T to G, chromosome 3 at 63,731,705 bp
  • C to T, chromosome 3 at 89,142,305 bp
  • T to A, chromosome 3 at 152,374,783 bp
  • T to A, chromosome 4 at 3,834,617 bp
  • T to A, chromosome 4 at 107,381,693 bp
  • A to C, chromosome 5 at 30,622,038 bp
  • A to T, chromosome 5 at 71,006,182 bp
  • A to G, chromosome 5 at 87,929,950 bp
  • A to G, chromosome 5 at 149,427,300 bp
  • G to T, chromosome 6 at 40,571,742 bp
  • T to C, chromosome 6 at 91,915,021 bp
  • T to A, chromosome 6 at 113,760,669 bp
  • T to C, chromosome 6 at 115,441,546 bp
  • T to C, chromosome 7 at 99,315,871 bp
  • G to A, chromosome 7 at 107,968,044 bp
  • A to G, chromosome 7 at 110,124,484 bp
  • A to T, chromosome 7 at 116,388,085 bp
  • T to G, chromosome 7 at 128,273,506 bp
  • T to C, chromosome 7 at 130,625,757 bp
  • T to G, chromosome 8 at 69,816,777 bp
  • T to C, chromosome 8 at 83,684,186 bp
  • A to G, chromosome 8 at 85,091,910 bp
  • T to A, chromosome 8 at 104,468,799 bp
  • T to C, chromosome 8 at 124,675,349 bp
  • C to A, chromosome 9 at 21,210,734 bp
  • T to A, chromosome 9 at 73,932,762 bp
  • A to T, chromosome 9 at 106,693,262 bp
  • G to A, chromosome 9 at 106,858,343 bp
  • T to C, chromosome 9 at 123,609,189 bp
  • C to A, chromosome 10 at 81,248,437 bp
  • T to A, chromosome 10 at 114,503,061 bp
  • A to T, chromosome 11 at 4,221,249 bp
  • A to G, chromosome 11 at 46,756,179 bp
  • G to T, chromosome 11 at 61,492,966 bp
  • A to G, chromosome 11 at 71,161,806 bp
  • G to T, chromosome 11 at 75,906,575 bp
  • A to G, chromosome 11 at 101,771,687 bp
  • A to T, chromosome 11 at 118,125,412 bp
  • A to G, chromosome 12 at 55,820,761 bp
  • A to G, chromosome 12 at 85,476,052 bp
  • A to G, chromosome 12 at 88,177,300 bp
  • A to T, chromosome 12 at 103,404,326 bp
  • C to A, chromosome 13 at 111,706,053 bp
  • G to A, chromosome 15 at 6,794,447 bp
  • T to A, chromosome 16 at 19,286,519 bp
  • C to A, chromosome 17 at 24,299,041 bp
  • T to A, chromosome 17 at 46,420,430 bp
  • T to A, chromosome 17 at 56,991,373 bp
  • A to T, chromosome 18 at 21,131,331 bp
  • C to T, chromosome 19 at 10,940,422 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8953 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068789-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.