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Strain Name:
C57BL/6J-MtgxR8985Btlr/Mmmh
Stock Number:
068818-MU
Citation ID:
RRID:MMRRC_068818-MU
Other Names:
R8985 (G1)
Major Collection:

Strain Information

Rgs14
Name: regulator of G-protein signaling 14
Synonyms: Rap1/rap2 interacting protein
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 51791
HGNC: HGNC:9996
Homologene: 4735
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Jade1
Name: jade family PHD finger 1
Synonyms: D530048A03Rik, Phf17
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269424
Homologene: 18162
Pds5b
Name: PDS5 cohesin associated factor B
Synonyms: AS3, Aprin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100710
Homologene: 41001
Uck2
Name: uridine-cytidine kinase 2
Synonyms: TSA903, Umpk
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 80914
Homologene: 40850
Fzd6
Name: frizzled class receptor 6
Synonyms: Fz6, rst
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14368
VEGA: 15
HGNC: HGNC:4044
Homologene: 2617
Drosha
Name: drosha, ribonuclease type III
Synonyms: 1110013A17Rik, Etohi2, Rnasen
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14000
Homologene: 8293
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 13,700,766 bp
  • T to C, chromosome 1 at 34,249,805 bp
  • C to T, chromosome 1 at 86,386,381 bp
  • T to A, chromosome 1 at 136,027,407 bp
  • T to C, chromosome 1 at 167,243,112 bp
  • G to A, chromosome 1 at 172,172,632 bp
  • T to C, chromosome 2 at 120,535,596 bp
  • T to C, chromosome 2 at 131,193,260 bp
  • T to A, chromosome 2 at 152,933,138 bp
  • T to C, chromosome 2 at 160,896,754 bp
  • A to G, chromosome 3 at 9,280,747 bp
  • T to A, chromosome 3 at 36,087,711 bp
  • A to C, chromosome 3 at 41,613,713 bp
  • G to T, chromosome 4 at 73,790,723 bp
  • A to G, chromosome 4 at 96,022,231 bp
  • T to C, chromosome 5 at 108,430,637 bp
  • T to A, chromosome 5 at 120,630,058 bp
  • C to A, chromosome 5 at 136,982,554 bp
  • T to A, chromosome 5 at 143,090,425 bp
  • T to A, chromosome 5 at 150,800,774 bp
  • T to A, chromosome 6 at 4,624,399 bp
  • T to C, chromosome 6 at 18,051,337 bp
  • T to A, chromosome 6 at 29,440,500 bp
  • A to G, chromosome 6 at 90,108,035 bp
  • T to A, chromosome 6 at 140,016,177 bp
  • C to G, chromosome 6 at 143,195,227 bp
  • A to G, chromosome 7 at 6,238,835 bp
  • A to C, chromosome 7 at 10,046,047 bp
  • A to G, chromosome 7 at 37,568,803 bp
  • A to G, chromosome 7 at 41,399,835 bp
  • A to G, chromosome 7 at 58,788,344 bp
  • C to A, chromosome 7 at 76,320,156 bp
  • TCCCAGG to T, chromosome 7 at 80,098,331 bp
  • A to T, chromosome 7 at 104,012,160 bp
  • A to G, chromosome 7 at 107,197,229 bp
  • A to T, chromosome 8 at 36,993,666 bp
  • T to A, chromosome 8 at 47,878,884 bp
  • T to G, chromosome 8 at 70,402,442 bp
  • G to T, chromosome 8 at 90,994,473 bp
  • T to C, chromosome 8 at 117,038,110 bp
  • A to G, chromosome 9 at 10,171,955 bp
  • A to T, chromosome 9 at 38,658,325 bp
  • T to A, chromosome 9 at 64,288,103 bp
  • G to A, chromosome 9 at 103,072,635 bp
  • T to C, chromosome 9 at 110,256,434 bp
  • A to G, chromosome 10 at 41,556,106 bp
  • A to T, chromosome 10 at 86,731,092 bp
  • G to A, chromosome 10 at 108,412,000 bp
  • T to C, chromosome 10 at 128,387,109 bp
  • C to T, chromosome 11 at 50,855,710 bp
  • T to C, chromosome 11 at 73,375,426 bp
  • T to A, chromosome 11 at 94,513,896 bp
  • C to A, chromosome 11 at 102,465,462 bp
  • T to C, chromosome 11 at 106,250,769 bp
  • T to C, chromosome 12 at 35,526,737 bp
  • A to G, chromosome 12 at 81,179,487 bp
  • T to C, chromosome 12 at 113,258,991 bp
  • G to A, chromosome 13 at 55,383,421 bp
  • A to G, chromosome 13 at 93,097,156 bp
  • A to T, chromosome 13 at 113,059,796 bp
  • A to T, chromosome 14 at 51,130,175 bp
  • A to G, chromosome 14 at 87,506,161 bp
  • A to C, chromosome 14 at 113,315,324 bp
  • G to T, chromosome 15 at 12,924,101 bp
  • A to T, chromosome 15 at 39,031,624 bp
  • A to C, chromosome 15 at 74,979,957 bp
  • A to T, chromosome 16 at 18,072,498 bp
  • G to T, chromosome 17 at 71,806,532 bp
  • C to T, chromosome 17 at 73,921,351 bp
  • T to C, chromosome 18 at 22,952,237 bp
  • T to C, chromosome 18 at 52,869,097 bp
  • C to T, chromosome 19 at 11,254,691 bp
  • A to G, chromosome 19 at 39,563,975 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R8985 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068818-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.