Strain Name:
C57BL/6J-MtgxR9181Btlr/Mmmh
Stock Number:
069031-MU
Citation ID:
RRID:MMRRC_069031-MU
Other Names:
R9181 (G1)
Major Collection:

Strain Information

Lmf1
Name: lipase maturation factor 1
Synonyms: Tmem112, 2400010G15Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 76483
Homologene: 23384
Tert
Name: telomerase reverse transcriptase
Synonyms: TR
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21752
VEGA: 13
Homologene: 31141
Gsta4
Name: glutathione S-transferase, alpha 4
Synonyms: mGsta4, GST 5.7
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 14860
VEGA: 9
Homologene: 135605
Acvr2a
Name: activin receptor IIA
Synonyms: ActRIIa, tActRII, Acvr2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11480
HGNC: HGNC:173
Homologene: 20391
Dst
Name: dystonin
Synonyms: A830042E19Rik, nmf339, bullous pemphigoid antigen 1, Bpag1, 2310001O04Rik, Bpag, Macf2, BPAG1, BPAG1-n, athetoid, bullous pemphigoid antigen 1, ah, nmf203
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Trim13
Name: tripartite motif-containing 13
Synonyms: RNF77, Rfp2, LEU5, 3110001L12Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66597
VEGA: 14
HGNC: HGNC:9976
Homologene: 4234
Pmpca
Name: peptidase (mitochondrial processing) alpha
Synonyms: INPP5E, 4933435E07Rik, Alpha-MPP
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66865
Homologene: 6078
Znfx1
Name: zinc finger, NFX1-type containing 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 98999
Homologene: 10877
Mbtd1
Name: mbt domain containing 1
Synonyms: hemp
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103537
Homologene: 41185
Xdh
Name: xanthine dehydrogenase
Synonyms: Xox1, Xox-1, xanthine oxidase, Xor, XO
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22436
VEGA: 17
Homologene: 324
Ankrd28
Name: ankyrin repeat domain 28
Synonyms: E430019N21Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105522
VEGA: 14
Homologene: 35374
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: SYNE-1, A330049M09Rik, enaptin165, nesprin-1, C130039F11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Dbf4
Name: DBF4 zinc finger
Synonyms: Ask
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 27214
Homologene: 40892
Polg
Name: polymerase (DNA directed), gamma
Synonyms: polymerase gamma, mitochondrial DNA polymerase-gamma, mitochondrial DNA polymerase gamma, Pol gamma, Polga
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18975
HGNC: HGNC:9179
Homologene: 2016
Ckmt1
Name: creatine kinase, mitochondrial 1, ubiquitous
Synonyms: Mt-CK, mi-CK, UbCKmit
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12716
Homologene: 69058
Minar1
Name: membrane integral NOTCH2 associated receptor 1
Synonyms: AF529169, DD1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 209743
Homologene: 17782
Fan1
Name: FANCD2/FANCI-associated nuclease 1
Synonyms: Mtmr15, 6030441H18Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330554
Homologene: 45598
Adam30
Name: a disintegrin and metallopeptidase domain 30
Synonyms: 4933424D07Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71078
HGNC: HGNC:208
Homologene: 11038
Wdr36
Name: WD repeat domain 36
Synonyms: 5730444A13Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225348
VEGA: 18
Homologene: 6536
Svil
Name: supervillin
Synonyms: B430302E16Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225115
Homologene: 25090
Gemin5
Name: gem nuclear organelle associated protein 5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216766
Homologene: 9155
Retnlb
Name: resistin like beta
Synonyms: 9030012B21Rik, Relmb, RELMbeta, Xcp3, Fizz2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 57263
VEGA: 16
Homologene: 10735
Mgat4c
Name: MGAT4 family, member C
Synonyms: 9130411I17Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67569
Homologene: 8297
Zyx
Name: zyxin
Synonyms: R75157
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22793
Homologene: 31164
Col13a1
Name: collagen, type XIII, alpha 1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12817
HGNC: HGNC:2190
Homologene: 22421
Bbs1
Name: Bardet-Biedl syndrome 1
Synonyms: D19Ertd609e
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 52028
VEGA: 19
HGNC: HGNC:966
Homologene: 11641
Kif27
Name: kinesin family member 27
Synonyms: 4930517I18Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75050
VEGA: 13
Homologene: 69235
Pkd1l3
Name: polycystic kidney disease 1 like 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244646
Homologene: 14627
F5
Name: coagulation factor V
Synonyms: Cf5, Cf-5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14067
HGNC: HGNC:3542
Homologene: 104
Rufy2
Name: RUN and FYVE domain-containing 2
Synonyms: ZFYVE13, 2610111M19Rik, Denn, LZ-FYVE
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70432
Homologene: 23064
Ildr2
Name: immunoglobulin-like domain containing receptor 2
Synonyms: 2810478N18Rik, 3110063L10Rik, ENSMUSG00000040612, OTTMUSG00000021748, Dbsm1, D1Ertd471e
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100039795
Homologene: 52388
Ssc5d
Name: scavenger receptor cysteine rich family, 5 domains
Synonyms: A430110N23Rik, s5d-srcrb
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269855
Homologene: 77555
Nlrp10
Name: NLR family, pyrin domain containing 10
Synonyms: Pynod, Nalp10, 6430548I20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244202
Homologene: 18468
Disp2
Name: dispatched RND transporter family member 2
Synonyms: DispB, B230210L08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214240
Homologene: 24916
Abcg3
Name: ATP binding cassette subfamily G member 3
Synonyms: Abcp2, Mxr2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 27405
HGNC: HGNC:74
Homologene: 86845
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: Dnahc7b, LOC227058
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227058
Homologene: 41287
Col15a1
Name: collagen, type XV, alpha 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12819
HGNC: HGNC:2192
Homologene: 1396
Mocs1
Name: molybdenum cofactor synthesis 1
Synonyms: 3110045D15Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 56738
HGNC: HGNC:7190
Homologene: 4343
Radil
Name: Ras association and DIL domains
Synonyms: D930005D10Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231858
Homologene: 77648
Plekhg6
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 6
Synonyms: LOC213522
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 213522
Homologene: 32395
Nlrp4e
Name: NLR family, pyrin domain containing 4E
Synonyms: 4930406H16Rik, Nalp-epsilon, Nalp4e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 446099
Homologene: 75315
Ap3m2
Name: adaptor-related protein complex 3, mu 2 subunit
Synonyms: 5830445E16Rik, AP-3B
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 64933
HGNC: HGNC:570
Homologene: 4950
Zfp971
Name: zinc finger protein 971
Synonyms: Etohi1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 626848
Homologene: 134324
H2-M3
Name: histocompatibility 2, M region locus 3
Synonyms: Hmt, R4B2, H-2M3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14991
HGNC: HGNC:4964
Homologene: 133255
Pigu
Name: phosphatidylinositol glycan anchor biosynthesis, class U
Synonyms: Cdc91l1, 5430426F17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228812
Homologene: 6553
Mettl25b
Name: methyltransferase like 25B
Synonyms: Rrnad1, BC023814
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229503
Homologene: 9332
Apoc4
Name: apolipoprotein C-IV
Synonyms: Acl
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11425
HGNC: HGNC:611
Homologene: 1245
Tpbgl
Name: trophoblast glycoprotein-like
Synonyms: Gm4980
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100503386
Homologene: 47844
Zscan4c
Name: zinc finger and SCAN domain containing 4C
Synonyms: LOC245109
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 245109
Homologene: 85986
Or4s2
Name: olfactory receptor family 4 subfamily S member 2
Synonyms: GA_x6K02T2Q125-50121628-50122030, Olfr526-ps1, GA_x6K02T2PRF0-44595-45531, MOR230-9, Olfr1191
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 404399
Cfap99
Name: cilia and flagella associated protein 99
Synonyms: Gm21446
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100862066
Homologene: 82544
Traj13
Name: T cell receptor alpha joining 13
Synonyms: Gm16660
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100124390
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • T to A, chromosome 1 at 34,192,737 bp (GRCm38)
  • T to C, chromosome 1 at 46,142,034 bp (GRCm38)
  • A to G, chromosome 1 at 164,192,326 bp (GRCm38)
  • A to T, chromosome 1 at 166,294,714 bp (GRCm38)
  • T to C, chromosome 2 at 26,393,353 bp (GRCm38)
  • T to A, chromosome 2 at 48,870,295 bp (GRCm38)
  • T to C, chromosome 2 at 88,643,004 bp (GRCm38)
  • T to A, chromosome 2 at 118,786,912 bp (GRCm38)
  • T to A, chromosome 2 at 121,359,389 bp (GRCm38)
  • T to C, chromosome 2 at 155,299,189 bp (GRCm38)
  • C to T, chromosome 2 at 167,037,818 bp (GRCm38)
  • T to A, chromosome 2 at 167,038,217 bp (GRCm38)
  • T to C, chromosome 2 at 178,032,943 bp (GRCm38)
  • A to G, chromosome 3 at 87,928,085 bp (GRCm38)
  • C to G, chromosome 3 at 98,162,878 bp (GRCm38)
  • G to C, chromosome 4 at 47,288,200 bp (GRCm38)
  • A to T, chromosome 4 at 88,850,216 bp (GRCm38)
  • A to G, chromosome 5 at 8,412,206 bp (GRCm38)
  • A to T, chromosome 5 at 34,314,258 bp (GRCm38)
  • A to T, chromosome 5 at 95,270,555 bp (GRCm38)
  • G to T, chromosome 5 at 104,974,096 bp (GRCm38)
  • A to G, chromosome 5 at 142,494,967 bp (GRCm38)
  • T to A, chromosome 6 at 42,357,884 bp (GRCm38)
  • A to C, chromosome 6 at 125,378,891 bp (GRCm38)
  • A to G, chromosome 7 at 4,942,815 bp (GRCm38)
  • A to G, chromosome 7 at 11,009,814 bp (GRCm38)
  • A to G, chromosome 7 at 19,678,740 bp (GRCm38)
  • C to T, chromosome 7 at 23,361,845 bp (GRCm38)
  • A to G, chromosome 7 at 64,366,652 bp (GRCm38)
  • A to T, chromosome 7 at 79,454,673 bp (GRCm38)
  • A to T, chromosome 7 at 99,625,569 bp (GRCm38)
  • A to T, chromosome 7 at 108,924,901 bp (GRCm38)
  • A to G, chromosome 8 at 22,799,758 bp (GRCm38)
  • T to A, chromosome 8 at 109,648,686 bp (GRCm38)
  • A to G, chromosome 9 at 78,198,315 bp (GRCm38)
  • A to G, chromosome 9 at 89,603,341 bp (GRCm38)
  • T to C, chromosome 10 at 5,113,994 bp (GRCm38)
  • T to C, chromosome 10 at 61,867,833 bp (GRCm38)
  • A to T, chromosome 10 at 63,000,387 bp (GRCm38)
  • A to T, chromosome 10 at 102,389,262 bp (GRCm38)
  • C to T, chromosome 11 at 58,130,209 bp (GRCm38)
  • A to G, chromosome 11 at 93,912,415 bp (GRCm38)
  • G to T, chromosome 13 at 58,344,729 bp (GRCm38)
  • A to T, chromosome 13 at 73,637,175 bp (GRCm38)
  • A to C, chromosome 14 at 31,748,670 bp (GRCm38)
  • G to A, chromosome 14 at 54,205,791 bp (GRCm38)
  • G to A, chromosome 14 at 61,604,597 bp (GRCm38)
  • A to G, chromosome 16 at 48,818,721 bp (GRCm38)
  • T to A, chromosome 17 at 25,585,744 bp (GRCm38)
  • C to A, chromosome 17 at 37,272,281 bp (GRCm38)
  • T to A, chromosome 17 at 49,449,773 bp (GRCm38)
  • G to A, chromosome 17 at 73,925,011 bp (GRCm38)
  • C to A, chromosome 18 at 5,090,833 bp (GRCm38)
  • T to C, chromosome 18 at 32,848,329 bp (GRCm38)
  • A to C, chromosome 19 at 4,891,042 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9181 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069031-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.