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Strain Name:
C57BL/6J-MtgxR9234Btlr/Mmmh
Stock Number:
069064-MU
Citation ID:
RRID:MMRRC_069064-MU
Other Names:
R9234 (G1)
Major Collection:

Strain Information

Smco3
Name: single-pass membrane protein with coiled-coil domains 3
Synonyms: C030030A07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 654818
Homologene: 79087
Nlgn3
Name: neuroligin 3
Synonyms: HNL3, A230085M13Rik, NL3, NLG3
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 245537
Homologene: 23133
Crkl
Name: v-crk avian sarcoma virus CT10 oncogene homolog-like
Synonyms: Crkol, 1110025F07Rik, snoop
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12929
HGNC: HGNC:2363
Homologene: 38021
Fzd9
Name: frizzled class receptor 9
Synonyms: mfz9, frizzled 9, Fz9
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14371
HGNC: HGNC:4047
Homologene: 2619
Ntrk1
Name: neurotrophic tyrosine kinase, receptor, type 1
Synonyms: TrkA, Tkr
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18211
HGNC: HGNC:8031
Homologene: 1898
Arid5b
Name: AT-rich interaction domain 5B
Synonyms: 5430435G07Rik, Desrt, Mrf2beta, Mrf2alpha, Mrf2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71371
VEGA: 10
Homologene: 45872
Snx4
Name: sorting nexin 4
Synonyms: 1810036H14Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 69150
VEGA: 16
Homologene: 36143
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • T to A, chromosome 1 at 39,990,101 bp (GRCm38)
  • A to T, chromosome 1 at 172,698,846 bp (GRCm38)
  • G to T, chromosome 2 at 32,578,199 bp (GRCm38)
  • G to A, chromosome 2 at 69,897,646 bp (GRCm38)
  • A to G, chromosome 2 at 156,003,878 bp (GRCm38)
  • A to G, chromosome 3 at 87,788,315 bp (GRCm38)
  • G to T, chromosome 3 at 96,140,460 bp (GRCm38)
  • G to T, chromosome 4 at 145,149,222 bp (GRCm38)
  • C to A, chromosome 4 at 152,132,923 bp (GRCm38)
  • T to A, chromosome 5 at 75,163,601 bp (GRCm38)
  • T to C, chromosome 5 at 106,893,468 bp (GRCm38)
  • G to T, chromosome 5 at 110,363,384 bp (GRCm38)
  • G to A, chromosome 5 at 112,378,039 bp (GRCm38)
  • A to T, chromosome 5 at 114,761,621 bp (GRCm38)
  • A to C, chromosome 5 at 124,741,925 bp (GRCm38)
  • A to C, chromosome 5 at 135,250,686 bp (GRCm38)
  • G to A, chromosome 6 at 113,702,722 bp (GRCm38)
  • C to A, chromosome 6 at 118,398,083 bp (GRCm38)
  • T to A, chromosome 6 at 136,831,412 bp (GRCm38)
  • A to T, chromosome 6 at 148,842,839 bp (GRCm38)
  • C to A, chromosome 7 at 4,142,248 bp (GRCm38)
  • G to T, chromosome 7 at 28,364,790 bp (GRCm38)
  • A to G, chromosome 7 at 42,012,483 bp (GRCm38)
  • A to G, chromosome 7 at 44,313,155 bp (GRCm38)
  • C to T, chromosome 7 at 88,074,232 bp (GRCm38)
  • A to G, chromosome 7 at 100,399,805 bp (GRCm38)
  • T to A, chromosome 7 at 103,660,743 bp (GRCm38)
  • A to G, chromosome 7 at 104,960,444 bp (GRCm38)
  • A to T, chromosome 8 at 4,748,800 bp (GRCm38)
  • C to A, chromosome 8 at 25,594,086 bp (GRCm38)
  • A to T, chromosome 8 at 28,760,849 bp (GRCm38)
  • A to G, chromosome 8 at 70,190,086 bp (GRCm38)
  • T to A, chromosome 8 at 124,883,440 bp (GRCm38)
  • A to T, chromosome 9 at 5,303,128 bp (GRCm38)
  • A to G, chromosome 9 at 95,678,386 bp (GRCm38)
  • A to G, chromosome 10 at 68,128,798 bp (GRCm38)
  • T to C, chromosome 11 at 60,710,130 bp (GRCm38)
  • T to A, chromosome 11 at 66,033,925 bp (GRCm38)
  • T to C, chromosome 11 at 87,145,567 bp (GRCm38)
  • A to T, chromosome 11 at 98,552,572 bp (GRCm38)
  • T to A, chromosome 11 at 119,450,117 bp (GRCm38)
  • C to T, chromosome 12 at 101,845,731 bp (GRCm38)
  • A to T, chromosome 12 at 117,987,360 bp (GRCm38)
  • T to C, chromosome 13 at 49,070,798 bp (GRCm38)
  • C to A, chromosome 13 at 53,111,338 bp (GRCm38)
  • A to G, chromosome 14 at 47,290,259 bp (GRCm38)
  • A to T, chromosome 14 at 54,511,217 bp (GRCm38)
  • T to A, chromosome 14 at 65,551,471 bp (GRCm38)
  • A to T, chromosome 14 at 72,458,346 bp (GRCm38)
  • A to G, chromosome 15 at 41,103,074 bp (GRCm38)
  • A to G, chromosome 15 at 103,251,209 bp (GRCm38)
  • A to G, chromosome 16 at 17,468,958 bp (GRCm38)
  • T to C, chromosome 16 at 32,360,077 bp (GRCm38)
  • C to A, chromosome 16 at 33,266,791 bp (GRCm38)
  • T to A, chromosome 16 at 33,287,699 bp (GRCm38)
  • T to C, chromosome 16 at 59,036,426 bp (GRCm38)
  • A to T, chromosome 16 at 87,397,201 bp (GRCm38)
  • T to A, chromosome 16 at 94,364,663 bp (GRCm38)
  • A to G, chromosome 16 at 97,578,621 bp (GRCm38)
  • C to T, chromosome 17 at 48,463,630 bp (GRCm38)
  • T to C, chromosome 18 at 23,804,179 bp (GRCm38)
  • A to T, chromosome 18 at 31,957,890 bp (GRCm38)
  • T to C, chromosome 18 at 37,320,642 bp (GRCm38)
  • T to A, chromosome 18 at 61,061,228 bp (GRCm38)
  • T to C, chromosome X at 101,308,784 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9234 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069064-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.