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Strain Name:
C57BL/6J-MtgxR9281Btlr/Mmmh
Stock Number:
069100-MU
Citation ID:
RRID:MMRRC_069100-MU
Other Names:
R9281 (G1)
Major Collection:

Strain Information

Slc12a6
Name: solute carrier family 12, member 6
Synonyms: KCC3, gaxp
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 107723
Homologene: 21069
Slc26a5
Name: solute carrier family 26, member 5
Synonyms: Pres, prestin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 80979
HGNC: HGNC:9359
Homologene: 69472
Kat2b
Name: K(lysine) acetyltransferase 2B
Synonyms: A930006P13Rik, Pcaf
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18519
HGNC: HGNC:8638
Homologene: 20834
Ano1
Name: anoctamin 1, calcium activated chloride channel
Synonyms: Tmem16a
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101772
Homologene: 75079
Ctdspl2
Name: CTD small phosphatase like 2
Synonyms: D2Ertd485e, SCP4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329506
Homologene: 32311
St13
Name: suppression of tumorigenicity 13
Synonyms: PRO0786, HSPABP1, SNC6, p48, Hsp70 interacting protein, 3110002K08Rik, 1110007I03Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70356
Homologene: 2921
Plxna1
Name: plexin A1
Synonyms: NOV, Plxn1, 2600013D04Rik, PlexA1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18844
HGNC: HGNC:9099
Homologene: 56426
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • G to A, chromosome 1 at 9,924,200 bp (GRCm38)
  • C to G, chromosome 1 at 37,371,769 bp (GRCm38)
  • A to G, chromosome 1 at 74,568,572 bp (GRCm38)
  • T to G, chromosome 1 at 174,219,878 bp (GRCm38)
  • C to A, chromosome 2 at 26,324,476 bp (GRCm38)
  • A to G, chromosome 2 at 29,065,890 bp (GRCm38)
  • A to T, chromosome 2 at 71,138,391 bp (GRCm38)
  • A to G, chromosome 2 at 76,789,582 bp (GRCm38)
  • A to G, chromosome 2 at 87,491,151 bp (GRCm38)
  • A to G, chromosome 2 at 112,334,409 bp (GRCm38)
  • A to G, chromosome 2 at 122,010,582 bp (GRCm38)
  • G to A, chromosome 2 at 150,117,695 bp (GRCm38)
  • T to A, chromosome 2 at 177,831,804 bp (GRCm38)
  • A to T, chromosome 3 at 93,773,584 bp (GRCm38)
  • A to G, chromosome 3 at 157,567,453 bp (GRCm38)
  • C to A, chromosome 4 at 12,079,962 bp (GRCm38)
  • G to T, chromosome 4 at 45,284,127 bp (GRCm38)
  • A to C, chromosome 4 at 87,789,329 bp (GRCm38)
  • A to G, chromosome 4 at 118,138,531 bp (GRCm38)
  • A to G, chromosome 4 at 118,709,395 bp (GRCm38)
  • A to G, chromosome 4 at 122,872,433 bp (GRCm38)
  • T to A, chromosome 5 at 21,814,053 bp (GRCm38)
  • A to G, chromosome 5 at 21,948,547 bp (GRCm38)
  • C to T, chromosome 5 at 62,749,505 bp (GRCm38)
  • C to A, chromosome 5 at 109,156,087 bp (GRCm38)
  • T to C, chromosome 6 at 85,341,852 bp (GRCm38)
  • A to G, chromosome 6 at 89,323,331 bp (GRCm38)
  • A to T, chromosome 6 at 127,091,194 bp (GRCm38)
  • T to A, chromosome 7 at 3,412,092 bp (GRCm38)
  • A to T, chromosome 7 at 7,291,814 bp (GRCm38)
  • G to T, chromosome 7 at 11,065,662 bp (GRCm38)
  • A to G, chromosome 7 at 27,191,626 bp (GRCm38)
  • A to G, chromosome 7 at 41,624,760 bp (GRCm38)
  • A to T, chromosome 7 at 67,736,300 bp (GRCm38)
  • A to T, chromosome 7 at 144,595,581 bp (GRCm38)
  • T to C, chromosome 8 at 25,662,945 bp (GRCm38)
  • G to T, chromosome 8 at 35,590,797 bp (GRCm38)
  • T to A, chromosome 8 at 70,620,596 bp (GRCm38)
  • T to A, chromosome 8 at 94,636,631 bp (GRCm38)
  • A to G, chromosome 9 at 50,522,553 bp (GRCm38)
  • T to C, chromosome 9 at 71,586,200 bp (GRCm38)
  • C to T, chromosome 9 at 73,084,996 bp (GRCm38)
  • T to C, chromosome 9 at 75,776,574 bp (GRCm38)
  • T to A, chromosome 9 at 80,254,882 bp (GRCm38)
  • A to T, chromosome 9 at 110,100,915 bp (GRCm38)
  • A to T, chromosome 10 at 79,542,460 bp (GRCm38)
  • T to A, chromosome 11 at 3,863,375 bp (GRCm38)
  • C to G, chromosome 11 at 35,889,384 bp (GRCm38)
  • C to T, chromosome 11 at 43,225,631 bp (GRCm38)
  • T to A, chromosome 11 at 73,589,307 bp (GRCm38)
  • T to C, chromosome 11 at 120,860,587 bp (GRCm38)
  • C to T, chromosome 12 at 50,489,975 bp (GRCm38)
  • G to A, chromosome 12 at 71,158,913 bp (GRCm38)
  • G to A, chromosome 12 at 84,791,090 bp (GRCm38)
  • A to G, chromosome 12 at 107,915,998 bp (GRCm38)
  • G to A, chromosome 12 at 116,248,057 bp (GRCm38)
  • A to G, chromosome 13 at 21,394,875 bp (GRCm38)
  • A to C, chromosome 13 at 54,733,890 bp (GRCm38)
  • A to T, chromosome 13 at 74,323,937 bp (GRCm38)
  • G to T, chromosome 13 at 108,183,830 bp (GRCm38)
  • A to T, chromosome 13 at 112,909,909 bp (GRCm38)
  • A to G, chromosome 13 at 112,941,706 bp (GRCm38)
  • T to A, chromosome 14 at 53,105,287 bp (GRCm38)
  • T to C, chromosome 14 at 72,561,657 bp (GRCm38)
  • A to G, chromosome 15 at 10,978,521 bp (GRCm38)
  • A to C, chromosome 15 at 47,596,876 bp (GRCm38)
  • A to T, chromosome 15 at 71,861,071 bp (GRCm38)
  • A to T, chromosome 15 at 81,377,726 bp (GRCm38)
  • T to A, chromosome 17 at 13,804,008 bp (GRCm38)
  • A to G, chromosome 17 at 53,624,397 bp (GRCm38)
  • T to C, chromosome 17 at 87,395,243 bp (GRCm38)
  • C to T, chromosome 18 at 10,080,479 bp (GRCm38)
  • T to C, chromosome 18 at 80,697,975 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9281 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069100-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.