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Strain Name:
C57BL/6J-MtgxR9291Btlr/Mmmh
Stock Number:
069110-MU
Citation ID:
RRID:MMRRC_069110-MU
Other Names:
R9291 (G1)
Major Collection:

Strain Information

Nefh
Name: neurofilament, heavy polypeptide
Synonyms: NF-H, NF200, NEFH
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380684
HGNC: HGNC:7737
Homologene: 40755
Sgcd
Name: sarcoglycan, delta (dystrophin-associated glycoprotein)
Synonyms: delta-SG
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 24052
Homologene: 285
Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: Megalin, Gp330, D230004K18Rik, b2b1625.2Clo
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Cenpv
Name: centromere protein V
Synonyms: 3110013H01Rik, Prr6
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 73139
Homologene: 42965
Atp6v1h
Name: ATPase, H+ transporting, lysosomal V1 subunit H
Synonyms: 0710001F19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108664
Homologene: 7139
Dscaml1
Name: DS cell adhesion molecule like 1
Synonyms: 4930435C18Rik, 4921507G06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 114873
VEGA: 9
Homologene: 79549
Swt1
Name: SWT1 RNA endoribonuclease homolog (S. cerevisiae)
Synonyms: 1200016B10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66875
Homologene: 32355
Dis3l2
Name: DIS3 like 3'-5' exoribonuclease 2
Synonyms: 8030493P09Rik, 4930429A22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 208718
Homologene: 62417
Tom1l2
Name: target of myb1-like 2 (chicken)
Synonyms: 2900016I08Rik, myb1-like protein 2, A730055F12Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216810
Homologene: 44901
Slx4ip
Name: SLX4 interacting protein
Synonyms: 2410004I22Rik, 2210009G21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74243
Homologene: 49913
Nup214
Name: nucleoporin 214
Synonyms: D2H9S46E, CAN
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227720
HGNC: HGNC:8064
Homologene: 38008
Abcg5
Name: ATP binding cassette subfamily G member 5
Synonyms: Sterolin-1, trac, cmp
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 27409
Homologene: 31909
Ehd4
Name: EH-domain containing 4
Synonyms: 2210022F10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 98878
HGNC: HGNC:3245
Homologene: 26430
Exosc2
Name: exosome component 2
Synonyms: Rrp4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227715
Homologene: 6095
Vps13b
Name: vacuolar protein sorting 13B
Synonyms: 1810042B05Rik, Coh1, C330002D13Rik, 2310042E16Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 666173
VEGA: 15
HGNC: HGNC:2183
Homologene: 49516
Epg5
Name: ectopic P-granules 5 autophagy tethering factor
Synonyms: 5430411K18Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 100502841
VEGA: 18
Homologene: 14575
Fam193a
Name: family with sequence homology 193, member A
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231128
Homologene: 2746
Trpv4
Name: transient receptor potential cation channel, subfamily V, member 4
Synonyms: VR-OAC, Trp12, 0610033B08Rik, OTRPC4, VROAC, VRL-2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 63873
Homologene: 11003
Kank4
Name: KN motif and ankyrin repeat domains 4
Synonyms: Ankrd38
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242553
Homologene: 18244
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, P1-Loop, Dnahc8
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Elac2
Name: elaC ribonuclease Z 2
Synonyms: 1110017O07Rik, D11Wsu80e, tRNase Z(L)
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68626
Homologene: 6403
Hectd4
Name: HECT domain E3 ubiquitin protein ligase 4
Synonyms: Gm15800
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269700
Homologene: 28297
Papln
Name: papilin, proteoglycan-like sulfated glycoprotein
Synonyms: E030033C16Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 170721
Homologene: 71541
Dennd6b
Name: DENN domain containing 6B
Synonyms: 1700027J05Rik, Fam116b
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 69440
VEGA: 15
Homologene: 57065
Kcnu1
Name: potassium channel, subfamily U, member 1
Synonyms: Slo3, Kcnma3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16532
Homologene: 7392
Trak2
Name: trafficking protein, kinesin binding 2
Synonyms: GRIF-1, CALS-C, OIP98, GRIF1, 4733401O11Rik, Als2cr3, 2900022D04Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70827
Homologene: 22861
Dnah11
Name: dynein, axonemal, heavy chain 11
Synonyms: lrd, b2b598Clo, b2b1289Clo, b2b1727Clo, b2b1203Clo, b2b1279Clo, Dnahc11, avc4
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13411
HGNC: HGNC:2942
Homologene: 2801
Col27a1
Name: collagen, type XXVII, alpha 1
Synonyms: 5730512J02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 373864
Homologene: 69400
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: D86 mRNA, PKHDL1, fibrocystin L
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 192190
Homologene: 16332
Slc44a5
Name: solute carrier family 44, member 5
Synonyms: LOC242259
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242259
Homologene: 72094
Rims1
Name: regulating synaptic membrane exocytosis 1
Synonyms: RIM1, RIM1a, C030033M19Rik, RIM1alpha
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 116837
Homologene: 128399
Nlrp9b
Name: NLR family, pyrin domain containing 9B
Synonyms: Nalp9b, Nalp-delta
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243874
Homologene: 18530
Entpd6
Name: ectonucleoside triphosphate diphosphohydrolase 6
Synonyms: NTPDase-6, Cd39l2, 2700026H11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12497
HGNC: HGNC:3368
Homologene: 68170
Irf2bp1
Name: interferon regulatory factor 2 binding protein 1
Synonyms: 6330414O09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 272359
Homologene: 32276
Vmn1r194
Name: vomeronasal 1 receptor 194
Synonyms: Gm11294
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 626299
Homologene: 110880
Tbc1d9
Name: TBC1 domain family, member 9
Synonyms: C76116, 4933431N12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71310
Homologene: 57079
Moxd2
Name: monooxygenase, DBH-like 2
Synonyms: Dbhl1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 194357
Homologene: 77226
Sspo
Name: SCO-spondin
Synonyms: C79529, Scospondin
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243369
Homologene: 45453
Vmn1r228
Name: vomeronasal 1 receptor 228
Synonyms: V1re3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 171226
Homologene: 74320
Pop7
Name: processing of precursor 7, ribonuclease P family, (S. cerevisiae)
Synonyms: 0610037N12Rik, Rpp20
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74097
Homologene: 4262
Or8k53
Name: olfactory receptor family 8 subfamily K member 53
Synonyms: GA_x6K02T2Q125-47819205-47818258, MOR186-1, Olfr1055
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259023
Homologene: 131140
Dlg5
Name: discs large MAGUK scaffold protein 5
Synonyms: 4933429D20Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 71228
HGNC: HGNC:2904
Homologene: 3486
Tbx18
Name: T-box18
Synonyms: 2810012F10Rik, 2810404D13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 76365
Homologene: 11384
Cdcp2
Name: CUB domain containing protein 2
Synonyms: D030010E02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242603
Homologene: 138406
Rchy1
Name: ring finger and CHY zinc finger domain containing 1
Synonyms: PRO1996, 6720407C15Rik, Zfp363, Pirh2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68098
Homologene: 22894
Zdhhc14
Name: zinc finger, DHHC domain containing 14
Synonyms: New1cp, B530001K09Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224454
VEGA: 17
Homologene: 62301
Pramel26
Name: PRAME like 26
Synonyms: Gm13084
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381569
Homologene: 77858
Zyg11b
Name: zyg-ll family member B, cell cycle regulator
Synonyms: LOC242610, 1110046I03Rik, D4Mgi23, 2810482G21Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 414872
Homologene: 14600
Kndc1
Name: kinase non-catalytic C-lobe domain (KIND) containing 1
Synonyms: VKIND, very-kind, 2410012C07Rik, B830014K08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76484
Homologene: 45138
Otud4
Name: OTU domain containing 4
Synonyms: 4930431L18Rik, D8Ertd69e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 73945
Homologene: 35370
Tmem25
Name: transmembrane protein 25
Synonyms: 0610039J01Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71687
Homologene: 12403
Acoxl
Name: acyl-Coenzyme A oxidase-like
Synonyms: 1200014P05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74121
Homologene: 75083
Hecw1
Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
Synonyms: NEDL1, E130207I19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 94253
VEGA: 13
Homologene: 9004
Cnfn
Name: cornifelin
Synonyms: 2210418J09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72383
Homologene: 13039
Maml3
Name: mastermind like transcriptional coactivator 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 433586
Homologene: 41284
Crb2
Name: crumbs family member 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241324
Homologene: 45474
Or6c206
Name: olfactory receptor family 6 subfamily C member 206
Synonyms: GA_x6K02T2PULF-10947193-10948131, MOR111-12, Olfr776
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 404321
Homologene: 115559
Or4c121
Name: olfactory receptor family 4 subfamily C member 121
Synonyms: GA_x6K02T2Q125-50672630-50671698, MOR233-2, Olfr1226
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258969
Homologene: 27315
Sftpb
Name: surfactant associated protein B
Synonyms: SF-B, SP-B, Sftp-3, Sftp3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20388
Homologene: 456
Ctf1
Name: cardiotrophin 1
Synonyms: CT-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13019
HGNC: HGNC:2499
Homologene: 1016
Gm8005
Name: predicted gene 8005
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 666253
Homologene: 128452
Ttc6
Name: tetratricopeptide repeat domain 6
Synonyms: LOC217602, EG639426, Gm9813, 4921506M07Rik, AU024163
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70846
Homologene: 78002
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • G to T, chromosome 1 at 5,150,061 bp (GRCm38)
  • T to C, chromosome 1 at 22,397,522 bp (GRCm38)
  • A to G, chromosome 1 at 58,903,899 bp (GRCm38)
  • A to G, chromosome 1 at 86,973,493 bp (GRCm38)
  • T to A, chromosome 1 at 151,410,943 bp (GRCm38)
  • G to T, chromosome 2 at 31,670,859 bp (GRCm38)
  • T to G, chromosome 2 at 31,977,794 bp (GRCm38)
  • G to A, chromosome 2 at 37,792,201 bp (GRCm38)
  • A to T, chromosome 2 at 69,480,035 bp (GRCm38)
  • A to T, chromosome 2 at 86,347,424 bp (GRCm38)
  • A to C, chromosome 2 at 89,193,794 bp (GRCm38)
  • G to T, chromosome 2 at 120,091,274 bp (GRCm38)
  • T to A, chromosome 2 at 127,972,573 bp (GRCm38)
  • T to A, chromosome 2 at 137,046,796 bp (GRCm38)
  • G to A, chromosome 2 at 150,767,039 bp (GRCm38)
  • G to A, chromosome 3 at 51,856,907 bp (GRCm38)
  • A to G, chromosome 3 at 138,066,703 bp (GRCm38)
  • G to A, chromosome 3 at 154,256,581 bp (GRCm38)
  • A to C, chromosome 4 at 63,224,302 bp (GRCm38)
  • A to T, chromosome 4 at 98,778,451 bp (GRCm38)
  • A to G, chromosome 4 at 107,106,856 bp (GRCm38)
  • A to G, chromosome 4 at 108,250,817 bp (GRCm38)
  • A to T, chromosome 4 at 143,812,681 bp (GRCm38)
  • T to C, chromosome 5 at 34,436,491 bp (GRCm38)
  • A to G, chromosome 5 at 91,951,906 bp (GRCm38)
  • G to A, chromosome 5 at 114,630,007 bp (GRCm38)
  • T to C, chromosome 5 at 121,348,965 bp (GRCm38)
  • A to G, chromosome 5 at 137,501,649 bp (GRCm38)
  • C to A, chromosome 6 at 40,880,428 bp (GRCm38)
  • C to T, chromosome 6 at 48,496,396 bp (GRCm38)
  • T to A, chromosome 6 at 72,309,897 bp (GRCm38)
  • T to C, chromosome 7 at 18,841,491 bp (GRCm38)
  • T to A, chromosome 7 at 19,004,533 bp (GRCm38)
  • T to A, chromosome 7 at 20,024,586 bp (GRCm38)
  • T to C, chromosome 7 at 25,368,051 bp (GRCm38)
  • T to A, chromosome 7 at 127,717,032 bp (GRCm38)
  • A to G, chromosome 7 at 139,895,224 bp (GRCm38)
  • A to G, chromosome 8 at 25,900,013 bp (GRCm38)
  • A to G, chromosome 8 at 79,646,323 bp (GRCm38)
  • A to G, chromosome 8 at 83,261,121 bp (GRCm38)
  • T to C, chromosome 9 at 44,795,502 bp (GRCm38)
  • T to C, chromosome 9 at 45,447,953 bp (GRCm38)
  • A to T, chromosome 9 at 87,729,482 bp (GRCm38)
  • T to C, chromosome 10 at 129,261,333 bp (GRCm38)
  • A to G, chromosome 11 at 4,940,871 bp (GRCm38)
  • C to T, chromosome 11 at 46,979,339 bp (GRCm38)
  • T to C, chromosome 11 at 60,262,730 bp (GRCm38)
  • T to C, chromosome 11 at 62,538,862 bp (GRCm38)
  • T to C, chromosome 11 at 64,992,316 bp (GRCm38)
  • G to T, chromosome 12 at 57,575,944 bp (GRCm38)
  • C to A, chromosome 12 at 83,778,510 bp (GRCm38)
  • C to T, chromosome 12 at 118,027,516 bp (GRCm38)
  • A to G, chromosome 13 at 13,709,353 bp (GRCm38)
  • A to G, chromosome 13 at 14,316,937 bp (GRCm38)
  • A to G, chromosome 13 at 22,244,705 bp (GRCm38)
  • T to C, chromosome 14 at 24,191,161 bp (GRCm38)
  • A to G, chromosome 14 at 42,436,928 bp (GRCm38)
  • C to A, chromosome 15 at 35,846,913 bp (GRCm38)
  • T to A, chromosome 15 at 44,569,976 bp (GRCm38)
  • C to T, chromosome 15 at 89,187,387 bp (GRCm38)
  • T to C, chromosome 17 at 5,647,962 bp (GRCm38)
  • T to C, chromosome 17 at 20,776,761 bp (GRCm38)
  • T to C, chromosome 17 at 30,725,125 bp (GRCm38)
  • C to A, chromosome 17 at 84,668,952 bp (GRCm38)
  • T to A, chromosome 18 at 78,012,850 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9291 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069110-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.