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Strain Name:
C57BL/6J-MtgxR9354Btlr/Mmmh
Stock Number:
069164-MU
Citation ID:
RRID:MMRRC_069164-MU
Other Names:
R9354 (G1)
Major Collection:

Strain Information

Itga8
Name: integrin alpha 8
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241226
HGNC: HGNC:6144
Homologene: 37396
Cemip2
Name: cell migration inducing hyaluronidase 2
Synonyms: 3110012M15Rik, Tmem2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 83921
VEGA: 19
Homologene: 75008
Jmjd1c
Name: jumonji domain containing 1C
Synonyms: TRIP8, 5430433L24Rik, D630035I23Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 108829
Homologene: 3129
Gid4
Name: GID complex subunit 4, VID24 homolog
Synonyms: 4933439F18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66771
Homologene: 5971
Wnk1
Name: WNK lysine deficient protein kinase 1
Synonyms: 6430573H23Rik, Prkwnk1, EG406236, Hsn2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232341
Homologene: 14253
Rps6ka1
Name: ribosomal protein S6 kinase polypeptide 1
Synonyms: Rsk1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20111
Homologene: 55703
Map4
Name: microtubule-associated protein 4
Synonyms: MAP 4, Mtap4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17758
HGNC: HGNC:6862
Homologene: 1780
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • A to T, chromosome 1 at 54,648,279 bp (GRCm38)
  • A to T, chromosome 1 at 91,344,601 bp (GRCm38)
  • G to A, chromosome 1 at 189,646,917 bp (GRCm38)
  • T to C, chromosome 2 at 12,232,857 bp (GRCm38)
  • A to G, chromosome 2 at 68,606,529 bp (GRCm38)
  • A to G, chromosome 2 at 158,437,393 bp (GRCm38)
  • A to T, chromosome 3 at 94,372,863 bp (GRCm38)
  • A to G, chromosome 3 at 100,027,589 bp (GRCm38)
  • A to T, chromosome 3 at 107,942,702 bp (GRCm38)
  • G to T, chromosome 4 at 44,981,465 bp (GRCm38)
  • A to T, chromosome 4 at 45,816,348 bp (GRCm38)
  • G to A, chromosome 4 at 116,987,035 bp (GRCm38)
  • G to T, chromosome 4 at 119,373,653 bp (GRCm38)
  • A to C, chromosome 4 at 133,867,121 bp (GRCm38)
  • T to C, chromosome 5 at 24,591,394 bp (GRCm38)
  • T to A, chromosome 5 at 45,733,626 bp (GRCm38)
  • T to A, chromosome 5 at 105,084,959 bp (GRCm38)
  • A to G, chromosome 5 at 139,392,611 bp (GRCm38)
  • G to A, chromosome 5 at 139,426,274 bp (GRCm38)
  • A to G, chromosome 5 at 143,715,272 bp (GRCm38)
  • A to G, chromosome 6 at 40,928,539 bp (GRCm38)
  • C to T, chromosome 6 at 119,965,699 bp (GRCm38)
  • A to G, chromosome 7 at 3,911,629 bp (GRCm38)
  • T to A, chromosome 7 at 13,084,798 bp (GRCm38)
  • T to C, chromosome 7 at 41,400,239 bp (GRCm38)
  • C to T, chromosome 7 at 81,332,871 bp (GRCm38)
  • G to A, chromosome 7 at 102,555,190 bp (GRCm38)
  • C to A, chromosome 7 at 128,185,974 bp (GRCm38)
  • A to G, chromosome 7 at 141,753,420 bp (GRCm38)
  • C to G, chromosome 8 at 33,573,316 bp (GRCm38)
  • T to G, chromosome 8 at 46,513,716 bp (GRCm38)
  • T to C, chromosome 9 at 64,314,640 bp (GRCm38)
  • A to G, chromosome 9 at 110,068,779 bp (GRCm38)
  • T to C, chromosome 10 at 67,224,096 bp (GRCm38)
  • A to C, chromosome 10 at 127,087,235 bp (GRCm38)
  • T to C, chromosome 11 at 20,238,569 bp (GRCm38)
  • G to T, chromosome 11 at 54,619,923 bp (GRCm38)
  • G to T, chromosome 11 at 60,417,792 bp (GRCm38)
  • A to C, chromosome 11 at 101,460,615 bp (GRCm38)
  • T to C, chromosome 11 at 113,834,931 bp (GRCm38)
  • G to A, chromosome 11 at 115,802,642 bp (GRCm38)
  • A to T, chromosome 12 at 31,535,256 bp (GRCm38)
  • A to T, chromosome 13 at 23,785,892 bp (GRCm38)
  • A to T, chromosome 13 at 64,369,036 bp (GRCm38)
  • A to G, chromosome 13 at 100,427,486 bp (GRCm38)
  • C to T, chromosome 13 at 104,205,572 bp (GRCm38)
  • T to A, chromosome 14 at 7,818,411 bp (GRCm38)
  • T to C, chromosome 14 at 50,892,928 bp (GRCm38)
  • T to A, chromosome 14 at 54,963,535 bp (GRCm38)
  • T to A, chromosome 15 at 32,562,756 bp (GRCm38)
  • T to A, chromosome 15 at 75,044,622 bp (GRCm38)
  • C to T, chromosome 15 at 77,525,912 bp (GRCm38)
  • T to C, chromosome 15 at 79,239,648 bp (GRCm38)
  • A to T, chromosome 15 at 97,796,888 bp (GRCm38)
  • A to G, chromosome 17 at 74,614,406 bp (GRCm38)
  • A to G, chromosome 18 at 37,816,587 bp (GRCm38)
  • A to G, chromosome 19 at 17,122,622 bp (GRCm38)
  • A to G, chromosome 19 at 21,802,025 bp (GRCm38)
  • G to A, chromosome 19 at 22,448,332 bp (GRCm38)
  • G to T, chromosome 19 at 37,207,865 bp (GRCm38)
  • T to A, chromosome 19 at 44,948,032 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9354 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069164-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.