Strain Name:
C57BL/6J-MtgxR9374Btlr/Mmmh
Stock Number:
069182-MU
Citation ID:
RRID:MMRRC_069182-MU
Other Names:
R9374 (G1)
Major Collection:

Strain Information

Slc32a1
Name: solute carrier family 32 (GABA vesicular transporter), member 1
Synonyms: VGAT, Viaat, R75019
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22348
Homologene: 56451
Erbb4
Name: erb-b2 receptor tyrosine kinase 4
Synonyms: Her4, ErbB4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13869
HGNC: HGNC:3432
Homologene: 21084
Rbpms
Name: RNA binding protein gene with multiple splicing
Synonyms: 2700019M19Rik, 2010300K22Rik, hermes
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 19663
Homologene: 38238
Tns3
Name: tensin 3
Synonyms: TEM6, F830010I22Rik, Tens1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 319939
Homologene: 49713
Mef2c
Name: myocyte enhancer factor 2C
Synonyms: 9930028G15Rik, 5430401D19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17260
HGNC: HGNC:6996
Homologene: 31087
Mtor
Name: mechanistic target of rapamycin kinase
Synonyms: flat, RAPT1, 2610315D21Rik, RAFT1, Frap1, mechanistic target of rapamycin (serine/threonine kinase), FKBP-rapamycin-associated protein FRAP
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56717
HGNC: HGNC:3942
Homologene: 3637
Mark2
Name: MAP/microtubule affinity regulating kinase 2
Synonyms: Emk, Par-1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13728
HGNC: HGNC:3332
Homologene: 69013
Arhgap21
Name: Rho GTPase activating protein 21
Synonyms: 5530401C11Rik, ARHGAP10
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71435
Homologene: 10822
Cep290
Name: centrosomal protein 290
Synonyms: Kiaa, b2b1454Clo, b2b1752Clo, Nphp6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216274
VEGA: 10
Homologene: 77213
Pi4ka
Name: phosphatidylinositol 4-kinase alpha
Synonyms: Pik4ca
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224020
HGNC: HGNC:8983
Homologene: 11171
Sorbs1
Name: sorbin and SH3 domain containing 1
Synonyms: Sh3d5, Ponsin, c-Cbl-associated protein, CAP, 9530001P15Rik, 2310065E01Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20411
VEGA: 19
Homologene: 83252
Xpo4
Name: exportin 4
Synonyms: B430309A01Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 57258
Homologene: 10733
Smchd1
Name: SMC hinge domain containing 1
Synonyms: MommeD1, 4931400A14Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74355
Homologene: 23665
Slitrk5
Name: SLIT and NTRK-like family, member 5
Synonyms: 2610019D03Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 75409
VEGA: 14
Homologene: 9193
Rpl10a
Name: ribosomal protein L10A
Synonyms: CsA-19, Nedd6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19896
Homologene: 68543
Pbx1
Name: pre B cell leukemia homeobox 1
Synonyms: Pbx1b, D230003C07Rik, Pbx1a, Pbx-1, 2310056B04Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18514
HGNC: HGNC:8632
Homologene: 20574
Celf2
Name: CUGBP, Elav-like family member 2
Synonyms: Cugbp2, Napor-2, B230345P09Rik, ETR-3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14007
HGNC: HGNC:2550
Homologene: 4783
Prpf4
Name: pre-mRNA processing factor 4
Synonyms: 1600015H11Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 70052
Homologene: 3446
Hnrnph3
Name: heterogeneous nuclear ribonucleoprotein H3
Synonyms: Hnrph3, hnRNP 2H9
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 432467
HGNC: HGNC:5043
Homologene: 11012
Mgst3
Name: microsomal glutathione S-transferase 3
Synonyms: 2700004G04Rik, 2010306B17Rik, GST-III, 2010012L10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66447
HGNC: HGNC:7064
Homologene: 3327
Tnfsf13b
Name: tumor necrosis factor (ligand) superfamily, member 13b
Synonyms: BLyS, D8Ertd387e, TALL-1, BAFF, zTNF4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 24099
Homologene: 48443
Fam124a
Name: family with sequence similarity 124, member A
Synonyms: EG629059
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 629059
Homologene: 86241
Unc80
Name: unc-80, NALCN activator
Synonyms: C230061B10Rik, C030018G13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329178
Homologene: 122243
Stc2
Name: stanniocalcin 2
Synonyms: mustc2, Stc2l
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20856
Homologene: 2753
Dscam
Name: DS cell adhesion molecule
Synonyms: Down syndrome cell adhesion molecule, 4932410A21Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13508
HGNC: HGNC:3039
Homologene: 74393
Tcaf2
Name: TRPM8 channel-associated factor 2
Synonyms: Fam115c
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232748
Homologene: 17147
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: OTTMUSG00000005786, LOC380698
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Vmn2r111
Name: vomeronasal 2, receptor 111
Synonyms: EG210876
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210876
Homologene: 86604
Slco6c1
Name: solute carrier organic anion transporter family, member 6c1
Synonyms: 4933404A18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74441
Homologene: 65259
Tle5
Name: TLE family member 5, transcriptional modulator
Synonyms: Aes, Grg5, AES, Grg
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14797
VEGA: 10
HGNC: HGNC:307
Homologene: 879
Pkn1
Name: protein kinase N1
Synonyms: PRK1, Stk3, Prkcl1, Pkn, F730027O18Rik, PAK1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 320795
HGNC: HGNC:9405
Homologene: 48130
Cpeb2
Name: cytoplasmic polyadenylation element binding protein 2
Synonyms: A630055H10Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231207
Homologene: 17995
Hipk3
Name: homeodomain interacting protein kinase 3
Synonyms: DYRK6, FIST3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15259
HGNC: HGNC:4915
Homologene: 55923
Map7d1
Name: MAP7 domain containing 1
Synonyms: Mtap7d1, Rprc1, Parcc1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 245877
Homologene: 17009
Or6k4
Name: olfactory receptor family 6 subfamily K member 4
Synonyms: GA_x6K02T2P20D-21025190-21024243, MOR105-2, Olfr424
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 258716
Homologene: 103798
Or5d14
Name: olfactory receptor family 5 subfamily D member 14
Synonyms: MOR174-14, GA_x6K02T2Q125-49542541-49541597, Olfr1162
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258105
Homologene: 79476
Vmn1r86
Name: vomeronasal 1 receptor 86
Synonyms: Gm10301
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100312473
Homologene: 74345
Pyroxd2
Name: pyridine nucleotide-disulphide oxidoreductase domain 2
Synonyms: 4833409A17Rik, 3830409H07Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 74580
VEGA: 19
Homologene: 13097
Tcerg1l
Name: transcription elongation regulator 1-like
Synonyms: 5730476P14Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70571
Homologene: 52165
Plin1
Name: perilipin 1
Synonyms: Plin, 6030432J05Rik, Peri, perilipin A, perilipin B
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 103968
HGNC: HGNC:9076
Homologene: 2001
Ccdc68
Name: coiled-coil domain containing 68
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 381175
Homologene: 11880
Vegfc
Name: vascular endothelial growth factor C
Synonyms: VEGF-C
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 22341
Homologene: 3962
Or11g1
Name: olfactory receptor family 11 subfamily G member 1
Synonyms: Olfr738, GA_x6K02T2PMLR-6110726-6111661, MOR106-3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258662
Homologene: 74220
Ndst1
Name: N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
Synonyms: glucosaminyl N-deacetylase/N-sulfotransferase 1, Ndst-1, Hsst, 1200015G06Rik, b2b2230Clo
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 15531
VEGA: 18
HGNC: HGNC:7680
Homologene: 20386
Nkain3
Name: Na+/K+ transporting ATPase interacting 3
Synonyms: E130310K16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269513
Homologene: 18265
Blvrb
Name: biliverdin reductase B
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233016
HGNC: HGNC:1063
Homologene: 573
Tcf15
Name: transcription factor 15
Synonyms: paraxis, bHLH-EC2, Meso1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 21407
Homologene: 37943
Tmem200c
Name: transmembrane protein 200C
Synonyms: Gm6338
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 622645
VEGA: 17
Homologene: 78765
Wdr49
Name: WD repeat domain 49
Synonyms: EG213248
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213248
Homologene: 18714
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • A to T, chromosome 1 at 66,590,301 bp (GRCm38)
  • G to A, chromosome 1 at 68,740,483 bp (GRCm38)
  • T to C, chromosome 1 at 97,128,102 bp (GRCm38)
  • T to C, chromosome 1 at 167,378,302 bp (GRCm38)
  • T to C, chromosome 1 at 168,431,341 bp (GRCm38)
  • A to T, chromosome 1 at 174,137,319 bp (GRCm38)
  • G to A, chromosome 2 at 6,586,075 bp (GRCm38)
  • A to T, chromosome 2 at 20,881,586 bp (GRCm38)
  • C to T, chromosome 2 at 88,050,165 bp (GRCm38)
  • T to C, chromosome 2 at 104,471,505 bp (GRCm38)
  • T to C, chromosome 2 at 152,144,119 bp (GRCm38)
  • A to G, chromosome 2 at 158,614,075 bp (GRCm38)
  • T to C, chromosome 3 at 75,323,624 bp (GRCm38)
  • C to A, chromosome 4 at 20,778,431 bp (GRCm38)
  • T to C, chromosome 4 at 62,417,894 bp (GRCm38)
  • T to C, chromosome 4 at 126,233,636 bp (GRCm38)
  • C to T, chromosome 4 at 148,514,940 bp (GRCm38)
  • C to A, chromosome 5 at 43,234,241 bp (GRCm38)
  • C to T, chromosome 6 at 42,642,794 bp (GRCm38)
  • A to T, chromosome 7 at 13,102,854 bp (GRCm38)
  • A to G, chromosome 7 at 27,459,361 bp (GRCm38)
  • T to C, chromosome 7 at 79,722,796 bp (GRCm38)
  • T to C, chromosome 7 at 138,394,269 bp (GRCm38)
  • A to G, chromosome 8 at 10,035,391 bp (GRCm38)
  • A to G, chromosome 8 at 33,804,145 bp (GRCm38)
  • A to G, chromosome 8 at 54,169,145 bp (GRCm38)
  • A to T, chromosome 8 at 83,677,738 bp (GRCm38)
  • T to C, chromosome 10 at 63,018,178 bp (GRCm38)
  • T to C, chromosome 10 at 81,564,154 bp (GRCm38)
  • T to C, chromosome 10 at 100,536,867 bp (GRCm38)
  • T to A, chromosome 11 at 8,492,606 bp (GRCm38)
  • A to G, chromosome 11 at 31,360,332 bp (GRCm38)
  • T to C, chromosome 11 at 59,031,961 bp (GRCm38)
  • A to G, chromosome 13 at 83,662,342 bp (GRCm38)
  • C to T, chromosome 14 at 50,414,168 bp (GRCm38)
  • A to G, chromosome 14 at 57,591,055 bp (GRCm38)
  • T to G, chromosome 14 at 62,606,539 bp (GRCm38)
  • C to T, chromosome 14 at 111,679,064 bp (GRCm38)
  • T to C, chromosome 16 at 17,307,710 bp (GRCm38)
  • A to T, chromosome 16 at 97,056,657 bp (GRCm38)
  • T to A, chromosome 17 at 22,568,878 bp (GRCm38)
  • T to A, chromosome 17 at 28,329,032 bp (GRCm38)
  • G to T, chromosome 17 at 68,841,687 bp (GRCm38)
  • T to C, chromosome 17 at 71,411,848 bp (GRCm38)
  • G to T, chromosome 18 at 60,712,859 bp (GRCm38)
  • T to A, chromosome 18 at 69,956,042 bp (GRCm38)
  • G to T, chromosome 19 at 7,285,898 bp (GRCm38)
  • G to A, chromosome 19 at 40,373,479 bp (GRCm38)
  • A to G, chromosome 19 at 42,731,317 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9374 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069182-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.