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Strain Name:
C57BL/6J-MtgxR9376Btlr/Mmmh
Stock Number:
069184-MU
Citation ID:
RRID:MMRRC_069184-MU
Other Names:
R9376 (G1)
Major Collection:

Strain Information

Ppp5c
Name: protein phosphatase 5, catalytic subunit
Synonyms: ANP receptor, PP5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19060
HGNC: HGNC:9322
Homologene: 4550
Sephs1
Name: selenophosphate synthetase 1
Synonyms: SPS1, 1110046B24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 109079
Homologene: 56558
Lrp5
Name: low density lipoprotein receptor-related protein 5
Synonyms: LRP7, LR3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16973
HGNC: HGNC:6697
Homologene: 1746
Zc3h13
Name: zinc finger CCCH type containing 13
Synonyms: C87618, 4930570G11Rik, 2600010B19Rik, 3110050K21Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67302
VEGA: 14
Ptpn11
Name: protein tyrosine phosphatase, non-receptor type 11
Synonyms: PTP2C, PTP1D, SH-PTP2, SHP-2, Syp, Shp2, SH2 domain-containing protein tyrosine phosphatase-2, 2700084A17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19247
HGNC: HGNC:9644
Homologene: 2122
Nup214
Name: nucleoporin 214
Synonyms: D2H9S46E, CAN
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227720
HGNC: HGNC:8064
Homologene: 38008
Prrc2a
Name: proline-rich coiled-coil 2A
Synonyms: G2, Bat-2, D17H6S51E, Wbp12, 3110039B05Rik, Bat2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 53761
Homologene: 10567
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • T to A, chromosome 1 at 53,528,899 bp (GRCm38)
  • C to T, chromosome 1 at 90,781,801 bp (GRCm38)
  • T to C, chromosome 1 at 174,026,655 bp (GRCm38)
  • T to A, chromosome 2 at 4,905,658 bp (GRCm38)
  • T to C, chromosome 2 at 32,034,232 bp (GRCm38)
  • A to G, chromosome 2 at 110,666,437 bp (GRCm38)
  • G to A, chromosome 2 at 169,884,093 bp (GRCm38)
  • A to G, chromosome 3 at 5,241,773 bp (GRCm38)
  • A to G, chromosome 3 at 5,400,335 bp (GRCm38)
  • T to C, chromosome 3 at 31,163,261 bp (GRCm38)
  • T to A, chromosome 3 at 96,165,055 bp (GRCm38)
  • A to G, chromosome 4 at 12,962,987 bp (GRCm38)
  • A to G, chromosome 4 at 13,865,225 bp (GRCm38)
  • A to G, chromosome 4 at 84,957,021 bp (GRCm38)
  • G to T, chromosome 4 at 156,027,991 bp (GRCm38)
  • A to T, chromosome 5 at 8,958,988 bp (GRCm38)
  • A to G, chromosome 5 at 28,339,166 bp (GRCm38)
  • T to A, chromosome 5 at 114,009,840 bp (GRCm38)
  • C to A, chromosome 5 at 120,848,180 bp (GRCm38)
  • C to A, chromosome 5 at 121,144,618 bp (GRCm38)
  • A to C, chromosome 5 at 137,290,763 bp (GRCm38)
  • T to C, chromosome 6 at 106,662,630 bp (GRCm38)
  • T to A, chromosome 6 at 108,349,677 bp (GRCm38)
  • A to T, chromosome 7 at 5,083,721 bp (GRCm38)
  • A to T, chromosome 7 at 17,009,924 bp (GRCm38)
  • A to T, chromosome 7 at 101,711,418 bp (GRCm38)
  • A to T, chromosome 7 at 103,097,764 bp (GRCm38)
  • A to G, chromosome 7 at 105,765,774 bp (GRCm38)
  • A to T, chromosome 7 at 108,095,264 bp (GRCm38)
  • T to A, chromosome 7 at 120,294,215 bp (GRCm38)
  • T to C, chromosome 7 at 128,148,763 bp (GRCm38)
  • A to G, chromosome 8 at 14,030,719 bp (GRCm38)
  • C to T, chromosome 8 at 61,516,657 bp (GRCm38)
  • T to C, chromosome 8 at 110,398,063 bp (GRCm38)
  • C to T, chromosome 8 at 112,011,882 bp (GRCm38)
  • A to G, chromosome 8 at 112,017,896 bp (GRCm38)
  • A to G, chromosome 9 at 22,158,028 bp (GRCm38)
  • A to T, chromosome 9 at 64,912,692 bp (GRCm38)
  • T to C, chromosome 9 at 122,826,930 bp (GRCm38)
  • T to C, chromosome 10 at 27,118,624 bp (GRCm38)
  • A to T, chromosome 11 at 17,208,791 bp (GRCm38)
  • T to A, chromosome 11 at 51,048,835 bp (GRCm38)
  • T to A, chromosome 11 at 58,566,857 bp (GRCm38)
  • T to C, chromosome 11 at 58,581,810 bp (GRCm38)
  • T to C, chromosome 11 at 69,984,768 bp (GRCm38)
  • T to C, chromosome 11 at 72,972,464 bp (GRCm38)
  • T to A, chromosome 12 at 98,275,264 bp (GRCm38)
  • T to C, chromosome 13 at 114,970,576 bp (GRCm38)
  • G to A, chromosome 14 at 75,323,688 bp (GRCm38)
  • G to A, chromosome 14 at 123,278,301 bp (GRCm38)
  • C to A, chromosome 15 at 76,334,626 bp (GRCm38)
  • T to A, chromosome 15 at 101,350,097 bp (GRCm38)
  • T to C, chromosome 16 at 20,241,183 bp (GRCm38)
  • G to T, chromosome 17 at 28,164,696 bp (GRCm38)
  • A to T, chromosome 17 at 35,150,622 bp (GRCm38)
  • A to T, chromosome 17 at 36,873,276 bp (GRCm38)
  • T to C, chromosome 18 at 34,837,665 bp (GRCm38)
  • G to T, chromosome 18 at 62,662,865 bp (GRCm38)
  • T to C, chromosome 19 at 3,620,286 bp (GRCm38)
  • A to T, chromosome 19 at 4,282,222 bp (GRCm38)
  • A to T, chromosome 19 at 39,638,734 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9376 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069184-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.