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Strain Name:
C57BL/6J-MtgxR9377Btlr/Mmmh
Stock Number:
069185-MU
Citation ID:
RRID:MMRRC_069185-MU
Other Names:
R9377 (G1)
Major Collection:

Strain Information

Rest
Name: RE1-silencing transcription factor
Synonyms: 2610008J04Rik, NRSF
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19712
HGNC: HGNC:9966
Homologene: 4099
Nr2f2
Name: nuclear receptor subfamily 2, group F, member 2
Synonyms: COUP-TFII, ARP-1, Tcfcoup2, Aporp1, COUP-TF2, 9430015G03Rik, EAR3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11819
HGNC: HGNC:7976
Homologene: 7628
Gli1
Name: GLI-Kruppel family member GLI1
Synonyms: Zfp-5, Zfp5
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14632
VEGA: 10
HGNC: HGNC:4317
Homologene: 3859
Sgsm1
Name: small G protein signaling modulator 1
Synonyms: 2410098H20Rik, D5Bwg1524e, Rutbc2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 52850
Homologene: 64485
Ucp2
Name: uncoupling protein 2 (mitochondrial, proton carrier)
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22228
Homologene: 2516
Enpp2
Name: ectonucleotide pyrophosphatase/phosphodiesterase 2
Synonyms: Autotaxin, Npps2, PD-Ialpha, Pdnp2, ATX
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18606
HGNC: HGNC:3357
Homologene: 4526
Mcmbp
Name: minichromosome maintenance complex binding protein
Synonyms: 1110007A13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210711
Homologene: 11749
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • G to T, chromosome 1 at 74,132,720 bp (GRCm38)
  • A to G, chromosome 1 at 90,816,239 bp (GRCm38)
  • T to C, chromosome 1 at 128,417,208 bp (GRCm38)
  • T to C, chromosome 1 at 153,239,263 bp (GRCm38)
  • A to T, chromosome 1 at 154,485,712 bp (GRCm38)
  • T to C, chromosome 1 at 191,177,313 bp (GRCm38)
  • T to A, chromosome 2 at 52,149,279 bp (GRCm38)
  • T to A, chromosome 2 at 52,226,534 bp (GRCm38)
  • G to A, chromosome 2 at 70,238,898 bp (GRCm38)
  • T to C, chromosome 2 at 104,839,383 bp (GRCm38)
  • T to C, chromosome 2 at 130,306,855 bp (GRCm38)
  • A to G, chromosome 2 at 148,828,245 bp (GRCm38)
  • A to T, chromosome 2 at 178,413,876 bp (GRCm38)
  • T to A, chromosome 2 at 181,379,853 bp (GRCm38)
  • A to T, chromosome 2 at 181,569,739 bp (GRCm38)
  • G to T, chromosome 3 at 55,521,953 bp (GRCm38)
  • A to T, chromosome 3 at 108,265,132 bp (GRCm38)
  • T to A, chromosome 3 at 131,297,800 bp (GRCm38)
  • T to C, chromosome 4 at 14,516,189 bp (GRCm38)
  • G to T, chromosome 4 at 96,236,549 bp (GRCm38)
  • A to C, chromosome 4 at 150,508,885 bp (GRCm38)
  • A to G, chromosome 5 at 31,191,156 bp (GRCm38)
  • T to C, chromosome 5 at 36,505,128 bp (GRCm38)
  • A to G, chromosome 5 at 63,800,397 bp (GRCm38)
  • T to C, chromosome 5 at 77,268,281 bp (GRCm38)
  • G to T, chromosome 5 at 96,128,967 bp (GRCm38)
  • C to T, chromosome 5 at 103,833,819 bp (GRCm38)
  • C to A, chromosome 5 at 113,288,875 bp (GRCm38)
  • T to C, chromosome 5 at 115,946,855 bp (GRCm38)
  • A to G, chromosome 5 at 116,409,428 bp (GRCm38)
  • C to T, chromosome 5 at 124,440,001 bp (GRCm38)
  • T to C, chromosome 5 at 137,485,755 bp (GRCm38)
  • T to A, chromosome 6 at 30,816,786 bp (GRCm38)
  • T to A, chromosome 6 at 83,403,614 bp (GRCm38)
  • A to T, chromosome 7 at 38,221,779 bp (GRCm38)
  • A to T, chromosome 7 at 44,509,575 bp (GRCm38)
  • T to A, chromosome 7 at 70,358,108 bp (GRCm38)
  • A to G, chromosome 7 at 86,795,234 bp (GRCm38)
  • A to G, chromosome 7 at 100,083,786 bp (GRCm38)
  • T to C, chromosome 7 at 100,496,833 bp (GRCm38)
  • C to T, chromosome 7 at 112,382,039 bp (GRCm38)
  • A to T, chromosome 7 at 128,133,677 bp (GRCm38)
  • A to T, chromosome 7 at 128,716,079 bp (GRCm38)
  • A to T, chromosome 7 at 131,093,102 bp (GRCm38)
  • G to A, chromosome 8 at 11,433,725 bp (GRCm38)
  • G to A, chromosome 8 at 24,614,843 bp (GRCm38)
  • C to T, chromosome 8 at 61,516,657 bp (GRCm38)
  • A to T, chromosome 8 at 63,345,712 bp (GRCm38)
  • A to T, chromosome 8 at 93,980,390 bp (GRCm38)
  • A to G, chromosome 9 at 52,068,868 bp (GRCm38)
  • G to A, chromosome 9 at 105,396,681 bp (GRCm38)
  • C to A, chromosome 9 at 107,750,053 bp (GRCm38)
  • C to A, chromosome 9 at 108,113,601 bp (GRCm38)
  • A to T, chromosome 9 at 108,116,162 bp (GRCm38)
  • C to T, chromosome 10 at 50,732,762 bp (GRCm38)
  • T to A, chromosome 10 at 127,337,490 bp (GRCm38)
  • A to G, chromosome 11 at 77,408,148 bp (GRCm38)
  • A to G, chromosome 11 at 78,499,761 bp (GRCm38)
  • G to A, chromosome 11 at 89,441,458 bp (GRCm38)
  • A to G, chromosome 11 at 96,754,095 bp (GRCm38)
  • A to G, chromosome 11 at 101,565,764 bp (GRCm38)
  • T to C, chromosome 12 at 36,130,132 bp (GRCm38)
  • G to A, chromosome 12 at 84,791,090 bp (GRCm38)
  • T to A, chromosome 13 at 32,968,511 bp (GRCm38)
  • T to C, chromosome 13 at 42,181,927 bp (GRCm38)
  • C to A, chromosome 13 at 73,544,847 bp (GRCm38)
  • T to C, chromosome 13 at 81,557,158 bp (GRCm38)
  • T to A, chromosome 13 at 91,770,102 bp (GRCm38)
  • T to C, chromosome 13 at 96,878,225 bp (GRCm38)
  • T to A, chromosome 13 at 119,488,286 bp (GRCm38)
  • G to T, chromosome 14 at 30,886,576 bp (GRCm38)
  • T to A, chromosome 14 at 51,455,144 bp (GRCm38)
  • C to T, chromosome 15 at 54,875,684 bp (GRCm38)
  • T to A, chromosome 15 at 74,824,108 bp (GRCm38)
  • T to C, chromosome 15 at 83,135,388 bp (GRCm38)
  • A to G, chromosome 17 at 22,374,944 bp (GRCm38)
  • T to C, chromosome 17 at 48,037,464 bp (GRCm38)
  • C to T, chromosome 17 at 88,545,387 bp (GRCm38)
  • T to C, chromosome 18 at 5,057,294 bp (GRCm38)
  • T to A, chromosome 18 at 37,499,246 bp (GRCm38)
  • C to T, chromosome 18 at 37,708,517 bp (GRCm38)
  • A to G, chromosome 18 at 53,718,520 bp (GRCm38)
  • A to G, chromosome 18 at 63,029,085 bp (GRCm38)
  • T to C, chromosome 19 at 5,758,995 bp (GRCm38)
  • T to C, chromosome 19 at 40,398,604 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9377 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069185-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.