Strain Name:
C57BL/6J-MtgxR9394Btlr/Mmmh
Stock Number:
069199-MU
Citation ID:
RRID:MMRRC_069199-MU
Other Names:
R9394 (G1)
Major Collection:

Strain Information

Met
Name: met proto-oncogene
Synonyms: HGF receptor, Par4, c-Met
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17295
HGNC: HGNC:7029
Homologene: 206
Arfgef2
Name: ADP ribosylation factor guanine nucleotide exchange factor 2
Synonyms: BIG2, E230011G24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99371
Homologene: 111880
Kcnq2
Name: potassium voltage-gated channel, subfamily Q, member 2
Synonyms: Nmf134, KQT2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16536
HGNC: HGNC:6296
Homologene: 26174
Oxsr1
Name: oxidative-stress responsive 1
Synonyms: Osr1, 2810422B09Rik, 2210022N24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 108737
HGNC: HGNC:8508
Homologene: 31288
Dscaml1
Name: DS cell adhesion molecule like 1
Synonyms: 4921507G06Rik, 4930435C18Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 114873
VEGA: 9
Homologene: 79549
Osbpl8
Name: oxysterol binding protein-like 8
Synonyms: D330025H14Rik, ORP-8
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237542
VEGA: 10
Homologene: 68813
Iars1
Name: isoleucyl-tRNA synthetase 1
Synonyms: E430001P04Rik, Iars, 2510016L12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105148
HGNC: HGNC:5330
Homologene: 5325
Ube3a
Name: ubiquitin protein ligase E3A
Synonyms: Hpve6a, A130086L21Rik, 5830462N02Rik, E6-AP ubiquitin protein ligase
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22215
Homologene: 7988
Tom1l2
Name: target of myb1-like 2 (chicken)
Synonyms: 2900016I08Rik, A730055F12Rik, myb1-like protein 2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216810
Homologene: 44901
Ranbp2
Name: RAN binding protein 2
Synonyms: A430087B05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19386
VEGA: 10
Homologene: 87808
Eif3c
Name: eukaryotic translation initiation factor 3, subunit C
Synonyms: NIPIL(A3), Xsl, Eif3s8, 3230401O13Rik, Xs, 110kDa
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56347
Homologene: 2781
Rnf123
Name: ring finger protein 123
Synonyms: KPC1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 84585
Homologene: 11112
Rasal1
Name: RAS protein activator like 1 (GAP1 like)
Synonyms: MRASAL
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19415
HGNC: HGNC:9873
Homologene: 3423
Sgcb
Name: sarcoglycan, beta (dystrophin-associated glycoprotein)
Synonyms: beta-SG
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 24051
Homologene: 195
Prune2
Name: prune homolog 2
Synonyms: 6330414G02Rik, A330102H22Rik, Olfaxin, A230083H22Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 353211
VEGA: 19
Homologene: 18939
Adamtsl1
Name: ADAMTS-like 1
Synonyms: 5930437A14Rik, punctin-1, 6720426B09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 77739
Homologene: 64642
Zfc3h1
Name: zinc finger, C3H1-type containing
Synonyms: Psrc2, Ccdc131
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216345
Homologene: 17017
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Trpm1
Name: transient receptor potential cation channel, subfamily M, member 1
Synonyms: 4732499L03Rik, Mlsn1, melastatin, LTRPC1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17364
HGNC: HGNC:7146
Homologene: 19940
Slc7a1
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
Synonyms: Atrc1, Cat1, Rec-1, 4831426K01Rik, Rev-1, mCAT-1, Atrc-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11987
Homologene: 20658
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: Mgr1, Mass1, Gpr98, VLGR1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110789
Homologene: 19815
Madd
Name: MAP-kinase activating death domain
Synonyms: Rab3 GEP, 9630059K23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228355
HGNC: HGNC:6766
Homologene: 14249
Scn5a
Name: sodium channel, voltage-gated, type V, alpha
Synonyms: Nav1.5, mH1, SkM2, Nav1.5c
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20271
Homologene: 22738
Rims1
Name: regulating synaptic membrane exocytosis 1
Synonyms: C030033M19Rik, RIM1alpha, RIM1, RIM1a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 116837
Homologene: 128399
Dis3l
Name: DIS3 like exosome 3'-5' exoribonuclease
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 213550
Homologene: 15797
Cfap52
Name: cilia and flagella associated protein 52
Synonyms: 1700019F09Rik, Wdr16, 4933417B11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71860
Homologene: 12416
Slc6a20a
Name: solute carrier family 6 (neurotransmitter transporter), member 20A
Synonyms: Xtrp3s1, A730081N20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102680
Homologene: 10625
Cacna2d1
Name: calcium channel, voltage-dependent, alpha2/delta subunit 1
Synonyms: Cchl2a, Ca(v)alpha2delta1, Cacna2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12293
HGNC: HGNC:1399
Homologene: 579
Zdhhc23
Name: zinc finger, DHHC domain containing 23
Synonyms: LOC385651, LOC332175
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 332175
VEGA: 16
Homologene: 17840
Apcdd1
Name: adenomatosis polyposis coli down-regulated 1
Synonyms: EIG180, Drapc1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 494504
VEGA: 18
Homologene: 77420
Apc2
Name: APC regulator of WNT signaling pathway 2
Synonyms: APCL
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 23805
Homologene: 4299
Or10g1
Name: olfactory receptor family 10 subfamily G member 1
Synonyms: GA_x6K02T2RJGY-583652-584608, MOR223-6, Olfr1510
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258423
HGNC: HGNC:8170
Homologene: 87788
Rigi
Name: RNA sensor RIG-I
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 58, RIG-I, Ddx58, 6430573D20Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230073
Homologene: 32215
Nacad
Name: NAC alpha domain containing
Synonyms: mKIAA0363
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192950
Homologene: 135717
Plekhg3
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 3
Synonyms: MGC40768
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 263406
VEGA: 12
Homologene: 77478
Wee2
Name: WEE1 homolog 2 (S. pombe)
Synonyms: LOC381759, Wee1b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 381759
Homologene: 52392
Alpk1
Name: alpha-kinase 1
Synonyms: 8430410J10Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71481
Homologene: 11849
Or5w12
Name: olfactory receptor family 5 subfamily W member 12
Synonyms: MOR177-2, GA_x6K02T2Q125-49177531-49176599, Olfr1135
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258654
Homologene: 17331
Or2l13
Name: olfactory receptor family 2 subfamily L member 13
Synonyms: MOR270-1, GA_x54KRFPKG5P-15934912-15935850, Olfr166
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 259071
Homologene: 88350
Mmd2
Name: monocyte to macrophage differentiation-associated 2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75104
Homologene: 18425
Ifitm10
Name: interferon induced transmembrane protein 10
Synonyms: 6330512M04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 320802
Stk26
Name: serine/threonine kinase 26
Synonyms: 2610018G03Rik, Mst4
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 70415
Homologene: 84402
Or2m13
Name: olfactory receptor family 2 subfamily M member 13
Synonyms: Olfr165, MOR279-1, GA_x54KRFPKG5P-15855164-15854223
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258458
Homologene: 128262
Mapk7
Name: mitogen-activated protein kinase 7
Synonyms: big MAP kinase 1, b2b2346Clo, Erk5-T, BMK1, ERK5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 23939
HGNC: HGNC:6880
Homologene: 2060
Igfbpl1
Name: insulin-like growth factor binding protein-like 1
Synonyms: IGFBP-like protein, 2810011G06Rik, 2810453O06Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 75426
Homologene: 10292
Zfp612
Name: zinc finger protein 612
Synonyms: B230354B21Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234725
Homologene: 27083
Rpl35rt
Name: ribosomal protein L35, retrotransposed
Synonyms: Gm2000
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100038991
Igkv3-1
Name: immunoglobulin kappa variable 3-1
Synonyms: V(kappa)21G
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 108004
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • T to C, chromosome 1 at 22,472,775 bp (GRCm38)
  • T to C, chromosome 1 at 156,366,223 bp (GRCm38)
  • A to C, chromosome 2 at 76,876,714 bp (GRCm38)
  • T to C, chromosome 2 at 87,671,750 bp (GRCm38)
  • G to A, chromosome 2 at 91,169,854 bp (GRCm38)
  • G to A, chromosome 2 at 166,834,549 bp (GRCm38)
  • A to T, chromosome 2 at 181,082,424 bp (GRCm38)
  • T to A, chromosome 3 at 127,672,538 bp (GRCm38)
  • T to C, chromosome 4 at 40,213,831 bp (GRCm38)
  • A to T, chromosome 4 at 45,826,792 bp (GRCm38)
  • A to G, chromosome 4 at 86,216,988 bp (GRCm38)
  • T to C, chromosome 5 at 15,935,015 bp (GRCm38)
  • T to C, chromosome 5 at 73,644,310 bp (GRCm38)
  • A to C, chromosome 5 at 120,678,681 bp (GRCm38)
  • A to T, chromosome 5 at 142,569,484 bp (GRCm38)
  • A to G, chromosome 5 at 148,333,902 bp (GRCm38)
  • A to C, chromosome 6 at 17,513,396 bp (GRCm38)
  • A to G, chromosome 6 at 40,456,944 bp (GRCm38)
  • T to A, chromosome 6 at 70,703,969 bp (GRCm38)
  • A to T, chromosome 7 at 59,272,212 bp (GRCm38)
  • G to T, chromosome 7 at 64,268,732 bp (GRCm38)
  • A to T, chromosome 7 at 126,557,378 bp (GRCm38)
  • A to T, chromosome 7 at 142,370,967 bp (GRCm38)
  • C to A, chromosome 8 at 110,084,361 bp (GRCm38)
  • G to A, chromosome 9 at 45,750,056 bp (GRCm38)
  • T to C, chromosome 9 at 64,317,735 bp (GRCm38)
  • T to C, chromosome 9 at 108,065,706 bp (GRCm38)
  • C to A, chromosome 9 at 119,322,068 bp (GRCm38)
  • T to A, chromosome 9 at 119,495,616 bp (GRCm38)
  • C to A, chromosome 9 at 123,678,740 bp (GRCm38)
  • T to C, chromosome 10 at 58,455,876 bp (GRCm38)
  • A to G, chromosome 10 at 80,309,172 bp (GRCm38)
  • C to T, chromosome 10 at 111,291,514 bp (GRCm38)
  • A to G, chromosome 10 at 115,418,695 bp (GRCm38)
  • T to C, chromosome 11 at 6,599,390 bp (GRCm38)
  • T to C, chromosome 11 at 60,241,889 bp (GRCm38)
  • A to T, chromosome 11 at 61,491,032 bp (GRCm38)
  • A to G, chromosome 11 at 67,925,095 bp (GRCm38)
  • A to G, chromosome 12 at 76,577,088 bp (GRCm38)
  • A to G, chromosome 13 at 49,730,060 bp (GRCm38)
  • A to G, chromosome 13 at 81,476,648 bp (GRCm38)
  • A to G, chromosome 14 at 52,410,113 bp (GRCm38)
  • A to G, chromosome 16 at 19,407,269 bp (GRCm38)
  • A to C, chromosome 16 at 19,487,671 bp (GRCm38)
  • T to A, chromosome 16 at 43,971,463 bp (GRCm38)
  • C to T, chromosome 18 at 62,922,660 bp (GRCm38)
  • C to T, chromosome 19 at 17,003,689 bp (GRCm38)
  • C to T, chromosome X at 50,841,741 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9394 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069199-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.