Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR9425Btlr/Mmmh
Stock Number:
069229-MU
Citation ID:
RRID:MMRRC_069229-MU
Other Names:
R9425 (G1)
Major Collection:

Strain Information

Arhgef7
Name: Rho guanine nucleotide exchange factor
Synonyms: Cool, PIX, Pak interacting exchange factor, p85SPR, betaPix-c, betaPix-b, cool-1, betaPix
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 54126
Homologene: 2895
Slc17a5
Name: solute carrier family 17 (anion/sugar transporter), member 5
Synonyms: 4631416G20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235504
Homologene: 56571
Upf1
Name: UPF1 RNA helicase and ATPase
Synonyms: PNORF-1, B430202H16Rik, Rent1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 19704
HGNC: HGNC:9962
Homologene: 2185
Agtrap
Name: angiotensin II, type I receptor-associated protein
Synonyms: Atrap, D4Wsu124e, 3300002E14Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11610
Homologene: 7621
Cpne3
Name: copine III
Synonyms: PRO1071, CPN3, 5730450C07Rik, 5430428M23Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 70568
HGNC: HGNC:2316
Homologene: 20839
Tnks
Name: tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
Synonyms: 4930554K12Rik, D130072O21Rik, tankyrase 1, TANK1, mTNKS1, Parp5a
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 21951
Homologene: 18405
Copb1
Name: coatomer protein complex, subunit beta 1
Synonyms: Copb1, 2610019B04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70349
HGNC: HGNC:2231
Homologene: 5664
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • A to G, chromosome 2 at 38,957,709 bp (GRCm38)
  • C to A, chromosome 2 at 88,592,533 bp (GRCm38)
  • T to C, chromosome 2 at 120,302,783 bp (GRCm38)
  • C to T, chromosome 2 at 166,795,622 bp (GRCm38)
  • C to T, chromosome 3 at 10,434,460 bp (GRCm38)
  • T to A, chromosome 3 at 29,985,448 bp (GRCm38)
  • G to T, chromosome 3 at 49,754,602 bp (GRCm38)
  • G to C, chromosome 3 at 122,132,695 bp (GRCm38)
  • C to A, chromosome 3 at 131,564,947 bp (GRCm38)
  • T to A, chromosome 3 at 142,542,957 bp (GRCm38)
  • A to T, chromosome 4 at 19,525,148 bp (GRCm38)
  • A to T, chromosome 4 at 100,974,860 bp (GRCm38)
  • G to A, chromosome 4 at 111,877,606 bp (GRCm38)
  • A to G, chromosome 4 at 148,080,562 bp (GRCm38)
  • T to C, chromosome 5 at 14,937,122 bp (GRCm38)
  • T to A, chromosome 5 at 21,303,137 bp (GRCm38)
  • T to A, chromosome 5 at 30,345,594 bp (GRCm38)
  • T to A, chromosome 5 at 31,200,351 bp (GRCm38)
  • C to T, chromosome 5 at 34,351,297 bp (GRCm38)
  • T to C, chromosome 5 at 120,817,628 bp (GRCm38)
  • G to C, chromosome 5 at 137,868,702 bp (GRCm38)
  • C to A, chromosome 5 at 143,381,680 bp (GRCm38)
  • C to A, chromosome 5 at 145,803,738 bp (GRCm38)
  • A to T, chromosome 6 at 18,423,881 bp (GRCm38)
  • T to A, chromosome 6 at 29,489,152 bp (GRCm38)
  • A to G, chromosome 6 at 97,172,332 bp (GRCm38)
  • G to A, chromosome 6 at 116,516,613 bp (GRCm38)
  • T to C, chromosome 6 at 124,508,363 bp (GRCm38)
  • G to A, chromosome 6 at 129,465,551 bp (GRCm38)
  • T to A, chromosome 6 at 141,657,523 bp (GRCm38)
  • T to C, chromosome 7 at 66,679,239 bp (GRCm38)
  • C to T, chromosome 7 at 114,248,947 bp (GRCm38)
  • C to T, chromosome 8 at 11,817,736 bp (GRCm38)
  • A to G, chromosome 8 at 27,086,066 bp (GRCm38)
  • G to A, chromosome 8 at 34,873,665 bp (GRCm38)
  • A to T, chromosome 8 at 70,339,353 bp (GRCm38)
  • C to A, chromosome 8 at 79,178,959 bp (GRCm38)
  • T to G, chromosome 9 at 7,476,209 bp (GRCm38)
  • G to A, chromosome 9 at 37,661,097 bp (GRCm38)
  • A to G, chromosome 9 at 38,430,990 bp (GRCm38)
  • C to T, chromosome 9 at 78,577,175 bp (GRCm38)
  • A to C, chromosome 10 at 8,330,109 bp (GRCm38)
  • T to C, chromosome 10 at 127,050,137 bp (GRCm38)
  • A to G, chromosome 11 at 68,922,984 bp (GRCm38)
  • G to A, chromosome 11 at 99,815,239 bp (GRCm38)
  • T to A, chromosome 11 at 118,393,925 bp (GRCm38)
  • A to G, chromosome 13 at 21,347,303 bp (GRCm38)
  • A to T, chromosome 13 at 93,744,305 bp (GRCm38)
  • T to A, chromosome 14 at 24,308,319 bp (GRCm38)
  • T to C, chromosome 14 at 36,879,206 bp (GRCm38)
  • T to C, chromosome 14 at 37,062,251 bp (GRCm38)
  • C to A, chromosome 14 at 54,440,347 bp (GRCm38)
  • T to C, chromosome 15 at 89,085,293 bp (GRCm38)
  • T to C, chromosome 16 at 37,174,344 bp (GRCm38)
  • A to G, chromosome 17 at 24,185,408 bp (GRCm38)
  • A to G, chromosome 17 at 34,576,827 bp (GRCm38)
  • A to G, chromosome 17 at 43,310,383 bp (GRCm38)
  • C to A, chromosome 17 at 65,864,511 bp (GRCm38)
  • C to T, chromosome 18 at 44,405,294 bp (GRCm38)
  • A to T, chromosome 19 at 7,896,791 bp (GRCm38)
  • C to T, chromosome 19 at 13,529,858 bp (GRCm38)
  • G to T, chromosome 19 at 32,638,350 bp (GRCm38)
  • A to T, chromosome 19 at 58,680,858 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9425 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069229-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.