Strain Name:
C57BL/6J-MtgxR9517Btlr/Mmmh
Stock Number:
069319-MU
Citation ID:
RRID:MMRRC_069319-MU
Other Names:
R9517 (G1)
Major Collection:

Strain Information

Mtrr
Name: 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 210009
VEGA: 13
HGNC: HGNC:7473
Homologene: 11419
Icos
Name: inducible T cell co-stimulator
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 54167
HGNC: HGNC:5351
Homologene: 8097
Inpp5d
Name: inositol polyphosphate-5-phosphatase D
Synonyms: Src homology 2 domain-containing inositol-5-phosphatase, s-SHIP, SHIP-1, SHIP, SHIP1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16331
HGNC: HGNC:6079
Homologene: 4046
Pzp
Name: PZP, alpha-2-macroglobulin like
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11287
Homologene: 104112
Osbpl1a
Name: oxysterol binding protein-like 1A
Synonyms: G430090F17Rik, LOC328902
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 64291
Homologene: 84746
Chst5
Name: carbohydrate sulfotransferase 5
Synonyms: I-GlcNAc6ST, GST-4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56773
Homologene: 56927
Hap1
Name: huntingtin-associated protein 1
Synonyms: HAP-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15114
HGNC: HGNC:4812
Homologene: 2935
Dock9
Name: dedicator of cytokinesis 9
Synonyms: Zizimin1, B230309H04Rik, D14Wsu89e
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105445
Homologene: 41026
Prmt7
Name: protein arginine N-methyltransferase 7
Synonyms: 4933402B05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 214572
Homologene: 10382
Aspm
Name: abnormal spindle microtubule assembly
Synonyms: Sha1, MCPH5, D330028K02Rik, Aspm, Calmbp1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12316
Homologene: 7650
Chchd3
Name: coiled-coil-helix-coiled-coil-helix domain containing 3
Synonyms: 1700039J09Rik, 0610041L09Rik, Micos19
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66075
Homologene: 9851
Gdf10
Name: growth differentiation factor 10
Synonyms: Bmp3b
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14560
VEGA: 14
HGNC: HGNC:4215
Homologene: 3640
Adnp
Name: activity-dependent neuroprotective protein
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11538
Homologene: 7617
Pgd
Name: phosphogluconate dehydrogenase
Synonyms: 0610042A05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 110208
HGNC: HGNC:8891
Homologene: 68268
Aip
Name: aryl-hydrocarbon receptor-interacting protein
Synonyms: Fkbp16, Ara9, D19Bwg1412e, Xap2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 11632
HGNC: HGNC:358
Homologene: 2959
Ldlr
Name: low density lipoprotein receptor
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16835
VEGA: 9
HGNC: HGNC:6547
Homologene: 55469
Lipc
Name: lipase, hepatic
Synonyms: HL, Hpl
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 15450
VEGA: 9
HGNC: HGNC:6619
Homologene: 199
Frem1
Name: Fras1 related extracellular matrix protein 1
Synonyms: heb, eyem02Jus, eyes2, QBRICK, crf11
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329872
Homologene: 27049
C6
Name: complement component 6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12274
HGNC: HGNC:1339
Homologene: 47
Aspn
Name: asporin
Synonyms: SLRR1C, PLAP-1, 4631401G09Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66695
VEGA: 13
Homologene: 32357
Clec4g
Name: C-type lectin domain family 4, member g
Synonyms: 4930572L20Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 75863
Homologene: 18879
Cdk12
Name: cyclin dependent kinase 12
Synonyms: Crk7, 1810022J16Rik, D11Ertd752e, Crkrs
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69131
Homologene: 128632
Eme2
Name: essential meiotic structure-specific endonuclease subunit 2
Synonyms: 2810013J18Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 193838
Homologene: 19180
Ell2
Name: elongation factor for RNA polymerase II 2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 192657
VEGA: 13
Homologene: 8094
Myo7a
Name: myosin VIIA
Synonyms: nmf371, polka, Myo7, Hdb, USH1B
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17921
HGNC: HGNC:7606
Homologene: 219
Sox6
Name: SRY (sex determining region Y)-box 6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20679
Homologene: 22631
Tent4a
Name: terminal nucleotidyltransferase 4A
Synonyms: TRF4-1, Papd7, TRF4, Pols, LAK-1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 210106
Homologene: 5089
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: LOC382552, Dnahcl1, Dnahc17, 2810003K23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Mcc
Name: mutated in colorectal cancers
Synonyms: D18Ertd451e
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 328949
HGNC: HGNC:6935
Homologene: 20539
Eps8l1
Name: EPS8-like 1
Synonyms: DRC3, EPS8R1, 2310051G19Rik, 4632407K17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67425
Homologene: 15767
Kcng4
Name: potassium voltage-gated channel, subfamily G, member 4
Synonyms: 4921535I01Rik, KV6.4, KV6.3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66733
Homologene: 23553
Nfatc1
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1
Synonyms: 2210017P03Rik, NF-ATc, NFATc, NFAT2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 18018
VEGA: 18
HGNC: HGNC:7775
Homologene: 32336
Abca15
Name: ATP-binding cassette, sub-family A member 15
Synonyms: 4930500I12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 320631
Homologene: 87255
Vipr1
Name: vasoactive intestinal peptide receptor 1
Synonyms: VIP-R1, VIP receptor subtype 1, VPAC1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22354
Homologene: 3399
Lrrc37
Name: leucine rich repeat containing 37
Synonyms: Gm884, LOC380730
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380730
Homologene: 134511
Actn2
Name: actinin alpha 2
Synonyms: 1110008F24Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 11472
HGNC: HGNC:164
Homologene: 31016
Or11g26
Name: olfactory receptor family 11 subfamily G member 26
Synonyms: MOR106-6, Olfr742, GA_x6K02T2PMLR-6224293-6225228
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258422
Homologene: 74163
Vmn2r82
Name: vomeronasal 2, receptor 82
Synonyms: EG624845
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 624845
Homologene: 83483
Rin3
Name: Ras and Rab interactor 3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217835
Homologene: 11748
Lrit2
Name: leucine-rich repeat, immunoglobulin-like and transmembrane domains 2
Synonyms: A930010E21Rik, Lrrc22
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239038
VEGA: 14
Homologene: 18292
Nrap
Name: nebulin-related anchoring protein
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18175
HGNC: HGNC:7988
Homologene: 4499
Pramel23
Name: PRAME like 23
Synonyms: Gm13089
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 277667
Aass
Name: aminoadipate-semialdehyde synthase
Synonyms: Lorsdh, LOR/SDH
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 30956
Homologene: 4212
Dcbld2
Name: discoidin, CUB and LCCL domain containing 2
Synonyms: CLCP1, 1700055P21Rik, Esdn
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 73379
Homologene: 12499
Vmn1r39
Name: vomeronasal 1 receptor 39
Synonyms: Gm5993
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 546903
Homologene: 110800
Or10j3
Name: olfactory receptor family 10 subfamily J member 3B
Synonyms: GA_x6K02T2R7CC-643715-642847, Olfr218, MOR267-3, Olfr1405-ps1, GA_x6K02SYWG4P-534-1100, MOR267-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 258880
Homologene: 105155
Arsk
Name: arylsulfatase K
Synonyms: 2810429K17Rik, 4833414G15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 77041
Homologene: 12670
Or4f54
Name: olfactory receptor family 4 subfamily F member 54
Synonyms: MOR245-11, Olfr1278, GA_x6K02T2Q125-72343713-72344654
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258389
Homologene: 74061
Sgce
Name: sarcoglycan, epsilon
Synonyms: e-SG
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20392
Homologene: 31205
Myb
Name: myeloblastosis oncogene
Synonyms: c-myb
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17863
HGNC: HGNC:7545
Homologene: 31311
Fam186b
Name: family with sequence similarity 186, member B
Synonyms: EG545136
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 545136
VEGA: 15
Homologene: 69502
Cela3a
Name: chymotrypsin-like elastase family, member 3A
Synonyms: Gm13011
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242711
Homologene: 129880
Plcxd3
Name: phosphatidylinositol-specific phospholipase C, X domain containing 3
Synonyms: B130016O10Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239318
Homologene: 45574
Or8b41
Name: olfactory receptor family 8 subfamily B member 41
Synonyms: Olfr890, MOR162-3, MOR162-15_p, GA_x6K02T2PVTD-31822365-31823309
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258474
Homologene: 138311
Zhx1
Name: zinc fingers and homeoboxes 1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22770
Homologene: 5225
Vmn1r11
Name: vomeronasal 1 receptor 11
Synonyms: V1rc3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113860
Homologene: 128345
Setbp1
Name: SET binding protein 1
Synonyms: Seb
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240427
Homologene: 9192
Mtfr1l
Name: mitochondrial fission regulator 1-like
Synonyms: Fam54b, 2410166I05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76824
Homologene: 10472
Or4c106
Name: olfactory receptor family 4 subfamily C member 106
Synonyms: Olfr1204, MOR232-6, GA_x6K02T2Q125-50322618-50323547
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258455
Homologene: 133021
Rilpl2
Name: Rab interacting lysosomal protein-like 2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 80291
Homologene: 12723
Fbxw25
Name: F-box and WD-40 domain protein 25
Synonyms: E330001B16Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 546160
Gm3415
Name: predicted gene 3415
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100041578
Homologene: 86127
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • T to C, chromosome 1 at 60,993,735 bp (GRCm38)
  • T to A, chromosome 1 at 87,711,131 bp (GRCm38)
  • T to A, chromosome 1 at 139,479,429 bp (GRCm38)
  • C to A, chromosome 1 at 173,203,779 bp (GRCm38)
  • G to A, chromosome 2 at 88,852,603 bp (GRCm38)
  • T to G, chromosome 2 at 111,292,688 bp (GRCm38)
  • A to T, chromosome 2 at 168,182,946 bp (GRCm38)
  • T to C, chromosome 4 at 82,983,477 bp (GRCm38)
  • T to C, chromosome 4 at 134,529,204 bp (GRCm38)
  • T to A, chromosome 4 at 137,404,514 bp (GRCm38)
  • T to A, chromosome 4 at 143,698,360 bp (GRCm38)
  • T to C, chromosome 4 at 149,165,211 bp (GRCm38)
  • A to G, chromosome 5 at 124,469,725 bp (GRCm38)
  • C to T, chromosome 5 at 146,556,596 bp (GRCm38)
  • A to T, chromosome 6 at 4,694,153 bp (GRCm38)
  • A to T, chromosome 6 at 23,113,529 bp (GRCm38)
  • A to T, chromosome 6 at 33,049,382 bp (GRCm38)
  • A to G, chromosome 6 at 57,137,570 bp (GRCm38)
  • A to C, chromosome 6 at 66,805,274 bp (GRCm38)
  • A to G, chromosome 6 at 128,512,154 bp (GRCm38)
  • T to A, chromosome 7 at 4,477,637 bp (GRCm38)
  • A to T, chromosome 7 at 98,071,959 bp (GRCm38)
  • A to G, chromosome 7 at 115,512,735 bp (GRCm38)
  • A to G, chromosome 7 at 120,388,201 bp (GRCm38)
  • C to A, chromosome 8 at 3,717,452 bp (GRCm38)
  • A to G, chromosome 8 at 106,227,298 bp (GRCm38)
  • A to G, chromosome 8 at 111,890,020 bp (GRCm38)
  • A to G, chromosome 8 at 119,626,331 bp (GRCm38)
  • T to C, chromosome 9 at 21,743,944 bp (GRCm38)
  • T to A, chromosome 9 at 38,143,327 bp (GRCm38)
  • T to C, chromosome 9 at 70,802,278 bp (GRCm38)
  • A to G, chromosome 9 at 109,651,824 bp (GRCm38)
  • G to A, chromosome 9 at 121,642,927 bp (GRCm38)
  • C to T, chromosome 10 at 21,154,713 bp (GRCm38)
  • C to T, chromosome 10 at 79,377,807 bp (GRCm38)
  • A to T, chromosome 11 at 98,219,084 bp (GRCm38)
  • A to T, chromosome 11 at 100,349,362 bp (GRCm38)
  • G to A, chromosome 11 at 103,542,590 bp (GRCm38)
  • A to G, chromosome 11 at 118,024,614 bp (GRCm38)
  • T to C, chromosome 12 at 102,368,636 bp (GRCm38)
  • G to T, chromosome 13 at 12,280,431 bp (GRCm38)
  • G to A, chromosome 13 at 49,551,799 bp (GRCm38)
  • A to T, chromosome 13 at 68,580,611 bp (GRCm38)
  • A to G, chromosome 13 at 69,506,940 bp (GRCm38)
  • A to G, chromosome 13 at 75,763,987 bp (GRCm38)
  • A to G, chromosome 13 at 76,062,519 bp (GRCm38)
  • A to G, chromosome 14 at 33,932,565 bp (GRCm38)
  • T to A, chromosome 14 at 37,072,315 bp (GRCm38)
  • C to A, chromosome 14 at 50,515,313 bp (GRCm38)
  • T to C, chromosome 14 at 121,591,824 bp (GRCm38)
  • G to T, chromosome 15 at 4,375,678 bp (GRCm38)
  • G to T, chromosome 15 at 4,798,432 bp (GRCm38)
  • A to T, chromosome 15 at 58,052,416 bp (GRCm38)
  • G to A, chromosome 15 at 99,279,735 bp (GRCm38)
  • T to G, chromosome 16 at 58,433,456 bp (GRCm38)
  • G to A, chromosome 17 at 24,895,059 bp (GRCm38)
  • A to G, chromosome 18 at 12,909,908 bp (GRCm38)
  • C to A, chromosome 18 at 44,661,727 bp (GRCm38)
  • T to C, chromosome 18 at 78,858,107 bp (GRCm38)
  • T to C, chromosome 18 at 80,682,191 bp (GRCm38)
  • A to T, chromosome 19 at 4,118,217 bp (GRCm38)
  • A to T, chromosome 19 at 56,371,845 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9517 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069319-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.