Strain Name:
C57BL/6J-MtgxR9553Btlr/Mmmh
Stock Number:
069349-MU
Citation ID:
RRID:MMRRC_069349-MU
Other Names:
R9553 (G1)
Major Collection:

Strain Information

Spry4
Name: sprouty RTK signaling antagonist 4
Synonyms: sprouty4, A030006O18Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 24066
VEGA: 18
Homologene: 8042
Coro7
Name: coronin 7
Synonyms: 0610011B16Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 78885
Homologene: 11573
Kcnk1
Name: potassium channel, subfamily K, member 1
Synonyms: TWIK-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16525
HGNC: HGNC:6272
Homologene: 1691
E2f8
Name: E2F transcription factor 8
Synonyms: 4432406C08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 108961
Homologene: 11654
Cntrob
Name: centrobin, centrosomal BRCA2 interacting protein
Synonyms: 9830165K03Rik, Lip8, Nip2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216846
Homologene: 14205
Eif3d
Name: eukaryotic translation initiation factor 3, subunit D
Synonyms: mouse translation initiation factor eIF3 p66, eIF3p66, 66/67kDa, Eif3s7
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 55944
VEGA: 15
HGNC: HGNC:3278
Homologene: 2782
Arhgef1
Name: Rho guanine nucleotide exchange factor 1
Synonyms: Lbcl2, Lsc
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16801
HGNC: HGNC:681
Homologene: 3454
Glg1
Name: golgi apparatus protein 1
Synonyms: CFR-1, ESL-1, MG-160, MG160, Selel, CFR
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20340
HGNC: HGNC:4316
Homologene: 7533
Ifrd2
Name: interferon-related developmental regulator 2
Synonyms: 1810034A24Rik, SKMc15
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 15983
HGNC: HGNC:5457
Homologene: 21341
Reck
Name: reversion-inducing-cysteine-rich protein with kazal motifs
Synonyms: St15
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 53614
Homologene: 9622
Tm7sf3
Name: transmembrane 7 superfamily member 3
Synonyms: 2010003B14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67623
Homologene: 9560
Elp6
Name: elongator acetyltransferase complex subunit 6
Synonyms: Tmem103, 2610002I17Rik, 2610001P13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72341
Homologene: 9794
Entpd3
Name: ectonucleoside triphosphate diphosphohydrolase 3
Synonyms: HB6, NTPDase-3, Cd39l3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 215446
HGNC: HGNC:3365
Homologene: 68171
Fgfr4
Name: fibroblast growth factor receptor 4
Synonyms: Fgfr-4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14186
HGNC: HGNC:3691
Homologene: 20461
Kcp
Name: kielin/chordin-like protein
Synonyms: KCP, LOC333088, Crim2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 333088
Homologene: 87817
Lama3
Name: laminin, alpha 3
Synonyms: nicein, 150kDa, [a]3B
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 16774
HGNC: HGNC:6483
Homologene: 18279
Gucy1b1
Name: guanylate cyclase 1, soluble, beta 1
Synonyms: Gucy1b3, beta 1 sGC
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 54195
HGNC: HGNC:4687
Homologene: 664
Cnga4
Name: cyclic nucleotide gated channel alpha 4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233649
HGNC: HGNC:2152
Homologene: 13579
Gas6
Name: growth arrest specific 6
Synonyms: growth arrest-specific, Gas-6, GAS 6
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14456
HGNC: HGNC:4168
Homologene: 638
Vwf
Name: Von Willebrand factor
Synonyms: B130011O06Rik, 6820430P06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22371
Homologene: 466
Madd
Name: MAP-kinase activating death domain
Synonyms: 9630059K23Rik, Rab3 GEP
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228355
HGNC: HGNC:6766
Homologene: 14249
Rnf135
Name: ring finger protein 135
Synonyms: 0610037N03Rik, U 2-3-0, MGC13061, 2410006N06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71956
Homologene: 12427
Fbxl13
Name: F-box and leucine-rich repeat protein 13
Synonyms: 4921539K22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320118
Homologene: 27057
Peli2
Name: pellino 2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 93834
VEGA: 14
HGNC: HGNC:8828
Homologene: 41431
Vmn2r80
Name: vomeronasal 2, receptor 80
Synonyms: EG624765
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 624765
Homologene: 83483
Flg2
Name: filaggrin family member 2
Synonyms: EG229574
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229574
Homologene: 134146
Speg
Name: SPEG complex locus
Synonyms: SPEGbeta, BPEG, SPEGalpha, Apeg1, SPEG, D1Bwg1450e
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11790
Homologene: 55619
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: LOC227058, Dnahc7b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227058
Homologene: 41287
Mak
Name: male germ cell-associated kinase
Synonyms: A930010O05Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17152
VEGA: 13
HGNC: HGNC:6816
Homologene: 31344
Ceacam20
Name: CEA cell adhesion molecule 20
Synonyms: 9130012D09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71601
Homologene: 19010
Ceacam15
Name: CEA cell adhesion molecule 15
Synonyms: C430002N04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101434
Homologene: 131210
Pcdhb19
Name: protocadherin beta 19
Synonyms: PcdhbS, Pcdhb11
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93890
Homologene: 128411
Fam186a
Name: family with sequence similarity 186, member A
Synonyms: 1700030F18Rik, LOC380973
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72277
Rars2
Name: arginyl-tRNA synthetase 2, mitochondrial
Synonyms: PRO1992, 1500002I10Rik, Rarsl
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 109093
Homologene: 5707
Sirpb1a
Name: signal-regulatory protein beta 1A
Synonyms: 9930027N05Rik, Sirpb1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 320832
Homologene: 82993
Tchh
Name: trichohyalin
Synonyms: AHF, Thh
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99681
Homologene: 136273
Vmn2r49
Name: vomeronasal 2, receptor 49
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 625605
Homologene: 113703
Plekhd1
Name: pleckstrin homology domain containing, family D (with coiled-coil domains) member 1
Synonyms: 3830431G21Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217682
Homologene: 15090
Or5w14
Name: olfactory receptor family 5 subfamily W member 14
Synonyms: Olfr1137, MOR40-9P, GA_x6K02T2Q125-49215724-49214792, MOR177-20
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258101
Homologene: 79380
Nfatc4
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4
Synonyms: 3110041H08Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 73181
VEGA: 14
HGNC: HGNC:7778
Homologene: 3349
Zpld2
Name: zona pellucida like domain containing 2
Synonyms: Gm7534
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 665186
Homologene: 104039
Cyp2t4
Name: cytochrome P450, family 2, subfamily t, polypeptide 4
Synonyms: LOC384724
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 384724
Homologene: 76639
Zfp428
Name: zinc finger protein 428
Synonyms: 2410005H09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232969
Homologene: 18789
2410002F23Rik
Name: RIKEN cDNA 2410002F23 gene
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 668661
Homologene: 105477
Cbx8
Name: chromobox 8
Synonyms: polycomb 3, Pc3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 30951
Homologene: 32199
Ankdd1b
Name: ankyrin repeat and death domain containing 1B
Synonyms: 9330128J19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 271144
Homologene: 19566
Fpr3
Name: formyl peptide receptor 3
Synonyms: Fpr-rs1, LXA4-R, Lxa4r, Fprl1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14294
Eif1ad7
Name: eukaryotic translation initiation factor 1A domain containing 7
Synonyms: Gm5662
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 435337
Homologene: 103865
Trav7d-3
Name: T cell receptor alpha variable 7D-3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100042419
Igkv4-91
Name: immunoglobulin kappa chain variable 4-91
Synonyms: ENSMUSG00000056850, Gm10879
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 434033
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • A to G, chromosome 1 at 46,225,796 bp (GRCm38)
  • A to C, chromosome 1 at 75,418,001 bp (GRCm38)
  • A to T, chromosome 2 at 87,711,648 bp (GRCm38)
  • A to G, chromosome 2 at 91,178,455 bp (GRCm38)
  • C to T, chromosome 3 at 15,411,260 bp (GRCm38)
  • T to C, chromosome 3 at 82,039,780 bp (GRCm38)
  • G to A, chromosome 3 at 93,214,594 bp (GRCm38)
  • C to T, chromosome 3 at 93,447,818 bp (GRCm38)
  • G to A, chromosome 4 at 34,637,014 bp (GRCm38)
  • T to C, chromosome 4 at 43,928,310 bp (GRCm38)
  • G to A, chromosome 4 at 134,202,001 bp (GRCm38)
  • C to T, chromosome 5 at 21,523,153 bp (GRCm38)
  • G to T, chromosome 6 at 29,485,101 bp (GRCm38)
  • C to T, chromosome 6 at 68,768,648 bp (GRCm38)
  • A to C, chromosome 6 at 125,600,699 bp (GRCm38)
  • C to T, chromosome 6 at 146,623,681 bp (GRCm38)
  • A to C, chromosome 7 at 9,986,922 bp (GRCm38)
  • T to C, chromosome 7 at 16,673,391 bp (GRCm38)
  • A to G, chromosome 7 at 19,990,001 bp (GRCm38)
  • A to G, chromosome 7 at 24,515,441 bp (GRCm38)
  • A to G, chromosome 7 at 24,919,690 bp (GRCm38)
  • G to A, chromosome 7 at 27,155,292 bp (GRCm38)
  • C to T, chromosome 7 at 44,250,910 bp (GRCm38)
  • A to G, chromosome 7 at 48,878,646 bp (GRCm38)
  • A to G, chromosome 7 at 105,405,770 bp (GRCm38)
  • T to C, chromosome 8 at 13,475,048 bp (GRCm38)
  • C to T, chromosome 8 at 111,200,138 bp (GRCm38)
  • C to A, chromosome 8 at 126,029,583 bp (GRCm38)
  • C to T, chromosome 9 at 107,591,086 bp (GRCm38)
  • T to A, chromosome 9 at 110,315,897 bp (GRCm38)
  • T to C, chromosome 9 at 120,558,480 bp (GRCm38)
  • T to C, chromosome 10 at 79,148,909 bp (GRCm38)
  • T to C, chromosome 11 at 69,314,853 bp (GRCm38)
  • T to A, chromosome 11 at 80,183,932 bp (GRCm38)
  • T to G, chromosome 11 at 119,040,138 bp (GRCm38)
  • A to T, chromosome 12 at 80,707,203 bp (GRCm38)
  • A to G, chromosome 12 at 88,271,706 bp (GRCm38)
  • T to A, chromosome 13 at 41,030,119 bp (GRCm38)
  • T to G, chromosome 13 at 55,161,415 bp (GRCm38)
  • G to T, chromosome 13 at 96,454,786 bp (GRCm38)
  • A to G, chromosome 14 at 48,250,693 bp (GRCm38)
  • G to T, chromosome 14 at 52,744,363 bp (GRCm38)
  • A to G, chromosome 14 at 55,832,802 bp (GRCm38)
  • T to C, chromosome 15 at 77,959,637 bp (GRCm38)
  • T to C, chromosome 15 at 99,946,680 bp (GRCm38)
  • A to G, chromosome 16 at 4,668,760 bp (GRCm38)
  • T to A, chromosome 17 at 17,971,350 bp (GRCm38)
  • G to A, chromosome 18 at 12,429,962 bp (GRCm38)
  • C to T, chromosome 18 at 37,498,795 bp (GRCm38)
  • T to C, chromosome 18 at 38,590,017 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9553 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069349-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.