Strain Name:
C57BL/6J-MtgxR9584Btlr/Mmmh
Stock Number:
069377-MU
Citation ID:
RRID:MMRRC_069377-MU
Other Names:
R9584 (G1)
Major Collection:

Strain Information

Tet1
Name: tet methylcytosine dioxygenase 1
Synonyms: BB001228, 2510010B09Rik, Cxxc6, D10Ertd17e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 52463
Homologene: 12735
Foxo3
Name: forkhead box O3
Synonyms: Foxo3a, Fkhr2, FKHRL1, 1110048B16Rik, 2010203A17Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 56484
Homologene: 31039
Thada
Name: thyroid adenoma associated
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240174
VEGA: 17
Homologene: 75175
Asxl2
Name: ASXL transcriptional regulator 2
Synonyms: 4930556B16Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 75302
Homologene: 10102
Dop1a
Name: DOP1 leucine zipper like protein A
Synonyms: D9Ertd809e, Dopey1, B130005I07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320615
Homologene: 26645
Trrap
Name: transformation/transcription domain-associated protein
Synonyms: transactivation/transformation-domain associated protein
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100683
Homologene: 39246
Pitpna
Name: phosphatidylinositol transfer protein, alpha
Synonyms: Pitp alpha, Pitpn
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18738
HGNC: HGNC:9001
Homologene: 55958
Nvl
Name: nuclear VCP-like
Synonyms: 1200009I24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67459
HGNC: HGNC:8070
Homologene: 1902
Topbp1
Name: topoisomerase (DNA) II binding protein 1
Synonyms: D430026L04Rik, 1110031N14Rik, 2810429C13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235559
Homologene: 38262
Ccdc80
Name: coiled-coil domain containing 80
Synonyms: Urb, DRO1, Ssg1, 2610001E17Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67896
Homologene: 12206
Dock7
Name: dedicator of cytokinesis 7
Synonyms: 3110056M06Rik, LOC242555, m
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67299
Homologene: 23566
Pacs1
Name: phosphofurin acidic cluster sorting protein 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107975
VEGA: 19
Homologene: 9970
Casz1
Name: castor zinc finger 1
Synonyms: D4Ertd432e, 2410019P08Rik, Cst, castor
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69743
Homologene: 9824
Synrg
Name: synergin, gamma
Synonyms: L71-5, Ap1gbp1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217030
HGNC: HGNC:557
Homologene: 105680
Knop1
Name: lysine rich nucleolar protein 1
Synonyms: Tsg118, 2310008H09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66356
Homologene: 49729
A830010M20Rik
Name: RIKEN cDNA A830010M20 gene
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231570
VEGA: 5
Homologene: 128318
Cacna2d2
Name: calcium channel, voltage-dependent, alpha 2/delta subunit 2
Synonyms: a2d2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56808
HGNC: HGNC:1400
Homologene: 4400
Impg1
Name: interphotoreceptor matrix proteoglycan 1
Synonyms: A930015H12Rik, IMP150, SPACR
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 63859
HGNC: HGNC:6055
Homologene: 1201
Nlrp2
Name: NLR family, pyrin domain containing 2
Synonyms: E330007A02Rik, Nalp2, Pan1, Nbs1, PYPAF2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232827
Homologene: 56789
Adamts16
Name: ADAM metallopeptidase with thrombospondin type 1 motif 16
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 271127
Homologene: 15146
Or5ac19
Name: olfactory receptor family 5 subfamily AC member 19
Synonyms: GA_x54KRFPKG5P-55483936-55483010, MOR182-2, Olfr201
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258996
Homologene: 37011
Vwa8
Name: von Willebrand factor A domain containing 8
Synonyms: 1300010F03Rik, 4932416F07Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219189
VEGA: 14
Homologene: 44881
Ankhd1
Name: ankyrin repeat and KH domain containing 1
Synonyms: 9130019P20Rik, 4933432B13Rik, A530027J04Rik, 1110004O12Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 108857
Homologene: 87006
Tshz1
Name: teashirt zinc finger family member 1
Synonyms: 5730407I04Rik, Mtsh1, D18Bwg1409e, teashirt1, Tsh1, NY-CO-33, Sdccag33
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 110796
Homologene: 4227
Kcnv2
Name: potassium channel, subfamily V, member 2
Synonyms: KV11.1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240595
Homologene: 26423
Hipk3
Name: homeodomain interacting protein kinase 3
Synonyms: DYRK6, FIST3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15259
HGNC: HGNC:4915
Homologene: 55923
Foxg1
Name: forkhead box G1
Synonyms: Hfh9, 2900064B05Rik, BF-1, Bf1, Hfhbf1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 15228
HGNC: HGNC:3811
Homologene: 3843
Grip1
Name: glutamate receptor interacting protein 1
Synonyms: eb, 4931400F03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 74053
Homologene: 12938
Pag1
Name: phosphoprotein associated with glycosphingolipid microdomains 1
Synonyms: Cbp, F730007C19Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 94212
Homologene: 10198
Gm10549
Name: predicted gene 10549
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 433171
VEGA: 18
Pde4c
Name: phosphodiesterase 4C, cAMP specific
Synonyms: E130301F19Rik, dunce, Dpde1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 110385
HGNC: HGNC:8782
Homologene: 20256
Pnpo
Name: pyridoxine 5'-phosphate oxidase
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103711
Homologene: 5364
Chil6
Name: chitinase-like 6
Synonyms: BC051070, BYm
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229688
Homologene: 77638
Cdh10
Name: cadherin 10
Synonyms: C030011H18Rik, A830016G23Rik, C030003B10Rik, T2-cadherin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 320873
HGNC: HGNC:1749
Homologene: 68530
Or8g17
Name: olfactory receptor family 8 subfamily G member 17
Synonyms: GA_x6K02T2PVTD-32715386-32714466, M15, Olfr146, MOR171-10
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258742
VEGA: 9
Psph
Name: phosphoserine phosphatase
Synonyms: PSPase
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100678
HGNC: HGNC:9577
Homologene: 31245
Brsk1
Name: BR serine/threonine kinase 1
Synonyms: SAD-B, LOC381979
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381979
Homologene: 57169
Pou5f2
Name: POU domain class 5, transcription factor 2
Synonyms: Sprm1, 1700013G10Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75507
Homologene: 83454
Sgsh
Name: N-sulfoglucosamine sulfohydrolase (sulfamidase)
Synonyms: 4632406A19Rik, sulphamidase
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 27029
Homologene: 167
Muc1
Name: mucin 1, transmembrane
Synonyms: CD227, EMA, Muc-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17829
HGNC: HGNC:7508
Homologene: 137248
Catsper2
Name: cation channel, sperm associated 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 212670
Homologene: 77423
Orai3
Name: ORAI calcium release-activated calcium modulator 3
Synonyms: Tmem142c
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269999
Homologene: 72082
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • A to G, chromosome 1 at 181,130,866 bp (GRCm38)
  • A to G, chromosome 2 at 104,471,565 bp (GRCm38)
  • A to T, chromosome 2 at 121,399,820 bp (GRCm38)
  • A to G, chromosome 3 at 9,696,154 bp (GRCm38)
  • C to T, chromosome 3 at 89,231,066 bp (GRCm38)
  • A to G, chromosome 3 at 106,394,356 bp (GRCm38)
  • G to A, chromosome 4 at 98,973,244 bp (GRCm38)
  • A to G, chromosome 4 at 148,901,247 bp (GRCm38)
  • A to T, chromosome 5 at 107,510,481 bp (GRCm38)
  • G to A, chromosome 5 at 129,770,688 bp (GRCm38)
  • G to A, chromosome 5 at 144,840,520 bp (GRCm38)
  • T to A, chromosome 7 at 4,706,663 bp (GRCm38)
  • C to A, chromosome 7 at 5,319,216 bp (GRCm38)
  • G to A, chromosome 7 at 118,848,486 bp (GRCm38)
  • G to T, chromosome 7 at 127,774,005 bp (GRCm38)
  • T to C, chromosome 8 at 70,748,079 bp (GRCm38)
  • G to A, chromosome 9 at 39,019,166 bp (GRCm38)
  • T to C, chromosome 9 at 80,440,796 bp (GRCm38)
  • C to A, chromosome 9 at 86,503,098 bp (GRCm38)
  • T to C, chromosome 9 at 103,342,043 bp (GRCm38)
  • T to C, chromosome 9 at 107,400,205 bp (GRCm38)
  • C to T, chromosome 10 at 42,197,025 bp (GRCm38)
  • A to T, chromosome 10 at 62,819,527 bp (GRCm38)
  • G to A, chromosome 10 at 120,038,664 bp (GRCm38)
  • C to A, chromosome 11 at 75,619,542 bp (GRCm38)
  • A to G, chromosome 11 at 84,009,374 bp (GRCm38)
  • C to A, chromosome 11 at 96,940,879 bp (GRCm38)
  • T to C, chromosome 11 at 119,350,963 bp (GRCm38)
  • T to C, chromosome 12 at 3,500,667 bp (GRCm38)
  • G to A, chromosome 12 at 49,385,623 bp (GRCm38)
  • T to G, chromosome 13 at 70,801,017 bp (GRCm38)
  • A to G, chromosome 13 at 78,025,473 bp (GRCm38)
  • A to G, chromosome 14 at 79,157,109 bp (GRCm38)
  • A to T, chromosome 15 at 18,992,009 bp (GRCm38)
  • A to G, chromosome 16 at 45,095,312 bp (GRCm38)
  • A to G, chromosome 16 at 59,269,217 bp (GRCm38)
  • G to A, chromosome 17 at 84,426,177 bp (GRCm38)
  • C to T, chromosome 18 at 33,464,322 bp (GRCm38)
  • A to T, chromosome 18 at 36,665,451 bp (GRCm38)
  • G to A, chromosome 18 at 84,014,964 bp (GRCm38)
  • T to C, chromosome 19 at 5,272,594 bp (GRCm38)
  • T to C, chromosome 19 at 27,322,865 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9584 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069377-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.