Strain Name:
C57BL/6J-MtgxR9662Btlr/Mmmh
Stock Number:
069455-MU
Citation ID:
RRID:MMRRC_069455-MU
Other Names:
R9662 (G1)
Major Collection:

Strain Information

Col1a1
Name: collagen, type I, alpha 1
Synonyms: Col1a-1, Cola-1, Mov-13, Cola1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12842
HGNC: HGNC:2197
Homologene: 73874
Cadps
Name: Ca2+-dependent secretion activator
Synonyms: CAPS1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 27062
VEGA: 14
HGNC: HGNC:1426
Homologene: 2755
Kcna6
Name: potassium voltage-gated channel, shaker-related, subfamily, member 6
Synonyms: MK1.6, Kv1.6
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16494
HGNC: HGNC:6225
Homologene: 1684
Grin3a
Name: glutamate receptor ionotropic, NMDA3A
Synonyms: NR3A, NMDAR-L, A830097C19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242443
Homologene: 128613
Sgsm1
Name: small G protein signaling modulator 1
Synonyms: 2410098H20Rik, D5Bwg1524e, Rutbc2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 52850
Homologene: 64485
Zfp207
Name: zinc finger protein 207
Synonyms: 8430401D15Rik, Zep
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22680
Homologene: 134624
Nup210l
Name: nucleoporin 210-like
Synonyms: 4930548O11Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77595
Homologene: 28122
Exog
Name: exo/endonuclease G
Synonyms: ENDOGL2, ENGL-a, ENGL-B, Endogl1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208194
VEGA: 9
HGNC: HGNC:3347
Homologene: 3745
Kmt2a
Name: lysine (K)-specific methyltransferase 2A
Synonyms: trithorax Drosophila, ALL-1, Mll1, Cxxc7, Mll, HTRX1, All1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214162
HGNC: HGNC:7132
Homologene: 4338
Mcm5
Name: minichromosome maintenance complex component 5
Synonyms: mCD46, Cdc46, Mcmd5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17218
HGNC: HGNC:6948
Homologene: 4904
Fnbp1
Name: formin binding protein 1
Synonyms: 1110057E06Rik, FBP17, FBP1, 2210010H06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14269
Homologene: 100983
Parg
Name: poly (ADP-ribose) glycohydrolase
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 26430
HGNC: HGNC:8605
Homologene: 50532
Mars1
Name: methionine-tRNA synthetase 1
Synonyms: methionyl-tRNA synthetase, methionine tRNA ligase, Mars, MetRS
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216443
HGNC: HGNC:6898
Homologene: 90878
Zfp318
Name: zinc finger protein 318
Synonyms: TZF, 2610034E08Rik, D530032D06Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 57908
Homologene: 22808
Robo2
Name: roundabout guidance receptor 2
Synonyms: D230004I22Rik, 2600013A04Rik, 9430089E08Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268902
Homologene: 43188
Raver1
Name: ribonucleoprotein, PTB-binding 1
Synonyms: 1300006N24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71766
VEGA: 9
Homologene: 12410
Celf6
Name: CUGBP, Elav-like family member 6
Synonyms: 6330569O16Rik, Brunol6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 76183
Homologene: 129318
Bcr
Name: BCR activator of RhoGEF and GTPase
Synonyms: 5133400C09Rik, breakpoint cluster region
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 110279
VEGA: 10
HGNC: HGNC:1014
Homologene: 3192
Ppp3ca
Name: protein phosphatase 3, catalytic subunit, alpha isoform
Synonyms: 2900074D19Rik, CnA, CN, Calna, Caln, PP2BA alpha, PP2B alpha 1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19055
HGNC: HGNC:9314
Homologene: 55497
Tbx1
Name: T-box 1
Synonyms: nmf219
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 21380
VEGA: 16
Homologene: 7966
Myo7a
Name: myosin VIIA
Synonyms: nmf371, polka, Myo7, Hdb, USH1B
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17921
HGNC: HGNC:7606
Homologene: 219
Arhgef28
Name: Rho guanine nucleotide exchange factor 28
Synonyms: D13Bwg1089e, Rho specific exchange factor, 9230110L08Rik, RIP2, Rgnef, p190RhoGEF, RhoGEF
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110596
VEGA: 13
Homologene: 8078
Ndst3
Name: N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
Synonyms: 4930511P15Rik, 4921531K01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 83398
HGNC: HGNC:7682
Homologene: 3513
Hmgcll1
Name: 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208982
Homologene: 27863
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Dnah2
Name: dynein, axonemal, heavy chain 2
Synonyms: Dnahc2, D330014H01Rik, Dnhd3, 2900022L05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327954
HGNC: HGNC:2948
Homologene: 72110
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: LOC382552, Dnahcl1, Dnahc17, 2810003K23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Zfp251
Name: zinc finger protein 251
Synonyms: 9130001M19Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71591
VEGA: 15
Homologene: 87789
Agbl3
Name: ATP/GTP binding protein-like 3
Synonyms: 2900053G10Rik, 4930431N21Rik, 6530406M24Rik, Ccp3, Ccp3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 76223
Homologene: 35330
Slc6a19
Name: solute carrier family 6 (neurotransmitter transporter), member 19
Synonyms: 4632401C08Rik, B0AT1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 74338
Homologene: 52819
Ppip5k1
Name: diphosphoinositol pentakisphosphate kinase 1
Synonyms: B430315C20Rik, Hisppd2a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 327655
Homologene: 49395
Clip2
Name: CAP-GLY domain containing linker protein 2
Synonyms: CLIP-115, WSCR4, Cyln2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269713
HGNC: HGNC:2586
Homologene: 20718
Zfp763
Name: zinc finger protein 763
Synonyms: 1700065O13Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 73451
Homologene: 66274
Tmem151a
Name: transmembrane protein 151A
Synonyms: Tmem151, LOC381199, Gm30627
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 381199
Homologene: 17721
H2-Q6
Name: histocompatibility 2, Q region locus 6
Synonyms: 0610037M15Rik, Qa6, Qa-6, H-2Q6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 110557
Homologene: 128352
Ltk
Name: leukocyte tyrosine kinase
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17005
HGNC: HGNC:6721
Homologene: 130502
Cdc14a
Name: CDC14 cell division cycle 14A
Synonyms: CDC14A2, CDC14a1, Cdc14, A830059A17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229776
HGNC: HGNC:1718
Homologene: 75343
Gm21149
Name: predicted gene, 21149
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100861702
Homologene: 69402
Gm7324
Name: predicted gene 7324
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 652988
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • T to A, chromosome 2 at 31,096,030 bp (GRCm38)
  • A to G, chromosome 2 at 76,841,260 bp (GRCm38)
  • G to T, chromosome 2 at 119,751,849 bp (GRCm38)
  • T to C, chromosome 2 at 121,343,573 bp (GRCm38)
  • C to T, chromosome 3 at 90,199,866 bp (GRCm38)
  • T to A, chromosome 3 at 116,294,835 bp (GRCm38)
  • T to A, chromosome 3 at 123,671,466 bp (GRCm38)
  • T to C, chromosome 3 at 136,877,740 bp (GRCm38)
  • A to T, chromosome 4 at 49,792,432 bp (GRCm38)
  • A to T, chromosome 5 at 15,476,359 bp (GRCm38)
  • G to A, chromosome 5 at 113,279,231 bp (GRCm38)
  • C to T, chromosome 5 at 134,504,762 bp (GRCm38)
  • T to A, chromosome 6 at 34,832,533 bp (GRCm38)
  • T to G, chromosome 6 at 126,738,417 bp (GRCm38)
  • T to A, chromosome 7 at 98,098,292 bp (GRCm38)
  • C to T, chromosome 8 at 75,117,540 bp (GRCm38)
  • C to T, chromosome 9 at 21,081,254 bp (GRCm38)
  • A to G, chromosome 9 at 44,820,131 bp (GRCm38)
  • C to T, chromosome 9 at 59,578,385 bp (GRCm38)
  • A to T, chromosome 9 at 76,015,115 bp (GRCm38)
  • A to G, chromosome 9 at 119,452,310 bp (GRCm38)
  • T to C, chromosome 10 at 75,175,320 bp (GRCm38)
  • A to G, chromosome 10 at 127,300,480 bp (GRCm38)
  • T to C, chromosome 11 at 69,452,937 bp (GRCm38)
  • G to A, chromosome 11 at 80,395,203 bp (GRCm38)
  • A to G, chromosome 11 at 94,945,841 bp (GRCm38)
  • A to T, chromosome 11 at 118,034,340 bp (GRCm38)
  • A to T, chromosome 13 at 73,691,703 bp (GRCm38)
  • C to A, chromosome 13 at 97,929,461 bp (GRCm38)
  • T to A, chromosome 14 at 12,411,567 bp (GRCm38)
  • T to C, chromosome 14 at 32,250,019 bp (GRCm38)
  • A to T, chromosome 14 at 43,714,977 bp (GRCm38)
  • A to T, chromosome 15 at 76,853,320 bp (GRCm38)
  • T to C, chromosome 16 at 18,582,132 bp (GRCm38)
  • C to T, chromosome 16 at 73,961,678 bp (GRCm38)
  • T to A, chromosome 17 at 33,021,813 bp (GRCm38)
  • C to T, chromosome 17 at 35,425,209 bp (GRCm38)
  • C to T, chromosome 17 at 46,413,457 bp (GRCm38)
  • C to A, chromosome 19 at 5,082,689 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9662 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069455-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.