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Strain Name:
C57BL/6J-MtgxR9663Btlr/Mmmh
Stock Number:
069456-MU
Citation ID:
RRID:MMRRC_069456-MU
Other Names:
R9663 (G1)
Major Collection:

Strain Information

Ext1
Name: exostosin glycosyltransferase 1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14042
HGNC: HGNC:3512
Homologene: 30957
Itga8
Name: integrin alpha 8
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241226
HGNC: HGNC:6144
Homologene: 37396
Myh7
Name: myosin, heavy polypeptide 7, cardiac muscle, beta
Synonyms: Myhc-b, Myhcb, beta-MHC, B-MHC, MYH-beta/slow, MyHC-I, betaMHC
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 140781
HGNC: HGNC:7577
Homologene: 68044
Luc7l3
Name: LUC7-like 3 (S. cerevisiae)
Synonyms: 3300001P08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67684
Homologene: 75056
Slc25a33
Name: solute carrier family 25, member 33
Synonyms: 5730438N18Rik, Pnc1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 70556
Homologene: 57076
Nisch
Name: nischarin
Synonyms: 1200007D05Rik, 3202002H23Rik, edsn
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 64652
Homologene: 136161
Usp19
Name: ubiquitin specific peptidase 19
Synonyms: 8430421I07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71472
Homologene: 41730
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • T to A, chromosome 1 at 3,216,296 bp (GRCm38)
  • G to T, chromosome 1 at 28,777,455 bp (GRCm38)
  • T to A, chromosome 1 at 87,088,031 bp (GRCm38)
  • A to C, chromosome 2 at 12,191,769 bp (GRCm38)
  • A to G, chromosome 2 at 30,281,058 bp (GRCm38)
  • A to G, chromosome 2 at 33,228,219 bp (GRCm38)
  • C to T, chromosome 2 at 76,885,013 bp (GRCm38)
  • A to T, chromosome 2 at 114,196,468 bp (GRCm38)
  • G to A, chromosome 2 at 118,119,416 bp (GRCm38)
  • A to C, chromosome 2 at 120,486,378 bp (GRCm38)
  • G to A, chromosome 2 at 172,557,293 bp (GRCm38)
  • A to T, chromosome 3 at 33,801,388 bp (GRCm38)
  • A to T, chromosome 3 at 64,556,128 bp (GRCm38)
  • A to T, chromosome 3 at 92,868,976 bp (GRCm38)
  • A to G, chromosome 3 at 101,003,906 bp (GRCm38)
  • A to T, chromosome 4 at 19,818,818 bp (GRCm38)
  • A to G, chromosome 4 at 48,426,218 bp (GRCm38)
  • A to G, chromosome 4 at 59,719,764 bp (GRCm38)
  • A to T, chromosome 4 at 106,747,697 bp (GRCm38)
  • G to A, chromosome 4 at 109,322,073 bp (GRCm38)
  • T to A, chromosome 4 at 149,752,456 bp (GRCm38)
  • A to G, chromosome 4 at 156,016,427 bp (GRCm38)
  • C to T, chromosome 5 at 134,504,762 bp (GRCm38)
  • C to A, chromosome 5 at 137,295,283 bp (GRCm38)
  • C to A, chromosome 5 at 137,380,857 bp (GRCm38)
  • A to T, chromosome 6 at 7,680,132 bp (GRCm38)
  • A to G, chromosome 6 at 37,379,991 bp (GRCm38)
  • G to A, chromosome 6 at 90,409,346 bp (GRCm38)
  • A to T, chromosome 6 at 121,880,504 bp (GRCm38)
  • T to A, chromosome 6 at 121,882,740 bp (GRCm38)
  • T to A, chromosome 7 at 24,638,924 bp (GRCm38)
  • T to C, chromosome 7 at 30,313,946 bp (GRCm38)
  • G to A, chromosome 7 at 30,554,289 bp (GRCm38)
  • G to A, chromosome 7 at 43,639,340 bp (GRCm38)
  • T to C, chromosome 7 at 122,127,081 bp (GRCm38)
  • T to G, chromosome 7 at 129,608,923 bp (GRCm38)
  • T to C, chromosome 7 at 144,457,724 bp (GRCm38)
  • G to T, chromosome 8 at 54,181,303 bp (GRCm38)
  • C to T, chromosome 8 at 75,117,540 bp (GRCm38)
  • C to T, chromosome 8 at 124,751,697 bp (GRCm38)
  • G to T, chromosome 9 at 21,073,421 bp (GRCm38)
  • A to G, chromosome 9 at 59,982,743 bp (GRCm38)
  • T to G, chromosome 9 at 108,494,695 bp (GRCm38)
  • C to T, chromosome 9 at 121,391,858 bp (GRCm38)
  • G to A, chromosome 10 at 39,047,948 bp (GRCm38)
  • A to G, chromosome 10 at 77,920,486 bp (GRCm38)
  • A to G, chromosome 10 at 80,801,475 bp (GRCm38)
  • G to A, chromosome 10 at 127,192,649 bp (GRCm38)
  • A to T, chromosome 10 at 129,437,060 bp (GRCm38)
  • A to G, chromosome 10 at 129,801,628 bp (GRCm38)
  • T to C, chromosome 11 at 50,969,338 bp (GRCm38)
  • T to A, chromosome 11 at 68,954,429 bp (GRCm38)
  • A to G, chromosome 11 at 94,296,930 bp (GRCm38)
  • A to G, chromosome 12 at 24,655,732 bp (GRCm38)
  • A to G, chromosome 12 at 69,175,110 bp (GRCm38)
  • T to C, chromosome 13 at 41,316,465 bp (GRCm38)
  • G to T, chromosome 14 at 24,003,829 bp (GRCm38)
  • C to A, chromosome 14 at 31,173,668 bp (GRCm38)
  • A to T, chromosome 14 at 33,009,064 bp (GRCm38)
  • T to C, chromosome 14 at 54,983,641 bp (GRCm38)
  • A to G, chromosome 14 at 69,191,872 bp (GRCm38)
  • C to T, chromosome 15 at 32,673,400 bp (GRCm38)
  • C to T, chromosome 15 at 39,118,783 bp (GRCm38)
  • A to G, chromosome 15 at 53,345,060 bp (GRCm38)
  • G to T, chromosome 15 at 58,108,144 bp (GRCm38)
  • G to A, chromosome 15 at 65,941,781 bp (GRCm38)
  • A to G, chromosome 15 at 83,496,378 bp (GRCm38)
  • T to A, chromosome 16 at 4,115,790 bp (GRCm38)
  • T to G, chromosome 17 at 8,326,980 bp (GRCm38)
  • T to A, chromosome 17 at 56,653,751 bp (GRCm38)
  • C to A, chromosome 17 at 56,780,895 bp (GRCm38)
  • T to C, chromosome 17 at 67,191,296 bp (GRCm38)
  • T to A, chromosome 18 at 20,038,148 bp (GRCm38)
  • C to A, chromosome 18 at 78,109,592 bp (GRCm38)
  • C to A, chromosome 19 at 3,265,325 bp (GRCm38)
  • C to T, chromosome 19 at 7,199,448 bp (GRCm38)
  • T to G, chromosome 19 at 10,726,494 bp (GRCm38)
  • A to T, chromosome 19 at 12,430,095 bp (GRCm38)
  • A to G, chromosome 19 at 39,090,626 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9663 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069456-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.