Strain Detail Sheet
Strain Name:
STOCK Basp1tm1Meka/RosteMmnc
Stock Number:
069568-UNC
Citation ID:
RRID:MMRRC_069568-UNC
Other Names:
BASP1fl+/+, Floxed-BASP1
Basp1tm1Meka
Name: brain abundant, membrane attached signal protein 1; targeted mutation 1, Kathryn Medler
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 15
Basp1
Name: brain abundant, membrane attached signal protein 1
Synonyms: Ckap3, CAP23, CAP-23, 2610024P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
MGI: MGI:1917600
NCBI: 70350
Ensembl: ENSMUSG00000045763
VEGA: 15
HGNC: HGNC:957
Homologene: 38168
CCDS: CCDS27398.1
UCSC: Chr15:25363363-25413850
Genome Browser [Click image to go to Jbrowse]
Additional Resources
Genetic Alterations
Entire coding region of Basp1 gene is floxed
Genotype Determination
ES Cell Line
Not specified
Phenotype
The strain contains a floxed Basp1 allele, which is phenotypically indistinguishable from the wild-type. Mice carrying the recombined (knockout) allele are not viable.
MeSH Terms
- Animals
- Biomarkers
- Calmodulin-Binding Proteins/genetics
- Calmodulin-Binding Proteins/metabolism
- Cell Differentiation/genetics
- Cytoskeletal Proteins/genetics
- Cytoskeletal Proteins/metabolism
- Fluorescent Antibody Technique
- Gene Expression
- Gene Knockdown Techniques
- Mice
- Mice, Transgenic
- Models, Biological
- Nerve Tissue Proteins/genetics
- Nerve Tissue Proteins/metabolism
- Phenotype
- Protein Binding
- Taste Buds/cytology
- Taste Buds/metabolism
- WT1 Proteins/genetics
- WT1 Proteins/metabolism
Strain Development
The mutation was introduced with C57BL/6-derived ES cells; the exact identity is unknown. Per submission information, the line is on C57BL/6 background (substrain unclear). The selection cassette was removed either by breeding to an unspecified Flp deleter or by Frt self-excision.
Suggested Control Mice
C57BL/6
- Cancer
- Neurobiology
Donor
Kathryn Medler, Ph.D., University of Buffalo.
Stefan Roberts, Ph.D., University at Buffalo, The State University of New York.
Stefan Roberts, Ph.D., University at Buffalo, The State University of New York.
Primary Reference
Gao Y, Dutta Banik D, Muna MM, Roberts SG, Medler KF. The WT1-BASP1 complex is required to maintain the differentiated state of taste receptor cells. Life Sci Alliance. 2019 Jun 5;2(3):e201800287. doi: 10.26508/lsa.201800287. (Medline PMID: 31167803)
Colony Surveillance Program and Current Health Reports
For more information about this colony's health status contact mmrrc_health@med.unc.eduCoat Color
Black
Eye
Black
MMRRC Breeding System
Backcross and random intra-strain mating
Generation
N10+ (C57BL/6), F1
Overall Breeding Performance
Good
| Viability and Fertility: | Female | Male | Comments |
|---|---|---|---|
| Homozygotes are viable: | Yes | Yes | |
| Homozygotes are fertile: | Yes | Yes | |
| Heterozygotes are fertile: | Yes | Yes | |
| Age Reproductive Decline: | 7 to 9 months | 7 to 9 months |
Average litter size
7 to 9
Recommended wean age
3 Weeks
Average Pups Weaned
7 to 9
The availability level for this product has not been determined.
Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.
The donor or their institution limits the distribution to non-profit institutions only.
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