Strain Name:
STOCK Basp1tm1Meka/RosteMmnc
Stock Number:
069568-UNC
Citation ID:
RRID:MMRRC_069568-UNC
Other Names:
BASP1fl+/+, Floxed-BASP1

Gene Information

Basp1tm1Meka
Name: brain abundant, membrane attached signal protein 1; targeted mutation 1, Kathryn Medler
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 15
Basp1
Name: brain abundant, membrane attached signal protein 1
Synonyms: Ckap3, CAP23, CAP-23, 2610024P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 70350
VEGA: 15
HGNC: HGNC:957
Homologene: 38168
Genetic Alterations
Entire coding region of Basp1 gene is floxed
Genotype Determination
  • Genotyping Protocol(s)
  • Center protocol and contact for technical support will be shipped with mice.
  • ES Cell Line
    Not specified
    Phenotype
    The strain contains a floxed Basp1 allele, which is phenotypically indistinguishable from the wild-type. Mice carrying the recombined (knockout) allele are not viable.
    MeSH Terms
    • Animals
    • Biomarkers
    • Calmodulin-Binding Proteins/genetics
    • Calmodulin-Binding Proteins/metabolism
    • Cell Differentiation/genetics
    • Cytoskeletal Proteins/genetics
    • Cytoskeletal Proteins/metabolism
    • Fluorescent Antibody Technique
    • Gene Expression
    • Gene Knockdown Techniques
    • Mice
    • Mice, Transgenic
    • Models, Biological
    • Nerve Tissue Proteins/genetics
    • Nerve Tissue Proteins/metabolism
    • Phenotype
    • Protein Binding
    • Taste Buds/cytology
    • Taste Buds/metabolism
    • WT1 Proteins/genetics
    • WT1 Proteins/metabolism
    Strain Development
    The mutation was introduced with C57BL/6-derived ES cells; the exact identity is unknown. Per submission information, the line is on C57BL/6 background (substrain unclear). The selection cassette was removed either by breeding to an unspecified Flp deleter or by Frt self-excision.
    Suggested Control Mice
    C57BL/6
    • Cancer
    • Neurobiology
    Donor
    Kathryn Medler, Ph.D., University of Buffalo.
    Stefan Roberts, Ph.D., University at Buffalo, The State University of New York.
    Primary Reference

    Gao Y, Dutta Banik D, Muna MM, Roberts SG, Medler KF. The WT1-BASP1 complex is required to maintain the differentiated state of taste receptor cells. Life Sci Alliance. 2019 Jun 5;2(3):e201800287. doi: 10.26508/lsa.201800287. (Medline PMID: 31167803)

    Colony and Husbandry Information

    Coat Color
    Black
    Eye
    Black
    MMRRC Breeding System
    Backcross and random intra-strain mating
    Generation
    N10+ (C57BL/6), F1
    Overall Breeding Performance
    Good
    Viability and Fertility: Female Male Comments
    Homozygotes are viable: Yes Yes
    Homozygotes are fertile: Yes Yes
    Heterozygotes are fertile: Yes Yes
    Age Reproductive Decline: 7 to 9 months 7 to 9 months
    Average litter size
    7 to 9
    Recommended wean age
    3 Weeks
    Average Pups Weaned
    7 to 9

    Order Request Information

    The availability level for this product has not been determined.

    Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

    The donor or their institution limits the distribution to non-profit institutions only.

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    - If you register interest in this strain, you will be notified when it becomes available for ordering.

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