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Strain Name:
C57BL/6J-MtgxR9709Btlr/Mmmh
Stock Number:
069956-MU
Citation ID:
RRID:MMRRC_069956-MU
Other Names:
R9709 (G1)
Major Collection:

Strain Information

Nefh
Name: neurofilament, heavy polypeptide
Synonyms: NF-H, NF200, NEFH
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380684
HGNC: HGNC:7737
Homologene: 40755
Dnmt3a
Name: DNA methyltransferase 3A
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13435
HGNC: HGNC:2978
Homologene: 7294
Shprh
Name: SNF2 histone linker PHD RING helicase
Synonyms: 2610103K11Rik, D230017O13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268281
Homologene: 6489
Sbf2
Name: SET binding factor 2
Synonyms: SBF2, 4833411B01Rik, mMTMH1, B430219L04Rik, Mtmr13
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319934
HGNC: HGNC:2135
Homologene: 41810
Sez6
Name: seizure related gene 6
Synonyms: sez-6, D11Bhm177e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20370
Homologene: 10948
Rgs10
Name: regulator of G-protein signalling 10
Synonyms: 2310010N19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67865
HGNC: HGNC:9992
Homologene: 37710
Cdc42se2
Name: CDC42 small effector 2
Synonyms: SPEC2, 2810404F18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72729
Homologene: 41356
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • A to G, chromosome 1 at 4,042,032 bp (GRCm38)
  • T to C, chromosome 1 at 15,710,299 bp (GRCm38)
  • T to C, chromosome 1 at 78,390,563 bp (GRCm38)
  • C to A, chromosome 1 at 171,343,739 bp (GRCm38)
  • A to G, chromosome 1 at 181,838,469 bp (GRCm38)
  • A to G, chromosome 1 at 183,418,816 bp (GRCm38)
  • T to A, chromosome 1 at 191,831,177 bp (GRCm38)
  • C to A, chromosome 2 at 36,251,192 bp (GRCm38)
  • T to C, chromosome 2 at 52,211,495 bp (GRCm38)
  • T to G, chromosome 2 at 85,071,781 bp (GRCm38)
  • T to C, chromosome 2 at 91,281,754 bp (GRCm38)
  • C to T, chromosome 2 at 126,658,568 bp (GRCm38)
  • T to A, chromosome 2 at 150,268,385 bp (GRCm38)
  • T to C, chromosome 2 at 180,732,528 bp (GRCm38)
  • T to C, chromosome 3 at 36,476,207 bp (GRCm38)
  • T to A, chromosome 3 at 55,786,458 bp (GRCm38)
  • T to A, chromosome 3 at 72,891,741 bp (GRCm38)
  • C to A, chromosome 3 at 88,108,869 bp (GRCm38)
  • T to A, chromosome 3 at 117,328,327 bp (GRCm38)
  • A to G, chromosome 4 at 45,018,678 bp (GRCm38)
  • A to G, chromosome 4 at 103,235,481 bp (GRCm38)
  • A to T, chromosome 4 at 116,315,847 bp (GRCm38)
  • T to C, chromosome 4 at 141,685,118 bp (GRCm38)
  • C to T, chromosome 4 at 145,149,345 bp (GRCm38)
  • T to C, chromosome 4 at 153,974,664 bp (GRCm38)
  • A to T, chromosome 5 at 3,661,809 bp (GRCm38)
  • T to C, chromosome 5 at 8,520,982 bp (GRCm38)
  • G to A, chromosome 5 at 15,472,112 bp (GRCm38)
  • C to T, chromosome 5 at 53,702,859 bp (GRCm38)
  • T to C, chromosome 5 at 77,401,537 bp (GRCm38)
  • T to A, chromosome 5 at 89,040,346 bp (GRCm38)
  • T to C, chromosome 5 at 105,083,676 bp (GRCm38)
  • A to T, chromosome 5 at 111,285,771 bp (GRCm38)
  • G to A, chromosome 5 at 128,797,811 bp (GRCm38)
  • G to T, chromosome 6 at 43,153,535 bp (GRCm38)
  • A to G, chromosome 6 at 80,809,173 bp (GRCm38)
  • A to T, chromosome 6 at 83,306,683 bp (GRCm38)
  • A to G, chromosome 6 at 85,447,970 bp (GRCm38)
  • A to G, chromosome 6 at 87,891,975 bp (GRCm38)
  • T to A, chromosome 7 at 16,793,804 bp (GRCm38)
  • A to G, chromosome 7 at 30,579,803 bp (GRCm38)
  • T to C, chromosome 7 at 74,303,209 bp (GRCm38)
  • A to G, chromosome 7 at 98,094,329 bp (GRCm38)
  • A to T, chromosome 7 at 109,831,764 bp (GRCm38)
  • G to T, chromosome 7 at 110,428,307 bp (GRCm38)
  • T to A, chromosome 7 at 120,289,516 bp (GRCm38)
  • A to G, chromosome 7 at 121,910,470 bp (GRCm38)
  • G to T, chromosome 7 at 128,136,328 bp (GRCm38)
  • A to C, chromosome 7 at 128,374,005 bp (GRCm38)
  • T to A, chromosome 8 at 47,493,313 bp (GRCm38)
  • T to C, chromosome 8 at 67,741,762 bp (GRCm38)
  • T to C, chromosome 8 at 75,115,976 bp (GRCm38)
  • A to G, chromosome 9 at 21,745,839 bp (GRCm38)
  • A to G, chromosome 9 at 43,320,500 bp (GRCm38)
  • A to G, chromosome 9 at 96,828,977 bp (GRCm38)
  • A to T, chromosome 9 at 102,542,212 bp (GRCm38)
  • T to A, chromosome 10 at 7,799,577 bp (GRCm38)
  • C to T, chromosome 10 at 11,162,830 bp (GRCm38)
  • T to A, chromosome 10 at 62,449,802 bp (GRCm38)
  • C to T, chromosome 11 at 4,940,042 bp (GRCm38)
  • C to T, chromosome 11 at 8,849,016 bp (GRCm38)
  • A to G, chromosome 11 at 54,723,591 bp (GRCm38)
  • A to G, chromosome 11 at 58,982,038 bp (GRCm38)
  • G to A, chromosome 11 at 77,974,295 bp (GRCm38)
  • T to C, chromosome 11 at 85,583,923 bp (GRCm38)
  • G to A, chromosome 11 at 94,284,734 bp (GRCm38)
  • C to A, chromosome 11 at 110,211,763 bp (GRCm38)
  • A to G, chromosome 11 at 115,566,637 bp (GRCm38)
  • T to A, chromosome 12 at 3,907,701 bp (GRCm38)
  • A to T, chromosome 12 at 32,176,688 bp (GRCm38)
  • A to G, chromosome 12 at 34,312,603 bp (GRCm38)
  • G to T, chromosome 12 at 70,102,694 bp (GRCm38)
  • A to C, chromosome 12 at 104,392,749 bp (GRCm38)
  • A to T, chromosome 12 at 105,644,881 bp (GRCm38)
  • A to G, chromosome 12 at 115,834,171 bp (GRCm38)
  • G to T, chromosome 13 at 18,239,804 bp (GRCm38)
  • A to G, chromosome 13 at 21,959,495 bp (GRCm38)
  • A to G, chromosome 13 at 102,774,203 bp (GRCm38)
  • C to A, chromosome 14 at 21,076,318 bp (GRCm38)
  • A to G, chromosome 14 at 30,915,630 bp (GRCm38)
  • T to A, chromosome 14 at 60,033,738 bp (GRCm38)
  • C to G, chromosome 15 at 82,343,334 bp (GRCm38)
  • G to T, chromosome 15 at 82,343,336 bp (GRCm38)
  • A to G, chromosome 15 at 103,503,558 bp (GRCm38)
  • A to T, chromosome 16 at 32,770,270 bp (GRCm38)
  • A to T, chromosome 17 at 13,235,165 bp (GRCm38)
  • T to C, chromosome 17 at 15,370,936 bp (GRCm38)
  • T to C, chromosome 17 at 24,298,960 bp (GRCm38)
  • A to T, chromosome 17 at 36,964,357 bp (GRCm38)
  • G to A, chromosome 17 at 88,985,837 bp (GRCm38)
  • C to T, chromosome 18 at 3,431,560 bp (GRCm38)
  • A to G, chromosome 18 at 34,940,241 bp (GRCm38)
  • A to C, chromosome 18 at 46,873,780 bp (GRCm38)
  • C to A, chromosome 19 at 4,142,641 bp (GRCm38)
  • A to T, chromosome 19 at 5,081,848 bp (GRCm38)
  • T to G, chromosome 19 at 7,530,556 bp (GRCm38)
  • A to T, chromosome 19 at 41,868,792 bp (GRCm38)
  • A to G, chromosome 19 at 46,310,343 bp (GRCm38)
  • T to C, chromosome 19 at 47,975,553 bp (GRCm38)
  • C to A, chromosome 19 at 56,329,020 bp (GRCm38)
  • T to C, chromosome 19 at 56,329,021 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9709 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069956-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.