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Strain Name:
C57BL/6J-MtgxR9718Btlr/Mmmh
Stock Number:
069965-MU
Citation ID:
RRID:MMRRC_069965-MU
Other Names:
R9718 (G1)
Major Collection:

Strain Information

Shprh
Name: SNF2 histone linker PHD RING helicase
Synonyms: 2610103K11Rik, D230017O13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268281
Homologene: 6489
Acvr1c
Name: activin A receptor, type IC
Synonyms: ALK7, Alk-7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269275
Homologene: 26724
Omd
Name: osteomodulin
Synonyms: osteoadherin, SLRR2C, OSAD
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 27047
VEGA: 13
HGNC: HGNC:8134
Homologene: 3677
Tjp2
Name: tight junction protein 2
Synonyms: ZO-2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 21873
VEGA: 19
Homologene: 3541
Strn4
Name: striatin, calmodulin binding protein 4
Synonyms: ZIN, zinedin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 97387
Homologene: 8378
L3mbtl2
Name: L3MBTL2 polycomb repressive complex 1 subunit
Synonyms: 4732493N06Rik, m4mbt
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 214669
Homologene: 12882
Ckap5
Name: cytoskeleton associated protein 5
Synonyms: 3110043H24Rik, 4930432B04Rik, D730027C18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75786
Homologene: 8844
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • T to A, chromosome 1 at 89,145,750 bp (GRCm38)
  • A to T, chromosome 1 at 181,622,979 bp (GRCm38)
  • A to T, chromosome 2 at 6,721,538 bp (GRCm38)
  • A to T, chromosome 2 at 26,378,521 bp (GRCm38)
  • A to T, chromosome 2 at 29,747,536 bp (GRCm38)
  • A to C, chromosome 2 at 32,575,235 bp (GRCm38)
  • A to T, chromosome 2 at 58,315,995 bp (GRCm38)
  • T to C, chromosome 2 at 76,794,683 bp (GRCm38)
  • A to T, chromosome 2 at 91,548,832 bp (GRCm38)
  • A to G, chromosome 2 at 119,705,505 bp (GRCm38)
  • G to T, chromosome 2 at 120,724,169 bp (GRCm38)
  • A to G, chromosome 3 at 62,472,045 bp (GRCm38)
  • A to G, chromosome 3 at 96,855,858 bp (GRCm38)
  • T to A, chromosome 4 at 96,016,441 bp (GRCm38)
  • T to C, chromosome 4 at 141,249,292 bp (GRCm38)
  • T to C, chromosome 4 at 155,891,637 bp (GRCm38)
  • T to A, chromosome 5 at 23,800,723 bp (GRCm38)
  • T to A, chromosome 5 at 87,242,943 bp (GRCm38)
  • A to G, chromosome 5 at 129,539,784 bp (GRCm38)
  • T to A, chromosome 6 at 15,770,515 bp (GRCm38)
  • T to G, chromosome 6 at 132,700,802 bp (GRCm38)
  • G to T, chromosome 7 at 16,811,187 bp (GRCm38)
  • G to A, chromosome 7 at 16,838,571 bp (GRCm38)
  • T to G, chromosome 7 at 45,095,429 bp (GRCm38)
  • A to T, chromosome 7 at 46,855,032 bp (GRCm38)
  • T to C, chromosome 7 at 103,085,989 bp (GRCm38)
  • G to A, chromosome 8 at 23,748,491 bp (GRCm38)
  • A to G, chromosome 8 at 26,129,215 bp (GRCm38)
  • A to T, chromosome 8 at 45,320,666 bp (GRCm38)
  • T to C, chromosome 8 at 60,937,400 bp (GRCm38)
  • T to A, chromosome 8 at 71,968,089 bp (GRCm38)
  • T to C, chromosome 8 at 90,986,173 bp (GRCm38)
  • T to A, chromosome 8 at 122,638,197 bp (GRCm38)
  • A to G, chromosome 9 at 8,634,189 bp (GRCm38)
  • A to G, chromosome 9 at 65,182,998 bp (GRCm38)
  • A to G, chromosome 9 at 65,233,727 bp (GRCm38)
  • G to A, chromosome 9 at 110,072,706 bp (GRCm38)
  • T to C, chromosome 10 at 11,213,504 bp (GRCm38)
  • C to T, chromosome 10 at 23,869,556 bp (GRCm38)
  • A to T, chromosome 10 at 75,992,497 bp (GRCm38)
  • G to A, chromosome 11 at 60,189,339 bp (GRCm38)
  • G to T, chromosome 11 at 67,025,260 bp (GRCm38)
  • C to T, chromosome 11 at 79,515,757 bp (GRCm38)
  • T to A, chromosome 11 at 83,575,412 bp (GRCm38)
  • G to T, chromosome 11 at 121,069,664 bp (GRCm38)
  • T to A, chromosome 12 at 87,224,918 bp (GRCm38)
  • G to A, chromosome 12 at 98,259,314 bp (GRCm38)
  • C to T, chromosome 12 at 114,523,634 bp (GRCm38)
  • G to T, chromosome 12 at 115,387,085 bp (GRCm38)
  • T to C, chromosome 13 at 49,589,860 bp (GRCm38)
  • T to C, chromosome 14 at 33,125,936 bp (GRCm38)
  • T to G, chromosome 14 at 47,673,051 bp (GRCm38)
  • G to A, chromosome 14 at 53,882,206 bp (GRCm38)
  • C to A, chromosome 15 at 47,696,687 bp (GRCm38)
  • T to A, chromosome 15 at 59,345,343 bp (GRCm38)
  • A to G, chromosome 15 at 81,687,922 bp (GRCm38)
  • G to T, chromosome 16 at 3,986,464 bp (GRCm38)
  • T to A, chromosome 16 at 45,781,393 bp (GRCm38)
  • T to A, chromosome 16 at 56,123,914 bp (GRCm38)
  • A to G, chromosome 16 at 58,614,611 bp (GRCm38)
  • T to C, chromosome 16 at 88,611,490 bp (GRCm38)
  • C to T, chromosome 17 at 37,590,023 bp (GRCm38)
  • C to T, chromosome 17 at 42,502,750 bp (GRCm38)
  • T to C, chromosome 17 at 83,834,786 bp (GRCm38)
  • C to T, chromosome 18 at 42,530,771 bp (GRCm38)
  • C to T, chromosome 19 at 4,262,409 bp (GRCm38)
  • A to C, chromosome 19 at 24,100,843 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9718 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069965-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.