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Strain Name:
C57BL/6J-MtgxR9721Btlr/Mmmh
Stock Number:
069968-MU
Citation ID:
RRID:MMRRC_069968-MU
Other Names:
R9721 (G1)
Major Collection:

Strain Information

Cdh11
Name: cadherin 11
Synonyms: osteoblast-cadherin, OB-cadherin, Cad11
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12552
HGNC: HGNC:1750
Homologene: 1361
Pzp
Name: PZP, alpha-2-macroglobulin like
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11287
Homologene: 104112
Il4i1
Name: interleukin 4 induced 1
Synonyms: Fig1-ps, Fig1, H46, H4, H-46, H-4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14204
Homologene: 22567
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Ggta1
Name: glycoprotein galactosyltransferase alpha 1, 3
Synonyms: GALT, alpha Gal, Gal, glycoprotein alpha galactosyl transferase 1, alpha3GalT, Ggta-1, Ggta
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14594
HGNC: HGNC:4253
Homologene: 7730
Nup93
Name: nucleoporin 93
Synonyms: 2410008G02Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71805
Homologene: 40971
Zc3h4
Name: zinc finger CCCH-type containing 4
Synonyms: LOC330474, Bwq1, Kiaa1064-hp
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330474
Homologene: 87150
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • A to G, chromosome 1 at 34,192,785 bp (GRCm38)
  • T to C, chromosome 1 at 38,037,659 bp (GRCm38)
  • A to G, chromosome 1 at 52,212,268 bp (GRCm38)
  • T to C, chromosome 1 at 74,919,342 bp (GRCm38)
  • T to A, chromosome 1 at 87,479,135 bp (GRCm38)
  • C to T, chromosome 1 at 126,027,280 bp (GRCm38)
  • C to A, chromosome 1 at 173,184,348 bp (GRCm38)
  • T to C, chromosome 1 at 173,527,913 bp (GRCm38)
  • C to T, chromosome 2 at 15,696,827 bp (GRCm38)
  • G to T, chromosome 2 at 35,413,406 bp (GRCm38)
  • T to C, chromosome 2 at 89,001,716 bp (GRCm38)
  • T to C, chromosome 2 at 109,293,055 bp (GRCm38)
  • G to A, chromosome 2 at 178,256,250 bp (GRCm38)
  • A to T, chromosome 3 at 124,419,283 bp (GRCm38)
  • A to G, chromosome 4 at 43,101,869 bp (GRCm38)
  • A to T, chromosome 4 at 58,850,938 bp (GRCm38)
  • T to G, chromosome 4 at 94,804,302 bp (GRCm38)
  • T to A, chromosome 4 at 108,555,581 bp (GRCm38)
  • G to A, chromosome 4 at 126,839,648 bp (GRCm38)
  • A to T, chromosome 4 at 144,703,372 bp (GRCm38)
  • A to G, chromosome 5 at 123,801,885 bp (GRCm38)
  • A to T, chromosome 5 at 124,298,675 bp (GRCm38)
  • T to C, chromosome 6 at 3,375,854 bp (GRCm38)
  • G to A, chromosome 6 at 90,179,026 bp (GRCm38)
  • A to T, chromosome 6 at 91,988,297 bp (GRCm38)
  • A to T, chromosome 6 at 108,406,102 bp (GRCm38)
  • G to A, chromosome 6 at 125,307,385 bp (GRCm38)
  • A to G, chromosome 6 at 128,495,191 bp (GRCm38)
  • T to A, chromosome 6 at 137,056,417 bp (GRCm38)
  • A to G, chromosome 7 at 15,979,176 bp (GRCm38)
  • C to A, chromosome 7 at 16,434,845 bp (GRCm38)
  • A to T, chromosome 7 at 30,039,184 bp (GRCm38)
  • A to G, chromosome 7 at 44,839,689 bp (GRCm38)
  • T to C, chromosome 7 at 66,274,875 bp (GRCm38)
  • A to T, chromosome 7 at 117,549,020 bp (GRCm38)
  • A to G, chromosome 7 at 127,136,265 bp (GRCm38)
  • A to G, chromosome 8 at 69,799,437 bp (GRCm38)
  • T to C, chromosome 8 at 94,303,685 bp (GRCm38)
  • A to T, chromosome 8 at 102,679,625 bp (GRCm38)
  • A to T, chromosome 8 at 105,283,188 bp (GRCm38)
  • A to G, chromosome 8 at 110,978,475 bp (GRCm38)
  • T to C, chromosome 10 at 27,467,342 bp (GRCm38)
  • G to A, chromosome 11 at 49,644,433 bp (GRCm38)
  • T to A, chromosome 11 at 67,815,078 bp (GRCm38)
  • T to A, chromosome 11 at 69,197,085 bp (GRCm38)
  • A to G, chromosome 11 at 71,001,598 bp (GRCm38)
  • T to C, chromosome 11 at 116,966,769 bp (GRCm38)
  • T to A, chromosome 12 at 24,660,241 bp (GRCm38)
  • C to G, chromosome 12 at 69,371,855 bp (GRCm38)
  • T to C, chromosome 13 at 50,246,652 bp (GRCm38)
  • A to G, chromosome 15 at 8,225,409 bp (GRCm38)
  • A to G, chromosome 15 at 57,986,117 bp (GRCm38)
  • A to G, chromosome 15 at 81,608,315 bp (GRCm38)
  • A to T, chromosome 15 at 90,971,127 bp (GRCm38)
  • A to T, chromosome 15 at 101,628,147 bp (GRCm38)
  • C to A, chromosome 17 at 13,234,978 bp (GRCm38)
  • G to A, chromosome 17 at 24,599,642 bp (GRCm38)
  • C to A, chromosome 18 at 37,309,852 bp (GRCm38)
  • G to C, chromosome 19 at 12,428,933 bp (GRCm38)
  • A to T, chromosome 19 at 13,410,970 bp (GRCm38)
  • A to G, chromosome 19 at 18,829,972 bp (GRCm38)
  • A to T, chromosome 19 at 22,889,398 bp (GRCm38)
  • C to T, chromosome 19 at 46,323,189 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9721 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069968-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.