Strain Detail Sheet

Strain Name:
Epilepsy
Stock Number:
037617-MU
Citation ID:
RRID:MMRRC_037617-MU
Other Names:
EPL
Major Collection:
Peromyscus Mice

Strain Information

Gene Details

Genotype Determination

Strain Description

Phenotype
These deer mice, when subjected to certain stimuli, especially high pitched sound, go into convulsions, whirl rapidly, become stuporous or exhibit other abnormal behaviors. Maximum reaction occurs between one and four months of age, and diminishes thereafter. Most become deaf before four months, although a few retain hearing for a year or longer. There is a degeneration of the auditory neural pathway in older deer mice. Chance and Yaxley (1948) present a detailed account of the seizure pattern. Whirling behavior may or may not accompany convulsive seizures, and some individuals do not show this facet of the syndrome.
Strain Development
Source: About 1933. University of Michigan. This trait appeared among laboratory stocks ofP.m. artemisiae originating from deer mice trapped at Lyon's Ferry, Washington.

MMRRC Genetic QC

MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.

Strain Origin

Donor
Michael Felder, The Peromyscus Genetic Stock Center, University of South Carolina.
Primary Reference

Chance MRA, Yaxley DC. New Aspects of the Behavior of Peromyscus Uncer Audiogenic Hyper-excitement. Behavior, Volumen 2, Issue 1,pp 96-105, 1950.

For more information, please see Epilepsy on the Peromyscus Genetic Stock Center website.

Colony and Husbandry Information

Health Status Report

Colony Surveillance Program and Current Health Reports

For more information about this colony's health status contact mmrrc@missouri.edu

Breeding

MMRRC Breeding System
Not applicable; only cryopreserved sperm is available. The parent colony was sufficiently large to use a random breeding scheme
Breeding Scheme(s)
Not applicable; only cryopreserved sperm is available; mice cryorecovered (see below) can be bred Wild-type female x Wild-type male
Overall Breeding Performance
Peromyscus mice breed best in a 16:8 light / dark cycle.

Reproductive Statistics

Average litter size
4.3
Recommended wean age
25 days

Order Request Information

Availability Level

Male mice were obtained from the Peromyscus Genetic Stock Center as part of a long term project to develop cropreservation techniques for Peromyscus. Sperm have been cryopreserved and are available. However, cryorecovery techniques have yet to be developed.

Conditions of Distribution

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Fees

- Products for this strain are Not Yet Available for Ordering
- If you register interest in this strain, you will be notified when it becomes available for ordering.
To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.