Strain Name:
Cataract-webbed
Stock Number:
037619-MU
Citation ID:
RRID:MMRRC_037619-MU
Major Collection:

Gene Information

Genetic Alterations
Spontaneous mutation found in a laboratory colony of P. maniculatus.
Genotype Determination
ES Cell Line
N/A
Phenotype
Two visible manifestations of the mutant are co-inherited. Cataract-webbed deer mice show webbed toes as soon as toes are sufficiently developed, and the webbing involves digits 3=4 or 2=3=4 on the hind foot and 3=4 or 3=4/5 in front with many variations. The syndactyly component, which involves only soft tissues of the toes, is more than 98% penetrant, but variably expressed. The second and third digits of the hind foot are nearly always involved, and syndactyly is much more evident on the hind foot that the front. It is virtually always bilaterally expressed. Beginning at about three months homozygotes develop lenticular cataracts. About 63% of the known homozygous animals had cataracts by one year of age and an additional 25% exhibited other opthalmic lesions, for a total penetrance of 88%. Although some of the deer mice show developing cataracts by three months of age, more typically they appear between 6 and 12 months, and in a few after one year of age. Prior to manifestations of cataracts, the animals may have eye hemorrages or other opthalmic changes. In some animals the eye condition is unilaterally expressed, but more commonly it is bilateral. There is no strong correlation between the degrees of expression of syndactyly versus onset time or severity of cataracts. 
MeSH Terms
  • Animals
  • Cataract/genetics
  • Cataract/veterinary
  • Crosses, Genetic
  • Genes, Recessive
  • Limb Deformities, Congenital
  • Mice
  • Peromyscus/genetics
  • Phenotype
  • Rodent Diseases/genetics
Strain Development
Source: About 1960. University of Oregon. The mutation appeared in the laboratory colony of P. maniculatus.
Primary Reference

Anderson RS, Burns RP. Cataract--webbed Peromyscus. I. Genetics of cataract in P. maniculatus. J Hered. 1979 Jan-Feb;70(1):27-30. (Medline PMID: 469220).

For more information, please see Cataract-webbed on the Peromyscus Genetic Stock Center website.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice derived from requested cell lines via Microinjection services will be pathogen tested prior to delivery of mice and health reports will be provided. If you require additional health status information prior to requesting microinjection please email mmrrc@missouri.edu.
MMRRC Breeding System
Not applicable; only cryopreserved sperm is available. The parent colony was sufficiently large to use a random breeding scheme
Breeding Scheme(s)
Not applicable; only cryopreserved sperm is available; mice cryorecovered (see below) can be bred Wild-type female x Wild-type male
Overall Breeding Performance
Peromyscus mice breed best in a 16:8 light / dark cycle.
Viability and Fertility: Female Male Comments
Homozygotes are viable: Yes Yes
Homozygotes are fertile: Yes Yes
Heterozygotes are fertile: Yes Yes
Age Reproductive Decline: Unknown Unknown
Average litter size
3.5
Recommended wean age
25 days

Order Request Information

Male mice were obtained from the Peromyscus Genetic Stock Center as part of a long term project to develop cropreservation techniques for Peromyscus. Sperm have been cryopreserved and are available. However, cryorecovery techniques have yet to be developed.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

- Products for this strain are Not Yet Available for Ordering
- If you register interest in this strain, you will be notified when it becomes available for ordering.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.