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Strain Detail Sheet

Strain Name:
C57BL/6J-Malt1m1Btlr/Mmmh
Stock Number:
038188--TBD-
Citation ID:
RRID:MMRRC_038188--TBD-
Other Names:
mousebird
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Malt1m1Btlr
Name: MALT1 paracaspase; mutation 1, Bruce Beutler
Synonyms: mousebird
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
Malt1
Name: MALT1 paracaspase
Synonyms: D430033E09Rik, paracaspase, Pcasp1
Type: Gene
Species: Mouse
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 240354
HGNC: HGNC:6819
Homologene: 4938

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Genetic Alterations
ENU-induced T to A transversion at base pair 65,475,260 (v38) on chromosome 18, or base pair 44,325 in the GenBank genomic region NC_000084 for the Malt1 gene. The mutation corresponds to nucleotide two within the donor splice site of intron 15. The effect of the mutation at the cDNA and protein level has not been tested, but the mutation is predicted to result in skipping of the 126-base pair exon 15 (out of 16 total exons). Skipping of exon 15 would cause an in-frame deletion of amino acids 635-676.

Strain Description

Phenotype

Homozygous: Homozygous mousbird animals displayed a diminished T-dependent antibody response to ovalbumin administered with aluminum hydroxide, a diminished T-dependent antibody response to Semliki Forest virus (rSFV)-β-galactosidase (rSFV-β-gal), and a diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll).

Heterozygous: Mice exhibited diminished T-independent antibody response to 4-hydroxy-3-nitrophenylacetyl-Ficoll (NP-Ficoll) compared to wild-type, but not as severe as homozygous mousebird mice.

Mammalian Phenotype Terms
Allelic Composition: (Genetic Background: )
  • immune system
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.

Research Applications

  • Immunology and Inflammation
  • Models for Human Disease
    • Immunodeficiency-12 [IMD12; alternatively, combined immunodeficiency (CID); OMIM: #615468)

Strain Origin

Primary Reference

Wang K-W, Choi JH, Watthanasurorot A, Murray AR, Beutler B. Record for mousebird. MUTAGENETIX, B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Strain Development
Original mutant was a C57BL/6J G3 ENU-induced mutant; all subsequent crosses to maintain strain were on C57BL/6J background only.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Health Status Report

For more information about this colony's health status contact

Appearance

Coat Color
Black

Reproductive Statistics

Viability and Fertility: Female Male Comments
Homozygotes are viable: Yes Yes
Homozygotes are fertile: Yes Yes
Heterozygotes are fertile: Yes Yes
Age Reproductive Decline: Unknown Unknown

Order Request Information

Availability Level

The availability level for this product has not been determined.

Conditions of Distribution

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Fees

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