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Gene Information

Name: Fas ligand (TNF superfamily, member 6); mutation 2, Bruce Beutler
Synonyms: riogrande2
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
Name: Fas ligand (TNF superfamily, member 6)
Synonyms: Fasl, CD95L, Fas-L, APT1LG1, Tnfsf6, CD178
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 14103
Homologene: 533
Genetic Alterations
ENU-induced A to C transversion at base pair 161,787,138 (v38) on chromosome 1, or base pair 8,401 in the GenBank genomic region NC_000067 for the Fasl gene. The mutation corresponds to residue 565 in the mRNA sequence NM_010177 within exon 2 of 4 total exons. The mutation results in a serine (S) to arginine (R) substitution at position 119 (S119R) in the FasL protein.

Homozygous: Mice exhibited diminished T-dependent antibody response to recombinant Semliki Forest virus (rSFV)-β-galactosidase (rSFV-β-gal).

Heterozygous: No abnormal phenotype detected.

Mammalian Phenotype Terms
Allelic Composition: (Genetic Background: )

Strain Development
Original mutant was a C57BL/6J G3 ENU-induced mutant; all subsequent crosses to maintain strain were on C57BL/6J background only.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
  • Apoptosis
  • Immunology and Inflammation
  • Cancer
  • Models for Human Disease
    • Autoimmune lymphoproliferative syndrome, type IB (ALPS; OMIM: #601859)
Primary Reference

Wang K-W, Choi JH, Murray AR, Beutler B. Record for riogrande2. MUTAGENETIX, B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

For more information about this colony's health status contact
Coat Color
Viability and Fertility: Female Male Comments
Homozygotes are viable: Yes Yes
Homozygotes are fertile: Yes Yes
Heterozygotes are fertile: Yes Yes
Age Reproductive Decline: Unknown Unknown

Order Request Information

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