Strain Name:
C57BL/6J-MtgxR0118Btlr/Mmmh
Stock Number:
038404-MU
Citation ID:
RRID:MMRRC_038404-MU
Other Names:
R0118 (G1), C57BL/6J-MtgxR0118Btlr
Major Collection:

Gene Information

Nfat5
Name: nuclear factor of activated T cells 5
Synonyms: nfatz, TonEBP, B130038B15Rik, OREBP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 54446
HGNC: HGNC:7774
Homologene: 4811
Cntnap2
Name: contactin associated protein-like 2
Synonyms: 5430425M22Rik, Caspr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 66797
Homologene: 69159
Trib2
Name: tribbles pseudokinase 2
Synonyms: TRB2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217410
Homologene: 41445
Frem2
Name: Fras1 related extracellular matrix protein 2
Synonyms: 8430406N05Rik, 6030440P17Rik, my, ne, b2b1562Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 242022
Homologene: 18454
Slc35a1
Name: solute carrier family 35 (CMP-sialic acid transporter), member 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 24060
Homologene: 38181
Iqgap1
Name: IQ motif containing GTPase activating protein 1
Synonyms: D7Ertd237e, D7Ertd257e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 29875
HGNC: HGNC:6110
Homologene: 74514
Cers2
Name: ceramide synthase 2
Synonyms: Trh3, 0610013I17Rik, CerS2, Lass2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 76893
Homologene: 39581
Ppm1e
Name: protein phosphatase 1E (PP2C domain containing)
Synonyms: PP2CH, POPX1, B930008A12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 320472
Homologene: 22848
Plxdc1
Name: plexin domain containing 1
Synonyms: Tem7, 2410003I07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 72324
Homologene: 10700
Yeats2
Name: YEATS domain containing 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 208146
VEGA: 16
Homologene: 9967
Asxl2
Name: ASXL transcriptional regulator 2
Synonyms: 4930556B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 75302
Homologene: 10102
Kat6b
Name: K(lysine) acetyltransferase 6B
Synonyms: qkf, querkopf, Morf, B130044K16Rik, monocytic leukemia, Myst4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 54169
Homologene: 136480
Vps35
Name: VPS35 retromer complex component
Synonyms: Mem3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 65114
Homologene: 6221
Nfs1
Name: nitrogen fixation gene 1 (S. cerevisiae)
Synonyms: m-Nfs1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18041
Homologene: 5463
St7l
Name: suppression of tumorigenicity 7-like
Synonyms: St7r
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229681
Homologene: 14910
Dmap1
Name: DNA methyltransferase 1-associated protein 1
Synonyms: 1500016M21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66233
Homologene: 41311
Cic
Name: capicua transcriptional repressor
Synonyms: 1200010B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71722
Homologene: 87637
Mesd
Name: mesoderm development LRP chaperone
Synonyms: 2210015O11Rik, msd, Mesdc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67943
Homologene: 11347
Uimc1
Name: ubiquitin interaction motif containing 1
Synonyms: D630032M02Rik, D330018D10Rik, 9430016E08Rik, Rxrip110
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20184
Homologene: 9455
Polr3g
Name: polymerase (RNA) III (DNA directed) polypeptide G
Synonyms: RPC32, 2310047G20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 67486
Homologene: 38184
Tbc1d32
Name: TBC1 domain family, member 32
Synonyms: C6orf170, Bromi, D630037F22Rik, b2b2284Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 544696
VEGA: 10
Homologene: 51889
Tctn1
Name: tectonic family member 1
Synonyms: Tect1, G730031O11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 654470
Homologene: 49770
Cacna1a
Name: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Synonyms: Cacnl1a4, alpha1A, Ccha1a, SCA6, nmf352, smrl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12286
HGNC: HGNC:1388
Homologene: 56383
Gdpd3
Name: glycerophosphodiester phosphodiesterase domain containing 3
Synonyms: 1110015E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 68616
Homologene: 23441
Rpgrip1l
Name: Rpgrip1-like
Synonyms: Ftm, 1700047E16Rik, fantom, Nphp8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244585
Homologene: 18296
Mrm3
Name: mitochondrial rRNA methyltransferase 3
Synonyms: HC90, 4833420N02Rik, Rnmtl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67390
Homologene: 10033
Fmnl3
Name: formin-like 3
Synonyms: 2700073B04Rik, Wbp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 22379
Homologene: 69101
Olfr1500
Name: olfactory receptor 1500
Synonyms: GA_x6K02T2RE5P-4160554-4159619, MOR212-4P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258097
Homologene: 72644
Ndst4
Name: N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
Synonyms: 4930439H17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 64580
Homologene: 11208
Zfp282
Name: zinc finger protein 282
Synonyms: HUB1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 101095
Homologene: 2647
Rims1
Name: regulating synaptic membrane exocytosis 1
Synonyms: RIM1, RIM1a, C030033M19Rik, RIM1alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 116837
Homologene: 128399
Map6
Name: microtubule-associated protein 6
Synonyms: F-STOP, STOP, 2810411E12Rik, Mtap6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17760
HGNC: HGNC:6868
Homologene: 7850
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: bl, E130113P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231470
Homologene: 23516
Entpd7
Name: ectonucleoside triphosphate diphosphohydrolase 7
Synonyms: LALP1, 2810003F23Rik, 1810020C02Rik, Lysal2, 1810012B13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 93685
Homologene: 122202
Ccr3
Name: chemokine (C-C motif) receptor 3
Synonyms: MIP-1 alphaRL2, CC-CKR3, CKR3, Cmkbr3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12771
VEGA: 9
HGNC: HGNC:1604
Homologene: 20436
Pik3r5
Name: phosphoinositide-3-kinase regulatory subunit 5
Synonyms: Foap2, p101
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 320207
Homologene: 8627
Sfi1
Name: Sfi1 homolog, spindle assembly associated (yeast)
Synonyms: 2310047I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 78887
Homologene: 12707
Pcdh8
Name: protocadherin 8
Synonyms: Papc, 1700080P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 18530
HGNC: HGNC:8660
Homologene: 1943
Olfr353
Name: olfactory receptor 353
Synonyms: GA_x6K02T2NLDC-33585366-33584431, MOR127-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258943
HGNC: HGNC:8221
Homologene: 115503
Olfr923
Name: olfactory receptor 923
Synonyms: GA_x6K02T2PVTD-32530445-32531380, MOR164-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258812
VEGA: 9
Olfr27
Name: olfactory receptor 27
Synonyms: MTPCR56, MOR171-6, GA_x6K02T2PVTD-32841223-32842158
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258826
VEGA: 9
Homologene: 110610
Tnfaip6
Name: tumor necrosis factor alpha induced protein 6
Synonyms: Tsg6, Tnfip6, TSG-6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 21930
Homologene: 5162
Mapkbp1
Name: mitogen-activated protein kinase binding protein 1
Synonyms: Jnkbp1, 2810483F24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 26390
Homologene: 69109
Mertk
Name: MER proto-oncogene tyrosine kinase
Synonyms: Tyro 12, Nyk, Eyk, Mer, nmf12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17289
HGNC: HGNC:7027
Homologene: 4626
Gjb3
Name: gap junction protein, beta 3
Synonyms: Cnx31, connexin 31, Gjb-3, D4Wsu144e, Cx31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 14620
HGNC: HGNC:4285
Homologene: 7338
Azin2
Name: antizyme inhibitor 2
Synonyms: 4933429I20Rik, Odcp, AZIN2, Adc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242669
Homologene: 62172
Rap1gap
Name: Rap1 GTPase-activating protein
Synonyms: 2310004O14Rik, 1300019I11Rik, Rap1ga1, Gap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 110351
HGNC: HGNC:9858
Homologene: 2163
Megf6
Name: multiple EGF-like-domains 6
Synonyms: 2600001P17Rik, Egfl3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230971
HGNC: HGNC:3232
Homologene: 45412
Klra17
Name: killer cell lectin-like receptor, subfamily A, member 17
Synonyms: Ly49q1, Ly-49Q, Ly49Q
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 170733
Vmn1r63
Name: vomeronasal 1 receptor 63
Synonyms: V1R1, V1rd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 81017
Homologene: 41799
Odad3
Name: outer dynein arm docking complex subunit 3
Synonyms: Ccdc151, C330001K17Rik, b2b1885Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 77609
VEGA: 9
Homologene: 16533
Adamts15
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235130
VEGA: 9
Homologene: 8610
Spem1
Name: sperm maturation 1
Synonyms: 1700095G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 74288
Homologene: 45717
Ctdnep1
Name: CTD nuclear envelope phosphatase 1
Synonyms: 2610507E10Rik, Dullard
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67181
Homologene: 9100
Tbc1d16
Name: TBC1 domain family, member 16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 207592
Homologene: 10380
Dennd3
Name: DENN/MADD domain containing 3
Synonyms: E030003N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105841
Homologene: 28254
Cpn2
Name: carboxypeptidase N, polypeptide 2
Synonyms: 1300018K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 71756
VEGA: 16
HGNC: HGNC:2313
Homologene: 19487
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 22,346,407 bp
  • A to G, chromosome 2 at 36,890,023 bp
  • G to T, chromosome 2 at 52,043,815 bp
  • T to C, chromosome 2 at 120,025,215 bp
  • C to T, chromosome 2 at 128,759,166 bp
  • T to C, chromosome 2 at 156,134,524 bp
  • A to T, chromosome 3 at 53,535,243 bp
  • T to C, chromosome 3 at 95,320,226 bp
  • T to C, chromosome 3 at 104,889,303 bp
  • T to A, chromosome 3 at 125,611,561 bp
  • A to G, chromosome 4 at 34,669,067 bp
  • T to G, chromosome 4 at 117,676,483 bp
  • A to G, chromosome 4 at 127,326,658 bp
  • A to C, chromosome 4 at 128,949,637 bp
  • A to T, chromosome 4 at 137,711,639 bp
  • C to A, chromosome 4 at 154,254,641 bp
  • T to C, chromosome 5 at 96,570,966 bp
  • A to G, chromosome 5 at 122,248,995 bp
  • T to C, chromosome 6 at 45,060,392 bp
  • A to G, chromosome 6 at 47,892,932 bp
  • A to T, chromosome 6 at 129,831,589 bp
  • T to A, chromosome 7 at 5,802,839 bp
  • C to T, chromosome 7 at 25,286,034 bp
  • A to T, chromosome 7 at 80,759,745 bp
  • T to A, chromosome 7 at 83,895,627 bp
  • A to G, chromosome 7 at 99,317,617 bp
  • A to G, chromosome 7 at 126,770,993 bp
  • C to T, chromosome 8 at 84,536,083 bp
  • G to A, chromosome 8 at 85,294,953 bp
  • A to T, chromosome 8 at 91,270,122 bp
  • C to T, chromosome 8 at 107,339,075 bp
  • A to T, chromosome 9 at 21,995,057 bp
  • T to C, chromosome 9 at 30,911,744 bp
  • T to C, chromosome 9 at 38,827,858 bp
  • T to A, chromosome 9 at 39,144,103 bp
  • C to A, chromosome 9 at 124,029,610 bp
  • T to A, chromosome 10 at 56,017,605 bp
  • CCTCTC to CCTCTCTC, chromosome 11 at 3,177,419 bp
  • T to A, chromosome 11 at 68,490,480 bp
  • T to C, chromosome 11 at 69,821,545 bp
  • T to C, chromosome 11 at 69,988,731 bp
  • T to A, chromosome 11 at 76,249,955 bp
  • T to A, chromosome 11 at 87,231,738 bp
  • A to G, chromosome 11 at 97,978,497 bp
  • T to C, chromosome 11 at 119,157,816 bp
  • T to G, chromosome 12 at 3,496,923 bp
  • A to T, chromosome 12 at 15,793,928 bp
  • G to T, chromosome 13 at 55,085,644 bp
  • T to C, chromosome 13 at 81,676,121 bp
  • T to C, chromosome 14 at 21,669,974 bp
  • T to C, chromosome 14 at 79,767,408 bp
  • T to A, chromosome 15 at 73,565,076 bp
  • G to C, chromosome 15 at 99,322,738 bp
  • T to A, chromosome 16 at 20,156,942 bp
  • T to C, chromosome 16 at 30,260,368 bp
  • A to G, chromosome 19 at 13,827,565 bp
  • G to A, chromosome 19 at 43,704,312 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0118 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038404-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.