Strain Name:
C57BL/6J-MtgxR0218Btlr/Mmmh
Stock Number:
038467-MU
Citation ID:
RRID:MMRRC_038467-MU
Other Names:
R0218 (G1), C57BL/6J-MtgxR0218Btlr
Major Collection:

Gene Information

Dlc1
Name: deleted in liver cancer 1
Synonyms: STARD12, Arhgap7, A730069N07Rik, p122-RhoGAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 50768
HGNC: HGNC:2897
Homologene: 4442
Ciapin1
Name: cytokine induced apoptosis inhibitor 1
Synonyms: 2810413N20Rik, anamorsin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 109006
Homologene: 10658
Sephs1
Name: selenophosphate synthetase 1
Synonyms: SPS1, 1110046B24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 109079
Homologene: 56558
Gpr1
Name: G protein-coupled receptor 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241070
HGNC: HGNC:4463
Homologene: 21094
Washc2
Name: WASH complex subunit 2`
Synonyms: C530005J20Rik, D6Wsu116e, Fam21
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 28006
Homologene: 41686
Cenpp
Name: centromere protein P
Synonyms: 1700022C02Rik, 4921518G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 66336
VEGA: 13
Homologene: 23543
Fancl
Name: Fanconi anemia, complementation group L
Synonyms: Pog, Phf9, 2010322C19Rik, B230118H11Rik, gcd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67030
Homologene: 9987
Cdx1
Name: caudal type homeobox 1
Synonyms: Cdx, Cdx-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 12590
HGNC: HGNC:1805
Homologene: 1366
Zfp30
Name: zinc finger protein 30
Synonyms: 2610306P15Rik, Zfp-30
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22693
Homologene: 84799
Osr1
Name: odd-skipped related transcription factor 1
Synonyms: Odd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 23967
VEGA: 12
HGNC: HGNC:8111
Homologene: 8035
Enpp3
Name: ectonucleotide pyrophosphatase/phosphodiesterase 3
Synonyms: CD203c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 209558
VEGA: 10
HGNC: HGNC:3358
Homologene: 3683
Dgcr2
Name: DiGeorge syndrome critical region gene 2
Synonyms: DGS-C, Idd, Sez12, Dgcr2, Dgsc, Lan, 9930034O06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 13356
HGNC: HGNC:2845
Homologene: 31292
Cd200r1
Name: CD200 receptor 1
Synonyms: CD200R, OX2R, Mox2r
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 57781
Homologene: 10957
Ppp3cb
Name: protein phosphatase 3, catalytic subunit, beta isoform
Synonyms: 1110063J16Rik, Calnb, PP2BA beta, Cnab, CnAbeta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 19056
HGNC: HGNC:9315
Homologene: 56429
Gga2
Name: golgi associated, gamma adaptin ear containing, ARF binding protein 2
Synonyms: 1200007E24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 74105
Homologene: 22860
Ehbp1
Name: EH domain binding protein 1
Synonyms: Flj21950, KIAA0903-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216565
Homologene: 22880
Mcc
Name: mutated in colorectal cancers
Synonyms: D18Ertd451e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 328949
HGNC: HGNC:6935
Homologene: 20539
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: Gpr98, Mgr1, Mass1, VLGR1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 110789
Homologene: 19815
Fbp2
Name: fructose bisphosphatase 2
Synonyms: Fbp-1, FBPase muscle
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 14120
VEGA: 13
HGNC: HGNC:3607
Homologene: 55784
Hc
Name: hemolytic complement
Synonyms: C5a, He, Hfib2, C5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 15139
HGNC: HGNC:1331
Homologene: 20412
Unc79
Name: unc-79 homolog
Synonyms: 9030205A07Rik, Mlca3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217843
Homologene: 41397
Ccdc110
Name: coiled-coil domain containing 110
Synonyms: LOC212392
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 212392
Homologene: 17668
Adam34l
Name: a disintegrin and metallopeptidase domain 34 like
Synonyms: Gm5346
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 384813
Homologene: 78104
Cep162
Name: centrosomal protein 162
Synonyms: 4922501C03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 382090
Homologene: 8930
Slc25a39
Name: solute carrier family 25, member 39
Synonyms: 3010027G13Rik, D11Ertd333e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 68066
Homologene: 69200
Mdm1
Name: transformed mouse 3T3 cell double minute 1
Synonyms: Mdm-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 17245
VEGA: 10
Homologene: 9692
Heca
Name: hdc homolog, cell cycle regulator
Synonyms: LOC380629
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 380629
VEGA: 10
Homologene: 32300
Map1a
Name: microtubule-associated protein 1 A
Synonyms: Mtap-1, 6330416M19Rik, Mtap1a, Mtap1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17754
HGNC: HGNC:6835
Homologene: 1778
Mdga2
Name: MAM domain containing glycosylphosphatidylinositol anchor 2
Synonyms: Mdga2, Tg(Prnp-PFN1*G118V)838Kiaei, 6720489L24Rik, Adp, Mamdc1, 9330209L04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 320772
Homologene: 45659
Zfp518a
Name: zinc finger protein 518A
Synonyms: 2810401C22Rik, Zfp518, 6330417C12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 72672
VEGA: 19
Homologene: 19378
Simc1
Name: SUMO-interacting motifs containing 1
Synonyms: 4732471D19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 319719
Homologene: 131217
Ms4a20
Name: membrane-spanning 4-domains, subfamily A, member 20
Synonyms: 1700017D01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 69369
Unc45b
Name: unc-45 myosin chaperone B
Synonyms: D230041A13Rik, Cmya4, UNC45
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217012
Homologene: 14666
Mael
Name: maelstrom spermatogenic transposon silencer
Synonyms: 4933405K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98558
Homologene: 13143
Chac1
Name: ChaC, cation transport regulator 1
Synonyms: 1810008K03Rik, Botch
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 69065
Homologene: 11470
Gm13103
Name: predicted gene 13103
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 194225
Homologene: 129883
Herc6
Name: hect domain and RLD 6
Synonyms: CEB1, Herc5, 2510038N07Rik, 1700121D12Rik, 4930427L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 67138
Homologene: 70768
Efcab12
Name: EF-hand calcium binding domain 12
Synonyms: BC060267
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 212516
Homologene: 18905
Tas2r104
Name: taste receptor, type 2, member 104
Synonyms: T2R04, mt2r45, mGR04, Tas2r4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 387340
Homologene: 130072
Npas1
Name: neuronal PAS domain protein 1
Synonyms: bHLHe11, MOP5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18142
HGNC: HGNC:7894
Homologene: 1886
AC163020.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
A830073O21Rik
Name: RIKEN cDNA A830073O21 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Mex3b
Name: mex3 RNA binding family member B
Synonyms: 4931439A04Rik, Rkhd3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 108797
Homologene: 13570
Olfr513
Name: olfactory receptor 513
Synonyms: MOR195-1, GA_x6K02T2PBJ9-11084889-11085818
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258718
Homologene: 64908
Smg8
Name: smg-8 homolog, nonsense mediated mRNA decay factor (C. elegans)
Synonyms: 1200011M11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 74133
Homologene: 32393
Nfe2l1
Name: nuclear factor, erythroid derived 2,-like 1
Synonyms: NRF1, TCF-11, TCF11, Lcrf1, LCR-F1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18023
HGNC: HGNC:7781
Homologene: 20685
Cdkl1
Name: cyclin-dependent kinase-like 1 (CDC2-related kinase)
Synonyms: 4933411O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 71091
VEGA: 12
HGNC: HGNC:1781
Homologene: 55805
Irf2bpl
Name: interferon regulatory factor 2 binding protein-like
Synonyms: 6430527G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238330
VEGA: 12
Homologene: 11555
Galc
Name: galactosylceramidase
Synonyms: A930008M05Rik, 2310068B06Rik, Gacy, galactocerebrosidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 14420
VEGA: 12
HGNC: HGNC:4115
Homologene: 124
Olfr187
Name: olfactory receptor 187
Synonyms: MOR183-8, GA_x54KRFPKG5P-55265713-55264787
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 258319
Homologene: 133069
Apbb3
Name: amyloid beta (A4) precursor protein-binding, family B, member 3
Synonyms: Rirl2, Fe65l2, TR2S
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225372
VEGA: 18
Homologene: 21221
Sncaip
Name: synuclein, alpha interacting protein (synphilin)
Synonyms: SYPH1, synphilin-1, 4933427B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 67847
Homologene: 3987
Olfr1499
Name: olfactory receptor 1499
Synonyms: GA_x6K02T2RE5P-4147744-4146800, MOR211-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258792
Homologene: 17393
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 63,183,531 bp
  • C to T, chromosome 1 at 166,238,590 bp
  • A to G, chromosome 2 at 4,899,560 bp
  • G to T, chromosome 2 at 35,028,074 bp
  • T to A, chromosome 2 at 119,353,460 bp
  • A to G, chromosome 2 at 121,305,425 bp
  • A to G, chromosome 4 at 143,851,831 bp
  • C to A, chromosome 6 at 57,619,601 bp
  • T to C, chromosome 6 at 115,814,650 bp
  • T to A, chromosome 6 at 116,248,046 bp
  • T to G, chromosome 6 at 131,685,092 bp
  • C to T, chromosome 7 at 16,461,893 bp
  • A to G, chromosome 7 at 29,793,638 bp
  • T to C, chromosome 7 at 47,309,406 bp
  • A to G, chromosome 7 at 73,740,764 bp
  • A to T, chromosome 7 at 82,869,104 bp
  • T to A, chromosome 7 at 108,755,574 bp
  • T to C, chromosome 7 at 121,998,900 bp
  • A to G, chromosome 8 at 36,850,229 bp
  • T to G, chromosome 8 at 43,626,440 bp
  • A to G, chromosome 8 at 45,934,724 bp
  • G to T, chromosome 8 at 94,828,310 bp
  • A to G, chromosome 9 at 87,211,809 bp
  • T to C, chromosome 10 at 17,915,715 bp
  • A to T, chromosome 10 at 24,776,869 bp
  • A to G, chromosome 10 at 118,156,878 bp
  • A to T, chromosome 11 at 22,231,992 bp
  • A to G, chromosome 11 at 26,471,337 bp
  • A to G, chromosome 11 at 82,911,860 bp
  • A to G, chromosome 11 at 87,086,122 bp
  • A to T, chromosome 11 at 96,827,613 bp
  • A to G, chromosome 11 at 102,406,230 bp
  • A to G, chromosome 12 at 9,579,639 bp
  • A to G, chromosome 12 at 66,655,120 bp
  • A to T, chromosome 12 at 69,790,035 bp
  • A to T, chromosome 12 at 86,882,624 bp
  • A to G, chromosome 12 at 98,222,647 bp
  • A to G, chromosome 12 at 103,108,781 bp
  • T to A, chromosome 13 at 49,647,632 bp
  • T to C, chromosome 13 at 54,526,604 bp
  • A to T, chromosome 13 at 62,854,048 bp
  • C to T, chromosome 13 at 81,106,898 bp
  • A to T, chromosome 14 at 20,523,976 bp
  • A to G, chromosome 16 at 17,849,786 bp
  • T to A, chromosome 16 at 44,788,743 bp
  • C to T, chromosome 16 at 59,036,093 bp
  • T to C, chromosome 18 at 36,676,609 bp
  • C to G, chromosome 18 at 44,519,516 bp
  • A to G, chromosome 18 at 52,907,328 bp
  • A to G, chromosome 18 at 61,020,364 bp
  • A to T, chromosome 19 at 11,116,437 bp
  • T to C, chromosome 19 at 13,814,978 bp
  • A to G, chromosome 19 at 40,912,628 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0218 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038467-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.