Strain Name:
C57BL/6J-MtgxR0533Btlr/Mmmh
Stock Number:
038725-MU
Citation ID:
RRID:MMRRC_038725-MU
Other Names:
R0533 (G1), C57BL/6J-MtgxR0533Btlr
Major Collection:

Gene Information

Tnrc6b
Name: trinucleotide repeat containing 6b
Synonyms: D230019K20Rik, A730065C02Rik, 2700090M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 213988
VEGA: 15
Homologene: 66194
Nrg1
Name: neuregulin 1
Synonyms: 6030402G23Rik, NDF, GGFII, HRG, Hgl, HRGalpha, D230005F13Rik, SMDF, GGF, ARIA, heregulin, HGL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 211323
HGNC: HGNC:7997
Homologene: 138451
Gpm6a
Name: glycoprotein m6a
Synonyms: Gpm6, M6A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234267
HGNC: HGNC:4460
Homologene: 3864
Adcy10
Name: adenylate cyclase 10
Synonyms: 4930431D04Rik, soluble adenylyl cyclase, sAC, Sacy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 271639
Homologene: 10188
Arpp21
Name: cyclic AMP-regulated phosphoprotein, 21
Synonyms: ARPP-21, Tarpp, 0710001E13Rik, R3hdm3, D9Bwg1012e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74100
Homologene: 32306
Etv5
Name: ets variant 5
Synonyms: 1110005E01Rik, 8430401F14Rik, erm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 104156
HGNC: HGNC:3494
Homologene: 3276
Ccdc88c
Name: coiled-coil domain containing 88C
Synonyms: 0610010D24Rik, Daple
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 68339
VEGA: 12
Homologene: 18903
Arid5b
Name: AT rich interactive domain 5B (MRF1-like)
Synonyms: Mrf2alpha, 5430435G07Rik, Mrf2beta, Desrt, Mrf2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71371
VEGA: 10
Homologene: 45872
Wfs1
Name: wolframin ER transmembrane glycoprotein
Synonyms: Wolfram syndrome 1 homolog (human), wolframin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22393
Homologene: 4380
Hmmr
Name: hyaluronan mediated motility receptor (RHAMM)
Synonyms: CD168, Rhamm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 15366
HGNC: HGNC:5012
Homologene: 8271
Sel1l
Name: sel-1 suppressor of lin-12-like (C. elegans)
Synonyms: Sel1h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20338
Homologene: 31286
G3bp1
Name: GTPase activating protein (SH3 domain) binding protein 1
Synonyms: GAP SH3 binding protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 27041
Homologene: 38096
Kif15
Name: kinesin family member 15
Synonyms: 3930402I10Rik, HKLP2, N-10 kinesin, Knsl7, 3110023M17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 209737
VEGA: 9
Homologene: 23210
Cux1
Name: cut-like homeobox 1
Synonyms: Cutl1, Cux, CDP, Cux-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13047
HGNC: HGNC:2557
Tbc1d8
Name: TBC1 domain family, member 8
Synonyms: GRAM domain, HBLP1, AD3, BUB2-like protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 54610
Homologene: 31421
Zfp335
Name: zinc finger protein 335
Synonyms: 1810045J01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329559
Homologene: 11129
Mctp2
Name: multiple C2 domains, transmembrane 2
Synonyms: LOC244049
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244049
Homologene: 69254
Zfhx2
Name: zinc finger homeobox 2
Synonyms: zfh-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239102
Homologene: 52657
Ptger2
Name: prostaglandin E receptor 2 (subtype EP2)
Synonyms: EP2, EP2 receptor, Ptgerep2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 19217
HGNC: HGNC:9594
Homologene: 739
Ryr1
Name: ryanodine receptor 1, skeletal muscle
Synonyms: skrr, Ryr, calcium release channel isoform 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20190
Homologene: 68069
Gstm4
Name: glutathione S-transferase, mu 4
Synonyms: Gstb4, 1110004G14Rik, Gstb-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14865
HGNC: HGNC:4636
Homologene: 37357
Dnah10
Name: dynein, axonemal, heavy chain 10
Synonyms: Dnahc10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 56087
HGNC: HGNC:2941
Homologene: 25816
AC159748.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: 2810003K23Rik, Dnahcl1, Dnahc17, LOC382552
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Naip2
Name: NLR family, apoptosis inhibitory protein 2
Synonyms: Naip-rs6, Naip2, Birc1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17948
HGNC: HGNC:7634
Homologene: 136092
Myog
Name: myogenin
Synonyms: bHLHc3, myo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17928
HGNC: HGNC:7612
Homologene: 1854
Aadat
Name: aminoadipate aminotransferase
Synonyms: Kyat2, KATII, Kat2, mKat-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 23923
Homologene: 56540
Ust
Name: uronyl-2-sulfotransferase
Synonyms: D930010O20Rik, UA2OST
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 338362
VEGA: 10
Homologene: 4174
Skint5
Name: selection and upkeep of intraepithelial T cells 5
Synonyms: OTTMUSG00000008560
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242627
Homologene: 135888
Capn12
Name: calpain 12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 60594
Homologene: 77333
Abcb1b
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 1B
Synonyms: Pgy1, Mdr1, Abcb1, mdr, Pgy-1, Mdr1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18669
Homologene: 69084
Atg4b
Name: autophagy related 4B, cysteine peptidase
Synonyms: Apg4b, 2510009N07Rik, autophagin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 66615
Homologene: 100868
Morc2b
Name: microrchidia 2B
Synonyms: 4932411A10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 240069
Homologene: 18615
Slc39a12
Name: solute carrier family 39 (zinc transporter), member 12
Synonyms: LOC277468
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 277468
Homologene: 17654
Krt81
Name: keratin 81
Synonyms: Krt2-19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 64818
VEGA: 15
HGNC: HGNC:6458
Homologene: 55645
Fam83a
Name: family with sequence similarity 83, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239463
Homologene: 13158
Gm13089
Name: predicted gene 13089
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 277667
Hid1
Name: HID1 domain containing
Synonyms: C630004H02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217310
Homologene: 12737
Wrap73
Name: WD repeat containing, antisense to Trp73
Synonyms: 2610044M17Rik, 5330425N03Rik, DD57, Wdr8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 59002
Homologene: 9857
Ago4
Name: argonaute RISC catalytic subunit 4
Synonyms: argonaute 4, Eif2c4, 5730550L01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 76850
Homologene: 41184
Vstm2a
Name: V-set and transmembrane domain containing 2A
Synonyms: 9330184N17Rik, Vstm2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 211739
Homologene: 17123
Adgrb1
Name: adhesion G protein-coupled receptor B1
Synonyms: Bai1, B830018M07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 107831
HGNC: HGNC:943
Homologene: 1287
Ttll6
Name: tubulin tyrosine ligase-like family, member 6
Synonyms: 4932418K24Rik, t8130b59, D11Moh44e, D11Moh43e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237930
Homologene: 18229
Myrf
Name: myelin regulatory factor
Synonyms: LOC225908, Gm98, LOC386531
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 225908
HGNC: HGNC:1181
Homologene: 32167
Olfr689
Name: olfactory receptor 689
Synonyms: GA_x6K02T2PBJ9-7942985-7943947, MOR40-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258745
Homologene: 128074
Xrra1
Name: X-ray radiation resistance associated 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 446101
Homologene: 19547
Itgb6
Name: integrin beta 6
Synonyms: 4831415H04Rik, 2210409C20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16420
HGNC: HGNC:6161
Homologene: 685
Neil3
Name: nei like 3 (E. coli)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234258
Homologene: 10094
Clic3
Name: chloride intracellular channel 3
Synonyms: 2300003G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 69454
HGNC: HGNC:2064
Homologene: 3432
Kbtbd4
Name: kelch repeat and BTB (POZ) domain containing 4
Synonyms: 2510026C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67136
Homologene: 32320
Pramef25
Name: PRAME family member 25
Synonyms: Gm13109
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329984
Homologene: 83161
Klre1
Name: killer cell lectin-like receptor family E member 1
Synonyms: NKG2I, Klre-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243655
Homologene: 17794
Vmn2r71
Name: vomeronasal 2, receptor 71
Synonyms: EG233445
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233445
Homologene: 115466
Olfr681
Name: olfactory receptor 681
Synonyms: GA_x6K02T2PBJ9-7750163-7751110, MOR40-14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 404318
Homologene: 81538
Grid1
Name: glutamate receptor, ionotropic, delta 1
Synonyms: GluRdelta1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 14803
HGNC: HGNC:4575
Homologene: 69017
Olfr99
Name: olfactory receptor 99
Synonyms: MOR156-1, GA_x6K02T2PSCP-1720261-1719344
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258508
Homologene: 74030
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 39,372,774 bp
  • T to A, chromosome 1 at 93,784,910 bp
  • A to C, chromosome 1 at 134,290,473 bp
  • A to G, chromosome 1 at 165,564,023 bp
  • A to G, chromosome 2 at 14,400,331 bp
  • A to G, chromosome 2 at 25,458,138 bp
  • A to G, chromosome 2 at 60,669,197 bp
  • A to G, chromosome 2 at 90,907,604 bp
  • A to T, chromosome 2 at 164,907,922 bp
  • T to C, chromosome 3 at 108,043,525 bp
  • A to G, chromosome 4 at 113,827,867 bp
  • A to G, chromosome 4 at 126,516,860 bp
  • G to T, chromosome 4 at 143,698,020 bp
  • A to T, chromosome 4 at 143,950,720 bp
  • G to A, chromosome 4 at 154,151,649 bp
  • G to A, chromosome 4 at 154,156,154 bp
  • A to T, chromosome 5 at 8,864,113 bp
  • T to A, chromosome 5 at 36,973,722 bp
  • G to A, chromosome 5 at 124,775,250 bp
  • T to C, chromosome 5 at 136,307,859 bp
  • T to C, chromosome 6 at 129,583,193 bp
  • T to C, chromosome 7 at 28,887,683 bp
  • T to A, chromosome 7 at 29,078,780 bp
  • G to T, chromosome 7 at 72,080,822 bp
  • GT to GTT, chromosome 7 at 85,619,218 bp
  • T to A, chromosome 7 at 99,875,145 bp
  • G to A, chromosome 7 at 105,122,350 bp
  • A to T, chromosome 7 at 105,314,372 bp
  • T to C, chromosome 8 at 31,831,245 bp
  • A to T, chromosome 8 at 53,638,775 bp
  • A to G, chromosome 8 at 55,055,374 bp
  • T to G, chromosome 8 at 60,531,763 bp
  • A to G, chromosome 9 at 112,126,505 bp
  • A to T, chromosome 9 at 123,009,433 bp
  • C to T, chromosome 10 at 5,358,438 bp
  • T to C, chromosome 10 at 8,248,080 bp
  • A to T, chromosome 10 at 68,186,033 bp
  • C to T, chromosome 11 at 16,263,041 bp
  • A to G, chromosome 11 at 40,709,989 bp
  • T to C, chromosome 11 at 55,498,626 bp
  • G to A, chromosome 11 at 96,154,756 bp
  • A to T, chromosome 11 at 115,348,809 bp
  • A to G, chromosome 11 at 118,110,537 bp
  • A to T, chromosome 12 at 91,820,094 bp
  • A to T, chromosome 12 at 100,954,282 bp
  • A to C, chromosome 13 at 100,161,782 bp
  • T to A, chromosome 14 at 35,309,385 bp
  • T to A, chromosome 14 at 44,988,982 bp
  • C to T, chromosome 14 at 55,064,090 bp
  • T to A, chromosome 15 at 58,009,811 bp
  • T to A, chromosome 15 at 74,541,559 bp
  • C to T, chromosome 15 at 80,876,653 bp
  • T to C, chromosome 15 at 101,461,389 bp
  • C to T, chromosome 16 at 22,436,075 bp
  • G to C, chromosome 17 at 33,135,932 bp
  • A to T, chromosome 17 at 37,280,291 bp
  • G to C, chromosome 19 at 10,218,162 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0533 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038725-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.