Strain Name:
C57BL/6J-MtgxR0761Btlr/Mmmh
Stock Number:
038941-MU
Citation ID:
RRID:MMRRC_038941-MU
Other Names:
R0761 (G1), C57BL/6J-MtgxR0761Btlr
Major Collection:

Gene Information

Kmt2e
Name: lysine (K)-specific methyltransferase 2E
Synonyms: 1810033J14Rik, D230038D11Rik, 9530077A04Rik, Mll5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 69188
Homologene: 18822
Cul3
Name: cullin 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 26554
HGNC: HGNC:2553
Homologene: 2661
Nup205
Name: nucleoporin 205
Synonyms: 3830404O05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 70699
Homologene: 45971
Xpo4
Name: exportin 4
Synonyms: B430309A01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 57258
Homologene: 10733
Rps6ka5
Name: ribosomal protein S6 kinase, polypeptide 5
Synonyms: 6330404E13Rik, MSK1, 3110005L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 73086
VEGA: 12
Homologene: 48302
Dcp2
Name: decapping mRNA 2
Synonyms: 2410015D23Rik, 5730537H01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 70640
Homologene: 13968
Polr3f
Name: polymerase (RNA) III (DNA directed) polypeptide F
Synonyms: 3110032A07Rik, 2810411G20Rik, RPC39, RPC6, 3010019O03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70408
Homologene: 4722
Nek1
Name: NIMA (never in mitosis gene a)-related expressed kinase 1
Synonyms: kat, kidney, anemia and testis, D8Ertd790e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18004
HGNC: HGNC:7744
Homologene: 14376
Ctr9
Name: CTR9 homolog, Paf1/RNA polymerase II complex component
Synonyms: Tsp, Tsbp, Sh2bp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22083
Homologene: 40668
Mtch1
Name: mitochondrial carrier 1
Synonyms: 2310034O17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 56462
Homologene: 22807
Psma6
Name: proteasome subunit alpha 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 26443
HGNC: HGNC:9535
Homologene: 2085
Mesd
Name: mesoderm development LRP chaperone
Synonyms: 2210015O11Rik, msd, Mesdc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 67943
Homologene: 11347
Ubr2
Name: ubiquitin protein ligase E3 component n-recognin 2
Synonyms: 9930021A08Rik, E130209G04Rik, ENSMUSG00000043296
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224826
VEGA: 17
Homologene: 26151
2610008E11Rik
Name: RIKEN cDNA 2610008E11 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 72128
Homologene: 86705
Clmn
Name: calmin
Synonyms: 9330188N17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 94040
VEGA: 12
Homologene: 11683
Pkd1l1
Name: polycystic kidney disease 1 like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 171395
Homologene: 51376
Kcna4
Name: potassium voltage-gated channel, shaker-related subfamily, member 4
Synonyms: Kv1.4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16492
HGNC: HGNC:6222
Homologene: 20514
Col1a2
Name: collagen, type I, alpha 2
Synonyms: Col1a-2, Cola2, Cola-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12843
HGNC: HGNC:2198
Homologene: 69
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Tnfrsf1b
Name: tumor necrosis factor receptor superfamily, member 1b
Synonyms: CD120b, TNF-R2, p75, p75 TNFR, Tnfr2, TNF-R75, TNF-R-II, TNFR80, TNFBR, TNFRII, TNF-alphaR2, TNFalpha-R2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 21938
Homologene: 829
Megf10
Name: multiple EGF-like-domains 10
Synonyms: LOC240312, 3000002B06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 70417
Homologene: 23771
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Mroh2a
Name: maestro heat-like repeat family member 2A
Synonyms: ENSMUSG00000044873, OTTMUSG00000020804, Heatr7b1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 100040766
Homologene: 85300
Trank1
Name: tetratricopeptide repeat and ankyrin repeat containing 1
Synonyms: A230061D21Rik, LOC235639, C030048J01Rik, Lba1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 320429
Homologene: 45845
Camk2g
Name: calcium/calmodulin-dependent protein kinase II gamma
Synonyms: CaMK II, Ca2+/calmodulin-dependent protein kinase II, Camkg, 5930429P18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12325
VEGA: 14
HGNC: HGNC:1463
Homologene: 15596
Olfr743
Name: olfactory receptor 743
Synonyms: GA_x6K02T2N6FY-3870-3385, GA_x6K02T2N6FY-2320-2039, GA_x6K02T2PMLR-6243196-6244132, MOR106-8P, MOR106-14, Olfr265, Olfr743-ps1, Olfr264
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219019
Homologene: 74163
Adcy5
Name: adenylate cyclase 5
Synonyms: AC5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224129
VEGA: 16
HGNC: HGNC:236
Homologene: 11213
Olfr137
Name: olfactory receptor 137
Synonyms: MOR256-18, GA_x6K02T2PSCP-2749525-2748587
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258481
HGNC: HGNC:8261
Homologene: 128084
L3mbtl1
Name: L3MBTL1 histone methyl-lysine binding protein
Synonyms: L3MBTL1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241764
Homologene: 41846
Rev3l
Name: REV3 like, DNA directed polymerase zeta catalytic subunit
Synonyms: Sez4, Rev
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19714
HGNC: HGNC:9968
Homologene: 48147
Unc5d
Name: unc-5 netrin receptor D
Synonyms: Unc5h4, D930029E11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 210801
Homologene: 15450
Asb17
Name: ankyrin repeat and SOCS box-containing 17
Synonyms: 4933436O18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66772
Homologene: 12031
Bbs10
Name: Bardet-Biedl syndrome 10 (human)
Synonyms: 1300007O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71769
VEGA: 10
Homologene: 49781
Dgkz
Name: diacylglycerol kinase zeta
Synonyms: mDGK[z], E130307B02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 104418
HGNC: HGNC:2857
Homologene: 37831
Nudt12
Name: nudix (nucleoside diphosphate linked moiety X)-type motif 12
Synonyms: 0610016O18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 67993
Homologene: 44188
Crocc
Name: ciliary rootlet coiled-coil, rootletin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230872
Homologene: 16811
Simc1
Name: SUMO-interacting motifs containing 1
Synonyms: 4732471D19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 319719
Homologene: 131217
Csgalnact2
Name: chondroitin sulfate N-acetylgalactosaminyltransferase 2
Synonyms: 4632415D10Rik, Galnact2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 78752
Homologene: 23109
Polr1e
Name: polymerase (RNA) I polypeptide E
Synonyms: 53kDa, D030019D19Rik, Paf53, Praf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 64424
Homologene: 41486
Pacs2
Name: phosphofurin acidic cluster sorting protein 2
Synonyms: 6720425G15Rik, Pacs1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217893
VEGA: 12
Homologene: 15016
Cdh18
Name: cadherin 18
Synonyms: B230220E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 320865
HGNC: HGNC:1757
Homologene: 55858
Lrrc34
Name: leucine rich repeat containing 34
Synonyms: 1700007J06Rik, Spata34
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 71827
Homologene: 27419
Fam166a
Name: family with sequence similarity 166, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 68222
Homologene: 12247
Cryzl2
Name: crystallin zeta like 2
Synonyms: quinone reductase-like 2, BC026585
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226527
Homologene: 41713
Olfr1248
Name: olfactory receptor 1248
Synonyms: GA_x6K02T2Q125-51059648-51058725, MOR231-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258787
Homologene: 133613
Olfr1152
Name: olfactory receptor 1152
Synonyms: GA_x6K02T2Q125-49372426-49373358, MOR177-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258103
Homologene: 79357
Klhl17
Name: kelch-like 17
Synonyms: actinfilin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 231003
VEGA: 4
Homologene: 27075
Pira12
Name: paired-Ig-like receptor A12
Synonyms: Gm14548
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100038909
HGNC: HGNC:6607
Homologene: 134028
Mfap3l
Name: microfibrillar-associated protein 3-like
Synonyms: 5430405D20Rik, NYD-sp9, 4933428A15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 71306
Homologene: 11013
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 80,277,486 bp
  • G to A, chromosome 1 at 88,243,950 bp
  • A to G, chromosome 1 at 157,465,724 bp
  • T to C, chromosome 2 at 25,220,123 bp
  • T to C, chromosome 2 at 41,185,935 bp
  • T to C, chromosome 2 at 76,746,758 bp
  • C to T, chromosome 2 at 87,868,536 bp
  • T to C, chromosome 2 at 89,617,835 bp
  • C to T, chromosome 2 at 91,945,351 bp
  • T to A, chromosome 2 at 107,296,072 bp
  • T to A, chromosome 2 at 144,534,407 bp
  • G to A, chromosome 2 at 162,966,047 bp
  • A to G, chromosome 3 at 30,631,276 bp
  • A to G, chromosome 3 at 153,844,415 bp
  • C to A, chromosome 4 at 45,027,392 bp
  • T to C, chromosome 4 at 141,029,776 bp
  • T to C, chromosome 4 at 145,216,100 bp
  • T to C, chromosome 4 at 156,232,747 bp
  • C to A, chromosome 5 at 23,503,034 bp
  • G to A, chromosome 6 at 4,518,822 bp
  • C to T, chromosome 6 at 35,196,428 bp
  • T to C, chromosome 6 at 118,126,112 bp
  • A to T, chromosome 7 at 3,893,979 bp
  • G to T, chromosome 7 at 83,895,743 bp
  • T to C, chromosome 7 at 111,046,272 bp
  • A to T, chromosome 8 at 28,696,532 bp
  • G to T, chromosome 8 at 60,671,581 bp
  • T to A, chromosome 8 at 61,089,455 bp
  • T to C, chromosome 9 at 111,366,613 bp
  • T to C, chromosome 10 at 39,874,195 bp
  • T to C, chromosome 10 at 79,067,999 bp
  • G to T, chromosome 10 at 111,299,383 bp
  • A to G, chromosome 11 at 8,854,375 bp
  • T to A, chromosome 12 at 55,412,342 bp
  • C to T, chromosome 12 at 100,570,882 bp
  • T to A, chromosome 12 at 104,781,558 bp
  • T to A, chromosome 12 at 113,060,068 bp
  • T to C, chromosome 13 at 54,526,574 bp
  • G to A, chromosome 14 at 20,766,212 bp
  • T to C, chromosome 14 at 50,533,702 bp
  • A to G, chromosome 14 at 57,613,383 bp
  • A to T, chromosome 15 at 23,226,752 bp
  • G to A, chromosome 16 at 35,270,825 bp
  • A to G, chromosome 17 at 29,336,212 bp
  • A to T, chromosome 17 at 38,305,391 bp
  • G to A, chromosome 17 at 46,983,316 bp
  • A to T, chromosome 17 at 59,011,069 bp
  • G to A, chromosome 18 at 44,410,233 bp
  • C to A, chromosome 18 at 57,287,976 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0761 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038941-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.