Strain Name:
C57BL/6J-MtgxR1014Btlr/Mmmh
Stock Number:
039118-MU
Citation ID:
RRID:MMRRC_039118-MU
Other Names:
R1014 (G1), C57BL/6J-MtgxR1014Btlr
Major Collection:

Strain Information

Ptprz1
Name: protein tyrosine phosphatase, receptor type Z, polypeptide 1
Synonyms: DSD-1-PG, phosphacan, PTPzeta, PTPbeta, Rptpbeta, Ptpz, Ptprz, RPTPz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19283
HGNC: HGNC:9685
Homologene: 2136
Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Nup210l
Name: nucleoporin 210-like
Synonyms: 4930548O11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 77595
Homologene: 28122
Slc2a3
Name: solute carrier family 2 (facilitated glucose transporter), member 3
Synonyms: Glut-3, Glut3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20527
Homologene: 74302
Slc12a2
Name: solute carrier family 12, member 2
Synonyms: sodium/potassium/chloride cotransporters, mBSC2, Nkcc1, sy-ns
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 20496
VEGA: 18
Homologene: 20283
Rtf1
Name: RTF1, Paf1/RNA polymerase II complex component
Synonyms: 6530416A09Rik, 2900005O08Rik, Gtl7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76246
Homologene: 133868
Zfp318
Name: zinc finger protein 318
Synonyms: TZF, 2610034E08Rik, D530032D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 57908
Homologene: 22808
Cul7
Name: cullin 7
Synonyms: p193, 2510004L20Rik, p185, C230011P08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 66515
Homologene: 56683
Nfix
Name: nuclear factor I/X
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18032
HGNC: HGNC:7788
Homologene: 1872
Hspg2
Name: perlecan (heparan sulfate proteoglycan 2)
Synonyms: per, Pcn, Plc, perlecan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 15530
HGNC: HGNC:5273
Homologene: 68473
Caap1
Name: caspase activity and apoptosis inhibitor 1
Synonyms: 5830433M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67770
Homologene: 32607
Spryd3
Name: SPRY domain containing 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223918
Homologene: 13138
Pcdh17
Name: protocadherin 17
Synonyms: LOC219228, C030033F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219228
VEGA: 14
Homologene: 8700
Or52h9
Name: olfactory receptor family 52 subfamily H member 9
Synonyms: GA_x6K02T2PBJ9-7179540-7180481, MOR31-11, Olfr651
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258809
Homologene: 64922
Pcdhb11
Name: protocadherin beta 11
Synonyms: Pcdhb5E, PcdhbK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93882
HGNC: HGNC:8690
Homologene: 62178
Pcsk5
Name: proprotein convertase subtilisin/kexin type 5
Synonyms: PC6, SPC6, PC5A, PC5/6A, b2b585Clo, b2b1549Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18552
VEGA: 19
HGNC: HGNC:8747
Homologene: 21244
Myh11
Name: myosin, heavy polypeptide 11, smooth muscle
Synonyms: smMHC, SM2, SM1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 17880
VEGA: 16
HGNC: HGNC:7569
Homologene: 128512
Anxa3
Name: annexin A3
Synonyms: Anx3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 11745
HGNC: HGNC:541
Homologene: 68445
Mrgprx2
Name: MAS-related GPR, member X2
Synonyms: MrgB10, Mrgprb10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243978
Homologene: 24986
D430041D05Rik
Name: RIKEN cDNA D430041D05 gene
Synonyms: G2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241589
Homologene: 115928
Pcdhb5
Name: protocadherin beta 5
Synonyms: Pcdhb4A, PcdhbE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93876
HGNC: HGNC:8689
Homologene: 75103
Wdr64
Name: WD repeat domain 64
Synonyms: 4930415O10Rik, 4930511H01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 75820
Homologene: 51634
Col19a1
Name: collagen, type XIX, alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12823
HGNC: HGNC:2196
Homologene: 55608
Cdh12
Name: cadherin 12
Synonyms: Br-cadherin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 215654
HGNC: HGNC:1751
Homologene: 37873
Tdrd5
Name: tudor domain containing 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 214575
Homologene: 18312
Ppm1d
Name: protein phosphatase 1D magnesium-dependent, delta isoform
Synonyms: Wip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 53892
HGNC: HGNC:9277
Homologene: 31185
Rims4
Name: regulating synaptic membrane exocytosis 4
Synonyms: Rim4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241770
Homologene: 18123
Ago4
Name: argonaute RISC catalytic subunit 4
Synonyms: 5730550L01Rik, argonaute 4, Eif2c4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 76850
Homologene: 41184
Tll2
Name: tolloid-like 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 24087
VEGA: 19
Homologene: 56545
Pkp3
Name: plakophilin 3
Synonyms: 2310056L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 56460
HGNC: HGNC:9025
Homologene: 5200
Poldip2
Name: polymerase (DNA-directed), delta interacting protein 2
Synonyms: 1300003F06Rik, mitogenin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67811
Homologene: 9201
Arg1
Name: arginase, liver
Synonyms: PGIF, Arg-1, AI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 11846
VEGA: 10
HGNC: HGNC:663
Homologene: 29
Pck2
Name: phosphoenolpyruvate carboxykinase 2 (mitochondrial)
Synonyms: 9130022B02Rik, 1810010O14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 74551
VEGA: 14
HGNC: HGNC:8725
Homologene: 3356
Ebf4
Name: early B cell factor 4
Synonyms: Olf-1/EBF-like 4, O/E-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228598
Homologene: 65064
Dll4
Name: delta like canonical Notch ligand 4
Synonyms: Delta4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 54485
HGNC: HGNC:2910
Homologene: 10411
1110020G09Rik
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Ttll3
Name: tubulin tyrosine ligase-like family, member 3
Synonyms: 4833441J24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 101100
Homologene: 134361
Musk
Name: muscle, skeletal, receptor tyrosine kinase
Synonyms: MDK4, Nsk2, Nsk3, Nsk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18198
HGNC: HGNC:7525
Homologene: 4084
Gm10300
Name: predicted gene 10300
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Tlr5
Name: toll-like receptor 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 53791
Homologene: 20698
Slc30a8
Name: solute carrier family 30 (zinc transporter), member 8
Synonyms: ZnT-8, C820002P14Rik, ZnT8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 239436
Homologene: 13795
Pcsk1
Name: proprotein convertase subtilisin/kexin type 1
Synonyms: PC3, prohormone convertase 1/3, Nec-1, Nec1, PC1, SPC3, Phpp-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 18548
HGNC: HGNC:8743
Homologene: 379
Bcl2a1d
Name: B cell leukemia/lymphoma 2 related protein A1d
Synonyms: A1-d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12047
HGNC: HGNC:991
Homologene: 2988
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 24,301,273 bp
  • T to C, chromosome 1 at 156,277,289 bp
  • A to G, chromosome 1 at 175,755,626 bp
  • G to A, chromosome 1 at 182,975,677 bp
  • T to C, chromosome 2 at 104,258,329 bp
  • T to C, chromosome 2 at 119,331,157 bp
  • T to G, chromosome 2 at 119,720,246 bp
  • T to C, chromosome 2 at 130,365,468 bp
  • C to T, chromosome 2 at 163,863,929 bp
  • C to T, chromosome 3 at 90,170,048 bp
  • T to C, chromosome 4 at 58,354,156 bp
  • C to T, chromosome 4 at 94,549,146 bp
  • T to C, chromosome 4 at 126,506,785 bp
  • A to G, chromosome 4 at 132,074,712 bp
  • A to G, chromosome 4 at 137,520,602 bp
  • T to G, chromosome 5 at 96,828,337 bp
  • A to G, chromosome 6 at 23,000,644 bp
  • A to T, chromosome 6 at 113,409,346 bp
  • T to C, chromosome 6 at 122,731,566 bp
  • A to G, chromosome 7 at 48,482,558 bp
  • T to C, chromosome 7 at 104,553,176 bp
  • A to G, chromosome 7 at 141,082,826 bp
  • G to A, chromosome 8 at 84,726,526 bp
  • A to T, chromosome 9 at 88,731,296 bp
  • C to A, chromosome 10 at 24,916,860 bp
  • T to A, chromosome 11 at 78,515,162 bp
  • C to A, chromosome 11 at 85,337,154 bp
  • T to C, chromosome 13 at 13,634,060 bp
  • A to G, chromosome 13 at 75,132,234 bp
  • A to G, chromosome 14 at 55,542,410 bp
  • A to G, chromosome 14 at 84,447,488 bp
  • T to C, chromosome 15 at 9,091,254 bp
  • A to T, chromosome 15 at 21,492,620 bp
  • A to G, chromosome 15 at 52,331,597 bp
  • T to A, chromosome 15 at 102,133,531 bp
  • T to C, chromosome 16 at 14,236,410 bp
  • GAA to GAANAA, chromosome 17 at 46,412,536 bp
  • T to A, chromosome 17 at 46,663,190 bp
  • T to C, chromosome 18 at 37,322,250 bp
  • T to A, chromosome 18 at 37,423,369 bp
  • T to C, chromosome 18 at 57,921,810 bp
  • G to T, chromosome 19 at 17,564,830 bp
  • A to T, chromosome 19 at 41,103,851 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1014 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039118-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.