Strain Name:
C57BL/6J-MtgxR1545Btlr/Mmmh
Stock Number:
039584-MU
Citation ID:
RRID:MMRRC_039584-MU
Other Names:
R1545 (G1), C57BL/6J-MtgxR1545Btlr
Major Collection:

Strain Information

Cntnap2
Name: contactin associated protein-like 2
Synonyms: 5430425M22Rik, Caspr2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66797
Homologene: 69159
Crkl
Name: v-crk avian sarcoma virus CT10 oncogene homolog-like
Synonyms: Crkol, snoop, 1110025F07Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12929
HGNC: HGNC:2363
Homologene: 38021
Snta1
Name: syntrophin, acidic 1
Synonyms: Snt1, alpha1-syntrophin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20648
Homologene: 2331
Lrig3
Name: leucine-rich repeats and immunoglobulin-like domains 3
Synonyms: 9130004I02Rik, 9430095K15Rik, 9030421L11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 320398
VEGA: 10
Homologene: 62452
Ppp1r9a
Name: protein phosphatase 1, regulatory subunit 9A
Synonyms: NRB, neurabin-I, 2810430P21Rik, A230094E16Rik, Neurabin I, 4930518N04Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243725
Homologene: 14247
Gprc5a
Name: G protein-coupled receptor, family C, group 5, member A
Synonyms: Raig1, Rai3, Gprc5a
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232431
HGNC: HGNC:9836
Homologene: 2961
Sema4b
Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
Synonyms: Semac, SemC
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20352
Homologene: 8426
Tfr2
Name: transferrin receptor 2
Synonyms: Trfr2, Tfr2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 50765
Homologene: 2428
Kif20b
Name: kinesin family member 20B
Synonyms: 33cex, N-6 kinesin, C330014J10Rik, Kif20b, Mphosph1, magoo
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240641
VEGA: 19
HGNC: HGNC:7212
Homologene: 9418
Nup98
Name: nucleoporin 98
Synonyms: Nup96
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269966
HGNC: HGNC:8068
Homologene: 35472
Depdc1b
Name: DEP domain containing 1B
Synonyms: XTP1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218581
Homologene: 10157
Prpf3
Name: pre-mRNA processing factor 3
Synonyms: 3632413F13Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70767
Homologene: 3447
Fbxl5
Name: F-box and leucine-rich repeat protein 5
Synonyms: Fbl4, Fir4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 242960
Homologene: 8129
Cul7
Name: cullin 7
Synonyms: p185, C230011P08Rik, p193, 2510004L20Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 66515
Homologene: 56683
Eps15
Name: epidermal growth factor receptor pathway substrate 15
Synonyms: 2410112D09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13858
HGNC: HGNC:3419
Homologene: 128359
Prkag1
Name: protein kinase, AMP-activated, gamma 1 non-catalytic subunit
Synonyms: Prkaac
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 19082
VEGA: 15
HGNC: HGNC:9385
Homologene: 99712
Nup50
Name: nucleoporin 50
Synonyms: 1700030K07Rik, Npap60
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18141
VEGA: 15
HGNC: HGNC:8065
Homologene: 5190
Cpq
Name: carboxypeptidase Q
Synonyms: Lal-1, Pgcp, 1190003P12Rik, HLS2, 2610034C17Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 54381
VEGA: 15
Homologene: 9401
Glt1d1
Name: glycosyltransferase 1 domain containing 1
Synonyms: 5730455A04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 319804
Homologene: 16965
Hectd4
Name: HECT domain E3 ubiquitin protein ligase 4
Synonyms: Gm15800
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269700
Homologene: 28297
Khdc3
Name: KH domain containing 3, subcortical maternal complex member
Synonyms: ecat1, FILIA, 2410004A20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66991
Homologene: 49842
Lep
Name: leptin
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16846
HGNC: HGNC:6553
Homologene: 193
Gabarapl2
Name: GABA type A receptor associated protein like 2
Synonyms: 2900019O08Rik, 0610012F20Rik, GATE-16, Gef2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 93739
Homologene: 68550
Cfap299
Name: cilia and flagella associated protein 299
Synonyms: 1700007G11Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75784
Homologene: 51893
Fhip1a
Name: FHF complex subunit HOOK interacting protein 1A
Synonyms: Fam160a1, 9930021J17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229488
Homologene: 85149
Tspear
Name: thrombospondin type laminin G domain and EAR repeats
Synonyms: ORF65, C330046G03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 252974
HGNC: HGNC:1268
Homologene: 36972
F5
Name: coagulation factor V
Synonyms: Cf-5, Cf5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14067
HGNC: HGNC:3542
Homologene: 104
Pcdhac1
Name: protocadherin alpha subfamily C, 1
Synonyms: CNRc1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 353236
HGNC: HGNC:8676
Homologene: 49561
Emid1
Name: EMI domain containing 1
Synonyms: Emu1, CO-5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 140703
Homologene: 135639
Mink1
Name: misshapen-like kinase 1 (zebrafish)
Synonyms: Map4k6, MINK, Misshapen/NIKs-related kinase, Ysk2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 50932
Homologene: 56762
Lrrc37
Name: leucine rich repeat containing 37
Synonyms: Gm884, LOC380730
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380730
Homologene: 134511
Slco1a1
Name: solute carrier organic anion transporter family, member 1a1
Synonyms: Oatp1, Oatp1a1, Slc21a1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 28248
Homologene: 137261
Peli2
Name: pellino 2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 93834
VEGA: 14
HGNC: HGNC:8828
Homologene: 41431
Ppp2r1b
Name: protein phosphatase 2, regulatory subunit A, beta
Synonyms: 2410091N08Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73699
HGNC: HGNC:9303
Homologene: 70244
Or8b1b
Name: olfactory receptor family 8 subfamily B member 1B
Synonyms: Olfr904, GA_x6K02T2PVTD-32156773-32157705, MOR167-3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258797
VEGA: 9
Homologene: 133629
Rida
Name: reactive intermediate imine deaminase A homolog
Synonyms: Hrsp12, HR12, HRP12
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 15473
Homologene: 4261
Ddx60
Name: DExD/H box helicase 60
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234311
Homologene: 23031
Abca2
Name: ATP-binding cassette, sub-family A member 2
Synonyms: Abc2, D2H0S1474E
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11305
HGNC: HGNC:32
Homologene: 55590
Slco6b1
Name: solute carrier organic anion transporter family, member 6b1
Synonyms: 1700022M03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67854
Homologene: 12199
Nrg3
Name: neuregulin 3
Synonyms: ska
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18183
HGNC: HGNC:7999
Homologene: 32051
Mdga1
Name: MAM domain containing glycosylphosphatidylinositol anchor 1
Synonyms: Mamdc3, 1200011I03Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74762
Homologene: 17780
Prex1
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Synonyms: P-REX1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 277360
Homologene: 10821
Cdkl1
Name: cyclin dependent kinase like 1
Synonyms: 4933411O17Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 71091
VEGA: 12
HGNC: HGNC:1781
Homologene: 55805
Pcsk7
Name: proprotein convertase subtilisin/kexin type 7
Synonyms: SPC7
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18554
VEGA: 9
HGNC: HGNC:8748
Homologene: 37955
Rgs6
Name: regulator of G-protein signaling 6
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 50779
Homologene: 68385
Ptprb
Name: protein tyrosine phosphatase receptor type B
Synonyms: VE-PTP, 3230402H02Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19263
VEGA: 10
HGNC: HGNC:9665
Homologene: 2125
Alkbh2
Name: alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase
Synonyms: mABH2, Abh2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231642
Homologene: 18393
Neu1
Name: neuraminidase 1
Synonyms: Map-2, Apl, Bat7, Neu-1, Bat-7, Aglp, sialidase 1, lysosomal sialidase, G9
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18010
HGNC: HGNC:7758
Homologene: 375
Kptn
Name: kaptin
Synonyms: actin-binding protein, C030013F01Rik, 2E4, 2310042D10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70394
HGNC: HGNC:6404
Homologene: 5127
Prss50
Name: serine protease 50
Synonyms: Tsp50
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235631
Homologene: 8314
Brinp1
Name: bone morphogenic protein/retinoic acid inducible neural specific 1
Synonyms: Dbc1, Dbccr1, Fam5a
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56710
HGNC: HGNC:2687
Homologene: 8754
Sel1l2
Name: sel-1 suppressor of lin-12-like 2 (C. elegans)
Synonyms: LOC228684
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228684
Homologene: 16802
Vmn1r17
Name: vomeronasal 1 receptor 17
Synonyms: V1rc16
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171189
Homologene: 115643
Rpe
Name: ribulose-5-phosphate-3-epimerase
Synonyms: 5730518J08Rik, 2810429B02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66646
Homologene: 12005
Actl9
Name: actin-like 9
Synonyms: 1700029I08Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 69481
Homologene: 77642
Asb3
Name: ankyrin repeat and SOCS box-containing 3
Synonyms: 2400011J03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 65257
Homologene: 9391
Sult1c1
Name: sulfotransferase family, cytosolic, 1C, member 1
Synonyms: (PST)G, Stp2, mOLFST, P-SULT, Sult1a2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20888
Homologene: 56817
AL844586.1
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Cdc14a
Name: CDC14 cell division cycle 14A
Synonyms: CDC14A2, CDC14a1, Cdc14, A830059A17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229776
HGNC: HGNC:1718
Homologene: 75343
Wfikkn1
Name: WAP, FS, Ig, KU, and NTR-containing protein 1
Synonyms: Gasp2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 215001
Homologene: 14244
Morc4
Name: microrchidia 4
Synonyms: Zcwcc2, 1600017G11Rik, 5630401M14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 75746
Homologene: 11644
Slc22a13
Name: solute carrier family 22 (organic cation transporter), member 13
Synonyms: OCTL3, ORCTL3, OCTL1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102570
VEGA: 9
HGNC: HGNC:8494
Homologene: 3140
Aaas
Name: achalasia, adrenocortical insufficiency, alacrimia
Synonyms: D030041N15Rik, GL003, Aladin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223921
VEGA: 15
Homologene: 9232
Bax
Name: BCL2-associated X protein
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12028
HGNC: HGNC:959
Homologene: 7242
Tmem221
Name: transmembrane protein 221
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 434325
Homologene: 110174
Vmn1r188
Name: vomeronasal 1 receptor 188
Synonyms: V1rh17
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 252912
Homologene: 110880
Otub1
Name: OTU domain, ubiquitin aldehyde binding 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107260
Homologene: 9772
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 66,701,010 bp
  • A to G, chromosome 1 at 96,947,621 bp
  • C to T, chromosome 1 at 164,208,960 bp
  • T to C, chromosome 2 at 25,442,358 bp
  • T to A, chromosome 2 at 128,595,712 bp
  • A to G, chromosome 2 at 140,265,692 bp
  • C to T, chromosome 2 at 154,377,006 bp
  • A to G, chromosome 2 at 166,586,699 bp
  • C to T, chromosome 3 at 85,665,954 bp
  • T to C, chromosome 3 at 95,847,803 bp
  • A to G, chromosome 3 at 116,293,724 bp
  • A to G, chromosome 4 at 68,762,955 bp
  • C to T, chromosome 4 at 109,312,329 bp
  • A to T, chromosome 5 at 43,770,798 bp
  • C to A, chromosome 5 at 98,329,432 bp
  • C to T, chromosome 5 at 114,124,226 bp
  • T to A, chromosome 5 at 121,323,956 bp
  • T to A, chromosome 5 at 127,664,637 bp
  • A to G, chromosome 5 at 137,583,299 bp
  • T to C, chromosome 6 at 5,156,242 bp
  • T to C, chromosome 6 at 29,070,832 bp
  • A to C, chromosome 6 at 47,107,997 bp
  • A to G, chromosome 6 at 57,361,332 bp
  • C to A, chromosome 6 at 135,083,461 bp
  • A to T, chromosome 6 at 141,913,405 bp
  • C to G, chromosome 7 at 16,123,963 bp
  • A to C, chromosome 7 at 45,461,933 bp
  • T to A, chromosome 7 at 80,219,023 bp
  • A to G, chromosome 7 at 102,134,880 bp
  • G to A, chromosome 8 at 61,942,646 bp
  • A to G, chromosome 8 at 71,558,538 bp
  • T to C, chromosome 8 at 111,941,221 bp
  • C to A, chromosome 9 at 38,464,519 bp
  • T to A, chromosome 9 at 45,914,348 bp
  • A to G, chromosome 9 at 50,862,425 bp
  • C to G, chromosome 9 at 73,103,660 bp
  • T to C, chromosome 9 at 110,861,268 bp
  • G to A, chromosome 9 at 119,209,047 bp
  • T to A, chromosome 10 at 77,870,419 bp
  • T to C, chromosome 10 at 116,380,869 bp
  • G to A, chromosome 10 at 126,008,547 bp
  • T to G, chromosome 11 at 5,132,044 bp
  • T to A, chromosome 11 at 31,056,217 bp
  • T to C, chromosome 11 at 70,598,891 bp
  • T to C, chromosome 11 at 103,608,919 bp
  • T to C, chromosome 12 at 69,760,095 bp
  • G to A, chromosome 12 at 83,116,177 bp
  • A to G, chromosome 13 at 22,088,433 bp
  • T to C, chromosome 13 at 108,357,535 bp
  • T to A, chromosome 14 at 38,407,154 bp
  • T to A, chromosome 14 at 48,252,717 bp
  • A to T, chromosome 15 at 33,250,000 bp
  • A to G, chromosome 15 at 34,495,104 bp
  • A to G, chromosome 15 at 84,939,792 bp
  • A to G, chromosome 15 at 98,814,052 bp
  • C to T, chromosome 15 at 102,339,206 bp
  • A to T, chromosome 16 at 17,483,692 bp
  • A to G, chromosome 17 at 25,878,591 bp
  • G to A, chromosome 17 at 29,842,902 bp
  • T to A, chromosome 17 at 33,433,257 bp
  • G to A, chromosome 17 at 34,934,398 bp
  • G to A, chromosome 17 at 46,651,553 bp
  • G to T, chromosome 17 at 53,962,148 bp
  • T to C, chromosome 18 at 37,146,133 bp
  • T to C, chromosome 19 at 7,199,206 bp
  • A to G, chromosome 19 at 34,928,918 bp
  • G to A, chromosome X at 139,837,845 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1545 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039584-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.