Strain Name:
C57BL/6J-MtgxR1586Btlr/Mmmh
Stock Number:
039623-MU
Citation ID:
RRID:MMRRC_039623-MU
Other Names:
R1586 (G1), C57BL/6J-MtgxR1586Btlr
Major Collection:

Gene Information

Cdh1
Name: cadherin 1
Synonyms: UM, E-cad, Ecad, L-CAM, uvomorulin, E-cadherin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12550
HGNC: HGNC:1748
Homologene: 20917
Epha2
Name: Eph receptor A2
Synonyms: Myk2, Sek2, Eck, Sek-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 13836
HGNC: HGNC:3386
Homologene: 20929
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: trabeculin alpha, Acf7, Aclp7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11426
Homologene: 136191
Ulk1
Name: unc-51 like kinase 1
Synonyms: Unc51.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22241
Homologene: 2640
Vps35l
Name: VPS35 endosomal protein sorting factor like
Synonyms: Vsp35l, 9030624J02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71517
Homologene: 10659
Tbc1d22a
Name: TBC1 domain family, member 22a
Synonyms: D15Ertd781e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223754
VEGA: 15
HGNC: HGNC:1309
Homologene: 105406
Rrm1
Name: ribonucleotide reductase M1
Synonyms: RnrM1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20133
Homologene: 806
Tbcd
Name: tubulin-specific chaperone d
Synonyms: 2310057L06Rik, A030005L14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 108903
Homologene: 4368
Mki67
Name: antigen identified by monoclonal antibody Ki 67
Synonyms: Ki-67, Ki67, D630048A14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17345
HGNC: HGNC:7107
Homologene: 1814
Fam222b
Name: family with sequence similarity 222, member B
Synonyms: BC017647
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216971
Homologene: 10054
Ank3
Name: ankyrin 3, epithelial
Synonyms: Ankyrin-G, AnkG, 2900054D09Rik, Ankyrin-3, Ank-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 11735
HGNC: HGNC:494
Homologene: 56908
Dmap1
Name: DNA methyltransferase 1-associated protein 1
Synonyms: 1500016M21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66233
Homologene: 41311
Oga
Name: O-GlcNAcase
Synonyms: Mgea5, 5830447M11Rik, Hy5, 4833427O07Rik, 2810009A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 76055
VEGA: 19
HGNC: HGNC:7056
Homologene: 8154
Cic
Name: capicua transcriptional repressor
Synonyms: 1200010B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 71722
Homologene: 87637
Rpl7
Name: ribosomal protein L7
Synonyms: Rpl7a, Surf-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19989
Homologene: 87772
Surf2
Name: surfeit gene 2
Synonyms: Surf-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20931
Homologene: 8430
Anapc10
Name: anaphase promoting complex subunit 10
Synonyms: 1500026N15Rik, A830003M23Rik, Apc10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 68999
Homologene: 32238
Snx11
Name: sorting nexin 11
Synonyms: 4933439F10Rik, A930041K09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 74479
Homologene: 12568
Znrf3
Name: zinc and ring finger 3
Synonyms: LOC382477
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 407821
Homologene: 46592
Atp2a3
Name: ATPase, Ca++ transporting, ubiquitous
Synonyms: Serca3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 53313
HGNC: HGNC:813
Homologene: 69131
Cilp
Name: cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
Synonyms: C130036G17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 214425
HGNC: HGNC:1980
Homologene: 2679
Fig4
Name: FIG4 phosphoinositide 5-phosphatase
Synonyms: A530089I17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 103199
VEGA: 10
Homologene: 6713
Psd
Name: pleckstrin and Sec7 domain containing
Synonyms: Psdl, Efa6, 1110007H17Rik, Efa6a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 73728
VEGA: 19
HGNC: HGNC:9507
Homologene: 31115
Kcp
Name: kielin/chordin-like protein
Synonyms: LOC333088, Crim2, KCP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 333088
Homologene: 87817
Spta1
Name: spectrin alpha, erythrocytic 1
Synonyms: ihj, Spna1, Spna-1, erythroid
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20739
Homologene: 74460
Atp1a3
Name: ATPase, Na+/K+ transporting, alpha 3 polypeptide
Synonyms: Atpa-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232975
HGNC: HGNC:801
Homologene: 113729
Wdr93
Name: WD repeat domain 93
Synonyms: EG626359
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 626359
Homologene: 56878
Nav3
Name: neuron navigator 3
Synonyms: unc53H3, 9630020C08Rik, Pomfil1p, steerin 3, 4732483H20Rik, POMFIL1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 260315
Homologene: 56688
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 329628
Homologene: 14377
Galnt11
Name: polypeptide N-acetylgalactosaminyltransferase 11
Synonyms: A430075I06Rik, E430002F06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231050
Homologene: 11126
1700022I11Rik
Name: RIKEN cDNA 1700022I11 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67317
Homologene: 52406
Clca3a2
Name: chloride channel accessory 3A2
Synonyms: Clca2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80797
Homologene: 77224
Cryz
Name: crystallin, zeta
Synonyms: Sez9, SEZ9, quinone reductase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12972
HGNC: HGNC:2419
Homologene: 133907
Tdrd7
Name: tudor domain containing 7
Synonyms: 5730495N10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100121
Homologene: 8618
Alpi
Name: alkaline phosphatase, intestinal
Synonyms: 2010001C14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 76768
Homologene: 122414
Smgc
Name: submandibular gland protein C
Synonyms: 2310010P21Rik, Sfc21, DXImx49e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223809
Kmt2d
Name: lysine (K)-specific methyltransferase 2D
Synonyms: Mll2, Mll4, C430014K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 381022
HGNC: HGNC:7133
Homologene: 86893
Anxa8
Name: annexin A8
Synonyms: Anx8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 11752
Homologene: 20393
Spag17
Name: sperm associated antigen 17
Synonyms: PF6, 4931427F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 74362
Homologene: 52601
Abca2
Name: ATP-binding cassette, sub-family A (ABC1), member 2
Synonyms: D2H0S1474E, Abc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11305
HGNC: HGNC:32
Homologene: 55590
Myo5c
Name: myosin VC
Synonyms: 9130003O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 208943
VEGA: 9
HGNC: HGNC:7604
Homologene: 135711
Ttc7
Name: tetratricopeptide repeat domain 7
Synonyms: hea, fsn, 1700007L07Rik, 1110035E02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 225049
Homologene: 12515
Serpinb9
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9
Synonyms: ovalbumin, Spi6, PI-9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20723
HGNC: HGNC:8955
Homologene: 37888
Cpvl
Name: carboxypeptidase, vitellogenic-like
Synonyms: 4933436L16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 71287
Homologene: 80235
Guk1
Name: guanylate kinase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14923
HGNC: HGNC:4693
Homologene: 665
Zscan29
Name: zinc finger SCAN domains 29
Synonyms: Zfp690
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99334
Homologene: 17586
Cbs
Name: cystathionine beta-synthase
Synonyms: HIP4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 12411
Homologene: 37258
Pde4c
Name: phosphodiesterase 4C, cAMP specific
Synonyms: Dpde1, E130301F19Rik, dunce
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 110385
HGNC: HGNC:8782
Homologene: 20256
Crx
Name: cone-rod homeobox
Synonyms: Crx1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12951
HGNC: HGNC:2383
Homologene: 467
Fastkd1
Name: FAST kinase domains 1
Synonyms: 5330408N05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 320720
Homologene: 36420
Tada1
Name: transcriptional adaptor 1
Synonyms: Tada1l, 2900026B15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 27878
Homologene: 41793
Slc35a4
Name: solute carrier family 35, member A4
Synonyms: 2610030J16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 67843
Homologene: 12195
Fbxo10
Name: F-box protein 10
Synonyms: FBX10, LOC269529
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269529
Homologene: 19544
Ms4a8a
Name: membrane-spanning 4-domains, subfamily A, member 8A
Synonyms: Ms4a8, 2010004L09Rik, CD20L5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 64381
Homologene: 111037
Tomm5
Name: translocase of outer mitochondrial membrane 5
Synonyms: 1110019J04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68512
Homologene: 104342
Speer4b
Name: spermatogenesis associated glutamate (E)-rich protein 4B
Synonyms: 1700081O22Rik, SPEER-4B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 73526
Homologene: 69402
AC123821.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Cidea
Name: cell death-inducing DNA fragmentation factor, alpha subunit-like effector A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 12683
VEGA: 18
HGNC: HGNC:1976
Homologene: 77852
Olfr1432
Name: olfactory receptor 1432
Synonyms: MOR202-32P, GA_x6K02T2RE5P-2593538-2592756
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 257961
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 16,102,583 bp
  • A to G, chromosome 1 at 87,100,201 bp
  • G to A, chromosome 1 at 166,386,750 bp
  • A to T, chromosome 1 at 174,213,495 bp
  • C to T, chromosome 2 at 25,447,216 bp
  • T to C, chromosome 2 at 26,919,755 bp
  • T to C, chromosome 2 at 69,712,148 bp
  • T to A, chromosome 2 at 121,161,160 bp
  • T to A, chromosome 3 at 38,888,860 bp
  • A to G, chromosome 3 at 100,021,752 bp
  • A to G, chromosome 3 at 144,810,716 bp
  • A to G, chromosome 3 at 154,611,510 bp
  • A to G, chromosome 4 at 42,971,512 bp
  • A to T, chromosome 4 at 45,042,036 bp
  • A to G, chromosome 4 at 45,107,915 bp
  • A to G, chromosome 4 at 45,994,445 bp
  • T to C, chromosome 4 at 117,676,122 bp
  • A to T, chromosome 4 at 123,509,846 bp
  • C to T, chromosome 4 at 141,318,605 bp
  • G to A, chromosome 5 at 25,257,381 bp
  • A to G, chromosome 5 at 27,497,013 bp
  • A to T, chromosome 5 at 110,789,516 bp
  • A to G, chromosome 6 at 29,496,539 bp
  • T to A, chromosome 6 at 53,926,901 bp
  • C to A, chromosome 7 at 15,869,330 bp
  • T to A, chromosome 7 at 24,979,383 bp
  • T to C, chromosome 7 at 25,285,961 bp
  • T to A, chromosome 7 at 31,375,963 bp
  • C to A, chromosome 7 at 79,768,361 bp
  • A to G, chromosome 7 at 102,466,905 bp
  • T to A, chromosome 7 at 118,809,972 bp
  • T to A, chromosome 7 at 135,713,972 bp
  • T to A, chromosome 8 at 70,746,859 bp
  • T to A, chromosome 8 at 79,775,143 bp
  • T to A, chromosome 8 at 106,648,987 bp
  • G to A, chromosome 9 at 65,279,715 bp
  • T to C, chromosome 9 at 75,267,031 bp
  • A to G, chromosome 10 at 41,265,427 bp
  • A to G, chromosome 10 at 69,877,878 bp
  • T to A, chromosome 10 at 109,853,254 bp
  • T to C, chromosome 11 at 5,281,477 bp
  • A to G, chromosome 11 at 59,186,849 bp
  • T to C, chromosome 11 at 72,991,744 bp
  • C to T, chromosome 11 at 78,154,521 bp
  • C to A, chromosome 11 at 96,770,696 bp
  • A to G, chromosome 11 at 121,497,060 bp
  • A to T, chromosome 13 at 33,015,486 bp
  • T to A, chromosome 14 at 34,093,937 bp
  • C to A, chromosome 15 at 86,351,651 bp
  • G to A, chromosome 15 at 91,838,393 bp
  • A to G, chromosome 15 at 98,865,053 bp
  • T to A, chromosome 17 at 31,622,474 bp
  • T to C, chromosome 17 at 87,361,945 bp
  • T to C, chromosome 18 at 36,683,005 bp
  • T to A, chromosome 18 at 67,360,160 bp
  • T to C, chromosome 19 at 11,076,332 bp
  • G to T, chromosome 19 at 12,228,877 bp
  • T to G, chromosome 19 at 45,776,910 bp
  • T to G, chromosome 19 at 46,314,798 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1586 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039623-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.