Strain Name:
C57BL/6J-MtgxR1614Btlr/Mmmh
Stock Number:
039651-MU
Citation ID:
RRID:MMRRC_039651-MU
Other Names:
R1614 (G1), C57BL/6J-MtgxR1614Btlr
Major Collection:

Gene Information

Slc17a6
Name: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
Synonyms: 2900073D12Rik, VGLUT2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 140919
Homologene: 121617
Dst
Name: dystonin
Synonyms: A830042E19Rik, 2310001O04Rik, Macf2, bullous pemphigoid antigen 1, BPAG1-n, BPAG1, athetoid, Bpag, ah, bullous pemphigoid antigen 1, Bpag1, nmf339, nmf203
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Ccdc88c
Name: coiled-coil domain containing 88C
Synonyms: Daple, 0610010D24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 68339
VEGA: 12
Homologene: 18903
Pecam1
Name: platelet/endothelial cell adhesion molecule 1
Synonyms: Cd31, PECAM-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 18613
HGNC: HGNC:8823
Homologene: 47925
Polr2a
Name: polymerase (RNA) II (DNA directed) polypeptide A
Synonyms: Rpo2-1, 220kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 20020
HGNC: HGNC:9187
Homologene: 721
Ppp2r5e
Name: protein phosphatase 2, regulatory subunit B', epsilon
Synonyms: B56beta, protein phosphatase 2A subunit beta, 4633401M22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 26932
VEGA: 12
HGNC: HGNC:9313
Homologene: 55962
Pop1
Name: processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae)
Synonyms: 4932434G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 67724
Homologene: 41000
Atp2c1
Name: ATPase, Ca++-sequestering
Synonyms: ATP2C1A, 1700121J11Rik, SPCA, PMR1, D930003G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235574
Homologene: 56672
Aspm
Name: abnormal spindle microtubule assembly
Synonyms: Sha1, D330028K02Rik, Calmbp1, Aspm, MCPH5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 12316
Homologene: 7650
Prmt3
Name: protein arginine N-methyltransferase 3
Synonyms: 2010005E20Rik, Hrmt1l3, 2410018A17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 71974
Homologene: 24255
Ipo13
Name: importin 13
Synonyms: Imp13, Kap13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230673
Homologene: 40968
Strada
Name: STE20-related kinase adaptor alpha
Synonyms: 2610019A05Rik, 6030402H20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 72149
Homologene: 12448
Ttll4
Name: tubulin tyrosine ligase-like family, member 4
Synonyms: 4632407P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 67534
Homologene: 8764
Dock7
Name: dedicator of cytokinesis 7
Synonyms: m, 3110056M06Rik, LOC242555
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 67299
Homologene: 23566
Zbtb18
Name: zinc finger and BTB domain containing 18
Synonyms: RP58, Zfp238
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 30928
Homologene: 21276
Itgb1
Name: integrin beta 1 (fibronectin receptor beta)
Synonyms: Gm9863, CD29, 4633401G24Rik, Fnrb, beta1 integrin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 16412
HGNC: HGNC:6153
Homologene: 22999
Uimc1
Name: ubiquitin interaction motif containing 1
Synonyms: D630032M02Rik, 9430016E08Rik, D330018D10Rik, Rxrip110
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 20184
Homologene: 9455
Raph1
Name: Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
Synonyms: Lpd, C730009O10Rik, lamellipodin, 9430025M21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 77300
Homologene: 71030
Nop53
Name: NOP53 ribosome biogenesis factor
Synonyms: 9430097C02Rik, Gltscr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 68077
HGNC: HGNC:4333
Homologene: 44130
Kcnv1
Name: potassium channel, subfamily V, member 1
Synonyms: 2700023A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 67498
VEGA: 15
Homologene: 22811
1700125H20Rik
Name: RIKEN cDNA 1700125H20 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 73634
Homologene: 18763
Pcsk5
Name: proprotein convertase subtilisin/kexin type 5
Synonyms: PC5A, PC6, PC5/6A, b2b585Clo, b2b1549Clo, SPC6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 18552
VEGA: 19
HGNC: HGNC:8747
Homologene: 21244
Olfr1318
Name: olfactory receptor 1318
Synonyms: MOR245-16, GA_x6K02T2Q125-73202172-73203134
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258022
Homologene: 134079
Ralgapa2
Name: Ral GTPase activating protein, alpha subunit 2 (catalytic)
Synonyms: AS250, RGC2, A230067G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241694
Homologene: 28131
Stard9
Name: START domain containing 9
Synonyms: E230025N21Rik, 4831403C07Rik, Kif16a, N-3 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 668880
Homologene: 130712
Arl9
Name: ADP-ribosylation factor-like 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 384185
Homologene: 66207
Chtf18
Name: CTF18, chromosome transmission fidelity factor 18
Synonyms: CTF18, 6030457M03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 214901
Homologene: 32532
Ptgfr
Name: prostaglandin F receptor
Synonyms: PGF, FP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 19220
HGNC: HGNC:9600
Homologene: 741
Tom1l1
Name: target of myb1-like 1 (chicken)
Synonyms: Srcasm, 2310045L10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 71943
Homologene: 38055
Cep162
Name: centrosomal protein 162
Synonyms: 4922501C03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 382090
Homologene: 8930
Cacna1b
Name: calcium channel, voltage-dependent, N type, alpha 1B subunit
Synonyms: Cchn1a, Cav2.2, alpha(1B)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 12287
HGNC: HGNC:1389
Homologene: 20184
Greb1
Name: gene regulated by estrogen in breast cancer protein
Synonyms: 5730583K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 268527
Homologene: 8780
Olfr346
Name: olfactory receptor 346
Synonyms: MOR136-11, GA_x6K02T2NLDC-33382467-33383396
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258940
Homologene: 133616
Gnptab
Name: N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
Synonyms: EG432486
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 432486
Homologene: 32576
Vmn2r27
Name: vomeronasal 2, receptor27
Synonyms: EG232367
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232367
Kcnh7
Name: potassium voltage-gated channel, subfamily H (eag-related), member 7
Synonyms: 9330137I11Rik, Kv11.3, erg3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 170738
Homologene: 13249
Smarcd3
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
Synonyms: 1500001J14Rik, 2210409C08Rik, BAF60C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 66993
Homologene: 2314
Zfp955a
Name: zinc finger protein 955A
Synonyms: AI842447
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 77652
VEGA: 17
Homologene: 104925
Rnf43
Name: ring finger protein 43
Synonyms: 4732452J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 207742
Homologene: 37742
Proz
Name: protein Z, vitamin K-dependent plasma glycoprotein
Synonyms: 1300015B06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 66901
HGNC: HGNC:9460
Homologene: 2890
Mrc2
Name: mannose receptor, C type 2
Synonyms: Endo180, novel lectin, uPARAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 17534
Homologene: 4408
Insl5
Name: insulin-like 5
Synonyms: relaxin/insulin-like factor 2, RIF2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 23919
HGNC: HGNC:6088
Homologene: 48350
Vmn2r68
Name: vomeronasal 2, receptor 68
Synonyms: EG620697, Vmn2r68-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 620697
Homologene: 115466
Olfr1278
Name: olfactory receptor 1278
Synonyms: MOR245-11, GA_x6K02T2Q125-72343713-72344654
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258389
Homologene: 74061
Slc25a19
Name: solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19
Synonyms: MUP1, TPC, 2900089E13Rik, DNC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 67283
Homologene: 5982
Fam13a
Name: family with sequence similarity 13, member A
Synonyms: D430015B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 58909
Homologene: 135847
Atpaf1
Name: ATP synthase mitochondrial F1 complex assembly factor 1
Synonyms: ATP11, ATP11p, 6330547J17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230649
Homologene: 41492
Olfr1246
Name: olfactory receptor 1246
Synonyms: MOR231-9, GA_x6K02T2Q125-51034790-51033846
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258788
Homologene: 74246
Zfp112
Name: zinc finger protein 112
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 57745
Homologene: 49338
Nabp1
Name: nucleic acid binding protein 1
Synonyms: Nbp1, 4933440J18Rik, 5830411E10Rik, Obfc2a, 4930434H03Rik, 4930488J04Rik, 4930442A21Rik, Ssb2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 109019
Homologene: 57094
Mesp2
Name: mesoderm posterior 2
Synonyms: bHLHc6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 17293
Homologene: 7420
Cox7c
Name: cytochrome c oxidase subunit 7C
Synonyms: Cox7c1, COXVIIc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 12867
HGNC: HGNC:2292
Homologene: 81691
Gm6741
Name: predicted gene 6741
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 627235
VEGA: 17
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 34,275,263 bp
  • T to C, chromosome 1 at 51,471,352 bp
  • G to A, chromosome 1 at 60,501,746 bp
  • T to C, chromosome 1 at 74,685,980 bp
  • A to G, chromosome 1 at 139,463,310 bp
  • T to C, chromosome 1 at 177,447,170 bp
  • G to T, chromosome 2 at 24,690,807 bp
  • T to G, chromosome 2 at 36,688,309 bp
  • G to T, chromosome 2 at 62,850,604 bp
  • T to A, chromosome 2 at 89,590,696 bp
  • T to A, chromosome 2 at 111,293,066 bp
  • T to A, chromosome 2 at 112,156,517 bp
  • T to C, chromosome 2 at 120,697,675 bp
  • G to T, chromosome 2 at 146,388,612 bp
  • A to C, chromosome 3 at 151,801,779 bp
  • C to T, chromosome 4 at 99,061,280 bp
  • A to T, chromosome 4 at 103,026,649 bp
  • A to T, chromosome 4 at 115,796,757 bp
  • A to G, chromosome 4 at 117,904,618 bp
  • A to G, chromosome 5 at 24,594,876 bp
  • A to G, chromosome 5 at 77,010,565 bp
  • T to A, chromosome 6 at 58,940,184 bp
  • T to G, chromosome 6 at 124,223,934 bp
  • A to G, chromosome 7 at 15,945,965 bp
  • G to T, chromosome 7 at 24,126,599 bp
  • A to T, chromosome 7 at 49,826,719 bp
  • G to A, chromosome 7 at 51,646,277 bp
  • T to C, chromosome 7 at 79,811,619 bp
  • A to T, chromosome 7 at 85,221,738 bp
  • G to A, chromosome 8 at 13,066,904 bp
  • G to A, chromosome 8 at 128,720,065 bp
  • T to C, chromosome 9 at 87,212,932 bp
  • T to A, chromosome 9 at 105,467,826 bp
  • A to G, chromosome 10 at 88,414,589 bp
  • T to C, chromosome 11 at 69,743,373 bp
  • T to G, chromosome 11 at 85,172,864 bp
  • C to T, chromosome 11 at 87,731,659 bp
  • T to C, chromosome 11 at 90,683,254 bp
  • T to C, chromosome 11 at 105,349,555 bp
  • A to C, chromosome 11 at 106,168,319 bp
  • T to C, chromosome 11 at 106,681,079 bp
  • A to T, chromosome 11 at 115,616,623 bp
  • A to G, chromosome 12 at 16,701,171 bp
  • C to G, chromosome 12 at 75,469,567 bp
  • A to T, chromosome 12 at 100,912,984 bp
  • C to T, chromosome 13 at 55,069,817 bp
  • A to G, chromosome 13 at 86,045,785 bp
  • C to A, chromosome 15 at 34,530,210 bp
  • G to A, chromosome 15 at 45,114,444 bp
  • A to G, chromosome 17 at 25,727,090 bp
  • A to T, chromosome 17 at 33,242,332 bp
  • T to A, chromosome 17 at 91,236,996 bp
  • G to A, chromosome 19 at 17,515,256 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1614 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039651-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.