Strain Name:
C57BL/6J-MtgxR1622Btlr/Mmmh
Stock Number:
039659-MU
Citation ID:
RRID:MMRRC_039659-MU
Other Names:
R1622 (G1), C57BL/6J-MtgxR1622Btlr
Major Collection:

Strain Information

Pkd1
Name: polycystin 1, transient receptor potential channel interacting
Synonyms: polycystin-1, PC-1, PC1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18763
VEGA: 17
HGNC: HGNC:9008
Homologene: 250
Gpr6
Name: G protein-coupled receptor 6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 140741
VEGA: 10
HGNC: HGNC:4515
Homologene: 38026
Pcdh9
Name: protocadherin 9
Synonyms: 1500001L12Rik, C630029H24Rik, A730003J17Rik, C530050I23Rik, LOC382930
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 211712
HGNC: HGNC:8661
Homologene: 10698
Mmp10
Name: matrix metallopeptidase 10
Synonyms: stromelysin 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17384
VEGA: 9
HGNC: HGNC:7156
Homologene: 20546
Atf2
Name: activating transcription factor 2
Synonyms: D130078H02Rik, ATF-2, Creb2, mXBP, CRE-BP
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11909
HGNC: HGNC:784
Homologene: 31061
Cadm1
Name: cell adhesion molecule 1
Synonyms: RA175A, Tslc1, SgIGSF, SynCam, RA175N, RA175C, RA175B, Necl2, Igsf4, Igsf4a, 2900073G06Rik, 3100001I08Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 54725
HGNC: HGNC:5951
Homologene: 8641
Ubr5
Name: ubiquitin protein ligase E3 component n-recognin 5
Synonyms: 4432411E13Rik, Edd, Edd1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70790
VEGA: 15
Homologene: 9295
Syt4
Name: synaptotagmin IV
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 20983
VEGA: 18
Homologene: 7559
Spag7
Name: sperm associated antigen 7
Synonyms: Fsa1l, FSA-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216873
Homologene: 3595
Arhgef18
Name: Rho/Rac guanine nucleotide exchange factor 18
Synonyms: A430078G23Rik, D030053O22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102098
Homologene: 32254
Pibf1
Name: progesterone immunomodulatory binding factor 1
Synonyms: 1700017E21Rik, 4933438D16Rik, 4930513H15Rik, D14Ertd581e, 4933439E17Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 52023
VEGA: 14
Homologene: 4628
Morc3
Name: microrchidia 3
Synonyms: D16Jhu32e, 1110051N18Rik, Zcwcc3, 1110051N18Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 338467
Homologene: 32257
Urb2
Name: URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382038
Homologene: 8859
Ncbp1
Name: nuclear cap binding protein subunit 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 433702
HGNC: HGNC:7658
Homologene: 1859
Tbc1d8
Name: TBC1 domain family, member 8
Synonyms: HBLP1, BUB2-like protein 1, AD3, GRAM domain
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 54610
Homologene: 31421
Fkbp15
Name: FK506 binding protein 15
Synonyms: C430014M02Rik, FKBP133
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 338355
Homologene: 28743
Pank2
Name: pantothenate kinase 2
Synonyms: 4933409I19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74450
Homologene: 65126
Nlrp3
Name: NLR family, pyrin domain containing 3
Synonyms: Mmig1, Cias1, NALP3, cryopyrin, Pypaf1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216799
Homologene: 3600
Nbeal2
Name: neurobeachin-like 2
Synonyms: 1110014F23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235627
Homologene: 86422
Prss58
Name: serine protease 58
Synonyms: BC048599
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232717
Homologene: 65285
Msh3
Name: mutS homolog 3
Synonyms: Rep3, D13Em1, Rep-3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17686
HGNC: HGNC:7326
Homologene: 1829
Arhgap19
Name: Rho GTPase activating protein 19
Synonyms: 4933411B03Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 71085
Homologene: 13159
Pbrm1
Name: polybromo 1
Synonyms: 2610016F04Rik, 2310032M22Rik, BAF180, Pb1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66923
Homologene: 10044
Clstn1
Name: calsyntenin 1
Synonyms: calsyntenin-1, Cst-1, alcadein alpha, 1810034E21Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 65945
Homologene: 8814
Zfp445
Name: zinc finger protein 445
Synonyms: ZNF168
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235682
VEGA: 9
Homologene: 27832
Pomt2
Name: protein-O-mannosyltransferase 2
Synonyms: A830009D15Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217734
VEGA: 12
Homologene: 5297
Irf8
Name: interferon regulatory factor 8
Synonyms: IRF-8, ICSBP, Myls, Icsbp1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 15900
HGNC: HGNC:5358
Homologene: 1629
Tmco5
Name: transmembrane and coiled-coil domains 5
Synonyms: 1700095F04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67356
Homologene: 41661
Gpn1
Name: GPN-loop GTPase 1
Synonyms: Xab1, 2410004J02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74254
Homologene: 5257
Col5a3
Name: collagen, type V, alpha 3
Synonyms: Pro-alpha3(V)
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 53867
Homologene: 9253
Glce
Name: glucuronyl C5-epimerase
Synonyms: C130034A12Rik, 1110017N23Rik, Hsepi, heparan sulfate-glucuronic acid C5-epimerase
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 93683
Homologene: 14111
Zfp608
Name: zinc finger protein 608
Synonyms: 4932417D18Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 269023
VEGA: 18
Homologene: 18485
Gm4884
Name: predicted gene 4884
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233164
Nfatc1
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1
Synonyms: NF-ATc, NFAT2, NFATc, 2210017P03Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 18018
VEGA: 18
HGNC: HGNC:7775
Homologene: 32336
Zfp629
Name: zinc finger protein 629
Synonyms: 9330199A09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 320683
Homologene: 65318
Hfm1
Name: HFM1, ATP-dependent DNA helicase homolog
Synonyms: A330009G12Rik, LOC381663, Mer3, Sec63d1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330149
Homologene: 87103
Hcrtr2
Name: hypocretin (orexin) receptor 2
Synonyms: mOX2aR, mOX2bR, mOXR2, OX2r
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 387285
HGNC: HGNC:4849
Homologene: 1168
Il4ra
Name: interleukin 4 receptor, alpha
Synonyms: CD124, IL-4 receptor alpha chain, Il4r
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16190
HGNC: HGNC:6015
Homologene: 7784
Sp140l2
Name: Sp140 nuclear body protein like 2
Synonyms: OTTMUSG00000029174, C130026I21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 620078
Homologene: 131208
Aldoart2
Name: aldolase 1 A, retrogene 2
Synonyms: Aldoa-ps1, Aldo1-ps1, 4933425L11Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 79459
Homologene: 134148
Gpat2
Name: glycerol-3-phosphate acyltransferase 2, mitochondrial
Synonyms: A530057A03Rik, Gpat2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 215456
Homologene: 19037
Cdh4
Name: cadherin 4
Synonyms: R-cadherin, R-Cadh, Rcad
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12561
HGNC: HGNC:1763
Homologene: 48044
Col6a4
Name: collagen, type VI, alpha 4
Synonyms: Dvwa, Vwa6, EG235580, 1110001D15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68553
Homologene: 130754
Ephb1
Name: Eph receptor B1
Synonyms: C130099E04Rik, Elk, Net, Hek6, Elkh, Cek6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270190
HGNC: HGNC:3392
Homologene: 20936
Cntln
Name: centlein, centrosomal protein
Synonyms: D530005L17Rik, B430108F07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 338349
Homologene: 9805
Trim34a
Name: tripartite motif-containing 34A
Synonyms: Trim34, Trim34-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 94094
Homologene: 128238
Lrrc4b
Name: leucine rich repeat containing 4B
Synonyms: Lrig4, NGL-3, Ngl3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 272381
Homologene: 45681
Itih2
Name: inter-alpha trypsin inhibitor, heavy chain 2
Synonyms: Itih-2, Intin2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16425
HGNC: HGNC:6167
Homologene: 1668
Rassf8
Name: Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
Synonyms: mHoj-1, 5133400D11Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71323
Homologene: 5219
Zfp52
Name: zinc finger protein 52
Synonyms: zfec29, KRAB11, Zfp76, Zfp-52
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22710
VEGA: 17
Homologene: 77326
Sult3a1
Name: sulfotransferase family 3A, member 1
Synonyms: Sultx2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 57430
VEGA: 10
Homologene: 111031
Trcg1
Name: taste receptor cell gene 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 541610
Homologene: 134171
Cnga3
Name: cyclic nucleotide gated channel alpha 3
Synonyms: CNG3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12790
HGNC: HGNC:2150
Homologene: 994
Zscan2
Name: zinc finger and SCAN domain containing 2
Synonyms: Zfp29, Zfp-29
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22691
Homologene: 56453
Gabra4
Name: gamma-aminobutyric acid type A receptor subunit alpha 4
Synonyms: Gabra-4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14397
HGNC: HGNC:4078
Homologene: 631
Ccdc159
Name: coiled-coil domain containing 159
Synonyms: 2510048L02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67119
VEGA: 9
Homologene: 12084
Onecut3
Name: one cut domain, family member 3
Synonyms: OC-3, Oc3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 246086
Homologene: 82258
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 37,244,828 bp
  • A to C, chromosome 1 at 39,380,236 bp
  • A to G, chromosome 1 at 85,254,186 bp
  • A to T, chromosome 2 at 10,102,079 bp
  • A to G, chromosome 2 at 73,853,789 bp
  • A to T, chromosome 2 at 116,880,315 bp
  • A to G, chromosome 2 at 127,430,843 bp
  • A to T, chromosome 2 at 131,273,969 bp
  • T to C, chromosome 2 at 179,889,092 bp
  • A to G, chromosome 4 at 46,171,963 bp
  • T to A, chromosome 4 at 62,323,202 bp
  • T to A, chromosome 4 at 85,063,181 bp
  • T to C, chromosome 4 at 149,629,407 bp
  • A to G, chromosome 5 at 31,503,404 bp
  • A to G, chromosome 5 at 71,571,986 bp
  • C to T, chromosome 5 at 106,893,523 bp
  • A to T, chromosome 6 at 40,897,314 bp
  • A to G, chromosome 6 at 145,820,103 bp
  • A to T, chromosome 7 at 41,042,841 bp
  • GAGAAG to GAG, chromosome 7 at 44,462,230 bp
  • A to G, chromosome 7 at 80,875,386 bp
  • A to T, chromosome 7 at 104,261,338 bp
  • T to A, chromosome 7 at 125,570,053 bp
  • A to G, chromosome 7 at 127,611,840 bp
  • T to A, chromosome 8 at 3,441,272 bp
  • G to C, chromosome 8 at 120,739,822 bp
  • A to G, chromosome 8 at 124,029,624 bp
  • T to A, chromosome 9 at 7,504,995 bp
  • C to T, chromosome 9 at 20,772,220 bp
  • A to T, chromosome 9 at 21,929,370 bp
  • A to G, chromosome 9 at 47,813,841 bp
  • A to G, chromosome 9 at 57,248,672 bp
  • T to C, chromosome 9 at 62,070,561 bp
  • T to C, chromosome 9 at 76,323,440 bp
  • T to C, chromosome 9 at 102,001,711 bp
  • A to C, chromosome 9 at 105,997,135 bp
  • G to A, chromosome 9 at 110,631,511 bp
  • A to G, chromosome 9 at 122,852,549 bp
  • A to T, chromosome 10 at 33,870,250 bp
  • A to T, chromosome 10 at 41,071,292 bp
  • A to G, chromosome 10 at 80,496,197 bp
  • T to A, chromosome 11 at 59,548,476 bp
  • T to A, chromosome 11 at 70,664,862 bp
  • A to G, chromosome 12 at 55,565,911 bp
  • A to G, chromosome 12 at 87,139,740 bp
  • A to G, chromosome 13 at 92,344,954 bp
  • A to G, chromosome 14 at 31,032,548 bp
  • T to C, chromosome 14 at 93,885,875 bp
  • G to A, chromosome 14 at 99,186,481 bp
  • T to C, chromosome 15 at 38,009,113 bp
  • T to A, chromosome 16 at 93,874,806 bp
  • G to A, chromosome 17 at 21,561,571 bp
  • G to A, chromosome 17 at 24,581,640 bp
  • T to C, chromosome 18 at 31,444,016 bp
  • A to G, chromosome 18 at 54,988,294 bp
  • A to G, chromosome 18 at 80,666,967 bp
  • T to A, chromosome 19 at 41,801,973 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1622 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039659-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.