Strain Name:
C57BL/6J-MtgxR1711Btlr/Mmmh
Stock Number:
039744-MU
Citation ID:
RRID:MMRRC_039744-MU
Other Names:
R1711 (G1), C57BL/6J-MtgxR1711Btlr
Major Collection:

Gene Information

Gene Symbol: Rubcn [MGI:1915160] (Mus musculus (mouse))
Name: RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein
Synonyms: 1700021K19Rik
Chromosome: 16
Alteration at locus: Chemically Induced
Gene Symbol: Kcnj5 [MGI:104755] (Mus musculus (mouse))
Name: potassium inwardly-rectifying channel, subfamily J, member 5
Synonyms: Kir3.4, GIRK4
Chromosome: 9
Alteration at locus: Chemically Induced
Gene Symbol: Gaa [MGI:95609] (Mus musculus (mouse))
Name: glucosidase, alpha, acid
Synonyms: E430018M07Rik
Chromosome: 11
Alteration at locus: Chemically Induced
Gene Symbol: Ep400 [MGI:1276124] (Mus musculus (mouse))
Name: E1A binding protein p400
Synonyms: 1700020J09Rik, p400, mDomino
Chromosome: 5
Alteration at locus: Chemically Induced
Gene Symbol: Dop1b [MGI:1917278] (Mus musculus (mouse))
Name: DOP1 leucine zipper like protein B
Synonyms: 0610038M01Rik, 2610510B01Rik, Dopey2
Chromosome: 16
Alteration at locus: Chemically Induced
Gene Symbol: Slc4a7 [MGI:2443878] (Mus musculus (mouse))
Name: solute carrier family 4, sodium bicarbonate cotransporter, member 7
Synonyms: E430014N10Rik, NBC3, NBCn1
Chromosome: 14
Alteration at locus: Chemically Induced
Gene Symbol: Stx1a [MGI:109355] (Mus musculus (mouse))
Name: syntaxin 1A (brain)
Synonyms: HPC-1
Chromosome: 5
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 38,813,276 bp
  • T to C, chromosome 1 at 52,106,925 bp
  • T to C, chromosome 1 at 56,850,289 bp
  • G to A, chromosome 1 at 67,168,374 bp
  • C to T, chromosome 1 at 72,277,409 bp
  • T to A, chromosome 1 at 80,560,888 bp
  • A to T, chromosome 1 at 90,830,213 bp
  • A to G, chromosome 1 at 174,241,042 bp
  • T to C, chromosome 2 at 10,115,222 bp
  • T to A, chromosome 2 at 17,388,754 bp
  • T to A, chromosome 2 at 35,315,917 bp
  • A to G, chromosome 2 at 76,863,561 bp
  • G to A, chromosome 2 at 83,661,148 bp
  • A to G, chromosome 2 at 102,640,852 bp
  • A to G, chromosome 2 at 120,605,939 bp
  • A to G, chromosome 2 at 130,358,831 bp
  • A to C, chromosome 2 at 154,564,519 bp
  • A to T, chromosome 2 at 155,657,744 bp
  • G to A, chromosome 2 at 164,949,422 bp
  • A to T, chromosome 2 at 181,411,684 bp
  • C to A, chromosome 3 at 87,457,414 bp
  • A to G, chromosome 3 at 89,089,293 bp
  • T to C, chromosome 3 at 95,011,889 bp
  • A to G, chromosome 4 at 3,598,658 bp
  • G to T, chromosome 4 at 41,725,947 bp
  • G to A, chromosome 4 at 56,740,165 bp
  • A to T, chromosome 4 at 109,066,218 bp
  • A to G, chromosome 4 at 116,637,974 bp
  • G to T, chromosome 4 at 117,904,522 bp
  • C to A, chromosome 4 at 129,992,624 bp
  • A to T, chromosome 4 at 132,858,477 bp
  • A to T, chromosome 4 at 144,555,406 bp
  • A to G, chromosome 5 at 33,216,385 bp
  • A to G, chromosome 5 at 73,083,118 bp
  • A to T, chromosome 5 at 110,693,308 bp
  • A to T, chromosome 5 at 117,255,926 bp
  • A to T, chromosome 5 at 129,656,673 bp
  • A to C, chromosome 5 at 135,042,009 bp
  • T to A, chromosome 6 at 49,469,304 bp
  • C to T, chromosome 6 at 87,921,592 bp
  • T to A, chromosome 6 at 131,168,081 bp
  • C to T, chromosome 7 at 28,294,497 bp
  • A to T, chromosome 7 at 28,989,352 bp
  • G to A, chromosome 7 at 30,657,903 bp
  • A to T, chromosome 7 at 79,880,490 bp
  • T to G, chromosome 7 at 80,099,158 bp
  • G to T, chromosome 7 at 102,670,162 bp
  • T to A, chromosome 7 at 103,906,699 bp
  • A to G, chromosome 7 at 104,232,837 bp
  • A to T, chromosome 7 at 105,180,760 bp
  • A to T, chromosome 7 at 109,918,712 bp
  • T to C, chromosome 7 at 111,055,663 bp
  • A to T, chromosome 7 at 116,417,927 bp
  • A to G, chromosome 7 at 120,078,571 bp
  • T to G, chromosome 7 at 126,584,979 bp
  • A to G, chromosome 7 at 126,876,131 bp
  • C to A, chromosome 7 at 126,995,735 bp
  • C to G, chromosome 7 at 128,004,585 bp
  • G to T, chromosome 7 at 140,220,609 bp
  • A to C, chromosome 7 at 140,335,999 bp
  • T to C, chromosome 7 at 142,512,027 bp
  • A to T, chromosome 8 at 40,985,794 bp
  • T to A, chromosome 8 at 85,364,831 bp
  • T to A, chromosome 8 at 105,973,693 bp
  • T to A, chromosome 8 at 106,918,720 bp
  • T to C, chromosome 8 at 109,638,321 bp
  • A to G, chromosome 8 at 119,681,037 bp
  • T to G, chromosome 8 at 124,886,952 bp
  • T to A, chromosome 8 at 125,124,610 bp
  • G to T, chromosome 9 at 3,759,622 bp
  • A to G, chromosome 9 at 8,922,714 bp
  • T to C, chromosome 9 at 15,059,246 bp
  • A to G, chromosome 9 at 32,322,569 bp
  • A to G, chromosome 9 at 39,840,285 bp
  • G to A, chromosome 9 at 40,911,157 bp
  • A to G, chromosome 9 at 44,841,621 bp
  • A to C, chromosome 9 at 44,974,342 bp
  • T to C, chromosome 9 at 78,087,247 bp
  • T to C, chromosome 9 at 118,698,461 bp
  • C to T, chromosome 10 at 45,347,865 bp
  • T to C, chromosome 10 at 58,460,519 bp
  • A to T, chromosome 10 at 60,523,536 bp
  • G to T, chromosome 10 at 60,768,500 bp
  • T to A, chromosome 10 at 80,333,981 bp
  • G to T, chromosome 10 at 86,694,525 bp
  • T to G, chromosome 10 at 93,011,020 bp
  • T to A, chromosome 10 at 107,534,699 bp
  • A to T, chromosome 10 at 112,190,978 bp
  • G to A, chromosome 11 at 22,173,009 bp
  • A to T, chromosome 11 at 48,895,026 bp
  • T to A, chromosome 11 at 55,395,776 bp
  • T to A, chromosome 11 at 90,264,589 bp
  • A to G, chromosome 11 at 103,732,128 bp
  • A to G, chromosome 11 at 104,720,688 bp
  • T to A, chromosome 11 at 119,280,460 bp
  • A to G, chromosome 12 at 52,519,345 bp
  • A to T, chromosome 12 at 84,053,573 bp
  • C to A, chromosome 12 at 84,773,619 bp
  • G to A, chromosome 13 at 21,116,306 bp
  • A to G, chromosome 13 at 33,200,748 bp
  • C to T, chromosome 13 at 61,352,810 bp
  • C to T, chromosome 13 at 77,269,920 bp
  • T to A, chromosome 13 at 92,022,554 bp
  • A to G, chromosome 14 at 14,765,709 bp
  • T to C, chromosome 14 at 30,066,056 bp
  • T to C, chromosome 14 at 32,526,176 bp
  • T to A, chromosome 14 at 37,055,050 bp
  • G to T, chromosome 14 at 62,944,097 bp
  • G to T, chromosome 14 at 65,980,905 bp
  • T to C, chromosome 14 at 73,523,336 bp
  • T to A, chromosome 14 at 108,913,096 bp
  • T to C, chromosome 15 at 6,580,479 bp
  • T to C, chromosome 15 at 7,289,915 bp
  • T to A, chromosome 15 at 103,533,492 bp
  • C to A, chromosome 16 at 32,843,101 bp
  • A to C, chromosome 16 at 49,017,486 bp
  • A to G, chromosome 16 at 91,660,226 bp
  • A to G, chromosome 16 at 93,799,926 bp
  • T to C, chromosome 17 at 17,446,058 bp
  • T to A, chromosome 17 at 53,515,310 bp
  • T to C, chromosome 18 at 32,127,406 bp
  • A to G, chromosome 18 at 36,771,103 bp
  • T to A, chromosome 18 at 37,403,327 bp
  • C to A, chromosome 19 at 34,474,286 bp
  • C to A, chromosome 19 at 39,566,891 bp
  • T to C, chromosome 19 at 45,045,511 bp
  • T to C, chromosome 19 at 47,050,518 bp
Genotype Determination
ES Cell Line
N/A
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
MeSH Terms
    Strain Development
    C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
    Suggested Control Mice
    Wild-type littermates or C57BL/6J mice
    Donor
    Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
    Primary Reference
    MUTAGENETIX record for R1711 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

    Colony and Husbandry Information

    Colony Surveillance Program and Current Health Reports

    Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
    Coat Color
    Black
    MMRRC Breeding System
    Random intra-strain mating
    Breeding Scheme(s)
    When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
    Overall Breeding Performance
    Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
    Average litter size
    Undetermined
    Recommended wean age
    3 weeks

    Order Request Information

    Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

    Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

    Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

    The donor or their institution limits the distribution to non-profit institutions only.

    Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

    Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
    MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
    039744-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
    Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

    Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

    1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

    2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

    3 An aliquot contains a sufficient number of embryos (in one or more vials and based on the transfer success rate of the MMRRC facility) to transfer to at least two recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

    To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.