Strain Name:
C57BL/6J-MtgxR1771Btlr/Mmmh
Stock Number:
039802-MU
Citation ID:
RRID:MMRRC_039802-MU
Other Names:
R1771 (G1), C57BL/6J-MtgxR1771Btlr
Major Collection:

Gene Information

Gene Symbol: Ncor1 [MGI:1349717] (Mus musculus (mouse))
Name: nuclear receptor co-repressor 1
Synonyms: Rxrip13, N-CoR, 5730405M06Rik, A230020K14Rik
Chromosome: 11
Alteration at locus: Chemically Induced
Gene Symbol: Sbf2 [MGI:1921831] (Mus musculus (mouse))
Name: SET binding factor 2
Synonyms: SBF2, Mtmr13, mMTMH1, B430219L04Rik, 4833411B01Rik
Chromosome: 7
Alteration at locus: Chemically Induced
Gene Symbol: Slc6a6 [MGI:98488] (Mus musculus (mouse))
Name: solute carrier family 6 (neurotransmitter transporter, taurine), member 6
Synonyms: Taut
Chromosome: 6
Alteration at locus: Chemically Induced
Gene Symbol: Gria2 [MGI:95809] (Mus musculus (mouse))
Name: glutamate receptor, ionotropic, AMPA2 (alpha 2)
Synonyms: GluA2, GluR-B, Glur2, GluR2, Glur-2
Chromosome: 3
Alteration at locus: Chemically Induced
Gene Symbol: Angpt2 [MGI:1202890] (Mus musculus (mouse))
Name: angiopoietin 2
Synonyms: Ang2, Ang-2
Chromosome: 8
Alteration at locus: Chemically Induced
Gene Symbol: Ntrk1 [MGI:97383] (Mus musculus (mouse))
Name: neurotrophic tyrosine kinase, receptor, type 1
Synonyms: TrkA, Tkr
Chromosome: 3
Alteration at locus: Chemically Induced
Gene Symbol: Hdac1 [MGI:108086] (Mus musculus (mouse))
Name: histone deacetylase 1
Synonyms: HD1, RPD3, MommeD5
Chromosome: 4
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 13,062,340 bp
  • T to C, chromosome 1 at 13,118,858 bp
  • A to G, chromosome 1 at 92,589,115 bp
  • T to C, chromosome 1 at 131,976,956 bp
  • T to C, chromosome 1 at 133,273,913 bp
  • C to A, chromosome 1 at 133,732,393 bp
  • C to T, chromosome 1 at 156,442,421 bp
  • A to G, chromosome 1 at 171,872,750 bp
  • A to G, chromosome 1 at 174,608,776 bp
  • C to T, chromosome 2 at 18,734,117 bp
  • A to G, chromosome 2 at 35,414,210 bp
  • T to A, chromosome 2 at 37,332,418 bp
  • T to G, chromosome 2 at 112,142,720 bp
  • T to C, chromosome 2 at 113,749,676 bp
  • C to T, chromosome 2 at 118,791,297 bp
  • C to T, chromosome 2 at 132,843,556 bp
  • C to A, chromosome 2 at 157,163,534 bp
  • A to G, chromosome 3 at 10,419,161 bp
  • T to C, chromosome 3 at 55,934,519 bp
  • T to A, chromosome 3 at 80,692,301 bp
  • T to C, chromosome 3 at 86,998,665 bp
  • A to G, chromosome 3 at 87,789,630 bp
  • T to C, chromosome 3 at 90,019,231 bp
  • T to C, chromosome 3 at 98,161,519 bp
  • T to C, chromosome 3 at 98,630,046 bp
  • T to C, chromosome 3 at 108,862,723 bp
  • A to T, chromosome 3 at 145,081,410 bp
  • T to C, chromosome 3 at 146,624,449 bp
  • C to T, chromosome 3 at 146,894,405 bp
  • A to C, chromosome 3 at 154,748,472 bp
  • A to T, chromosome 4 at 9,598,773 bp
  • A to G, chromosome 4 at 15,111,267 bp
  • T to C, chromosome 4 at 21,759,475 bp
  • A to G, chromosome 4 at 58,879,100 bp
  • A to G, chromosome 4 at 59,207,775 bp
  • A to G, chromosome 4 at 106,578,253 bp
  • A to T, chromosome 4 at 123,512,108 bp
  • A to T, chromosome 4 at 129,521,428 bp
  • A to T, chromosome 4 at 129,693,218 bp
  • T to C, chromosome 4 at 148,470,624 bp
  • T to A, chromosome 5 at 33,769,467 bp
  • A to G, chromosome 5 at 67,647,731 bp
  • G to A, chromosome 5 at 83,291,287 bp
  • A to T, chromosome 5 at 90,974,395 bp
  • A to T, chromosome 5 at 114,212,760 bp
  • T to C, chromosome 5 at 114,803,588 bp
  • T to C, chromosome 5 at 120,915,837 bp
  • T to A, chromosome 6 at 18,008,697 bp
  • T to C, chromosome 6 at 55,898,147 bp
  • A to T, chromosome 6 at 83,049,909 bp
  • G to A, chromosome 6 at 91,748,325 bp
  • A to T, chromosome 6 at 113,476,731 bp
  • A to T, chromosome 6 at 113,702,099 bp
  • A to T, chromosome 7 at 5,146,920 bp
  • G to T, chromosome 7 at 6,277,542 bp
  • A to G, chromosome 7 at 10,718,593 bp
  • T to A, chromosome 7 at 25,472,044 bp
  • A to T, chromosome 7 at 27,985,275 bp
  • A to G, chromosome 7 at 44,188,229 bp
  • T to G, chromosome 7 at 46,281,089 bp
  • A to G, chromosome 7 at 59,275,966 bp
  • A to T, chromosome 7 at 65,313,005 bp
  • A to C, chromosome 7 at 108,095,609 bp
  • T to C, chromosome 7 at 109,918,686 bp
  • G to A, chromosome 7 at 110,461,146 bp
  • G to A, chromosome 7 at 118,436,808 bp
  • A to G, chromosome 7 at 125,958,573 bp
  • A to G, chromosome 7 at 127,933,453 bp
  • A to G, chromosome 7 at 130,742,240 bp
  • A to G, chromosome 7 at 140,668,135 bp
  • G to T, chromosome 7 at 141,164,606 bp
  • G to T, chromosome 8 at 3,634,064 bp
  • C to T, chromosome 8 at 18,740,982 bp
  • A to G, chromosome 8 at 70,598,852 bp
  • C to A, chromosome 8 at 94,629,053 bp
  • A to T, chromosome 9 at 35,212,851 bp
  • G to T, chromosome 9 at 80,285,800 bp
  • A to G, chromosome 9 at 104,049,908 bp
  • G to A, chromosome 10 at 76,587,368 bp
  • A to T, chromosome 10 at 77,814,802 bp
  • A to G, chromosome 10 at 106,937,200 bp
  • A to C, chromosome 10 at 119,208,306 bp
  • T to G, chromosome 10 at 128,247,608 bp
  • T to C, chromosome 10 at 128,468,877 bp
  • G to A, chromosome 11 at 21,329,915 bp
  • A to G, chromosome 11 at 34,207,594 bp
  • A to T, chromosome 11 at 46,608,973 bp
  • G to A, chromosome 11 at 55,310,865 bp
  • A to T, chromosome 11 at 57,806,099 bp
  • T to C, chromosome 11 at 62,327,112 bp
  • A to G, chromosome 11 at 82,883,938 bp
  • G to A, chromosome 11 at 87,610,919 bp
  • A to T, chromosome 11 at 101,984,735 bp
  • T to A, chromosome 12 at 98,276,000 bp
  • T to A, chromosome 12 at 118,849,567 bp
  • A to C, chromosome 13 at 11,745,176 bp
  • C to A, chromosome 13 at 62,370,074 bp
  • A to T, chromosome 13 at 84,405,449 bp
  • T to G, chromosome 13 at 92,212,496 bp
  • A to G, chromosome 14 at 24,491,762 bp
  • A to T, chromosome 14 at 47,089,075 bp
  • A to G, chromosome 14 at 78,609,527 bp
  • A to G, chromosome 15 at 73,555,101 bp
  • A to C, chromosome 15 at 78,288,976 bp
  • T to A, chromosome 15 at 81,237,235 bp
  • A to C, chromosome 15 at 102,967,087 bp
  • C to T, chromosome 16 at 17,258,714 bp
  • A to T, chromosome 16 at 17,836,866 bp
  • C to A, chromosome 16 at 31,942,119 bp
  • A to T, chromosome 16 at 32,793,852 bp
  • A to C, chromosome 17 at 14,892,441 bp
  • A to G, chromosome 17 at 37,672,663 bp
  • A to T, chromosome 17 at 46,537,812 bp
  • A to G, chromosome 17 at 55,897,677 bp
  • T to A, chromosome 17 at 87,984,522 bp
  • T to A, chromosome 18 at 12,684,824 bp
  • T to A, chromosome 18 at 21,651,620 bp
  • T to C, chromosome 18 at 31,636,082 bp
  • G to T, chromosome 18 at 37,891,018 bp
  • C to T, chromosome 18 at 38,333,327 bp
  • G to A, chromosome 19 at 9,013,753 bp
  • A to G, chromosome X at 166,406,006 bp
Genotype Determination
ES Cell Line
N/A
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
MeSH Terms
    Strain Development
    C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
    Suggested Control Mice
    Wild-type littermates or C57BL/6J mice
    Donor
    Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
    Primary Reference
    MUTAGENETIX record for R1771 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

    Colony and Husbandry Information

    Colony Surveillance Program and Current Health Reports

    Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
    Coat Color
    Black
    MMRRC Breeding System
    Random intra-strain mating
    Breeding Scheme(s)
    When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
    Overall Breeding Performance
    Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
    Average litter size
    Undetermined
    Recommended wean age
    3 weeks

    Order Request Information

    Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

    Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

    Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

    The donor or their institution limits the distribution to non-profit institutions only.

    Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

    Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
    MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
    039802-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
    Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

    Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

    1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

    2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

    3 An aliquot contains a sufficient number of embryos (in one or more vials and based on the transfer success rate of the MMRRC facility) to transfer to at least two recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

    To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.