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Strain Detail Sheet

Strain Name:
C57BL/6J-MtgxR1848Btlr/Mmmh
Stock Number:
039873-MU
Citation ID:
RRID:MMRRC_039873-MU
Other Names:
R1848 (G1), C57BL/6J-MtgxR1848Btlr
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Dnm2
Name: dynamin 2
Synonyms: Dyn2, b2b2159Clo
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13430
HGNC: HGNC:2974
Homologene: 90883

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Lamb3
Name: laminin, beta 3
Synonyms: nicein, 125kDa
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16780
HGNC: HGNC:6490
Homologene: 191

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Gene Ontology
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ClinGen
Mta3
Name: metastasis associated 3
Synonyms: 1110002J22Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 116871
Homologene: 14282

Additional Resources
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ClinGen
Lpp
Name: LIM domain containing preferred translocation partner in lipoma
Synonyms: B130055L10Rik, 9430020K16Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 210126
VEGA: 16
HGNC: HGNC:6679
Homologene: 4075

Additional Resources
IMPC
Google
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Gene Ontology
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ClinGen
Nup188
Name: nucleoporin 188
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227699
Homologene: 45683

Additional Resources
IMPC
Google
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Gene Ontology
BioGPS
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Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: DNA-PKcs, slip, DNAPDcs, XRCC7, DNA-PK, DOXNPH, dxnph
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 4,347,232 bp
  • T to A, chromosome 1 at 72,383,467 bp
  • T to A, chromosome 1 at 86,099,429 bp
  • T to A, chromosome 1 at 139,237,012 bp
  • C to A, chromosome 1 at 152,756,230 bp
  • T to C, chromosome 1 at 153,465,753 bp
  • C to T, chromosome 1 at 153,850,448 bp
  • T to C, chromosome 1 at 155,953,651 bp
  • A to T, chromosome 1 at 193,334,616 bp
  • C to T, chromosome 2 at 18,219,713 bp
  • T to A, chromosome 2 at 30,331,029 bp
  • T to A, chromosome 2 at 31,821,549 bp
  • A to T, chromosome 2 at 62,316,606 bp
  • A to G, chromosome 2 at 66,684,013 bp
  • T to C, chromosome 2 at 163,645,489 bp
  • A to G, chromosome 3 at 60,039,697 bp
  • A to G, chromosome 3 at 93,471,101 bp
  • T to C, chromosome 3 at 103,324,640 bp
  • A to T, chromosome 3 at 108,401,310 bp
  • T to G, chromosome 4 at 43,632,384 bp
  • T to C, chromosome 4 at 46,739,823 bp
  • C to T, chromosome 4 at 49,529,266 bp
  • C to T, chromosome 4 at 49,644,628 bp
  • G to T, chromosome 4 at 81,421,161 bp
  • C to T, chromosome 4 at 104,731,751 bp
  • T to C, chromosome 4 at 125,694,138 bp
  • GCCCC to GCCCCC, chromosome 4 at 134,425,541 bp
  • A to C, chromosome 4 at 147,863,092 bp
  • T to A, chromosome 5 at 65,348,837 bp
  • A to G, chromosome 5 at 92,292,651 bp
  • G to A, chromosome 5 at 104,502,281 bp
  • C to A, chromosome 5 at 120,855,429 bp
  • A to T, chromosome 5 at 121,519,620 bp
  • G to A, chromosome 5 at 135,435,141 bp
  • C to G, chromosome 5 at 137,296,945 bp
  • A to G, chromosome 5 at 140,718,509 bp
  • T to G, chromosome 6 at 34,487,734 bp
  • T to A, chromosome 6 at 83,066,107 bp
  • T to C, chromosome 6 at 115,966,546 bp
  • T to A, chromosome 6 at 123,816,224 bp
  • T to C, chromosome 6 at 127,073,193 bp
  • T to A, chromosome 6 at 131,630,597 bp
  • T to C, chromosome 6 at 141,923,111 bp
  • G to A, chromosome 6 at 142,414,079 bp
  • T to A, chromosome 7 at 5,089,998 bp
  • C to A, chromosome 7 at 27,518,888 bp
  • C to T, chromosome 7 at 41,428,107 bp
  • T to A, chromosome 7 at 44,632,429 bp
  • A to T, chromosome 7 at 45,728,769 bp
  • A to T, chromosome 7 at 45,728,770 bp
  • A to T, chromosome 7 at 46,166,902 bp
  • A to G, chromosome 7 at 46,945,227 bp
  • C to A, chromosome 7 at 66,714,322 bp
  • T to C, chromosome 7 at 79,099,035 bp
  • T to A, chromosome 7 at 98,600,821 bp
  • T to C, chromosome 7 at 103,741,174 bp
  • T to C, chromosome 7 at 119,489,384 bp
  • T to C, chromosome 7 at 120,643,017 bp
  • T to C, chromosome 7 at 133,677,153 bp
  • T to A, chromosome 7 at 140,345,987 bp
  • G to T, chromosome 8 at 55,940,907 bp
  • G to A, chromosome 8 at 66,512,347 bp
  • G to A, chromosome 8 at 71,256,123 bp
  • T to C, chromosome 8 at 71,603,769 bp
  • A to T, chromosome 8 at 82,864,010 bp
  • C to A, chromosome 8 at 87,568,493 bp
  • A to C, chromosome 8 at 89,146,834 bp
  • T to C, chromosome 8 at 106,237,008 bp
  • T to A, chromosome 8 at 110,569,808 bp
  • T to A, chromosome 9 at 7,049,166 bp
  • C to T, chromosome 9 at 19,713,090 bp
  • C to T, chromosome 9 at 21,505,681 bp
  • A to T, chromosome 9 at 37,342,570 bp
  • A to G, chromosome 9 at 48,490,894 bp
  • A to T, chromosome 9 at 53,468,012 bp
  • G to T, chromosome 9 at 57,796,677 bp
  • A to G, chromosome 9 at 67,936,340 bp
  • A to T, chromosome 9 at 108,969,565 bp
  • A to G, chromosome 9 at 120,558,419 bp
  • T to C, chromosome 9 at 123,632,103 bp
  • A to G, chromosome 10 at 18,200,033 bp
  • A to G, chromosome 10 at 80,056,036 bp
  • T to C, chromosome 10 at 81,341,265 bp
  • A to G, chromosome 10 at 82,060,572 bp
  • A to G, chromosome 10 at 127,069,458 bp
  • A to G, chromosome 11 at 11,946,029 bp
  • A to G, chromosome 11 at 55,311,558 bp
  • A to T, chromosome 11 at 58,949,102 bp
  • A to G, chromosome 11 at 67,213,630 bp
  • A to G, chromosome 11 at 70,350,752 bp
  • G to T, chromosome 11 at 74,289,213 bp
  • A to T, chromosome 11 at 77,103,306 bp
  • A to G, chromosome 11 at 78,500,567 bp
  • C to A, chromosome 11 at 94,742,477 bp
  • A to T, chromosome 11 at 102,046,206 bp
  • T to C, chromosome 11 at 117,353,083 bp
  • G to A, chromosome 12 at 4,850,245 bp
  • A to C, chromosome 12 at 13,413,597 bp
  • A to T, chromosome 12 at 59,170,251 bp
  • A to G, chromosome 12 at 98,752,832 bp
  • C to A, chromosome 13 at 24,760,149 bp
  • A to G, chromosome 13 at 46,848,391 bp
  • C to T, chromosome 13 at 51,461,388 bp
  • T to C, chromosome 13 at 98,271,124 bp
  • T to C, chromosome 14 at 7,892,113 bp
  • G to T, chromosome 14 at 21,008,995 bp
  • A to T, chromosome 14 at 26,422,574 bp
  • A to G, chromosome 14 at 55,240,841 bp
  • G to T, chromosome 14 at 122,944,863 bp
  • A to G, chromosome 15 at 73,123,965 bp
  • A to G, chromosome 15 at 91,859,758 bp
  • A to G, chromosome 15 at 103,525,340 bp
  • A to G, chromosome 16 at 4,630,434 bp
  • T to A, chromosome 16 at 10,791,591 bp
  • T to C, chromosome 16 at 15,808,058 bp
  • G to C, chromosome 16 at 20,681,867 bp
  • G to A, chromosome 16 at 24,761,655 bp
  • T to A, chromosome 16 at 35,818,764 bp
  • A to G, chromosome 17 at 25,816,446 bp
  • T to A, chromosome 17 at 37,467,047 bp
  • T to C, chromosome 17 at 46,406,055 bp
  • T to A, chromosome 17 at 83,755,551 bp
  • T to A, chromosome 17 at 84,994,124 bp
  • T to A, chromosome 18 at 75,519,941 bp
  • A to G, chromosome 18 at 77,281,971 bp
  • T to C, chromosome 18 at 86,716,266 bp
  • C to T, chromosome 19 at 4,036,795 bp
  • C to A, chromosome 19 at 5,906,615 bp
  • T to C, chromosome 19 at 6,912,010 bp
  • T to A, chromosome 19 at 29,600,813 bp
  • T to G, chromosome 19 at 46,272,037 bp
  • T to A, chromosome 19 at 58,794,375 bp
Genotype Determination

Strain Description

Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.

Strain Origin

Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1848 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Health Status Report

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.

Appearance

Coat Color
Black

Breeding

MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain

Reproductive Statistics

Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Availability Level

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Conditions of Distribution

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Fees

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*		 Units Notes
039873-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.