Strain Name:
C57BL/6J-MtgxR1861Btlr/Mmmh
Stock Number:
039884-MU
Citation ID:
RRID:MMRRC_039884-MU
Other Names:
R1861 (G1), C57BL/6J-MtgxR1861Btlr
Major Collection:

Gene Information

Gene Symbol: Slc26a5 [MGI:1933154] (Mus musculus (mouse))
Name: solute carrier family 26, member 5
Synonyms: Pres, prestin
Chromosome: 5
Alteration at locus: Chemically Induced
Gene Symbol: Faah [MGI:109609] (Mus musculus (mouse))
Name: fatty acid amide hydrolase
Chromosome: 4
Alteration at locus: Chemically Induced
Gene Symbol: Irf1 [MGI:96590] (Mus musculus (mouse))
Name: interferon regulatory factor 1
Synonyms: Irf-1
Chromosome: 11
Alteration at locus: Chemically Induced
Gene Symbol: Gon4l [MGI:1917579] (Mus musculus (mouse))
Name: gon-4-like (C.elegans)
Synonyms: 1500041I23Rik, 2610100B20Rik
Chromosome: 3
Alteration at locus: Chemically Induced
Gene Symbol: Phf14 [MGI:1923539] (Mus musculus (mouse))
Name: PHD finger protein 14
Synonyms: 4932409F11Rik, 5730446A07Rik, 1110001C23Rik
Chromosome: 6
Alteration at locus: Chemically Induced
Gene Symbol: Clasp1 [MGI:1923957] (Mus musculus (mouse))
Name: CLIP associating protein 1
Synonyms: CLASP1alpha, mCLASP1, CLASP1, 1700030C23Rik, 5730583A19Rik, B130045P17Rik
Chromosome: 1
Alteration at locus: Chemically Induced
Gene Symbol: Aopep [MGI:1919311] (Mus musculus (mouse))
Name: aminopeptidase O
Synonyms: ApO, 2010111I01Rik
Chromosome: 13
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 22,596,558 bp
  • T to C, chromosome 1 at 54,438,838 bp
  • C to T, chromosome 1 at 63,147,417 bp
  • A to G, chromosome 1 at 75,389,005 bp
  • T to C, chromosome 1 at 118,570,931 bp
  • T to C, chromosome 1 at 174,431,091 bp
  • A to G, chromosome 2 at 62,777,392 bp
  • A to T, chromosome 2 at 76,772,648 bp
  • A to G, chromosome 2 at 83,663,990 bp
  • T to G, chromosome 2 at 88,729,330 bp
  • C to A, chromosome 2 at 90,282,158 bp
  • T to A, chromosome 2 at 120,486,482 bp
  • G to A, chromosome 2 at 181,411,995 bp
  • T to C, chromosome 3 at 39,010,484 bp
  • T to C, chromosome 3 at 88,895,487 bp
  • T to G, chromosome 3 at 118,917,131 bp
  • A to T, chromosome 3 at 122,560,932 bp
  • G to T, chromosome 3 at 132,983,107 bp
  • T to C, chromosome 3 at 135,268,979 bp
  • G to A, chromosome 3 at 145,537,267 bp
  • T to C, chromosome 3 at 146,083,046 bp
  • G to T, chromosome 4 at 14,522,873 bp
  • A to G, chromosome 4 at 34,044,206 bp
  • G to A, chromosome 4 at 43,372,906 bp
  • A to T, chromosome 4 at 43,727,404 bp
  • T to A, chromosome 4 at 47,471,670 bp
  • T to A, chromosome 4 at 52,856,373 bp
  • A to G, chromosome 4 at 57,709,468 bp
  • A to T, chromosome 4 at 101,836,938 bp
  • T to C, chromosome 4 at 108,091,321 bp
  • G to T, chromosome 4 at 108,682,295 bp
  • T to C, chromosome 4 at 112,647,118 bp
  • T to C, chromosome 4 at 116,008,235 bp
  • C to T, chromosome 4 at 126,311,624 bp
  • T to C, chromosome 4 at 130,061,724 bp
  • T to A, chromosome 5 at 8,442,431 bp
  • T to C, chromosome 5 at 9,120,347 bp
  • A to G, chromosome 5 at 12,497,603 bp
  • T to C, chromosome 5 at 21,816,958 bp
  • A to G, chromosome 5 at 33,729,746 bp
  • T to C, chromosome 5 at 63,804,854 bp
  • A to G, chromosome 5 at 92,412,235 bp
  • T to A, chromosome 5 at 98,947,416 bp
  • T to C, chromosome 5 at 107,359,458 bp
  • T to A, chromosome 5 at 144,815,917 bp
  • T to A, chromosome 6 at 4,640,951 bp
  • A to T, chromosome 6 at 11,987,611 bp
  • T to C, chromosome 6 at 30,374,838 bp
  • C to A, chromosome 6 at 42,313,991 bp
  • T to A, chromosome 6 at 102,245,071 bp
  • C to A, chromosome 6 at 115,891,928 bp
  • T to A, chromosome 6 at 149,068,262 bp
  • A to G, chromosome 7 at 12,480,931 bp
  • T to A, chromosome 7 at 24,003,724 bp
  • A to T, chromosome 7 at 24,309,116 bp
  • A to G, chromosome 7 at 28,154,732 bp
  • A to T, chromosome 7 at 29,009,552 bp
  • A to G, chromosome 7 at 43,352,224 bp
  • A to G, chromosome 7 at 43,355,543 bp
  • G to A, chromosome 7 at 46,078,101 bp
  • A to T, chromosome 7 at 98,641,615 bp
  • A to G, chromosome 7 at 100,882,268 bp
  • G to A, chromosome 7 at 121,914,261 bp
  • A to T, chromosome 8 at 22,580,499 bp
  • A to G, chromosome 8 at 43,569,541 bp
  • A to T, chromosome 8 at 45,339,362 bp
  • A to G, chromosome 8 at 105,240,071 bp
  • A to G, chromosome 8 at 105,268,929 bp
  • A to G, chromosome 8 at 105,308,581 bp
  • A to G, chromosome 8 at 105,334,806 bp
  • A to G, chromosome 8 at 121,609,251 bp
  • T to C, chromosome 8 at 122,495,750 bp
  • A to T, chromosome 8 at 123,997,990 bp
  • G to A, chromosome 9 at 36,923,661 bp
  • C to T, chromosome 9 at 38,367,606 bp
  • A to T, chromosome 9 at 65,589,453 bp
  • C to A, chromosome 9 at 89,152,831 bp
  • T to C, chromosome 10 at 75,309,859 bp
  • T to A, chromosome 11 at 53,774,357 bp
  • T to C, chromosome 11 at 57,528,206 bp
  • T to C, chromosome 11 at 70,703,342 bp
  • T to C, chromosome 11 at 76,784,382 bp
  • C to T, chromosome 11 at 78,287,929 bp
  • T to A, chromosome 11 at 96,138,874 bp
  • T to C, chromosome 11 at 98,412,737 bp
  • G to A, chromosome 11 at 106,375,438 bp
  • T to C, chromosome 11 at 114,752,951 bp
  • G to A, chromosome 11 at 120,611,142 bp
  • A to G, chromosome 12 at 69,617,363 bp
  • A to T, chromosome 13 at 34,932,507 bp
  • T to A, chromosome 13 at 59,717,336 bp
  • A to G, chromosome 13 at 63,015,783 bp
  • T to G, chromosome 13 at 74,356,979 bp
  • T to A, chromosome 14 at 43,783,739 bp
  • A to C, chromosome 14 at 51,920,605 bp
  • T to A, chromosome 14 at 65,642,001 bp
  • T to A, chromosome 14 at 78,578,792 bp
  • C to T, chromosome 14 at 117,964,886 bp
  • A to C, chromosome 14 at 120,479,044 bp
  • T to A, chromosome 15 at 9,108,311 bp
  • C to A, chromosome 15 at 41,869,034 bp
  • A to T, chromosome 15 at 47,659,192 bp
  • A to T, chromosome 15 at 58,096,718 bp
  • G to A, chromosome 15 at 64,135,798 bp
  • T to C, chromosome 15 at 81,452,854 bp
  • T to C, chromosome 15 at 85,114,896 bp
  • T to G, chromosome 17 at 18,452,268 bp
  • T to A, chromosome 17 at 32,797,425 bp
  • A to C, chromosome 17 at 35,150,915 bp
  • T to C, chromosome 17 at 36,978,118 bp
  • T to A, chromosome 17 at 46,411,440 bp
  • G to T, chromosome 17 at 71,874,938 bp
  • G to A, chromosome 17 at 88,714,954 bp
  • T to C, chromosome 18 at 73,785,714 bp
  • T to C, chromosome 19 at 7,290,763 bp
  • G to A, chromosome 19 at 8,606,139 bp
  • T to A, chromosome 19 at 13,365,341 bp
  • T to C, chromosome 19 at 23,359,153 bp
  • A to T, chromosome 19 at 26,623,884 bp
  • T to C, chromosome 19 at 39,786,875 bp
  • T to C, chromosome 19 at 46,384,275 bp
Genotype Determination
ES Cell Line
N/A
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
MeSH Terms
    Strain Development
    C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
    Suggested Control Mice
    Wild-type littermates or C57BL/6J mice
    Donor
    Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
    Primary Reference
    MUTAGENETIX record for R1861 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

    Colony and Husbandry Information

    Colony Surveillance Program and Current Health Reports

    Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
    Coat Color
    Black
    MMRRC Breeding System
    Random intra-strain mating
    Breeding Scheme(s)
    When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
    Overall Breeding Performance
    Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
    Average litter size
    Undetermined
    Recommended wean age
    3 weeks

    Order Request Information

    Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

    Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

    Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

    The donor or their institution limits the distribution to non-profit institutions only.

    Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

    Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
    MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
    039884-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
    Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

    Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

    1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

    2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

    3 An aliquot contains a sufficient number of embryos (in one or more vials and based on the transfer success rate of the MMRRC facility) to transfer to at least two recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

    To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.