Strain Name:
C57BL/6J-MtgxR1920Btlr/Mmmh
Stock Number:
039938-MU
Citation ID:
RRID:MMRRC_039938-MU
Other Names:
R1920 (G1), C57BL/6J-MtgxR1920Btlr
Major Collection:

Gene Information

Gene Symbol: Pkd1 [MGI:97603] (Mus musculus (mouse))
Name: polycystin 1, transient receptor poteintial channel interacting
Synonyms: polycystin-1, PC1, PC-1
Chromosome: 17
Alteration at locus: Chemically Induced
Gene Symbol: Ntf3 [MGI:97380] (Mus musculus (mouse))
Name: neurotrophin 3
Synonyms: NT-3, Ntf-3, NT3
Chromosome: 6
Alteration at locus: Chemically Induced
Gene Symbol: Atrn [MGI:1341628] (Mus musculus (mouse))
Name: attractin
Synonyms: Mgca
Chromosome: 2
Alteration at locus: Chemically Induced
Gene Symbol: Cadps [MGI:1350922] (Mus musculus (mouse))
Name: Ca2+-dependent secretion activator
Synonyms: CAPS1
Chromosome: 14
Alteration at locus: Chemically Induced
Gene Symbol: Ptch2 [MGI:1095405] (Mus musculus (mouse))
Name: patched 2
Synonyms: ptc2
Chromosome: 4
Alteration at locus: Chemically Induced
Gene Symbol: Vcan [MGI:102889] (Mus musculus (mouse))
Name: versican
Synonyms: Cspg2, DPEAAE, heart defect, PG-M, 5430420N07Rik, hdf
Chromosome: 13
Alteration at locus: Chemically Induced
Gene Symbol: Kl [MGI:1101771] (Mus musculus (mouse))
Name: klotho
Synonyms: alpha-kl
Chromosome: 5
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 34,161,029 bp
  • A to G, chromosome 1 at 133,003,800 bp
  • A to G, chromosome 1 at 184,033,631 bp
  • A to G, chromosome 2 at 22,564,996 bp
  • G to A, chromosome 2 at 34,822,764 bp
  • C to T, chromosome 2 at 35,029,395 bp
  • T to A, chromosome 2 at 73,440,155 bp
  • T to G, chromosome 2 at 80,446,428 bp
  • A to T, chromosome 2 at 82,986,820 bp
  • G to A, chromosome 2 at 87,213,377 bp
  • A to G, chromosome 2 at 89,156,581 bp
  • G to A, chromosome 2 at 120,930,968 bp
  • A to G, chromosome 2 at 129,101,111 bp
  • A to G, chromosome 2 at 130,995,051 bp
  • T to A, chromosome 2 at 136,013,027 bp
  • A to T, chromosome 2 at 143,988,291 bp
  • A to T, chromosome 2 at 153,812,615 bp
  • A to T, chromosome 2 at 164,255,928 bp
  • A to G, chromosome 2 at 165,514,630 bp
  • A to G, chromosome 3 at 69,033,068 bp
  • G to T, chromosome 4 at 52,910,849 bp
  • G to A, chromosome 4 at 56,744,135 bp
  • A to T, chromosome 4 at 96,663,254 bp
  • G to A, chromosome 4 at 105,036,753 bp
  • G to T, chromosome 4 at 117,108,661 bp
  • A to G, chromosome 4 at 136,933,819 bp
  • T to C, chromosome 5 at 35,517,668 bp
  • C to T, chromosome 5 at 114,124,226 bp
  • G to A, chromosome 5 at 128,988,839 bp
  • A to G, chromosome 5 at 136,965,607 bp
  • A to G, chromosome 5 at 150,982,667 bp
  • C to T, chromosome 6 at 48,838,204 bp
  • T to C, chromosome 6 at 72,616,101 bp
  • A to G, chromosome 6 at 117,845,720 bp
  • T to A, chromosome 6 at 122,736,741 bp
  • A to T, chromosome 6 at 126,102,522 bp
  • A to G, chromosome 6 at 147,107,929 bp
  • G to C, chromosome 7 at 3,897,872 bp
  • A to T, chromosome 7 at 4,549,395 bp
  • T to C, chromosome 7 at 24,125,237 bp
  • T to A, chromosome 7 at 26,384,894 bp
  • T to C, chromosome 7 at 28,298,923 bp
  • T to C, chromosome 7 at 42,300,286 bp
  • T to C, chromosome 7 at 105,713,407 bp
  • G to A, chromosome 7 at 131,309,696 bp
  • C to T, chromosome 8 at 14,956,987 bp
  • A to G, chromosome 8 at 58,535,897 bp
  • C to T, chromosome 8 at 64,965,583 bp
  • A to T, chromosome 8 at 104,211,110 bp
  • G to A, chromosome 8 at 110,088,463 bp
  • A to G, chromosome 9 at 31,089,870 bp
  • T to C, chromosome 9 at 38,061,685 bp
  • A to G, chromosome 9 at 65,484,497 bp
  • T to G, chromosome 9 at 86,558,478 bp
  • T to A, chromosome 9 at 86,790,150 bp
  • A to T, chromosome 9 at 97,093,082 bp
  • TAA to TAAA, chromosome 9 at 108,564,790 bp
  • T to C, chromosome 9 at 111,347,928 bp
  • C to T, chromosome 9 at 123,830,413 bp
  • A to G, chromosome 10 at 43,997,548 bp
  • T to C, chromosome 10 at 128,241,714 bp
  • T to C, chromosome 11 at 70,098,297 bp
  • A to G, chromosome 11 at 95,764,025 bp
  • T to A, chromosome 11 at 99,514,635 bp
  • T to A, chromosome 12 at 72,941,764 bp
  • C to A, chromosome 12 at 83,789,254 bp
  • T to A, chromosome 12 at 84,411,085 bp
  • C to T, chromosome 12 at 100,415,130 bp
  • G to C, chromosome 12 at 100,971,291 bp
  • A to T, chromosome 13 at 3,576,612 bp
  • T to A, chromosome 13 at 22,395,493 bp
  • A to T, chromosome 13 at 32,975,008 bp
  • A to T, chromosome 13 at 33,039,548 bp
  • A to G, chromosome 13 at 38,057,201 bp
  • A to G, chromosome 13 at 45,514,521 bp
  • A to G, chromosome 13 at 76,384,610 bp
  • T to C, chromosome 13 at 89,693,015 bp
  • A to G, chromosome 13 at 95,604,190 bp
  • A to T, chromosome 13 at 100,098,589 bp
  • T to C, chromosome 14 at 12,465,859 bp
  • C to T, chromosome 14 at 20,394,952 bp
  • T to C, chromosome 14 at 20,686,887 bp
  • T to C, chromosome 14 at 24,176,571 bp
  • A to G, chromosome 14 at 55,755,243 bp
  • A to G, chromosome 14 at 56,386,851 bp
  • C to A, chromosome 14 at 121,255,496 bp
  • G to T, chromosome 14 at 121,583,380 bp
  • G to A, chromosome 15 at 57,912,364 bp
  • C to G, chromosome 15 at 98,855,590 bp
  • T to A, chromosome 15 at 98,855,591 bp
  • T to C, chromosome 15 at 103,242,272 bp
  • T to G, chromosome 16 at 19,769,544 bp
  • A to G, chromosome 17 at 17,145,003 bp
  • C to A, chromosome 17 at 24,595,157 bp
  • G to A, chromosome 17 at 24,704,503 bp
  • T to C, chromosome 17 at 32,198,086 bp
  • T to G, chromosome 17 at 32,483,291 bp
  • T to C, chromosome 17 at 35,835,298 bp
  • C to T, chromosome 17 at 46,672,745 bp
  • T to A, chromosome 17 at 57,524,839 bp
  • T to A, chromosome 18 at 31,955,342 bp
  • T to C, chromosome 18 at 56,534,178 bp
  • C to T, chromosome 18 at 60,603,589 bp
  • T to C, chromosome 18 at 60,838,855 bp
  • G to A, chromosome 19 at 15,974,351 bp
  • C to A, chromosome 19 at 30,547,331 bp
Genotype Determination
ES Cell Line
N/A
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
MeSH Terms
    Strain Development
    C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
    Suggested Control Mice
    Wild-type littermates or C57BL/6J mice
    Donor
    Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
    Primary Reference
    MUTAGENETIX record for R1920 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

    Colony and Husbandry Information

    Colony Surveillance Program and Current Health Reports

    Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
    Coat Color
    Black
    MMRRC Breeding System
    Random intra-strain mating
    Breeding Scheme(s)
    When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
    Overall Breeding Performance
    Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
    Average litter size
    Undetermined
    Recommended wean age
    3 weeks

    Order Request Information

    Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

    Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

    Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

    The donor or their institution limits the distribution to non-profit institutions only.

    Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

    Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
    MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
    039938-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
    Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

    Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

    1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

    2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

    3 An aliquot contains a sufficient number of embryos (in one or more vials and based on the transfer success rate of the MMRRC facility) to transfer to at least two recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

    To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.