Strain Name:
C57BL/6J-MtgxR2278Btlr/Mmmh
Stock Number:
040277-MU
Citation ID:
RRID:MMRRC_040277-MU
Other Names:
R2278 (G1), C57BL/6J-MtgxR2278Btlr
Major Collection:

Gene Information

Nrxn2
Name: neurexin II
Synonyms: neurexin II beta, neurexin II alpha, 6430591O13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18190
HGNC: HGNC:8009
Homologene: 86984
Sae1
Name: SUMO1 activating enzyme subunit 1
Synonyms: 2610044L12Rik, 2400010M20Rik, SUMO-1 activating enzyme subunit 1, HSPC140, AOS1, D7Ertd177e, Uble1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 56459
Homologene: 4019
Slk
Name: STE20-like kinase
Synonyms: 9A2, mSLK, Etk4, SLK, Stk2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 20874
Homologene: 22515
Vps13c
Name: vacuolar protein sorting 13C
Synonyms: C230055H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 320528
VEGA: 9
Homologene: 41188
Gcn1
Name: GCN1 activator of EIF2AK4
Synonyms: GCN1L, G431004K08Rik, Gcn1l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231659
HGNC: HGNC:4199
Homologene: 5887
Zfp280d
Name: zinc finger protein 280D
Synonyms: Suhw4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235469
Homologene: 17151
Chd9
Name: chromodomain helicase DNA binding protein 9
Synonyms: 1810014J18Rik, AD013, A330063D19Rik, 9030205D12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 109151
Homologene: 11844
Gnpat
Name: glyceronephosphate O-acyltransferase
Synonyms: D1Ertd819e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14712
HGNC: HGNC:4416
Homologene: 40716
Kank2
Name: KN motif and ankyrin repeat domains 2
Synonyms: Ankrd25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235041
VEGA: 9
Homologene: 9163
Bdp1
Name: B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
Synonyms: TFIIIB150, TFIIIB90, TAF3B1, TFC5, Tfnr, G630013P12Rik, B130055N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 544971
Homologene: 34582
Hook1
Name: hook microtubule tethering protein 1
Synonyms: abnormal spermatozoon head shape, azh, A930033L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 77963
Homologene: 9289
Lypla1
Name: lysophospholipase 1
Synonyms: Pla1a, Gm39587
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18777
HGNC: HGNC:6737
Homologene: 100781
Ankrd27
Name: ankyrin repeat domain 27 (VPS9 domain)
Synonyms: D330003H11Rik, Varp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 245886
Homologene: 12956
Aqp3
Name: aquaporin 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11828
HGNC: HGNC:636
Homologene: 21025
Prune2
Name: prune homolog 2
Synonyms: 6330414G02Rik, A330102H22Rik, A230083H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 353211
VEGA: 19
Homologene: 18939
Gpihbp1
Name: GPI-anchored HDL-binding protein 1
Synonyms: GPI-HBP1, 1110002J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 68453
Homologene: 136164
Tmem170
Name: transmembrane protein 170
Synonyms: 9030409E16Rik, D8Bwg1414e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 66817
Homologene: 12040
Mknk1
Name: MAP kinase-interacting serine/threonine kinase 1
Synonyms: Mnk1, 2410048M24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 17346
HGNC: HGNC:7110
Homologene: 37838
Pfkp
Name: phosphofructokinase, platelet
Synonyms: PFK-C, 1200015H23Rik, 9330125N24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 56421
HGNC: HGNC:8878
Homologene: 20579
Znhit6
Name: zinc finger, HIT type 6
Synonyms: 2410019A14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229937
Homologene: 32378
Pja2
Name: praja ring finger ubiquitin ligase 2
Synonyms: Neurodap1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224938
Homologene: 32233
Zfp668
Name: zinc finger protein 668
Synonyms: E130018B19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244219
Homologene: 11667
Spink5
Name: serine peptidase inhibitor, Kazal type 5
Synonyms: LEKT1, 2310065D10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 72432
Homologene: 4987
Slc11a2
Name: solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
Synonyms: DMT1, DCT1, van, Nramp2, microcytic anemia, viable anaemia
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 18174
Homologene: 55471
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: nesprin-2, syne-2, D12Ertd777e, 6820443O06Rik, Nesp2g, Cpfl8, diminished cone electroretinogram, dice
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 319565
Homologene: 56700
Siglec1
Name: sialic acid binding Ig-like lectin 1, sialoadhesin
Synonyms: CD169, Siglec-1, Sn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20612
Homologene: 124458
Ncoa6
Name: nuclear receptor coactivator 6
Synonyms: PRIP, ASC2, RAP250, AIB3, NRC, ASC-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 56406
Homologene: 137337
Otog
Name: otogelin
Synonyms: Otgn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18419
HGNC: HGNC:8516
Homologene: 8421
Rp1
Name: retinitis pigmentosa 1 (human)
Synonyms: oxygen-regulated protein 1, Orp1, mG145, Dcdc3, Rp1h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19888
Homologene: 4564
Arhgef15
Name: Rho guanine nucleotide exchange factor (GEF) 15
Synonyms: D530030K12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 442801
Homologene: 18345
Npas3
Name: neuronal PAS domain protein 3
Synonyms: 4930423H22Rik, bHLHe12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 27386
VEGA: 12
Homologene: 8461
Ttc23l
Name: tetratricopeptide repeat domain 23-like
Synonyms: 4930401A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 75777
Homologene: 44907
Bpifb2
Name: BPI fold containing family B, member 2
Synonyms: 2310034L21Rik, 2310069A01Rik, Bpil1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66557
Homologene: 11884
Lgi4
Name: leucine-rich repeat LGI family, member 4
Synonyms: clp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243914
Homologene: 16408
Itgad
Name: integrin, alpha D
Synonyms: Cd11d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381924
HGNC: HGNC:6146
Homologene: 56919
Eml3
Name: echinoderm microtubule associated protein like 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 225898
VEGA: 19
Homologene: 27044
Zcchc9
Name: zinc finger, CCHC domain containing 9
Synonyms: 1810019C21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 69085
Homologene: 12999
Kcnma1
Name: potassium large conductance calcium-activated channel, subfamily M, alpha member 1
Synonyms: Slo, mSlo1, Slo1, MaxiK, BK channel alpha subunit, 5730414M22Rik, BKCa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 16531
HGNC: HGNC:6284
Homologene: 1693
Shank1
Name: SH3 and multiple ankyrin repeat domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243961
Homologene: 22949
Hsf4
Name: heat shock transcription factor 4
Synonyms: ldis1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 26386
HGNC: HGNC:5227
Homologene: 100128
Olfr494
Name: olfactory receptor 494
Synonyms: GA_x6K02T2PBJ9-10697517-10698461, MOR204-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258732
Homologene: 133602
Vwa5a
Name: von Willebrand factor A domain containing 5A
Synonyms: BCSC-1, 5830475I06Rik, Loh11cr2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 67776
HGNC: HGNC:6658
Homologene: 18222
Slc14a2
Name: solute carrier family 14 (urea transporter), member 2
Synonyms: UT-A3, UT-A5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 27411
VEGA: 18
Homologene: 5183
Ifi44
Name: interferon-induced protein 44
Synonyms: p44, MTAP44, A430056A10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99899
Homologene: 4683
Clca3a1
Name: chloride channel accessory 3A1
Synonyms: Clca1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12722
Homologene: 77224
Tiam2
Name: T cell lymphoma invasion and metastasis 2
Synonyms: STEF, 3000002F19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 24001
VEGA: 17
Homologene: 40796
Lrrcc1
Name: leucine rich repeat and coiled-coil domain containing 1
Synonyms: 4932441F23Rik, 1200008A14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 71710
Homologene: 12559
Olfr410
Name: olfactory receptor 410
Synonyms: GA_x6K02T2P1NL-4467421-4466474, MOR255-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258702
Homologene: 68262
Cep250
Name: centrosomal protein 250
Synonyms: Inmp, B230210E21Rik, Cep2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16328
HGNC: HGNC:1859
Homologene: 38286
Olfr93
Name: olfactory receptor 93
Synonyms: MOR256-39P, GA_x6K02T2PSCP-1592036-1591098
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 258051
HGNC: HGNC:8252
Homologene: 79436
Psg22
Name: pregnancy-specific glycoprotein 22
Synonyms: cea9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243862
Homologene: 110989
Adam3
Name: a disintegrin and metallopeptidase domain 3 (cyritestin)
Synonyms: Taz83, tMDC, Cyrn1, ADAM3, Taz83
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11497
HGNC: HGNC:209
Homologene: 69052
Olfr1135
Name: olfactory receptor 1135
Synonyms: GA_x6K02T2Q125-49177531-49176599, MOR177-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258654
Homologene: 17331
Igdcc4
Name: immunoglobulin superfamily, DCC subclass, member 4
Synonyms: 9330155G14Rik, WI-18508, Nope, WI-16786
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 56741
VEGA: 9
Homologene: 10570
Gm6994
Name: predicted gene 6994
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 629678
Dnajc28
Name: DnaJ heat shock protein family (Hsp40) member C28
Synonyms: ORF28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 246738
HGNC: HGNC:1297
Homologene: 9869
Bmp5
Name: bone morphogenetic protein 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12160
HGNC: HGNC:1072
Homologene: 22412
Kcnk18
Name: potassium channel, subfamily K, member 18
Synonyms: LOC332396, Tresk-2, Tresk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 332396
VEGA: 19
Homologene: 133808
Rps27l
Name: ribosomal protein S27-like
Synonyms: 1810034D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 67941
Homologene: 69197
Tmem255b
Name: transmembrane protein 255B
Synonyms: LOC272465, Fam70b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 272465
Homologene: 18804
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 4,348,027 bp
  • T to G, chromosome 1 at 4,841,098 bp
  • A to G, chromosome 2 at 87,671,945 bp
  • T to A, chromosome 2 at 131,071,337 bp
  • C to T, chromosome 2 at 153,878,479 bp
  • A to T, chromosome 2 at 155,407,650 bp
  • G to A, chromosome 2 at 155,992,632 bp
  • T to C, chromosome 3 at 14,554,292 bp
  • A to G, chromosome 3 at 144,758,024 bp
  • G to T, chromosome 3 at 145,576,236 bp
  • T to C, chromosome 3 at 151,732,388 bp
  • T to C, chromosome 4 at 41,093,836 bp
  • A to G, chromosome 4 at 95,998,720 bp
  • C to T, chromosome 4 at 115,875,493 bp
  • T to C, chromosome 5 at 115,611,175 bp
  • A to C, chromosome 7 at 16,370,366 bp
  • C to A, chromosome 7 at 18,726,837 bp
  • T to G, chromosome 7 at 31,060,612 bp
  • T to C, chromosome 7 at 35,615,840 bp
  • T to A, chromosome 7 at 44,319,774 bp
  • G to A, chromosome 7 at 46,300,044 bp
  • T to C, chromosome 7 at 108,368,081 bp
  • A to T, chromosome 7 at 127,866,826 bp
  • T to C, chromosome 7 at 128,205,170 bp
  • C to T, chromosome 8 at 13,451,081 bp
  • T to C, chromosome 8 at 24,711,384 bp
  • C to T, chromosome 8 at 91,033,987 bp
  • G to A, chromosome 8 at 105,269,996 bp
  • C to A, chromosome 8 at 111,869,717 bp
  • A to G, chromosome 8 at 124,876,920 bp
  • C to A, chromosome 9 at 21,769,784 bp
  • T to C, chromosome 9 at 38,723,207 bp
  • C to T, chromosome 9 at 65,130,743 bp
  • T to A, chromosome 9 at 66,946,926 bp
  • A to G, chromosome 9 at 67,939,072 bp
  • T to A, chromosome 9 at 72,338,773 bp
  • T to A, chromosome 9 at 75,776,548 bp
  • C to A, chromosome 11 at 68,951,691 bp
  • T to C, chromosome 11 at 74,335,165 bp
  • T to A, chromosome 12 at 53,640,502 bp
  • A to G, chromosome 12 at 75,927,466 bp
  • T to C, chromosome 13 at 6,619,209 bp
  • C to A, chromosome 13 at 91,800,714 bp
  • C to A, chromosome 13 at 100,061,330 bp
  • T to A, chromosome 13 at 100,061,339 bp
  • T to A, chromosome 14 at 23,543,083 bp
  • A to G, chromosome 14 at 77,485,995 bp
  • A to G, chromosome 15 at 10,523,592 bp
  • T to A, chromosome 15 at 75,597,637 bp
  • A to G, chromosome 15 at 100,410,081 bp
  • G to A, chromosome 16 at 91,616,867 bp
  • G to A, chromosome 17 at 3,427,220 bp
  • A to T, chromosome 17 at 37,151,254 bp
  • T to C, chromosome 17 at 64,292,870 bp
  • A to G, chromosome 18 at 43,986,329 bp
  • A to T, chromosome 18 at 78,159,944 bp
  • G to C, chromosome 19 at 6,481,853 bp
  • G to T, chromosome 19 at 8,937,295 bp
  • A to G, chromosome 19 at 17,118,555 bp
  • T to G, chromosome 19 at 47,619,749 bp
  • T to C, chromosome 19 at 59,235,494 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2278 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040277-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.