Strain Name:
C57BL/6J-MtgxR2362Btlr/Mmmh
Stock Number:
040343-MU
Citation ID:
RRID:MMRRC_040343-MU
Other Names:
R2362 (G1), C57BL/6J-MtgxR2362Btlr
Major Collection:

Gene Information

Polr3e
Name: polymerase (RNA) III (DNA directed) polypeptide E
Synonyms: Sin, RPC5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 26939
Homologene: 14052
Sort1
Name: sortilin 1
Synonyms: Ntr3, neurotensin receptor 3, 2900053A11Rik, sortilin, Ntsr3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 20661
Homologene: 136097
Cdr2
Name: cerebellar degeneration-related 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 12585
HGNC: HGNC:1799
Homologene: 7262
Dtx4
Name: deltex 4, E3 ubiquitin ligase
Synonyms: RNF155
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 207521
VEGA: 19
Homologene: 27781
Prex2
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Synonyms: Depdc2, 6230420N16Rik, C030045D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 109294
Homologene: 23523
Rapgef6
Name: Rap guanine nucleotide exchange factor (GEF) 6
Synonyms: Pdzgef2, PDZ-GEF2, C030018K18Rik, RA-GEF-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 192786
Homologene: 22968
Slc10a7
Name: solute carrier family 10 (sodium/bile acid cotransporter family), member 7
Synonyms: 2410193C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 76775
Homologene: 81628
Asxl1
Name: additional sex combs like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228790
Homologene: 9098
Dab1
Name: disabled 1
Synonyms: C630028C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 13131
HGNC: HGNC:2661
Homologene: 32084
Ift122
Name: intraflagellar transport 122
Synonyms: Wdr10, sopb, C86139
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 81896
Homologene: 12819
Wbp11
Name: WW domain binding protein 11
Synonyms: Npwbp, 2510026P17Rik, SIPP1, D6Wsu113e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 60321
Homologene: 134037
Inpp5j
Name: inositol polyphosphate 5-phosphatase J
Synonyms: Pib5pa, Pipp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 170835
HGNC: HGNC:8956
Homologene: 8682
Rnf103
Name: ring finger protein 103
Synonyms: Zfp103, kf-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 22644
Homologene: 4146
Eps15
Name: epidermal growth factor receptor pathway substrate 15
Synonyms: 2410112D09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 13858
HGNC: HGNC:3419
Homologene: 128359
Pes1
Name: pescadillo ribosomal biogenesis factor 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 64934
HGNC: HGNC:8848
Homologene: 5984
Dapk1
Name: death associated protein kinase 1
Synonyms: 2810425C21Rik, 2310039H24Rik, DAP-Kinase, D13Ucla1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 69635
VEGA: 13
HGNC: HGNC:2674
Homologene: 3626
Rbm14
Name: RNA binding motif protein 14
Synonyms: p16, 1300007E16Rik, PSP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 56275
Homologene: 4614
Ndst3
Name: N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
Synonyms: 4921531K01Rik, 4930511P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 83398
HGNC: HGNC:7682
Homologene: 3513
Txnip
Name: thioredoxin interacting protein
Synonyms: VDUP1, mVDUP1, THIF, Hyplip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 56338
Homologene: 38186
Cntn3
Name: contactin 3
Synonyms: Pang
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 18488
HGNC: HGNC:2173
Homologene: 7461
Avl9
Name: AVL9 cell migration associated
Synonyms: 5830411G16Rik, D730049P16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 78937
Homologene: 62425
Wdr11
Name: WD repeat domain 11
Synonyms: 2900055P10Rik, Wdr11, Brwd2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 207425
Homologene: 41229
Aadat
Name: aminoadipate aminotransferase
Synonyms: mKat-2, Kyat2, Kat2, KATII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 23923
Homologene: 56540
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 22635
Homologene: 124417
Macc1
Name: metastasis associated in colon cancer 1
Synonyms: 4732474O15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 238455
Homologene: 18813
Fam160b2
Name: family with sequence similarity 160, member B2
Synonyms: Rai16, G430067P06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 239170
VEGA: 14
Homologene: 23379
Cyp2b19
Name: cytochrome P450, family 2, subfamily b, polypeptide 19
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 13090
Homologene: 104114
Olfr1477
Name: olfactory receptor 1477
Synonyms: GA_x6K02T2RE5P-3834960-3835907, MOR202-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 258691
Homologene: 110492
Clk3
Name: CDC-like kinase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 102414
VEGA: 9
HGNC: HGNC:2071
Homologene: 101534
Gm5155
Name: predicted gene 5155
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 381852
Homologene: 115938
Thbd
Name: thrombomodulin
Synonyms: TM, CD141
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 21824
Homologene: 308
Dlg5
Name: discs large MAGUK scaffold protein 5
Synonyms: 4933429D20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 71228
HGNC: HGNC:2904
Homologene: 3486
Ccdc30
Name: coiled-coil domain containing 30
Synonyms: 1700041C02Rik, 4930445I03Rik, 1700111D19Rik, 1700001O02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 73332
Homologene: 137391
Lrrcc1
Name: leucine rich repeat and coiled-coil domain containing 1
Synonyms: 4932441F23Rik, 1200008A14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 71710
Homologene: 12559
Acsm5
Name: acyl-CoA synthetase medium-chain family member 5
Synonyms: C730027J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 272428
Homologene: 69242
A630073D07Rik
Name: RIKEN cDNA A630073D07 gene
Synonyms: LOC381819
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 381819
Stambpl1
Name: STAM binding protein like 1
Synonyms: 1700095N21Rik, 8230401J17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 76630
Homologene: 23253
Fxyd1
Name: FXYD domain-containing ion transport regulator 1
Synonyms: 1110006M24Rik, 0610012C17Rik, PML, PLM, phospholemman
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 56188
HGNC: HGNC:4025
Homologene: 3691
Fxyd5
Name: FXYD domain-containing ion transport regulator 5
Synonyms: EF-8, Oit2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 18301
HGNC: HGNC:4029
Homologene: 7458
Ctsr
Name: cathepsin R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 56835
VEGA: 13
Homologene: 75127
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 11,139,947 bp
  • A to G, chromosome 2 at 148,406,364 bp
  • T to A, chromosome 2 at 153,396,719 bp
  • A to G, chromosome 3 at 14,563,024 bp
  • C to G, chromosome 3 at 96,559,447 bp
  • C to T, chromosome 3 at 108,346,665 bp
  • T to A, chromosome 3 at 123,552,678 bp
  • C to T, chromosome 4 at 104,731,751 bp
  • T to C, chromosome 4 at 109,361,230 bp
  • T to A, chromosome 4 at 119,324,056 bp
  • T to C, chromosome 5 at 137,406,314 bp
  • A to T, chromosome 6 at 56,736,570 bp
  • A to G, chromosome 6 at 71,510,017 bp
  • A to G, chromosome 6 at 102,170,704 bp
  • A to G, chromosome 6 at 115,884,350 bp
  • A to T, chromosome 6 at 132,627,479 bp
  • A to T, chromosome 6 at 136,824,332 bp
  • T to G, chromosome 7 at 17,902,473 bp
  • A to G, chromosome 7 at 26,764,377 bp
  • T to C, chromosome 7 at 31,036,471 bp
  • G to A, chromosome 7 at 31,053,878 bp
  • T to C, chromosome 7 at 119,528,426 bp
  • C to G, chromosome 7 at 120,942,564 bp
  • T to G, chromosome 7 at 120,970,331 bp
  • T to A, chromosome 7 at 129,634,836 bp
  • A to G, chromosome 8 at 60,532,298 bp
  • A to G, chromosome 8 at 78,509,632 bp
  • T to C, chromosome 9 at 57,754,619 bp
  • G to T, chromosome 11 at 3,501,438 bp
  • T to C, chromosome 11 at 3,977,123 bp
  • T to C, chromosome 11 at 54,694,272 bp
  • T to C, chromosome 12 at 119,447,658 bp
  • A to G, chromosome 13 at 60,730,931 bp
  • T to A, chromosome 13 at 61,162,796 bp
  • A to T, chromosome 14 at 24,158,687 bp
  • A to G, chromosome 14 at 70,586,365 bp
  • T to C, chromosome 19 at 4,801,707 bp
  • A to G, chromosome 19 at 12,492,535 bp
  • A to T, chromosome 19 at 13,502,508 bp
  • G to A, chromosome 19 at 34,236,354 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2362 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040343-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.