Strain Name:
C57BL/6J-MtgxR2906Btlr/Mmmh
Stock Number:
040493-MU
Citation ID:
RRID:MMRRC_040493-MU
Other Names:
R2906 (G1), C57BL/6J-MtgxR2906Btlr
Major Collection:

Strain Information

Nefh
Name: neurofilament, heavy polypeptide
Synonyms: NF-H, NF200, NEFH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 380684
HGNC: HGNC:7737
Homologene: 40755
Fryl
Name: FRY like transcription coactivator
Synonyms: 2310004H21Rik, 2510002A14Rik, 9030227G01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 72313
Homologene: 103956
Ddx4
Name: DEAD box helicase 4
Synonyms: mvh / m'vasa, VASA, Mvh, DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 13206
VEGA: 13
Homologene: 49227
Dnm1l
Name: dynamin 1-like
Synonyms: 6330417M19Rik, Drp1, python, Dnmlp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 74006
VEGA: 16
HGNC: HGNC:2973
Homologene: 6384
Kcnk1
Name: potassium channel, subfamily K, member 1
Synonyms: TWIK-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 16525
HGNC: HGNC:6272
Homologene: 1691
Rbm26
Name: RNA binding motif protein 26
Synonyms: Pro1777, C230097K14Rik, 1700009P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 74213
Homologene: 41468
Afg3l2
Name: AFG3-like AAA ATPase 2
Synonyms: 2310036I02Rik, par, Emv66
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 69597
VEGA: 18
HGNC: HGNC:315
Homologene: 4947
Rxrb
Name: retinoid X receptor beta
Synonyms: RCoR-1, H-2RIIBP, Nr2b2, Rub
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 20182
Homologene: 7923
Rassf3
Name: Ras association (RalGDS/AF-6) domain family member 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 192678
VEGA: 10
Homologene: 16365
Rpusd1
Name: RNA pseudouridylate synthase domain containing 1
Synonyms: 2310051D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 106707
VEGA: 17
Homologene: 12424
Gucy2c
Name: guanylate cyclase 2c
Synonyms: GC-C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14917
HGNC: HGNC:4688
Homologene: 3641
Ptprc
Name: protein tyrosine phosphatase, receptor type, C
Synonyms: T200, B220, CD45, Lyt-4, Ly-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19264
HGNC: HGNC:9666
Homologene: 2126
Adam32
Name: a disintegrin and metallopeptidase domain 32
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 353188
Homologene: 17021
Ap1b1
Name: adaptor protein complex AP-1, beta 1 subunit
Synonyms: beta-prime adaptin, Adtb1, b2b1660Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11764
HGNC: HGNC:554
Homologene: 21972
Mtx2
Name: metaxin 2
Synonyms: 1500012G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 53375
HGNC: HGNC:7506
Homologene: 4777
Scamp5
Name: secretory carrier membrane protein 5
Synonyms: Sc5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 56807
VEGA: 9
Homologene: 56880
Col13a1
Name: collagen, type XIII, alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 12817
HGNC: HGNC:2190
Homologene: 22421
Med12l
Name: mediator complex subunit 12-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 329650
Homologene: 43143
Uggt2
Name: UDP-glucose glycoprotein glucosyltransferase 2
Synonyms: 3110001A05Rik, 1810064L21Rik, 3110027P15Rik, A230065J02Rik, Ugcgl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 66435
Homologene: 56875
Klra3
Name: killer cell lectin-like receptor, subfamily A, member 3
Synonyms: 5E6, Ly49C, Nk-2, Ly49c, NK-2.1, Nk2.1, Nk2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16634
Homologene: 110821
Naip2
Name: NLR family, apoptosis inhibitory protein 2
Synonyms: Naip2, Naip-rs6, Birc1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17948
HGNC: HGNC:7634
Homologene: 136092
Atp7b
Name: ATPase, Cu++ transporting, beta polypeptide
Synonyms: WND, Wilson protein, Atp7a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11979
HGNC: HGNC:870
Homologene: 20063
Snx25
Name: sorting nexin 25
Synonyms: LOC382008, SBBI31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 102141
Homologene: 23744
Npr2
Name: natriuretic peptide receptor 2
Synonyms: guanylyl cyclase-B, cn, pwe
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230103
HGNC: HGNC:7944
Homologene: 2970
Dpy19l1
Name: dpy-19-like 1 (C. elegans)
Synonyms: 1100001I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244745
Homologene: 14762
Cd96
Name: CD96 antigen
Synonyms: Tactile, 1700109I12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 84544
Homologene: 68489
Ms4a15
Name: membrane-spanning 4-domains, subfamily A, member 15
Synonyms: LOC383468, E530011F12Rik, Gm1286
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 545279
Homologene: 27391
Adgrg6
Name: adhesion G protein-coupled receptor G6
Synonyms: LOC215798, 1190004A11Rik, DREG, Gpr126
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215798
Homologene: 10724
Usp45
Name: ubiquitin specific petidase 45
Synonyms: 3110003C05Rik, Gcap7, 4930550B20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 77593
Homologene: 17674
Ttll3
Name: tubulin tyrosine ligase-like family, member 3
Synonyms: 4833441J24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 101100
Homologene: 134361
Tmprss11g
Name: transmembrane protease, serine 11g
Synonyms: 9930032O22Rik, Desc4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 320454
Homologene: 82239
Lax1
Name: lymphocyte transmembrane adaptor 1
Synonyms: E430019B13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240754
Homologene: 49504
Zfp639
Name: zinc finger protein 639
Synonyms: 6230400O18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 67778
Homologene: 9473
Oxct2b
Name: 3-oxoacid CoA transferase 2B
Synonyms: Scot-t2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 353371
Homologene: 137359
Or8g24
Name: olfactory receptor family 8 subfamily G member 24
Synonyms: GA_x6K02T2PVTD-32774646-32773699, MOR171-25, Olfr938
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258430
VEGA: 9
Duoxa1
Name: dual oxidase maturation factor 1
Synonyms: Nip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 213696
Homologene: 16043
Zfp995
Name: zinc finger protein 995
Synonyms: 2210404O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 70081
Homologene: 133253
AC127247.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Gm6430
Name: predicted gene 6430
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 623430
Armcx6
Name: armadillo repeat containing, X-linked 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 278097
Homologene: 10373
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 97,024,829 bp
  • A to T, chromosome 1 at 133,688,905 bp
  • G to A, chromosome 1 at 138,064,534 bp
  • T to C, chromosome 2 at 74,866,909 bp
  • C to T, chromosome 2 at 122,304,674 bp
  • T to C, chromosome 3 at 32,519,751 bp
  • T to C, chromosome 3 at 59,257,082 bp
  • T to C, chromosome 3 at 92,806,575 bp
  • T to A, chromosome 4 at 21,834,338 bp
  • T to C, chromosome 4 at 43,643,421 bp
  • A to G, chromosome 4 at 123,117,030 bp
  • A to T, chromosome 5 at 73,076,757 bp
  • A to G, chromosome 5 at 86,492,802 bp
  • G to C, chromosome 6 at 113,392,510 bp
  • G to T, chromosome 6 at 130,333,339 bp
  • A to T, chromosome 6 at 136,708,387 bp
  • G to A, chromosome 8 at 22,011,554 bp
  • A to T, chromosome 8 at 24,863,504 bp
  • T to C, chromosome 8 at 46,049,523 bp
  • G to T, chromosome 8 at 125,995,799 bp
  • A to T, chromosome 9 at 24,430,420 bp
  • A to G, chromosome 9 at 39,078,373 bp
  • A to G, chromosome 9 at 57,443,863 bp
  • A to G, chromosome 10 at 14,432,950 bp
  • T to C, chromosome 10 at 61,860,488 bp
  • A to G, chromosome 10 at 121,414,392 bp
  • A to G, chromosome 11 at 4,940,216 bp
  • T to A, chromosome 11 at 5,031,641 bp
  • A to C, chromosome 13 at 100,161,996 bp
  • G to T, chromosome 13 at 112,620,777 bp
  • T to A, chromosome 14 at 105,142,834 bp
  • C to T, chromosome 14 at 119,019,507 bp
  • A to T, chromosome 16 at 16,314,311 bp
  • T to C, chromosome 16 at 46,051,487 bp
  • T to C, chromosome 17 at 21,880,266 bp
  • T to C, chromosome 17 at 25,730,731 bp
  • T to A, chromosome 17 at 34,036,463 bp
  • G to A, chromosome 18 at 67,440,222 bp
  • A to G, chromosome 19 at 10,993,113 bp
  • A to T, chromosome X at 134,749,450 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2906 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040493-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.