Strain Name:
C57BL/6J-MtgxR2910Btlr/Mmmh
Stock Number:
040497-MU
Citation ID:
RRID:MMRRC_040497-MU
Other Names:
R2910 (G1), C57BL/6J-MtgxR2910Btlr
Major Collection:

Gene Information

Sema6d
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
Synonyms: Sema6D-2, Sema6D-4, Sema6D-1, Sema6D-6, 1110067B02Rik, Sema6D-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 214968
Homologene: 16195
Snx2
Name: sorting nexin 2
Synonyms: 0610030A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 67804
VEGA: 18
Homologene: 2332
Tfpi
Name: tissue factor pathway inhibitor
Synonyms: A630013F22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 21788
Homologene: 4579
Mbtps1
Name: membrane-bound transcription factor peptidase, site 1
Synonyms: S1P, SKI-1, 0610038M03Rik, site-1 protease, subtilisin/kexin isozyme-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 56453
Homologene: 2808
Odf2l
Name: outer dense fiber of sperm tails 2-like
Synonyms: 4733401D09Rik, 9630045K08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 52184
Homologene: 12011
Rgs3
Name: regulator of G-protein signaling 3
Synonyms: C2PA-RGS3, RGS3S, 4930506N09Rik, C2pa, PDZ-RGS3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 50780
HGNC: HGNC:9999
Homologene: 32440
Cep104
Name: centrosomal protein 104
Synonyms: BC046331
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230967
Homologene: 44919
Ddx1
Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 104721
VEGA: 12
HGNC: HGNC:2734
Homologene: 3627
Ankrd11
Name: ankyrin repeat domain 11
Synonyms: 3010027A04Rik, Yod, 9530048I21Rik, 2410104C19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 77087
Homologene: 69134
Fbxo38
Name: F-box protein 38
Synonyms: 6030410I24Rik, SP329
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 107035
VEGA: 18
Homologene: 34526
Asxl1
Name: additional sex combs like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228790
Homologene: 9098
Cog8
Name: component of oligomeric golgi complex 8
Synonyms: C87832
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 97484
Homologene: 13018
Tmeff1
Name: transmembrane protein with EGF-like and two follistatin-like domains 1
Synonyms: tomoregulin-like, M7365
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230157
Homologene: 130458
Vps50
Name: VPS50 EARP/GARPII complex subunit
Synonyms: 1700034M03Rik, Ccdc132, 8430415E05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 73288
Homologene: 11498
Pigr
Name: polymeric immunoglobulin receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 18703
HGNC: HGNC:8968
Homologene: 1984
Grhl3
Name: grainyhead like transcription factor 3
Synonyms: ct, Som, Get1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230824
Homologene: 18864
Mme
Name: membrane metallo endopeptidase
Synonyms: neprilysin, NEP, neutral endopeptidase, CD10, 6030454K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 17380
HGNC: HGNC:7154
Homologene: 5275
Abcf3
Name: ATP-binding cassette, sub-family F (GCN20), member 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 27406
HGNC: HGNC:72
Homologene: 22784
Plekhm3
Name: pleckstrin homology domain containing, family M, member 3
Synonyms: Plekhm1l, A230102O09Rik, 9430067K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 241075
Homologene: 18459
Tac1
Name: tachykinin 1
Synonyms: SP, 4930528L02Rik, NK-1, substance P, preprotachykinin A, PPT-A, Nkna, neurokinin 1, PPTA, neurokinin A, NK1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 21333
Homologene: 2394
Dock2
Name: dedicator of cyto-kinesis 2
Synonyms: MBC, Hch, CED-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 94176
HGNC: HGNC:2988
Homologene: 37984
Lcp2
Name: lymphocyte cytosolic protein 2
Synonyms: SLP76, SLP-76, twm, m1Khoe
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 16822
HGNC: HGNC:6529
Homologene: 4065
Trpc1
Name: transient receptor potential cation channel, subfamily C, member 1
Synonyms: Mtrp1, Trrp1, Trp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 22063
Homologene: 2478
Muc5ac
Name: mucin 5, subtypes A and C, tracheobronchial/gastric
Synonyms: MGM, 2210005L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 17833
HGNC: HGNC:7515
Homologene: 137237
Zfhx4
Name: zinc finger homeodomain 4
Synonyms: Zfh-4, C130041O22Rik, Zfh4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 80892
Homologene: 23477
Kcnq1
Name: potassium voltage-gated channel, subfamily Q, member 1
Synonyms: KVLQT1, Kcna9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 16535
HGNC: HGNC:6294
Homologene: 85014
Agbl1
Name: ATP/GTP binding protein-like 1
Synonyms: EG244071, Nna1-l1, Ccp4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 244071
Homologene: 17552
Pkd1l3
Name: polycystic kidney disease 1 like 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 244646
Homologene: 14627
F5
Name: coagulation factor V
Synonyms: Cf5, Cf-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 14067
HGNC: HGNC:3542
Homologene: 104
Plekhg4
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 4
Synonyms: 4931414L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 102075
Homologene: 18516
Slc7a1
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
Synonyms: Rev-1, Rec-1, Cat1, 4831426K01Rik, Atrc1, mCAT-1, Atrc-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 11987
Homologene: 20658
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: VLGR1, Mgr1, Mass1, Gpr98
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 110789
Homologene: 19815
Rubcnl
Name: RUN and cysteine rich domain containing beclin 1 interacting protein like
Synonyms: 5031414D18Rik, LOC380917
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 271221
VEGA: 14
Homologene: 57021
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 20192
Homologene: 68151
4930458L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
Tnxb
Name: tenascin XB
Synonyms: Tnx, TN-MHC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 81877
Homologene: 49589
Ahnak
Name: AHNAK nucleoprotein (desmoyokin)
Synonyms: 1110004P15Rik, 2310047C17Rik, DY6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Iqcm
Name: IQ motif containing M
Synonyms: 1700007B14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 71831
Homologene: 53050
Cts6
Name: cathepsin 6
Synonyms: 1600022N02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 58518
Homologene: 75165
Fam227a
Name: family with sequence similarity 227, member A
Synonyms: 4933432B09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 75729
Homologene: 123434
Acap1
Name: ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
Synonyms: Centb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 216859
Homologene: 22835
F11
Name: coagulation factor XI
Synonyms: plasma thromboplastin antecedent, Cf11, 1600027G01Rik, FXI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 109821
HGNC: HGNC:3529
Homologene: 86654
Atp8b3
Name: ATPase, class I, type 8B, member 3
Synonyms: SAPLT, 1700056N23Rik, 1700042F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 67331
VEGA: 10
Homologene: 19034
Cnnm1
Name: cyclin M1
Synonyms: Acdp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 83674
VEGA: 19
HGNC: HGNC:102
Homologene: 10673
Ggt1
Name: gamma-glutamyltransferase 1
Synonyms: dwg, CD224, Ggtp, GGT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 14598
HGNC: HGNC:4250
Homologene: 68450
Vmn2r106
Name: vomeronasal 2, receptor 106
Synonyms: EG224576
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 224576
Homologene: 135824
2210407C18Rik
Name: RIKEN cDNA 2210407C18 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 78354
Homologene: 87212
Shcbp1l
Name: Shc SH2-domain binding protein 1-like
Synonyms: 1700012A16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 71836
Homologene: 12800
Vmn2r69
Name: vomeronasal 2, receptor 69
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 330581
Homologene: 115466
Gm20518
Name: predicted gene 20518
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
Olfr193
Name: olfactory receptor 193
Synonyms: GA_x54KRFPKG5P-55338697-55337768, MOR113-7P, MOR113-7P, MOR183-7P, Olfr1540-ps1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 257972
Homologene: 128162
Olfr993
Name: olfactory receptor 993
Synonyms: MOR203-2, GA_x6K02T2Q125-46891524-46890580
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258427
Homologene: 79352
Gm9875
Name: predicted gene 9875
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 105244085
VEGA: 2
Ero1lb
Name: ERO1-like beta (S. cerevisiae)
Synonyms: 1300013B24Rik, 1700065B09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 67475
VEGA: 13
Homologene: 8740
Reep2
Name: receptor accessory protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 225362
VEGA: 18
Homologene: 41146
AL670114.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 64,937,683 bp
  • A to G, chromosome 1 at 130,849,533 bp
  • C to A, chromosome 1 at 153,428,626 bp
  • A to G, chromosome 1 at 164,204,820 bp
  • ACCCCCCCCCC to ACCCCCCCCCCCCCC, chromosome 2 at 13,558,074 bp
  • A to C, chromosome 2 at 84,444,093 bp
  • T to A, chromosome 2 at 85,414,351 bp
  • C to T, chromosome 2 at 112,730,556 bp
  • C to A, chromosome 2 at 124,665,037 bp
  • T to C, chromosome 2 at 153,401,039 bp
  • C to T, chromosome 3 at 5,397,111 bp
  • A to T, chromosome 3 at 63,327,875 bp
  • A to C, chromosome 3 at 145,124,323 bp
  • C to A, chromosome 4 at 48,614,961 bp
  • C to T, chromosome 4 at 62,697,344 bp
  • T to C, chromosome 4 at 135,559,146 bp
  • T to A, chromosome 4 at 153,995,427 bp
  • T to C, chromosome 5 at 148,352,257 bp
  • T to A, chromosome 6 at 3,536,986 bp
  • A to G, chromosome 6 at 7,559,097 bp
  • A to G, chromosome 7 at 76,419,838 bp
  • G to T, chromosome 7 at 85,406,710 bp
  • C to T, chromosome 7 at 141,807,641 bp
  • T to G, chromosome 7 at 143,425,962 bp
  • C to G, chromosome 8 at 45,241,449 bp
  • A to T, chromosome 8 at 75,714,776 bp
  • TAGTCGATGCCCGAGTC to TAGTC, chromosome 8 at 105,376,452 bp
  • A to T, chromosome 8 at 107,054,221 bp
  • A to G, chromosome 8 at 109,667,636 bp
  • A to G, chromosome 8 at 119,546,037 bp
  • A to T, chromosome 8 at 122,908,798 bp
  • C to A, chromosome 9 at 95,749,842 bp
  • G to A, chromosome 10 at 75,580,596 bp
  • G to A, chromosome 10 at 80,519,912 bp
  • G to A, chromosome 11 at 34,068,970 bp
  • A to G, chromosome 11 at 34,232,910 bp
  • G to A, chromosome 11 at 58,608,426 bp
  • A to G, chromosome 11 at 69,887,076 bp
  • C to T, chromosome 12 at 13,231,440 bp
  • T to A, chromosome 13 at 12,600,289 bp
  • A to G, chromosome 13 at 61,196,401 bp
  • T to G, chromosome 13 at 64,920,436 bp
  • G to A, chromosome 13 at 81,557,119 bp
  • C to T, chromosome 14 at 75,040,808 bp
  • A to T, chromosome 15 at 79,636,734 bp
  • G to A, chromosome 16 at 17,838,142 bp
  • A to G, chromosome 16 at 20,560,232 bp
  • C to T, chromosome 16 at 59,110,181 bp
  • A to C, chromosome 17 at 20,278,684 bp
  • A to G, chromosome 17 at 34,672,450 bp
  • T to C, chromosome 18 at 34,845,690 bp
  • C to T, chromosome 18 at 53,199,874 bp
  • T to C, chromosome 18 at 62,519,807 bp
  • A to G, chromosome 19 at 9,011,654 bp
  • A to G, chromosome 19 at 43,469,647 bp
  • A to C, chromosome X at 108,664,765 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2910 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040497-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.