Strain Name:
C57BL/6J-MtgxR2923Btlr/Mmmh
Stock Number:
040508-MU
Citation ID:
RRID:MMRRC_040508-MU
Other Names:
R2923 (G1), C57BL/6J-MtgxR2923Btlr
Major Collection:

Gene Information

St8sia1
Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
Synonyms: Siat8, GD3 synthase, ST8Sia I, Siat8a, 9330109E03Rik, alpha-2,8-sialyltransferase, GD3S
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 20449
Homologene: 2282
Ppp1r16b
Name: protein phosphatase 1, regulatory subunit 16B
Synonyms: C130078N17Rik, Wdt4, ANKRD4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228852
Homologene: 9194
Cemip2
Name: cell migration inducing hyaluronidase 2
Synonyms: 3110012M15Rik, Tmem2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 83921
VEGA: 19
Homologene: 75008
Rpl22
Name: ribosomal protein L22
Synonyms: 2700038K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 19934
Homologene: 37378
Carmil1
Name: capping protein regulator and myosin 1 linker 1
Synonyms: Carmil, Lrrc16, Lrrc16a, 1110037D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 68732
Homologene: 9757
Golga4
Name: golgi autoantigen, golgin subfamily a, 4
Synonyms: golgin-245, Olp-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 54214
HGNC: HGNC:4427
Homologene: 68224
Mib1
Name: mindbomb E3 ubiquitin protein ligase 1
Synonyms: Mib, mind bomb-1, E430019M12Rik, skeletrophin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 225164
Homologene: 10810
Setx
Name: senataxin
Synonyms: A930037J23Rik, Als4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 269254
HGNC: HGNC:445
Homologene: 41003
Camsap2
Name: calmodulin regulated spectrin-associated protein family, member 2
Synonyms: 4930541M15Rik, Camsap1l1, 1600013L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 67886
Homologene: 18927
Gapvd1
Name: GTPase activating protein and VPS9 domains 1
Synonyms: 4432404J10Rik, 2010005B09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 66691
Homologene: 32637
Ncor2
Name: nuclear receptor co-repressor 2
Synonyms: SMRT, SMRTe
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 20602
HGNC: HGNC:7673
Homologene: 31370
Dhx40
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 40
Synonyms: ARG147, 2410016C14Rik, DDX40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 67487
Homologene: 57000
Clpb
Name: ClpB caseinolytic peptidase B
Synonyms: Skd3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 20480
Homologene: 32067
Tmx1
Name: thioredoxin-related transmembrane protein 1
Synonyms: Txndc1, 2810425A04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 72736
Homologene: 12482
Ipo9
Name: importin 9
Synonyms: 0710008K06Rik, Imp9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 226432
Homologene: 5874
Grm7
Name: glutamate receptor, metabotropic 7
Synonyms: Tg(SMN2)89Ahmb, SMN2, 6330570A01Rik, mGlu7a receptor, E130018M02Rik, Gpr1g, mGluR7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 108073
HGNC: HGNC:4599
Homologene: 20233
Zdhhc18
Name: zinc finger, DHHC domain containing 18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 503610
Homologene: 110918
Hdc
Name: histidine decarboxylase
Synonyms: Hdc-c, Hdc-e, Hdc-s, L-histidine decarboxylase, Hdc-a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 15186
HGNC: HGNC:4855
Homologene: 20490
Nipal3
Name: NIPA-like domain containing 3
Synonyms: 9130020G22Rik, Npal3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 74552
Homologene: 10722
Atp12a
Name: ATPase, H+/K+ transporting, nongastric, alpha polypeptide
Synonyms: Atp1al1, cHKA, HKalpha2, ATPase H+K+-transporting, alpha 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 192113
VEGA: 14
Homologene: 68197
Grm6
Name: glutamate receptor, metabotropic 6
Synonyms: nerg1, mGluR6, nob3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 108072
HGNC: HGNC:4598
Homologene: 20232
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: LOC382552, 2810003K23Rik, Dnahcl1, Dnahc17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Ccdc116
Name: coiled-coil domain containing 116
Synonyms: 4930432J16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 76872
Homologene: 51873
Astn2
Name: astrotactin 2
Synonyms: 1d8, Astnl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 56079
Homologene: 77850
Stab2
Name: stabilin 2
Synonyms: STAB-2, FEEL-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 192188
Homologene: 23022
AC225448.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
D430041D05Rik
Name: RIKEN cDNA D430041D05 gene
Synonyms: G2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 241589
Homologene: 115928
Ccdc88b
Name: coiled-coil domain containing 88B
Synonyms: 2610041P08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 78317
VEGA: 19
Homologene: 49992
Tuba8
Name: tubulin, alpha 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 53857
Homologene: 56766
Adamts3
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3
Synonyms: 1100001H14Rik, 6330442E02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 330119
HGNC: HGNC:219
Homologene: 8596
Cap2
Name: CAP, adenylate cyclase-associated protein, 2 (yeast)
Synonyms: 2810452G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 67252
Homologene: 101397
Atp6v0a2
Name: ATPase, H+ transporting, lysosomal V0 subunit A2
Synonyms: TJ6s, ATP6a2, Atp6n2, 8430408C20Rik, Tj6, V-ATPase a2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 21871
Homologene: 56523
Cpb2
Name: carboxypeptidase B2 (plasma)
Synonyms: carboxypeptidase U, CPR, CPU, carboxypeptidase R, 1110032P04Rik, 4930405E17Rik, TAFI, thrombin-activatable fibrinolysis inhibitor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 56373
VEGA: 14
HGNC: HGNC:2300
Homologene: 55610
Kcnk3
Name: potassium channel, subfamily K, member 3
Synonyms: Task-1, cTBAK-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 16527
HGNC: HGNC:6278
Homologene: 1692
Pnpla2
Name: patatin-like phospholipase domain containing 2
Synonyms: desnutrin, Atgl, 1110001C14Rik, 0610039C21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 66853
Homologene: 10687
Ccn5
Name: cellular communication network factor 5
Synonyms: CCN5, Crgr4, Wisp2, rCop1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22403
Homologene: 2882
Olfr1218
Name: olfactory receptor 1218
Synonyms: GA_x6K02T2Q125-50536041-50535106, MOR233-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258815
Homologene: 73986
Ovch2
Name: ovochymase 2
Synonyms: 9230106D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 244199
Homologene: 18255
Syne3
Name: spectrin repeat containing, nuclear envelope family member 3
Synonyms: nesprin-3, nesprin-3beta, nesprin-3alpha, 4831426I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 212073
VEGA: 12
Homologene: 17625
Olfr644
Name: olfactory receptor 644
Synonyms: GA_x6K02T2PBJ9-6803062-6802118, MOR13-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 259125
Homologene: 17491
Rdm1
Name: RAD52 motif 1
Synonyms: 2410008M22Rik, Rad52b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 66599
Homologene: 11992
Adam4
Name: a disintegrin and metallopeptidase domain 4
Synonyms: tMDCV
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 11498
Homologene: 86950
Fhl3
Name: four and a half LIM domains 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 14201
HGNC: HGNC:3704
Homologene: 37928
Ttll1
Name: tubulin tyrosine ligase-like 1
Synonyms: 6330444E16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 319953
HGNC: HGNC:1312
Homologene: 8174
Zhx1
Name: zinc fingers and homeoboxes 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 22770
Homologene: 5225
Rptn
Name: repetin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 20129
Homologene: 84780
Mboat2
Name: membrane bound O-acyltransferase domain containing 2
Synonyms: 2810049G06Rik, Oact2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 67216
VEGA: 12
Homologene: 6971
Serpinb5
Name: serine (or cysteine) peptidase inhibitor, clade B, member 5
Synonyms: ovalbumin, Spi7, Maspin, 1110036M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 20724
HGNC: HGNC:8949
Homologene: 20580
Gm10604
Name: predicted gene 10604
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
Hoxb1
Name: homeobox B1
Synonyms: Hox-2.9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 15407
HGNC: HGNC:5111
Homologene: 1615
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 106,876,040 bp
  • G to T, chromosome 1 at 135,400,129 bp
  • G to A, chromosome 1 at 136,280,809 bp
  • GTGGCT to GT, chromosome 2 at 29,154,061 bp
  • A to T, chromosome 2 at 34,688,863 bp
  • A to G, chromosome 2 at 89,054,499 bp
  • G to A, chromosome 2 at 104,255,315 bp
  • G to A, chromosome 2 at 126,593,990 bp
  • G to T, chromosome 2 at 158,756,957 bp
  • G to A, chromosome 2 at 163,832,346 bp
  • A to G, chromosome 3 at 93,398,708 bp
  • C to T, chromosome 4 at 11,980,122 bp
  • T to C, chromosome 4 at 65,913,773 bp
  • T to C, chromosome 4 at 124,705,670 bp
  • G to T, chromosome 4 at 133,633,144 bp
  • A to T, chromosome 4 at 135,477,465 bp
  • C to A, chromosome 4 at 152,327,545 bp
  • T to C, chromosome 5 at 30,622,070 bp
  • T to C, chromosome 5 at 89,861,534 bp
  • C to T, chromosome 5 at 124,717,917 bp
  • A to G, chromosome 5 at 125,055,791 bp
  • T to A, chromosome 6 at 111,495,905 bp
  • G to T, chromosome 6 at 121,220,369 bp
  • A to T, chromosome 6 at 142,829,237 bp
  • A to G, chromosome 7 at 101,722,828 bp
  • A to G, chromosome 7 at 104,068,587 bp
  • A to G, chromosome 7 at 107,790,389 bp
  • T to A, chromosome 7 at 141,455,467 bp
  • T to A, chromosome 9 at 118,559,343 bp
  • A to G, chromosome 10 at 86,861,461 bp
  • G to C, chromosome 11 at 50,864,521 bp
  • T to G, chromosome 11 at 86,789,263 bp
  • T to C, chromosome 11 at 96,366,293 bp
  • T to A, chromosome 11 at 101,630,890 bp
  • A to G, chromosome 11 at 118,093,547 bp
  • T to A, chromosome 12 at 24,954,240 bp
  • T to A, chromosome 12 at 70,466,121 bp
  • A to T, chromosome 12 at 81,420,744 bp
  • A to T, chromosome 12 at 104,968,084 bp
  • A to G, chromosome 13 at 24,075,754 bp
  • A to T, chromosome 13 at 46,635,819 bp
  • A to T, chromosome 14 at 56,374,622 bp
  • T to C, chromosome 14 at 75,256,033 bp
  • T to C, chromosome 15 at 58,053,681 bp
  • T to C, chromosome 15 at 83,492,559 bp
  • T to C, chromosome 16 at 17,142,443 bp
  • T to A, chromosome 17 at 94,877,293 bp
  • C to T, chromosome 18 at 10,760,831 bp
  • A to T, chromosome 19 at 6,854,173 bp
  • A to G, chromosome 19 at 21,817,939 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R2923 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040508-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.