Strain Name:
C57BL/6J-MtgxR3410Btlr/Mmmh
Stock Number:
040628-MU
Citation ID:
RRID:MMRRC_040628-MU
Other Names:
R3410 (G1), C57BL/6J-MtgxR3410Btlr
Major Collection:

Gene Information

Ptch1
Name: patched 1
Synonyms: wig, Ptc1, Ptc, A230106A15Rik, Patched 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 19206
HGNC: HGNC:9585
Homologene: 223
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: C130061D10Rik, Pam, Phr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105689
Homologene: 9005
Ascc3
Name: activating signal cointegrator 1 complex subunit 3
Synonyms: Helic1, ASC1p200, B630009I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 77987
VEGA: 10
Homologene: 4973
Hsf2
Name: heat shock factor 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 15500
VEGA: 10
HGNC: HGNC:5225
Homologene: 37931
Cct2
Name: chaperonin containing Tcp1, subunit 2 (beta)
Synonyms: Cctb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 12461
VEGA: 10
HGNC: HGNC:1615
Homologene: 4696
Mcm5
Name: minichromosome maintenance complex component 5
Synonyms: Mcmd5, mCD46, Cdc46
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 17218
HGNC: HGNC:6948
Homologene: 4904
Gspt1
Name: G1 to S phase transition 1
Synonyms: Gst-1, G1st, Gst-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 14852
HGNC: HGNC:4621
Homologene: 68226
Klhl7
Name: kelch-like 7
Synonyms: SBBI26, 2700038B03Rik, D5Ertd363e, Klhl6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 52323
Homologene: 10317
Sltm
Name: SAFB-like, transcription modulator
Synonyms: 5730555F13Rik, 5730455C01Rik, 9130215G10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 66660
VEGA: 9
Homologene: 11696
Snw1
Name: SNW domain containing 1
Synonyms: 2310008B08Rik, SKIP, NCoA-62, Skiip, SNW1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 66354
VEGA: 12
Homologene: 56557
L3mbtl3
Name: L3MBTL3 histone methyl-lysine binding protein
Synonyms: MBT-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 237339
Homologene: 18226
Clock
Name: circadian locomotor output cycles kaput
Synonyms: bHLHe8, KAT13D, 5330400M04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12753
HGNC: HGNC:2082
Homologene: 3603
Tenm4
Name: teneurin transmembrane protein 4
Synonyms: l7Rn3, Ten-m4, ELM2, Doc4, Odz4, l(7)-3Rn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 23966
Homologene: 8034
Sptb
Name: spectrin beta, erythrocytic
Synonyms: LOC383567, brain erythroid spectrin (235E), spectrin R, Spnb-1, Spnb1, D330027P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20741
Homologene: 295
Adgra3
Name: adhesion G protein-coupled receptor A3
Synonyms: Tem5-like, 3830613O22Rik, Gpr125
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 70693
Homologene: 19235
Atp5o
Name: ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
Synonyms: D12Wsu28e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 28080
HGNC: HGNC:850
Homologene: 1283
Ccdc88a
Name: coiled coil domain containing 88A
Synonyms: GIV, A430106J12Rik, C130096N06Rik, C330012F17Rik, D130005J21Rik, HkRP1, Girdin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 108686
Homologene: 41180
Rhbdf2
Name: rhomboid 5 homolog 2
Synonyms: Rhbdl6, iRhom2, cub, 4732465I17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217344
Homologene: 11612
Dnah1
Name: dynein, axonemal, heavy chain 1
Synonyms: E030034C22Rik, Dnahc1, B230373P09Rik, MDHC7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 110084
VEGA: 14
HGNC: HGNC:2940
Homologene: 67131
Ttn
Name: titin
Synonyms: D330041I19Rik, mdm, L56, connectin, 2310074I15Rik, 2310057K23Rik, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Cpsf1
Name: cleavage and polyadenylation specific factor 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 94230
VEGA: 15
HGNC: HGNC:2324
Homologene: 40865
Lama3
Name: laminin, alpha 3
Synonyms: [a]3B, nicein, 150kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 16774
HGNC: HGNC:6483
Homologene: 18279
Arnt2
Name: aryl hydrocarbon receptor nuclear translocator 2
Synonyms: bHLHe1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 11864
Homologene: 7230
Sycp1
Name: synaptonemal complex protein 1
Synonyms: SCP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20957
Homologene: 2389
Fbxw28
Name: F-box and WD-40 domain protein 28
Synonyms: Gm9337
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 668758
Homologene: 110776
Dxo
Name: decapping exoribonuclease
Synonyms: Dom3z
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 112403
HGNC: HGNC:2992
Homologene: 38061
Slc22a26
Name: solute carrier family 22 (organic cation transporter), member 26
Synonyms: BC014805
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 236149
Adamts16
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 271127
Homologene: 15146
Nlrp4b
Name: NLR family, pyrin domain containing 4B
Synonyms: Nalp-gamma, Nalp4b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 210045
Homologene: 65242
Ripk4
Name: receptor-interacting serine-threonine kinase 4
Synonyms: RIP4, PKK, DIk, ANKK2, Ankrd3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 72388
HGNC: HGNC:496
Homologene: 10772
Grik5
Name: glutamate receptor, ionotropic, kainate 5 (gamma 2)
Synonyms: KA2, GluRgamma2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14809
HGNC: HGNC:4583
Homologene: 1578
Gpat2
Name: glycerol-3-phosphate acyltransferase 2, mitochondrial
Synonyms: Gpat2, A530057A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 215456
Homologene: 19037
Ovol2
Name: ovo like zinc finger 2
Synonyms: M-OVO, Zfp339, M-OVO-B, movo2, M-OVO-A, 1810007D21Rik, Ovol2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 107586
Homologene: 10930
Atp13a4
Name: ATPase type 13A4
Synonyms: 4631413J11Rik, 9330174J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224079
Homologene: 75330
Nod1
Name: nucleotide-binding oligomerization domain containing 1
Synonyms: Card4, Nlrc1, F830007N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 107607
Homologene: 4440
Serpina3n
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3N
Synonyms: antitrypsin, Spi2-2, Spi2/eb.4, Spi2.2, alpha-1 antiproteinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20716
HGNC: HGNC:16
Homologene: 111129
Olfr1453
Name: olfactory receptor 1453
Synonyms: MOR202-6, GA_x6K02T2RE5P-3357666-3356743
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 258695
Homologene: 120159
Scml4
Name: Scm polycomb group protein like 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 268297
Homologene: 18262
Vmn2r89
Name: vomeronasal 2, receptor 89
Synonyms: V2r10, V2r11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 22301
Jade2
Name: jade family PHD finger 2
Synonyms: 1200017K05Rik, Phf15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76901
Homologene: 9082
Klra17
Name: killer cell lectin-like receptor, subfamily A, member 17
Synonyms: Ly49Q, Ly-49Q, Ly49q1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 170733
Olfr494
Name: olfactory receptor 494
Synonyms: MOR204-10, GA_x6K02T2PBJ9-10697517-10698461
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258732
Homologene: 133602
Col6a2
Name: collagen, type VI, alpha 2
Synonyms: Col6a-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 12834
HGNC: HGNC:2212
Homologene: 1392
Olfr487
Name: olfactory receptor 487
Synonyms: Olfr1538-ps1, GA_x6K02T2PBJ9-10541702-10540758, MOR204-29P, MOR204-31P, MOR204-31P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258042
Homologene: 110483
Sec14l5
Name: SEC14-like lipid binding 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 665119
VEGA: 16
Homologene: 96163
Adgrg6
Name: adhesion G protein-coupled receptor G6
Synonyms: DREG, 1190004A11Rik, Gpr126, LOC215798
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215798
Homologene: 10724
Tmem67
Name: transmembrane protein 67
Synonyms: 5330408M12Rik, b2b1163.1Clo, b2b1291.1Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329795
Homologene: 71886
Alcam
Name: activated leukocyte cell adhesion molecule
Synonyms: SC1, DM-GRASP, CD166, MuSC, BEN
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 11658
HGNC: HGNC:400
Homologene: 1229
Vmn2r65
Name: vomeronasal 2, receptor 65
Synonyms: ENSMUSG00000070600
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100009609
Galnt6
Name: polypeptide N-acetylgalactosaminyltransferase 6
Synonyms: GalNAc-T6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 207839
HGNC: HGNC:4128
Homologene: 5218
Nudcd1
Name: NudC domain containing 1
Synonyms: 4921532K09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 67429
VEGA: 15
Homologene: 12128
Nlrp4c
Name: NLR family, pyrin domain containing 4C
Synonyms: Nalp-alpha, Rnh2, Nalp4c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 83564
Homologene: 75315
Ccdc185
Name: coiled-coil domain containing 185
Synonyms: 4922505E12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 433386
Homologene: 17631
Toporsl
Name: topoisomerase I binding, arginine/serine-rich like
Synonyms: 4930547C10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68274
Homologene: 130753
Adad2
Name: adenosine deaminase domain containing 2
Synonyms: 4930403J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 75773
Homologene: 16392
Adgra1
Name: adhesion G protein-coupled receptor A1
Synonyms: 2900059M17Rik, D7Ertd680e, Gpr123
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 52389
Homologene: 18582
Ppl
Name: periplakin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 19041
VEGA: 16
HGNC: HGNC:9273
Homologene: 2026
Gsdmc4
Name: gasdermin C4
Synonyms: 9030605I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 74548
HGNC: HGNC:7151
Homologene: 69487
Wdr81
Name: WD repeat domain 81
Synonyms: shakey 5, MGC32441, nur5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 192652
Homologene: 13983
Olfr945
Name: olfactory receptor 945
Synonyms: MOR171-20, GA_x6K02T2PVTD-32955932-32954982
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258499
VEGA: 9
Homologene: 133643
Six4
Name: sine oculis-related homeobox 4
Synonyms: TrexBF, AREC3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20474
Homologene: 69089
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 182,748,748 bp
  • A to C, chromosome 2 at 76,942,405 bp
  • G to A, chromosome 2 at 127,428,291 bp
  • A to G, chromosome 2 at 144,317,876 bp
  • T to C, chromosome 3 at 102,841,041 bp
  • A to T, chromosome 4 at 12,073,952 bp
  • T to C, chromosome 4 at 52,610,970 bp
  • G to T, chromosome 5 at 24,138,321 bp
  • A to G, chromosome 5 at 50,001,930 bp
  • G to A, chromosome 5 at 76,229,554 bp
  • G to T, chromosome 6 at 54,944,917 bp
  • T to A, chromosome 6 at 129,874,846 bp
  • A to G, chromosome 7 at 6,092,570 bp
  • A to G, chromosome 7 at 10,715,529 bp
  • T to C, chromosome 7 at 25,062,972 bp
  • G to A, chromosome 7 at 84,275,447 bp
  • T to C, chromosome 7 at 84,946,688 bp
  • T to C, chromosome 7 at 96,852,530 bp
  • G to A, chromosome 7 at 108,212,283 bp
  • A to T, chromosome 7 at 108,368,344 bp
  • T to C, chromosome 7 at 139,847,703 bp
  • T to C, chromosome 8 at 75,121,644 bp
  • T to C, chromosome 8 at 119,615,969 bp
  • G to T, chromosome 9 at 39,258,601 bp
  • T to G, chromosome 9 at 70,585,958 bp
  • A to T, chromosome 9 at 109,338,404 bp
  • A to G, chromosome 10 at 14,440,370 bp
  • T to C, chromosome 10 at 26,339,299 bp
  • A to G, chromosome 10 at 42,957,671 bp
  • T to C, chromosome 10 at 50,700,100 bp
  • T to C, chromosome 10 at 57,505,282 bp
  • T to C, chromosome 10 at 76,603,359 bp
  • T to C, chromosome 10 at 117,062,063 bp
  • T to A, chromosome 11 at 29,486,006 bp
  • T to C, chromosome 11 at 51,817,223 bp
  • A to G, chromosome 11 at 75,452,932 bp
  • A to G, chromosome 11 at 116,604,365 bp
  • A to G, chromosome 12 at 73,112,883 bp
  • T to G, chromosome 12 at 76,610,815 bp
  • A to T, chromosome 12 at 87,464,724 bp
  • A to G, chromosome 12 at 104,411,277 bp
  • T to G, chromosome 13 at 63,524,959 bp
  • T to C, chromosome 13 at 70,753,226 bp
  • A to T, chromosome 14 at 31,269,817 bp
  • A to T, chromosome 14 at 51,456,171 bp
  • T to C, chromosome 14 at 103,135,117 bp
  • T to C, chromosome 15 at 44,420,811 bp
  • A to G, chromosome 15 at 63,892,046 bp
  • G to T, chromosome 15 at 76,601,781 bp
  • T to C, chromosome 15 at 100,699,137 bp
  • T to C, chromosome 16 at 5,107,517 bp
  • C to T, chromosome 16 at 5,165,654 bp
  • A to T, chromosome 16 at 11,229,245 bp
  • G to T, chromosome 16 at 29,413,749 bp
  • T to C, chromosome 16 at 52,309,898 bp
  • C to T, chromosome 16 at 91,928,906 bp
  • T to C, chromosome 16 at 97,743,957 bp
  • A to G, chromosome 17 at 34,838,849 bp
  • G to C, chromosome 18 at 12,413,858 bp
  • G to T, chromosome 19 at 7,782,770 bp
  • G to C, chromosome 19 at 13,028,047 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3410 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040628-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.