Strain Name:
C57BL/6J-MtgxR3498Btlr/Mmmh
Stock Number:
040661-MU
Citation ID:
RRID:MMRRC_040661-MU
Other Names:
R3498 (G1), C57BL/6J-MtgxR3498Btlr
Major Collection:

Gene Information

Ptprf
Name: protein tyrosine phosphatase, receptor type, F
Synonyms: RPTP-LAR, LAR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 19268
HGNC: HGNC:9670
Homologene: 20623
Ranbp17
Name: RAN binding protein 17
Synonyms: 4932704E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 66011
Homologene: 36409
Serpinb6a
Name: serine (or cysteine) peptidase inhibitor, clade B, member 6a
Synonyms: Spi3, ovalbumin, 4930482L21Rik, D330015H01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20719
HGNC: HGNC:8950
Homologene: 20956
Bcat1
Name: branched chain aminotransferase 1, cytosolic
Synonyms: BCATc, Eca39, Bcat-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12035
HGNC: HGNC:976
Homologene: 20320
Polr2j
Name: polymerase (RNA) II (DNA directed) polypeptide J
Synonyms: RNA polymerase II subunit RPB14, 14.5kDa, Rpb11a, Rpo2-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20022
HGNC: HGNC:9197
Homologene: 4542
Map4
Name: microtubule-associated protein 4
Synonyms: Mtap4, MAP 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 17758
HGNC: HGNC:6862
Homologene: 1780
Ddx42
Name: DEAD box helicase 42
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 42, SF3b125, 1810047H21Rik, B430002H05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 72047
Homologene: 49137
Gnb1
Name: guanine nucleotide binding protein (G protein), beta 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 14688
HGNC: HGNC:4396
Homologene: 55532
Sde2
Name: SDE2 telomere maintenance homolog (S. pombe)
Synonyms: BC031781
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 208768
Homologene: 134327
Fosb
Name: FBJ osteosarcoma oncogene B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14282
HGNC: HGNC:3797
Homologene: 31403
Ino80d
Name: INO80 complex subunit D
Synonyms: A430093A21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227195
Homologene: 9819
Sec1
Name: secretory blood group 1
Synonyms: Fut3, GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase FUT-III
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 56546
Homologene: 431
Azi2
Name: 5-azacytidine induced gene 2
Synonyms: AZ2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 27215
Homologene: 8443
Vac14
Name: Vac14 homolog (S. cerevisiae)
Synonyms: D8Wsu151e, Tax1bp2, ingls, Trx
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234729
Homologene: 6528
Tstd2
Name: thiosulfate sulfurtransferase (rhodanese)-like domain containing 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 272027
Homologene: 16403
Kcnj11
Name: potassium inwardly rectifying channel, subfamily J, member 11
Synonyms: Kir6.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16514
HGNC: HGNC:6257
Homologene: 441
Slc7a2
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
Synonyms: Atrc2, Cat2, Tea
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 11988
Homologene: 20659
Dmpk
Name: dystrophia myotonica-protein kinase
Synonyms: Dm15, DM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13400
HGNC: HGNC:2933
Homologene: 3247
Hmcn1
Name: hemicentin 1
Synonyms: EG545370, LOC240793
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 545370
Homologene: 23741
Nell1
Name: NEL-like 1
Synonyms: B230343H07Rik, l7R6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 338352
HGNC: HGNC:7750
Homologene: 4486
Slc22a4
Name: solute carrier family 22 (organic cation transporter), member 4
Synonyms: Octn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 30805
Homologene: 81701
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: Dnahcl1, Dnahc17, LOC382552, 2810003K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Gpr35
Name: G protein-coupled receptor 35
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 64095
HGNC: HGNC:4492
Homologene: 3874
Cass4
Name: Cas scaffolding protein family member 4
Synonyms: F730031O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 320664
Homologene: 75128
Lyplal1
Name: lysophospholipase-like 1
Synonyms: Q96AVO
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226791
Homologene: 13683
Ghrhr
Name: growth hormone releasing hormone receptor
Synonyms: Ghrfr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14602
HGNC: HGNC:4266
Homologene: 640
Tmem127
Name: transmembrane protein 127
Synonyms: 2310003P10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 69470
Homologene: 9877
Slc1a4
Name: solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
Synonyms: ASCT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 55963
Homologene: 20655
Sspo
Name: SCO-spondin
Synonyms: C79529, Scospondin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243369
Homologene: 45453
Pcid2
Name: PCI domain containing 2
Synonyms: A730042J05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234069
Homologene: 10168
Prdm9
Name: PR domain containing 9
Synonyms: Meisetz, repro7, Rcr1, Dsbc1, G1-419-29
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 213389
Homologene: 104139
Vmn1r176
Name: vomeronasal 1 receptor 176
Synonyms: Gm5998
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 546943
Homologene: 128341
Slc24a4
Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
Synonyms: NCKX4, A930002M03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238384
Homologene: 17798
Slc6a21
Name: solute carrier family 6 member 21
Synonyms: 1700039E15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76713
Homologene: 66347
Prr5
Name: proline rich 5 (renal)
Synonyms: C030017C09Rik, Protor-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 109270
Homologene: 17132
Aurkc
Name: aurora kinase C
Synonyms: AIK3, IAK3, Stk13, AIE1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20871
Homologene: 68302
Olfr1031
Name: olfactory receptor 1031
Synonyms: GA_x6K02T2Q125-47470765-47471775, MOR200-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 257916
Homologene: 73973
Olfr792
Name: olfactory receptor 792
Synonyms: GA_x6K02T2PULF-11219415-11220350, MOR108-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258150
Homologene: 133881
Mindy4
Name: MINDY lysine 48 deubiquitinase 4
Synonyms: Fam188b, C330043M08Rik, LOC384387
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330323
Homologene: 49991
P4ha2
Name: procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha II polypeptide
Synonyms: P4hl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18452
HGNC: HGNC:8547
Homologene: 55806
Mgat5
Name: mannoside acetylglucosaminyltransferase 5
Synonyms: 5330407H02Rik, 4930471A21Rik, GlcNAc-TV, beta1,6N-acetylglucosaminyltransferase V
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 107895
HGNC: HGNC:7049
Homologene: 1808
Ighe
Name: Immunoglobulin heavy constant epsilon
Synonyms: LOC380792, Gm900
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 380792
1700001C19Rik
Name: RIKEN cDNA 1700001C19 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 75462
Homologene: 129540
Gm6729
Name: predicted gene 6729
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 627035
VEGA: 10
Homologene: 141143
Tmem229b-ps
Name: transmembrane protein 229B, pseudogene
Synonyms: Gm5423
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 432460
VEGA: 10
Taco1
Name: translational activator of mitochondrially encoded cytochrome c oxidase I
Synonyms: Ccdc44, 2310066I18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 70207
Homologene: 39079
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 63,061,210 bp
  • A to G, chromosome 1 at 92,983,391 bp
  • A to G, chromosome 1 at 127,384,834 bp
  • A to T, chromosome 1 at 150,605,102 bp
  • T to A, chromosome 1 at 180,858,185 bp
  • A to G, chromosome 1 at 186,088,660 bp
  • T to A, chromosome 2 at 85,992,430 bp
  • T to A, chromosome 2 at 127,256,120 bp
  • C to T, chromosome 2 at 172,432,558 bp
  • A to G, chromosome 4 at 46,124,031 bp
  • A to T, chromosome 4 at 118,224,930 bp
  • T to A, chromosome 4 at 155,555,026 bp
  • T to C, chromosome 5 at 136,122,770 bp
  • A to G, chromosome 6 at 48,467,980 bp
  • A to G, chromosome 6 at 55,216,525 bp
  • A to G, chromosome 6 at 55,383,771 bp
  • A to G, chromosome 6 at 145,019,342 bp
  • A to G, chromosome 7 at 7,000,030 bp
  • T to C, chromosome 7 at 19,086,381 bp
  • C to T, chromosome 7 at 19,306,632 bp
  • T to A, chromosome 7 at 23,835,242 bp
  • T to A, chromosome 7 at 45,280,842 bp
  • T to C, chromosome 7 at 45,679,239 bp
  • T to C, chromosome 7 at 46,099,602 bp
  • T to A, chromosome 7 at 50,258,179 bp
  • A to G, chromosome 8 at 13,100,413 bp
  • A to G, chromosome 8 at 40,912,530 bp
  • A to G, chromosome 8 at 110,671,090 bp
  • G to T, chromosome 9 at 110,035,212 bp
  • A to G, chromosome 9 at 118,049,407 bp
  • C to T, chromosome 10 at 53,475,127 bp
  • T to C, chromosome 10 at 86,540,718 bp
  • T to A, chromosome 10 at 129,540,909 bp
  • A to T, chromosome 11 at 20,313,973 bp
  • GCCTGGATACTGACC to GCC, chromosome 11 at 33,219,203 bp
  • T to G, chromosome 11 at 53,992,053 bp
  • T to C, chromosome 11 at 54,119,253 bp
  • A to G, chromosome 11 at 106,072,538 bp
  • A to G, chromosome 11 at 106,231,193 bp
  • C to T, chromosome 11 at 118,080,849 bp
  • A to T, chromosome 12 at 102,234,692 bp
  • G to A, chromosome 12 at 113,271,374 bp
  • A to T, chromosome 13 at 33,918,781 bp
  • T to A, chromosome 15 at 84,703,144 bp
  • A to G, chromosome 17 at 15,562,945 bp
  • AC to A, chromosome 17 at 47,433,423 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3498 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040661-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.