Strain Name:
C57BL/6J-MtgxR3879Btlr/Mmmh
Stock Number:
040793-MU
Citation ID:
RRID:MMRRC_040793-MU
Other Names:
R3879 (G1), C57BL/6J-MtgxR3879Btlr
Major Collection:

Gene Information

Rasgrp2
Name: RAS, guanyl releasing protein 2
Synonyms: CalDAG-GEFI, Caldaggef1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 19395
HGNC: HGNC:9879
Homologene: 4250
Actn4
Name: actinin alpha 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 60595
HGNC: HGNC:166
Homologene: 55857
Pcif1
Name: PDX1 C-terminal inhibiting factor 1
Synonyms: F730014I05Rik, 2310022K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228866
Homologene: 11134
Eps8
Name: epidermal growth factor receptor pathway substrate 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 13860
HGNC: HGNC:3420
Homologene: 3272
Pdzd2
Name: PDZ domain containing 2
Synonyms: Gm21706, 4930537L06Rik, LOC223364, Pdzk3, A930022H17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 68070
Homologene: 23393
Nup210l
Name: nucleoporin 210-like
Synonyms: 4930548O11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 77595
Homologene: 28122
Abcc8
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 8
Synonyms: D930031B21Rik, SUR1, Sur
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20927
HGNC: HGNC:59
Homologene: 68048
Clasp2
Name: CLIP associating protein 2
Synonyms: CLASP2, 1500004F14Rik, CLASP2beta, CLASP2alpha, 8030404L10Rik, CLASP2gamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 76499
VEGA: 9
Homologene: 24944
Zfp462
Name: zinc finger protein 462
Synonyms: Zfpip, Gt4-2, 9430078C22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242466
Homologene: 41430
Ubfd1
Name: ubiquitin family domain containing 1
Synonyms: D7Wsu128e, D7Wsu105e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 28018
Homologene: 10430
St7l
Name: suppression of tumorigenicity 7-like
Synonyms: St7r
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229681
Homologene: 14910
Psmd9
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
Synonyms: 1500011J20Rik, P27, Bridge-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 67151
HGNC: HGNC:9567
Homologene: 2106
Calcoco1
Name: calcium binding and coiled coil domain 1
Synonyms: 1810009B06Rik, CoCoA, Gcap11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 67488
Homologene: 10845
Zfp37
Name: zinc finger protein 37
Synonyms: Tzn, Zfp-37
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 22696
Homologene: 40682
Top3a
Name: topoisomerase (DNA) III alpha
Synonyms: Top IIIa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 21975
Homologene: 3394
Nup153
Name: nucleoporin 153
Synonyms: B130015D15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218210
HGNC: HGNC:8062
Homologene: 68442
Ttn
Name: titin
Synonyms: shru, L56, mdm, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, 1100001C23Rik, connectin, D330041I19Rik, D830007G01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Zmiz2
Name: zinc finger, MIZ-type containing 2
Synonyms: 2410117E06Rik, D11Bwg0280e, Zimp7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 52915
Homologene: 18000
Trim16
Name: tripartite motif-containing 16
Synonyms: 9130006M08Rik, EBBP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 94092
Homologene: 4726
Ccdc175
Name: coiled-coil domain containing 175
Synonyms: 4930403N07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 73936
VEGA: 12
Homologene: 79144
Rnf112
Name: ring finger protein 112
Synonyms: Zfp179, neurolastin, bfp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 22671
Homologene: 5176
Tshz3
Name: teashirt zinc finger family member 3
Synonyms: Zfp537, Tsh3, teashirt3, A630038G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243931
Homologene: 10835
Grm8
Name: glutamate receptor, metabotropic 8
Synonyms: mGluR8, Gprc1h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14823
HGNC: HGNC:4600
Homologene: 654
Cyp46a1
Name: cytochrome P450, family 46, subfamily a, polypeptide 1
Synonyms: cholestrol 24-hydroxylase, Cyp46
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 13116
VEGA: 12
HGNC: HGNC:2641
Homologene: 134501
Aass
Name: aminoadipate-semialdehyde synthase
Synonyms: LOR/SDH, Lorsdh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 30956
Homologene: 4212
Ugt1a8
Name: UDP glucuronosyltransferase 1 family, polypeptide A8
Synonyms: OTTMUSG00000020811, A116
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Rgs22
Name: regulator of G-protein signalling 22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 626596
Homologene: 75047
Sned1
Name: sushi, nidogen and EGF-like domains 1
Synonyms: D430044C15Rik, Snep, 6720455I24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 208777
Homologene: 14708
Tnfrsf11a
Name: tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Synonyms: TRANCE-R, Rank
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 21934
Homologene: 2848
Gm9894
Name: predicted gene 9894
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 100417934
VEGA: 13
1700094D03Rik
Name: RIKEN cDNA 1700094D03 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 73545
VEGA: 3
Homologene: 78671
Kcnd3
Name: potassium voltage-gated channel, Shal-related family, member 3
Synonyms: potassium channel Kv4.3M, potassium channel Kv4.3L, Kv4.3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56543
HGNC: HGNC:6239
Homologene: 21036
Slc26a9
Name: solute carrier family 26, member 9
Synonyms: E030002L01Rik, anion transporter/exchanger-9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 320718
Homologene: 14179
Olfr1480
Name: olfactory receptor 1480
Synonyms: MOR202-44, GA_x6K02T2RE5P-3862389-3863336
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 404339
Homologene: 110492
Olfr286
Name: olfactory receptor 286
Synonyms: MOR286-2, EG629524, GA_x6K02T2NBG7-5528233-5529186
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 629524
Homologene: 134078
Zfp607b
Name: zinc finger protein 607B
Synonyms: C030039L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 112415
Homologene: 134321
Ccnl1
Name: cyclin L1
Synonyms: ania-6a, 2610030E23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56706
Homologene: 10541
Pigu
Name: phosphatidylinositol glycan anchor biosynthesis, class U
Synonyms: 5430426F17Rik, Cdc91l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228812
Homologene: 6553
Prame
Name: preferentially expressed antigen in melanoma
Synonyms: 4930534P07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 75829
Homologene: 87352
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 88,088,726 bp
  • A to G, chromosome 1 at 93,265,030 bp
  • C to T, chromosome 1 at 105,809,360 bp
  • A to T, chromosome 1 at 131,769,231 bp
  • A to G, chromosome 2 at 76,736,062 bp
  • A to T, chromosome 2 at 155,299,143 bp
  • G to A, chromosome 2 at 164,885,958 bp
  • A to G, chromosome 3 at 65,948,758 bp
  • T to C, chromosome 3 at 90,063,254 bp
  • A to G, chromosome 3 at 90,185,473 bp
  • G to A, chromosome 3 at 104,926,447 bp
  • C to T, chromosome 3 at 105,658,766 bp
  • G to A, chromosome 4 at 55,060,095 bp
  • A to T, chromosome 4 at 62,191,335 bp
  • C to T, chromosome 5 at 123,234,590 bp
  • G to A, chromosome 6 at 23,122,521 bp
  • A to T, chromosome 6 at 27,761,374 bp
  • A to G, chromosome 6 at 137,527,362 bp
  • A to G, chromosome 7 at 27,704,051 bp
  • G to A, chromosome 7 at 28,898,266 bp
  • C to T, chromosome 7 at 36,771,537 bp
  • T to A, chromosome 7 at 46,104,627 bp
  • T to A, chromosome 7 at 122,068,776 bp
  • T to C, chromosome 9 at 113,889,961 bp
  • T to C, chromosome 11 at 6,396,653 bp
  • A to G, chromosome 11 at 60,743,939 bp
  • G to A, chromosome 11 at 61,451,049 bp
  • G to A, chromosome 11 at 62,840,607 bp
  • C to A, chromosome 12 at 72,136,018 bp
  • A to G, chromosome 12 at 108,358,130 bp
  • A to T, chromosome 13 at 46,683,960 bp
  • T to C, chromosome 13 at 67,764,797 bp
  • A to G, chromosome 15 at 12,375,508 bp
  • T to G, chromosome 15 at 36,106,905 bp
  • C to T, chromosome 15 at 98,227,204 bp
  • T to C, chromosome 15 at 102,707,388 bp
  • A to T, chromosome 19 at 6,413,890 bp
  • A to G, chromosome 19 at 13,530,249 bp
  • T to C, chromosome X at 135,613,445 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R3879 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
040793-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.