Strain Name:
C57BL/6J-MtgxR4074Btlr/Mmmh
Stock Number:
040855-MU
Citation ID:
RRID:MMRRC_040855-MU
Other Names:
R4074 (G1), C57BL/6J-MtgxR4074Btlr
Major Collection:

Gene Information

Egf
Name: epidermal growth factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 13645
HGNC: HGNC:3229
Homologene: 1483
Slco1a5
Name: solute carrier organic anion transporter family, member 1a5
Synonyms: Oatp3, Slc21a7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 108096
Homologene: 56603
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Lrig3
Name: leucine-rich repeats and immunoglobulin-like domains 3
Synonyms: 9030421L11Rik, 9130004I02Rik, 9430095K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 320398
VEGA: 10
Homologene: 62452
Crybg3
Name: beta-gamma crystallin domain containing 3
Synonyms: Gm9581
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224273
Homologene: 28544
Chgb
Name: chromogranin B
Synonyms: secretogranin I, Scg-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12653
HGNC: HGNC:1930
Homologene: 1375
Swt1
Name: SWT1 RNA endoribonuclease homolog (S. cerevisiae)
Synonyms: 1200016B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 66875
Homologene: 32355
Rev1
Name: REV1, DNA directed polymerase
Synonyms: REV1, 1110027I23Rik, Rev1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 56210
Homologene: 32309
Etl4
Name: enhancer trap locus 4
Synonyms: Etl-4, E330027G05Rik, 6620402G01Rik, 9430077C05Rik, Skt, Sickle tail
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 208618
Homologene: 10477
Nup205
Name: nucleoporin 205
Synonyms: 3830404O05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 70699
Homologene: 45971
Zmym2
Name: zinc finger, MYM-type 2
Synonyms: SCLL, RAMP, MYM, FIM, Zfp198
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 76007
VEGA: 14
Homologene: 12631
Cnot10
Name: CCR4-NOT transcription complex, subunit 10
Synonyms: 2600001P13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 78893
VEGA: 9
Homologene: 41040
Eps15l1
Name: epidermal growth factor receptor pathway substrate 15-like 1
Synonyms: Eps15R, 9830147J04Rik, Eps15-rs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 13859
Homologene: 31881
Fcho1
Name: FCH domain only 1
Synonyms: 3322402E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74015
Homologene: 22869
Arfgap3
Name: ADP-ribosylation factor GTPase activating protein 3
Synonyms: 1810004P07Rik, 1810035F16Rik, 0610009H19Rik, 9130416J18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 66251
VEGA: 15
HGNC: HGNC:661
Homologene: 134103
Cytl1
Name: cytokine-like 1
Synonyms: C17, 4930443F05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231162
Homologene: 10254
Il17f
Name: interleukin 17F
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 257630
Homologene: 17115
Ero1a
Name: endoplasmic reticulum oxidoreductase 1 alpha
Synonyms: Ero1l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 50527
VEGA: 14
Homologene: 49392
Rrbp1
Name: ribosome binding protein 1
Synonyms: mRRp0, ES/130, p180, mRRp1.8, mRRp2, mRRp5.4, mRRp10, mRRp16.8, mRRp15b, mRRp15a, mRRp41, mRRp47, 1700087N07Rik, 5730465C04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 81910
Homologene: 68138
Usp8
Name: ubiquitin specific peptidase 8
Synonyms: Ubpy
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 84092
Homologene: 3782
Pot1a
Name: protection of telomeres 1A
Synonyms: 1500031H18Rik, Pot1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 101185
Homologene: 32263
Pdk4
Name: pyruvate dehydrogenase kinase, isoenzyme 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 27273
HGNC: HGNC:8812
Homologene: 129720
Itpr2
Name: inositol 1,4,5-triphosphate receptor 2
Synonyms: Ip3r2, Itpr5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16439
HGNC: HGNC:6181
Homologene: 37593
Dnah11
Name: dynein, axonemal, heavy chain 11
Synonyms: lrd, b2b1279Clo, b2b598Clo, b2b1289Clo, b2b1727Clo, b2b1203Clo, Dnahc11, avc4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 13411
HGNC: HGNC:2942
Homologene: 2801
Naip5
Name: NLR family, apoptosis inhibitory protein 5
Synonyms: Naip-rs3, Birc1e, Lgn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17951
HGNC: HGNC:7634
Homologene: 113589
Zfp608
Name: zinc finger protein 608
Synonyms: 4932417D18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 269023
VEGA: 18
Homologene: 18485
Tesk1
Name: testis specific protein kinase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 21754
Homologene: 4577
Srp72
Name: signal recognition particle 72
Synonyms: 72kDa, 5730576P14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 66661
Homologene: 38254
Glt6d1
Name: glycosyltransferase 6 domain containing 1
Synonyms: 4933411C14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 71103
Homologene: 18826
Myh7b
Name: myosin, heavy chain 7B, cardiac muscle, beta
Synonyms: Myh14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 668940
Homologene: 66117
Gm5134
Name: predicted gene 5134
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 333669
Homologene: 129891
D930020B18Rik
Name: RIKEN cDNA D930020B18 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216393
Homologene: 87610
Gnb3
Name: guanine nucleotide binding protein (G protein), beta 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14695
HGNC: HGNC:4400
Homologene: 55628
Tuba8
Name: tubulin, alpha 8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 53857
Homologene: 56766
Tnxb
Name: tenascin XB
Synonyms: Tnx, TN-MHC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 81877
Homologene: 49589
Olfr670
Name: olfactory receptor 670
Synonyms: GA_x6K02T2PBJ9-7589577-7588639, MOR32-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 384703
Homologene: 105163
Adam34l
Name: a disintegrin and metallopeptidase domain 34 like
Synonyms: Gm5346
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 384813
Homologene: 78104
Ighv1-4
Name: immunoglobulin heavy variable 1-4
Synonyms: Gm16694
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 432702
Myo3b
Name: myosin IIIB
Synonyms: A430065P19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 329421
Homologene: 51393
Sel1l3
Name: sel-1 suppressor of lin-12-like 3 (C. elegans)
Synonyms: 2310045A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231238
Homologene: 9054
Eqtn
Name: equatorin, sperm acrosome associated
Synonyms: 1700028B15Rik, Afaf, equatorin, 4930579C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 67753
HGNC: HGNC:1359
Homologene: 75250
Albfm1
Name: albumin superfamily member 1
Synonyms: ARG, Gm17754, 5830473C10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 622307
Homologene: 129803
Psg23
Name: pregnancy-specific glycoprotein 23
Synonyms: 1620401C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 56868
Homologene: 110989
Tm2d3
Name: TM2 domain containing 3
Synonyms: 5930422O05Rik, 1110025I09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 68634
Homologene: 12275
Vmn2r13
Name: vomeronasal 2, receptor 13
Synonyms: Gm4867
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231589
Homologene: 129606
Axl
Name: AXL receptor tyrosine kinase
Synonyms: Tyro7, Ark, Ufo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 26362
HGNC: HGNC:905
Homologene: 7583
Lilra6
Name: leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
Synonyms: 7M1, Pira3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18726
HGNC: HGNC:6607
Homologene: 134028
Scg2
Name: secretogranin II
Synonyms: SgII, Chgc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20254
Homologene: 2591
Pde11a
Name: phosphodiesterase 11A
Synonyms: A630086N24Rik, 6330414F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241489
HGNC: HGNC:8773
Homologene: 56763
Vmn2r24
Name: vomeronasal 2, receptor 24
Synonyms: EG243628
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243628
Homologene: 135915
Ttc4
Name: tetratricopeptide repeat domain 4
Synonyms: L62, 2810002P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 72354
Homologene: 31249
Atg12
Name: autophagy related 12
Synonyms: 4931423H11Rik, A330058M13Rik, Apg12l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 67526
VEGA: 18
HGNC: HGNC:588
Homologene: 37953
4921504E06Rik
Name: RIKEN cDNA 4921504E06 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70909
Homologene: 87049
Tmprss11e
Name: transmembrane protease, serine 11e
Synonyms: DESC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 243084
Homologene: 8543
Crb2
Name: crumbs family member 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241324
Homologene: 45474
Depp1
Name: DEPP1 autophagy regulator
Synonyms: Depp, 8430408G22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 213393
Homologene: 48491
Cmtr2
Name: cap methyltransferase 2
Synonyms: C730036L12Rik, Ftsjd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234728
Homologene: 10144
Ace3
Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 3
Synonyms: EG217246
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217246
Homologene: 80337
Krtap31-1
Name: keratin associated protein 31-1
Synonyms: 4733401H21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 70831
Homologene: 134336
Gm5414
Name: predicted gene 5414
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 406223
VEGA: 15
Pramel33
Name: PRAME like 33
Synonyms: Gm16427
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100040885
Homologene: 133100
Olfr1274
Name: olfactory receptor 1274
Synonyms: GA_x6K02T2Q125-51676372-51677301, MOR228-4, MOR228-5, Olfr1274-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258330
Homologene: 133650
Igkv1-133
Name: immunoglobulin kappa variable 1-133
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 628027
Ighv1-29
Name: immunoglobulin heavy variable V1-29
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 780887
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 20,777,763 bp
  • A to G, chromosome 1 at 34,192,269 bp
  • T to C, chromosome 1 at 34,228,461 bp
  • T to G, chromosome 1 at 38,054,238 bp
  • A to C, chromosome 1 at 79,436,857 bp
  • A to G, chromosome 1 at 151,394,769 bp
  • T to C, chromosome 2 at 19,480,590 bp
  • T to C, chromosome 2 at 20,809,219 bp
  • T to C, chromosome 2 at 25,794,127 bp
  • G to T, chromosome 2 at 37,786,843 bp
  • T to C, chromosome 2 at 70,289,464 bp
  • C to T, chromosome 2 at 76,337,898 bp
  • T to C, chromosome 2 at 90,400,993 bp
  • A to G, chromosome 2 at 126,752,370 bp
  • C to A, chromosome 2 at 132,793,927 bp
  • T to G, chromosome 2 at 143,963,110 bp
  • T to C, chromosome 2 at 155,618,758 bp
  • C to T, chromosome 3 at 129,735,969 bp
  • A to G, chromosome 4 at 43,443,606 bp
  • A to G, chromosome 4 at 94,919,962 bp
  • T to C, chromosome 4 at 106,670,485 bp
  • A to G, chromosome 5 at 37,735,596 bp
  • A to G, chromosome 5 at 53,154,287 bp
  • C to A, chromosome 5 at 76,998,251 bp
  • T to C, chromosome 5 at 86,715,643 bp
  • T to A, chromosome 5 at 90,592,868 bp
  • A to T, chromosome 5 at 93,485,198 bp
  • T to A, chromosome 5 at 109,156,700 bp
  • T to C, chromosome 6 at 5,491,865 bp
  • T to C, chromosome 6 at 25,752,357 bp
  • T to A, chromosome 6 at 35,192,040 bp
  • T to G, chromosome 6 at 67,725,521 bp
  • A to G, chromosome 6 at 116,652,068 bp
  • T to A, chromosome 6 at 121,222,797 bp
  • A to T, chromosome 6 at 123,787,415 bp
  • T to A, chromosome 6 at 124,836,979 bp
  • A to T, chromosome 6 at 142,268,224 bp
  • C to T, chromosome 6 at 146,373,244 bp
  • A to T, chromosome 7 at 3,914,890 bp
  • A to T, chromosome 7 at 18,607,118 bp
  • A to G, chromosome 7 at 25,763,911 bp
  • T to A, chromosome 7 at 65,697,750 bp
  • A to T, chromosome 7 at 104,960,716 bp
  • A to T, chromosome 8 at 43,626,350 bp
  • T to C, chromosome 8 at 71,710,369 bp
  • A to G, chromosome 8 at 72,380,284 bp
  • T to A, chromosome 8 at 110,221,217 bp
  • A to G, chromosome 9 at 114,622,947 bp
  • T to A, chromosome 10 at 76,008,531 bp
  • A to G, chromosome 10 at 121,656,218 bp
  • C to T, chromosome 10 at 126,013,408 bp
  • T to C, chromosome 11 at 99,908,232 bp
  • A to G, chromosome 11 at 105,997,214 bp
  • A to G, chromosome 12 at 114,487,527 bp
  • C to T, chromosome 12 at 114,817,401 bp
  • A to G, chromosome 12 at 118,045,678 bp
  • G to A, chromosome 13 at 100,246,064 bp
  • A to T, chromosome 14 at 45,292,436 bp
  • T to C, chromosome 14 at 56,903,004 bp
  • C to T, chromosome 15 at 83,303,129 bp
  • T to C, chromosome 15 at 101,625,553 bp
  • A to T, chromosome 16 at 59,555,757 bp
  • A to G, chromosome 17 at 34,671,871 bp
  • A to G, chromosome 18 at 46,737,424 bp
  • A to T, chromosome 18 at 54,898,108 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4074 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
040855-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.