Strain Name:
C57BL/6J-MtgxR4409Btlr/Mmmh
Stock Number:
041691-MU
Citation ID:
RRID:MMRRC_041691-MU
Other Names:
R4409 (G1), C57BL/6J-MtgxR4409Btlr
Major Collection:

Gene Information

Myo10
Name: myosin X
Synonyms: D15Ertd600e, myosin-X
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 17909
HGNC: HGNC:7593
Homologene: 36328
Zic4
Name: zinc finger protein of the cerebellum 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22774
Homologene: 32075
Plg
Name: plasminogen
Synonyms: Pg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18815
VEGA: 17
HGNC: HGNC:9071
Homologene: 55452
Tmem59l
Name: transmembrane protein 59-like
Synonyms: 5330410G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 67937
Homologene: 8104
Spag7
Name: sperm associated antigen 7
Synonyms: Fsa1l, FSA-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216873
Homologene: 3595
Col6a1
Name: collagen, type VI, alpha 1
Synonyms: Col6a-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 12833
HGNC: HGNC:2211
Homologene: 1391
Nacc1
Name: nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
Synonyms: 4930511N13Rik, Btbd14b, Nac1, 2010001H03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 66830
VEGA: 8
Homologene: 12042
Plk4
Name: polo like kinase 4
Synonyms: Sak, Stk18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20873
Homologene: 7962
Ccdc18
Name: coiled-coil domain containing 18
Synonyms: 1700021E15Rik, 4932411G06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 73254
Homologene: 35455
Ash1l
Name: ASH1 like histone lysine methyltransferase
Synonyms: 8030453L17Rik, KMT2H, E430018P19Rik, chromatin remodeling factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 192195
Homologene: 10225
Casr
Name: calcium-sensing receptor
Synonyms: cation sensing receptor, Gprc2a, CaR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 12374
HGNC: HGNC:1514
Homologene: 332
Macrod2
Name: mono-ADP ribosylhydrolase 2
Synonyms: 2610107G07Rik, 2900006F19Rik, 1110033L15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 72899
Homologene: 85987
Pcx
Name: pyruvate carboxylase
Synonyms: Pc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18563
VEGA: 19
HGNC: HGNC:8636
Homologene: 5422
Zfp451
Name: zinc finger protein 451
Synonyms: Kiaa0576-hp, 4930515K21Rik, 4933435G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 98403
Homologene: 9188
Ighmbp2
Name: immunoglobulin mu binding protein 2
Synonyms: RIPE3b1, Smbp2, sma, AEP, Smubp2, p110 subunit, Smbp-2, Catf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 20589
HGNC: HGNC:5542
Homologene: 1642
Sorl1
Name: sortilin-related receptor, LDLR class A repeats-containing
Synonyms: LR11, mSorLA, 2900010L19Rik, Sorla
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20660
Homologene: 2336
Sdccag8
Name: serologically defined colon cancer antigen 8
Synonyms: 5730470G24Rik, 2700048G21Rik, CCCAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 76816
Homologene: 4839
Grin1
Name: glutamate receptor, ionotropic, NMDA1 (zeta 1)
Synonyms: Rgsc174, NR1, GluRzeta1, NMDAR1, Nmdar, M100174
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14810
HGNC: HGNC:4584
Homologene: 7187
E2f1
Name: E2F transcription factor 1
Synonyms: E2F-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 13555
HGNC: HGNC:3113
Homologene: 3828
Lct
Name: lactase
Synonyms: LPH, Lphl, LOC226413
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226413
HGNC: HGNC:6530
Homologene: 124204
Adgrf5
Name: adhesion G protein-coupled receptor F5
Synonyms: 8430401C09Rik, Gpr116
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224792
VEGA: 17
Homologene: 9065
Ttn
Name: titin
Synonyms: L56, 2310074I15Rik, 2310036G12Rik, 1100001C23Rik, connectin, shru, D830007G01Rik, mdm, D330041I19Rik, 2310057K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
AAdacl4fm3
Name: AADACL4 family member 3
Synonyms: Gm13178
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 546849
Homologene: 82586
Tnfrsf1b
Name: tumor necrosis factor receptor superfamily, member 1b
Synonyms: TNFR80, TNF-alphaR2, Tnfr2, TNF-R75, TNF-R-II, TNFBR, TNFRII, TNF-R2, CD120b, p75, TNFalpha-R2, p75 TNFR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 21938
Homologene: 829
Vmn1r213
Name: vomeronasal 1 receptor 213
Synonyms: V1rh6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 171249
Homologene: 110880
Capn7
Name: calpain 7
Synonyms: PalBH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12339
HGNC: HGNC:1484
Homologene: 7651
Dnah9
Name: dynein, axonemal, heavy chain 9
Synonyms: Dnahc9, D11Ertd686e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 237806
HGNC: HGNC:2953
Homologene: 20357
Gm10226
Name: predicted gene 10226
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Zfp352
Name: zinc finger protein 352
Synonyms: 2czf48
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 236537
Homologene: 45160
Kdm1b
Name: lysine (K)-specific demethylase 1B
Synonyms: 4632428N09Rik, Aof1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218214
Homologene: 14695
Crybg1
Name: crystallin beta-gamma domain containing 1
Synonyms: Aim1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 11630
HGNC: HGNC:356
Homologene: 18168
Vmn2r73
Name: vomeronasal 2, receptor 73
Synonyms: EG620928
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 620928
Homologene: 115466
Abcb5
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 5
Synonyms: 9230106F14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 77706
HGNC: HGNC:46
Homologene: 83488
Gm8909
Name: predicted gene 8909
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 667977
HGNC: HGNC:4931
Homologene: 128352
Olfr998
Name: olfactory receptor 998
Synonyms: MOR175-5, GA_x6K02T2Q125-47069356-47070300
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258428
Homologene: 74236
Slc24a1
Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 214111
VEGA: 9
Homologene: 3472
Greb1l
Name: growth regulation by estrogen in breast cancer-like
Synonyms: mKIAA4095, AK220484
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 381157
Homologene: 73393
Vmn2r58
Name: vomeronasal 2, receptor 58
Synonyms: EG628422
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 628422
Fbxw24
Name: F-box and WD-40 domain protein 24
Synonyms: Gm5162
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 382106
Homologene: 110776
Msh5
Name: mutS homolog 5
Synonyms: G7, Mut5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 17687
HGNC: HGNC:7328
Homologene: 8415
Vmn2r120
Name: vomeronasal 2, receptor 120
Synonyms: EG224916
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224916
Car2
Name: carbonic anhydrase 2
Synonyms: Ltw-5, Lvtw-5, CA II, Car-2, CAII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12349
HGNC: HGNC:1373
Homologene: 37256
Fcgr1
Name: Fc receptor, IgG, high affinity I
Synonyms: CD64, FcgammaRI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14129
HGNC: HGNC:3613
Homologene: 475
Cd44
Name: CD44 antigen
Synonyms: Ly-24, Pgp-1, HERMES
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12505
HGNC: HGNC:1681
Homologene: 508
Cyp2c68
Name: cytochrome P450, family 2, subfamily c, polypeptide 68
Synonyms: 9030012A22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 433247
Homologene: 74936
Olfr1378
Name: olfactory receptor 1378
Synonyms: GA_x6K02T2QP88-4469162-4468215, MOR129-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258912
Homologene: 133679
Zbtb39
Name: zinc finger and BTB domain containing 39
Synonyms: 7030401O21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 320080
VEGA: 10
Homologene: 8890
Vmn1r54
Name: vomeronasal 1 receptor 54
Synonyms: V1ra9, VN7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 113851
Klhdc3
Name: kelch domain containing 3
Synonyms: Peas, 1300011D16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 71765
VEGA: 17
Homologene: 14290
Ambp
Name: alpha 1 microglobulin/bikunin precursor
Synonyms: Intin4, Itil, ASPI, HI-30, ulinastatin, Urinary Trypsin Inhibitor, UTI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11699
HGNC: HGNC:453
Homologene: 1234
Olfr722
Name: olfactory receptor 722
Synonyms: GA_x6K02T2PMLR-5566715-5565789, MOR241-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258487
Homologene: 17270
Oxgr1
Name: oxoglutarate (alpha-ketoglutarate) receptor 1
Synonyms: Cysltr3, P2Y15, Gpr99, LOC239283, Gpr80
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239283
VEGA: 14
HGNC: HGNC:4531
Homologene: 25878
Trim12a
Name: tripartite motif-containing 12A
Synonyms: 2310043C01Rik, Trim12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76681
Pcdha9
Name: protocadherin alpha 9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 192161
HGNC: HGNC:8664
Homologene: 130700
Vmn1r55
Name: vomeronasal 1 receptor 55
Synonyms: V1rd5, LOC236535, LOC384522
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 384522
Homologene: 41799
Morn4
Name: MORN repeat containing 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226123
VEGA: 19
Homologene: 16635
Msc
Name: musculin
Synonyms: MyoR, bHLHa22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17681
HGNC: HGNC:7321
Homologene: 3738
Leprel1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Gm26672
Name: predicted gene, 26672
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Gm5454
Name: predicted gene 5454
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 432800
VEGA: 13
Gm20319
Name: predicted gene, 20319
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 100504628
Gm17106
Name: predicted gene 17106
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to C, chromosome 1 at 14,755,678 bp
  • A to T, chromosome 1 at 33,777,413 bp
  • T to C, chromosome 1 at 128,304,226 bp
  • T to G, chromosome 1 at 176,868,366 bp
  • T to C, chromosome 2 at 25,310,439 bp
  • A to G, chromosome 2 at 76,897,643 bp
  • T to C, chromosome 2 at 85,590,930 bp
  • A to G, chromosome 2 at 102,865,340 bp
  • T to G, chromosome 2 at 140,418,857 bp
  • C to G, chromosome 2 at 154,564,022 bp
  • T to A, chromosome 3 at 14,895,102 bp
  • A to G, chromosome 3 at 40,806,549 bp
  • A to G, chromosome 3 at 89,007,199 bp
  • T to C, chromosome 3 at 96,284,577 bp
  • A to G, chromosome 3 at 145,006,027 bp
  • C to A, chromosome 4 at 63,152,647 bp
  • A to G, chromosome 4 at 90,225,164 bp
  • A to T, chromosome 4 at 144,721,302 bp
  • G to A, chromosome 4 at 145,224,285 bp
  • C to T, chromosome 5 at 108,220,842 bp
  • C to A, chromosome 6 at 90,269,882 bp
  • A to G, chromosome 7 at 5,147,076 bp
  • A to G, chromosome 7 at 41,872,627 bp
  • A to T, chromosome 7 at 85,871,560 bp
  • G to A, chromosome 7 at 104,306,994 bp
  • A to G, chromosome 8 at 70,487,301 bp
  • A to G, chromosome 8 at 84,673,044 bp
  • T to G, chromosome 9 at 42,035,448 bp
  • A to T, chromosome 9 at 64,948,224 bp
  • C to T, chromosome 9 at 91,372,631 bp
  • A to T, chromosome 9 at 109,608,188 bp
  • C to T, chromosome 10 at 43,998,758 bp
  • T to C, chromosome 10 at 76,721,500 bp
  • A to G, chromosome 10 at 127,742,827 bp
  • T to A, chromosome 11 at 50,969,396 bp
  • T to C, chromosome 11 at 66,085,477 bp
  • T to C, chromosome 11 at 70,664,862 bp
  • A to C, chromosome 12 at 118,872,922 bp
  • A to C, chromosome 13 at 23,011,423 bp
  • C to T, chromosome 13 at 47,072,050 bp
  • T to A, chromosome 13 at 103,357,176 bp
  • T to C, chromosome 14 at 31,355,339 bp
  • T to A, chromosome 14 at 49,895,773 bp
  • C to T, chromosome 14 at 120,022,160 bp
  • A to G, chromosome 15 at 25,807,869 bp
  • G to C, chromosome 16 at 26,105,290 bp
  • G to A, chromosome 16 at 26,712,265 bp
  • A to G, chromosome 16 at 33,045,518 bp
  • A to G, chromosome 16 at 36,500,341 bp
  • T to G, chromosome 17 at 12,390,263 bp
  • G to T, chromosome 17 at 21,691,969 bp
  • T to C, chromosome 17 at 35,039,250 bp
  • T to A, chromosome 17 at 36,165,850 bp
  • T to C, chromosome 17 at 43,441,847 bp
  • C to T, chromosome 17 at 46,677,018 bp
  • T to C, chromosome 17 at 57,509,477 bp
  • A to G, chromosome 18 at 10,503,182 bp
  • T to A, chromosome 18 at 36,999,145 bp
  • A to G, chromosome 18 at 37,768,085 bp
  • C to T, chromosome 19 at 3,271,536 bp
  • A to G, chromosome 19 at 4,610,003 bp
  • T to A, chromosome 19 at 39,739,452 bp
  • T to C, chromosome 19 at 42,078,547 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4409 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
041691-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.