Strain Name:
C57BL/6J-MtgxR5551Btlr/Mmmh
Stock Number:
043108-MU
Citation ID:
RRID:MMRRC_043108-MU
Other Names:
R5551 (G1), C57BL/6J-MtgxR5551Btlr
Major Collection:

Gene Information

Nfia
Name: nuclear factor I/A
Synonyms: NF1-A, 9430022M17Rik, 1110047K16Rik, NF1A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 18027
HGNC: HGNC:7784
Homologene: 4086
Nup155
Name: nucleoporin 155
Synonyms: D930027M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 170762
VEGA: 15
HGNC: HGNC:8063
Homologene: 43155
Tlk2
Name: tousled-like kinase 2 (Arabidopsis)
Synonyms: PKUalpha, 4933403M19Rik, protein kinase U-alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 24086
Homologene: 4993
Acap2
Name: ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
Synonyms: Centb2, 9530039J15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 78618
VEGA: 16
Homologene: 8182
Myh10
Name: myosin, heavy polypeptide 10, non-muscle
Synonyms: SMemb, nonmuscle myosin heavy chain IIB, Fltn, NMHC II-B, NMHC-B, Myosin IIB, nonmuscle myosin heavy chain II-B, Fltn, 9330167F11Rik, Myhn2, 5730504C04Rik, Myhn-2, myosin IIB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 77579
HGNC: HGNC:7568
Homologene: 55941
Dot1l
Name: DOT1-like, histone H3 methyltransferase (S. cerevisiae)
Synonyms: KMT4, mDot1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 208266
Homologene: 32779
Rtn4
Name: reticulon 4
Synonyms: Nogo-B, Nogo-A, C130026I10Rik, NOGO, 1110020G17Rik, NgA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 68585
Homologene: 10743
Nup205
Name: nucleoporin 205
Synonyms: 3830404O05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 70699
Homologene: 45971
Atp2c1
Name: ATPase, Ca++-sequestering
Synonyms: ATP2C1A, 1700121J11Rik, SPCA, PMR1, D930003G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235574
Homologene: 56672
Srrm2
Name: serine/arginine repetitive matrix 2
Synonyms: 5033413A03Rik, SRm300
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 75956
Phip
Name: pleckstrin homology domain interacting protein
Synonyms: Wdr11, 2810004D21Rik, 4632404O06Rik, Ndrp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 83946
Homologene: 41209
Abl1
Name: c-abl oncogene 1, non-receptor tyrosine kinase
Synonyms: c-Abl, E430008G22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 11350
HGNC: HGNC:76
Homologene: 3783
Ets2
Name: E26 avian leukemia oncogene 2, 3' domain
Synonyms: Ets-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 23872
HGNC: HGNC:3489
Homologene: 3838
Ssb
Name: Sjogren syndrome antigen B
Synonyms: SS-B, La protein, autoantigen La
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 20823
Homologene: 2366
Ehd4
Name: EH-domain containing 4
Synonyms: 2210022F10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 98878
HGNC: HGNC:3245
Homologene: 26430
Ccdc141
Name: coiled-coil domain containing 141
Synonyms: 2610301F02Rik, CAMDI, ENSMUSG00000075261
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 545428
Homologene: 52149
Sez6l2
Name: seizure related 6 homolog like 2
Synonyms: Psk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233878
Homologene: 8237
Lrrk2
Name: leucine-rich repeat kinase 2
Synonyms: cI-46, 4921513O20Rik, D630001M17Rik, 9330188B09Rik, LOC381026
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 66725
Homologene: 18982
Golph3
Name: golgi phosphoprotein 3
Synonyms: 4733401N08Rik, 5730410D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 66629
VEGA: 15
Homologene: 56942
Sema6a
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
Synonyms: Sema6A-1, sema, A730020P05Rik, VIa, Semaq
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 20358
Homologene: 32426
Rab23
Name: RAB23, member RAS oncogene family
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 19335
Homologene: 7503
Tars
Name: threonyl-tRNA synthetase
Synonyms: ThrRS, D15Wsu59e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 110960
VEGA: 15
Homologene: 11852
Dync2h1
Name: dynein cytoplasmic 2 heavy chain 1
Synonyms: 4432416O06Rik, DHC2, b2b414Clo, Dnchc2, m407Asp, m152Asp, D030010H02Rik, D330044F14Rik, DHC1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 110350
HGNC: HGNC:2962
Homologene: 14468
Smad5
Name: SMAD family member 5
Synonyms: Smad 5, MusMLP, Madh5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 17129
HGNC: HGNC:6771
Homologene: 4313
Gzf1
Name: GDNF-inducible zinc finger protein 1
Synonyms: Zfp336, 8430437G08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 74533
Homologene: 11200
Zfp473
Name: zinc finger protein 473
Synonyms: D030014N22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 243963
Homologene: 18698
D430042O09Rik
Name: RIKEN cDNA D430042O09 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233865
Homologene: 45841
Akap6
Name: A kinase (PRKA) anchor protein 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 238161
VEGA: 12
HGNC: HGNC:376
Homologene: 3157
Ttn
Name: titin
Synonyms: shru, connectin, mdm, 2310057K23Rik, D330041I19Rik, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, L56, 2310074I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22138
Homologene: 130650
Iqch
Name: IQ motif containing H
Synonyms: 4921504K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 78250
Homologene: 11258
Afm
Name: afamin
Synonyms: alpha albumin, Alf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 280662
HGNC: HGNC:316
Homologene: 881
Nalcn
Name: sodium leak channel, non-selective
Synonyms: A530023G15Rik, Vgcnl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 338370
VEGA: 14
Homologene: 21832
Zfp282
Name: zinc finger protein 282
Synonyms: HUB1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 101095
Homologene: 2647
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 239420
Homologene: 65982
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC5, MUC9, 2300002I04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Olfr1280
Name: olfactory receptor 1280
Synonyms: MOR248-1, GA_x6K02T2Q125-72366920-72367837
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258910
Homologene: 121540
Zfp541
Name: zinc finger protein 541
Synonyms: EG666528
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 666528
Homologene: 12991
Csmd2
Name: CUB and Sushi multiple domains 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 329942
Homologene: 89034
Adamts1
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1
Synonyms: METH-1, METH1, ADAM-TS1, ADAMTS-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 11504
HGNC: HGNC:217
Homologene: 21381
Tmc6
Name: transmembrane channel-like gene family 6
Synonyms: EVER1, D11Ertd204e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217353
Homologene: 5258
Alk
Name: anaplastic lymphoma kinase
Synonyms: CD246, Tcrz
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 11682
VEGA: 17
HGNC: HGNC:427
Homologene: 68387
Fignl1
Name: fidgetin-like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 60530
Homologene: 11063
Tex55
Name: testis expressed 55
Synonyms: 4930435E12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 74663
Homologene: 17614
Zfp946
Name: zinc finger protein 946
Synonyms: 1300003B13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 74149
Hook3
Name: hook microtubule tethering protein 3
Synonyms: E330005F07Rik, 5830454D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 320191
Homologene: 13022
Sema4c
Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
Synonyms: Semacl1, Semacl1, Semai, Semaf, M-Sema F
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 20353
Homologene: 23047
Acox1
Name: acyl-Coenzyme A oxidase 1, palmitoyl
Synonyms: AOX, D130055E20Rik, Acyl-CoA oxidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 11430
HGNC: HGNC:119
Homologene: 38299
Tcirg1
Name: T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3
Synonyms: OC-116, Atp6i, V-ATPase a3, TIRC7, ATP6a3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 27060
Homologene: 4392
Ifi209
Name: interferon activated gene 209
Synonyms: Pyhin-1, Pyhin1, Ifix
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 236312
HGNC: HGNC:5395
Homologene: 115929
Ttc12
Name: tetratricopeptide repeat domain 12
Synonyms: E330017O07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235330
Homologene: 32375
Nat8f1
Name: N-acetyltransferase 8 (GCN5-related) family member 1
Synonyms: 1110002I11Rik, Cml1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 66116
Homologene: 41446
Uqcrc2
Name: ubiquinol cytochrome c reductase core protein 2
Synonyms: 1500004O06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 67003
Homologene: 37764
Smim19
Name: small integral membrane protein 19
Synonyms: AI316807, EST-c39
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 102032
Homologene: 26703
Mesp2
Name: mesoderm posterior 2
Synonyms: bHLHc6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 17293
Homologene: 7420
Ankrd39
Name: ankyrin repeat domain 39
Synonyms: 9130416N05Rik, C030004B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 109346
Homologene: 9519
Snap23
Name: synaptosomal-associated protein 23
Synonyms: Sndt, Syndet, SNAP-23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 20619
Homologene: 37857
Ctsr
Name: cathepsin R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 56835
VEGA: 13
Homologene: 75127
Catspere1
Name: cation channel sperm associated auxiliary subunit epsilon 1
Synonyms: Gm7068, Catspere
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 631584
Homologene: 52161
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 33,734,805 bp
  • C to T, chromosome 1 at 36,541,981 bp
  • A to G, chromosome 1 at 36,552,317 bp
  • T to A, chromosome 1 at 173,641,197 bp
  • A to G, chromosome 1 at 177,872,242 bp
  • C to T, chromosome 2 at 31,801,670 bp
  • A to G, chromosome 2 at 69,871,130 bp
  • G to T, chromosome 2 at 76,889,062 bp
  • T to C, chromosome 2 at 77,014,409 bp
  • T to C, chromosome 2 at 111,315,571 bp
  • A to G, chromosome 2 at 120,127,619 bp
  • A to T, chromosome 2 at 120,594,804 bp
  • T to C, chromosome 2 at 148,684,328 bp
  • G to A, chromosome 4 at 98,014,260 bp
  • T to C, chromosome 4 at 128,510,948 bp
  • A to T, chromosome 5 at 90,531,652 bp
  • C to T, chromosome 6 at 35,223,595 bp
  • G to T, chromosome 6 at 47,890,645 bp
  • T to C, chromosome 6 at 85,910,909 bp
  • A to G, chromosome 7 at 16,090,861 bp
  • G to C, chromosome 7 at 44,734,151 bp
  • T to C, chromosome 7 at 79,811,619 bp
  • C to T, chromosome 7 at 120,645,238 bp
  • T to C, chromosome 7 at 125,820,077 bp
  • A to G, chromosome 7 at 126,966,830 bp
  • T to C, chromosome 7 at 141,868,503 bp
  • A to G, chromosome 8 at 22,463,367 bp
  • A to G, chromosome 8 at 26,068,611 bp
  • A to G, chromosome 9 at 7,031,718 bp
  • A to T, chromosome 9 at 49,471,911 bp
  • A to T, chromosome 9 at 63,496,253 bp
  • A to T, chromosome 9 at 82,926,389 bp
  • C to A, chromosome 9 at 105,459,737 bp
  • CCAGCCCCACCCTCAGCC to CCAGCC, chromosome 10 at 80,783,628 bp
  • A to T, chromosome 11 at 11,801,603 bp
  • G to A, chromosome 11 at 29,741,011 bp
  • A to G, chromosome 11 at 68,768,287 bp
  • A to G, chromosome 11 at 105,221,307 bp
  • A to G, chromosome 11 at 116,189,491 bp
  • A to G, chromosome 11 at 117,769,445 bp
  • C to T, chromosome 12 at 52,795,964 bp
  • T to C, chromosome 13 at 56,735,841 bp
  • A to T, chromosome 13 at 61,159,543 bp
  • A to T, chromosome 14 at 123,278,286 bp
  • A to G, chromosome 15 at 8,148,333 bp
  • G to A, chromosome 15 at 11,391,982 bp
  • C to A, chromosome 15 at 12,321,836 bp
  • T to C, chromosome 15 at 48,314,096 bp
  • C to T, chromosome 15 at 91,812,350 bp
  • A to G, chromosome 16 at 31,104,908 bp
  • A to G, chromosome 16 at 38,827,974 bp
  • A to G, chromosome 16 at 85,797,746 bp
  • T to C, chromosome 16 at 95,712,121 bp
  • A to G, chromosome 17 at 22,455,384 bp
  • C to A, chromosome 17 at 23,818,476 bp
  • T to C, chromosome 17 at 71,875,033 bp
  • A to G, chromosome 18 at 47,248,528 bp
  • A to T, chromosome 19 at 3,898,858 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R5551 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

The donor or their institution limits the distribution to non-profit institutions only.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
043108-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.